检索结果-南通市图书馆

Journal of Environmental Sciences 2024年第3期137卷 604-614页

作者： Di Wu Xing Lu Li-Xue Dong Juan Tian Jin Deng Lei Wei Hua Wen shan zhong Ming Jiang School of Basic Medical Sciences Wuhan UniversityWuhan 430071China Key Laboratory of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural AffairsYangtze River Fisheries Research InstituteChinese Academy of Fishery SciencesWuhan 430223China Hubei Province Key Laboratory of Allergy and Immunology Wuhan 430071China

Microplastics(MPs)have become a significant concern for their potential toxicity.However,the correlation between the size of plastic particles and their toxicity remains inconclusive.Here,we investigate the toxic effects of different sizes(80 nm,800 nm,8μm and 80μm)polystyrene MPs(PS-MPs)on the model organism Nile tilapia(Oreochromis niloticus).The results of bioluminescent imaging indicate that the 80 nm PS-MPs are more likely to invade the body.H&E staining shows severe damage on the intestinal villi and distinct hepatic steatosis in the 80 nm group.Ed U labeling shows that the proliferation activity of intestinal and liver cells reduces significantly in the 80 nm group.The gut microbiome analysis shows a severe imbalance of gut microbiota homeostasis in the 80 nm group.The analysis of liver transcriptomics and metabolomics shows that the liver lipid metabolism is disordered in the 80 nm group.In conclusion,this study confirms that the 80 nm PS-MPs are more likely to induce intestinal and liver toxicity.All the above lay the foundation for further study on the pathological damage of MPs to other organisms.

关键词： Microplastics(MPs) Intestinal toxicity Liver toxicity Gut microbiome Lipid metabolism

Influence of pore structure on thermal stress distribution inside coal particles during primary fragmentation

在线全文

学校读者我要写书评

暂无评论

Particuology 2024年第2期85卷 49-61页

作者： Kai Qiao shan zhong Siyang Tang Ke Yang Hairong Yue Kui Ma Lei Song Bin Liang School of Chemical Engineering Sichuan UniversityChengdu610065China Institute of New Energy and Low-carbon Technology Chengdu610207China

Thermal stress is an important reason of coal particle primary fragmentation,during which the role of pore structure is ambiguous.Thermal stress induced fragmentation experiments were conducted with low volatile coal/char particles,and the results show that the fragmentation severity enhances with increasing porosity.Various porous thermal stress models were developed with finite element method,and the influences of the pore shape,size,position and porosity on the thermal stress were discussed.The maximum thermal stress inside particle increases with pore curvature,the pore position affects the thermal stress more significantly at the particle center and surface.The expectation of the maximum tensile thermal stress linearly increases with porosity,making the particles with higher porosity easier to fragment,contrary to the conclusion deduced from the devolatilization theory.The obtained results are valuable for the analysis of different thermal processes concerning the thermal stresses of the solid feedstocks.

关键词： Coal particle Primary fragmentation Thermal stress Pore structure Porosity

Depletion of stearoyl-CoA desaturase(scd) leads to fatty liver disease and defective mating behavior in zebrafish

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Zoological Research 2023年第1期44卷 63-77页

作者： shan-shan Xu Yi Li Hou-Peng Wang Wen-Bo Chen Ya-Qing Wang Zi-Wei Song Hui Liu shan zhong Yong-Hua Sun Department of Genetics Wuhan University School of Basic Medical SciencesWuhanHubei 430071China State Key Laboratory of Freshwater Ecology and Biotechnology Hubei Hongshan LaboratoryInstitute of HydrobiologyInnovation Academy for Seed Design(INASEED)Chinese Academy of SciencesWuhanHubei 430072China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing 100049China Hubei Province Key Laboratory of Allergy and Immunology WuhanHubei 430071China

Stearyl coenzyme A desaturase(SCD), also known as delta-9 desaturase, catalyzes the rate-limiting step in the formation of monounsaturated fatty acids.In mammals, depletion or inhibition of SCD activity generally leads to a decrease in triglycerides and cholesteryl esters. However, the endogenous role of scd in teleost fish remains unknown. Here, we generated a zebrafish scd mutant(scd-/-) to elucidate the role of scd in lipid metabolism and sexual development. Gas chromatography-mass spectrometry(GC-MS) showed that the scd-/- mutants had increased levels of saturated fatty acids C16:0 and C18:0, and decreased levels of monounsaturated fatty acids C16:1 and C18:1. The mutant fish displayed a short stature and an enlarged abdomen during development. Unlike Scd-/ -mammals, the scd-/- zebrafish showed significantly increased fat accumulation in the whole body,especially in the liver, leading to hepatic mitochondrial dysfunction and severe cell apoptosis.Mechanistically, srebf1, a gene encoding a transcriptional activator related to adipogenesis,acc1 and acaca, genes involved in fatty acid synthesis, and dgat2, a key gene involved in triglyceride synthesis, were significantly upregulated in mutant livers to activate fatty acid biosynthesis and adipogenesis. The scd-/- males exhibited defective natural mating behavior due to defective genital papillae but possessed functional mature sperm. All defects in the scd-/- mutants could be rescued by ubiquitous transgenic overexpression of scd. In conclusion, our study demonstrates that scd is indispensable for maintaining lipid homeostasis and development of secondary sexual characteristics in zebrafish.

关键词： Zebrafish scd Liver Lipid homeostasis Reproduction

Application of pulsed chemical vapor deposition on the SiO_(2)-coated TiO_(2) production within a rotary reactor at room temperature

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2022年第5期35卷 22-31页

作者： Ke Yang shan zhong Hairong Yue Siyang Tang Kui Ma Changjun Liu Kai Qiao Bin Liang School of Chemical Engineering Sichuan UniversityChengdu 610065China Institute of New Energy and Low-carbon Technology Chengdu 610207China

Pulsed chemical vapor deposition(P-CVD)is a promising technology for the surface modification of TiO_(2) particles.For the scale-up application of P-CVD,a custom-designed rotary reactor and corresponding coating process at room temperature was developed in the present work.The obtained SiO_(2)-coated TiO_(2) particles were characterized by various measures including high-resolution transmission electron microscope,Fourier transform infrared spectroscopy,X-ray diffraction,etc.The results illustrated that the SiO_(2) films with a thickness of(3.7±0.7)nm were successfully deposited onto the surface of TiO_(2) particles.According to the dye degradation tests and acid solubility measurement,the deposited film can effectively inhibit the photocatalytic activity and enhance the weatherability of the TiO_(2) particles.Zeta potential measurements showed that the SiO_(2)-coated TiO_(2) is possible to be stably dispersed in the pH range of 6.9–11.6.The coating process made the whiteness of TiO_(2) particles decreased slightly but still sufficient(97.3±0.1)for application.Furthermore,the properties of the TiO_(2) particles coated by PCVD were compared with the particles coated by traditional wet chemical deposition.It is shown that the P-CVD can produce thinner but denser films with better photoactivity suppression performance.The developed coating process within the rotary reactor was proved practically feasible and convenient for the scale-up production of SiO_(2)-coated TiO_(2) via P-CVD.

关键词： Film Pulsed-CVD Scale-up Deactivation Pigmentary properties

Superior resistance to alkali metal potassium of vanadium-based NH_(3)-SCR catalyst promoted by the solid superacid SO_(4)^(2-)-TiO_(2)

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2023年第3期55卷 246-256页

作者： Yaoyao Peng Lei Song Siru Lu Ziyu Su Kui Ma Siyang Tang shan zhong Hairong Yue Bin Liang Low-Carbon Technology and Chemical Reaction Engineering Laboratory School of Chemical EngineeringSichuan UniversityChengdu 610065China Institute of New Energy and Low-Carbon Technology Sichuan UniversityChengdu 610207China

The significant decrease of acid sites caused by alkali metal poisoning is the major factor in the deactivation of commercial V_(2)O_(5)-WO_(3)/TiO_(2)NH_(3)-SCR catalysts.In this work,the solid superacid SO_(4)^(2-)-TiO_(2) modified by sulfate radicals,was selected as the catalyst support,which showed superior potassium resistance.The physicochemical properties and K-poisoning resistance of the V_(2)O_(5)-WO_(3)/SO_(4)^(2-)-TiO_(2)(VWSTi) catalyst were carried out by XRD,BET,H2-TPR,NH3-TPD,XPS,in situ DRIFTS and TG.The results pointed out that the introduction of SO_(4)^(2-)significantly increased the NH3-SCR catalytic activity at high temperatures,with an exceptionally high NO_(x) conversion over 90% between 275℃ and 500℃.When 0.5%(mass) K_(2)O was doped on the catalysts,the catalytic performance of the traditional V_(2)O_(5)-WO_(3)/TiO_(2)(VWTi) catalyst decreased significantly,while the VWSTi catalyst could still maintain a NOxconversion over 90%in the range of 300–500℃.The characterizations suggested that the support of SO_(4)^(2-)-TiO_(2) greatly increased the number of acidic sites,thereby enhancing the adsorption capacity of the reactant NH_(3).The results above demonstrated a potential approach to achieve superior potassium resistance for NH3-SCR catalysts using solid superacid.

关键词： Selective catalytic reduction(NH_(3)-SCR) V_(2)O_(5)-WO_(3)/TiO_(2) Solid superacid Anti-poisoning Acidity

Measurements of the effective mass transfer areas for the gas–liquid rotating packed bed

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2023年第3期55卷 13-19页

作者： Wen Tian Junyi Ji Hongjiao Li Changjun Liu Lei Song Kui Ma Siyang Tang shan zhong Hairong Yue Bin Liang Low-Carbon Technology and Chemical Reaction Engineering Laboratory School of Chemical EngineeringSichuan UniversityChengdu 610065China Institute of New Energy and Low-Carbon Technology Sichuan UniversityChengdu 610207China

Rotating packed bed(RPB) is one of the most effective gas–liquid mass transfer enhancement reactors, its effective specific mass transfer area(ae) is critical to understand the mass transfer process. By using the NaOH–CO_(2) chemical absorption method, the aevalues of three RPB reactors with different rotor sizes were measured under different operation conditions. The results showed that the high gravity factor and liquid flow rate were major affecting factors, while the gas flow rate exhibited minor influence.The radius of packing is the dominant equipment factor to affect aevalue. The results indicated that the contact area depends on the dispersion of the liquid phase, thus the centrifugal force of rotating packed bed greatly influenced the aevalue. Moreover, the measured ae/ap(effective specific mass transfer area/specific surface area of packing) values were fitted with dimensionless correlation formulas. The unified correlation formula with dimensionless bed size parameter can well predict the experimental data and the prediction errors were within 15%.

关键词： Gas-liquid Chemical absorption Mass transfer areas Rotating packed bed(RPB)

The quasi-activity coefficients of non-electrolytes in aqueous solution with organic ions and its application on the phase splitting behaviors prediction for CO_(2) absorption

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2022年第3期35卷 316-323页

作者： Xiaomeng Zhao Xingyu Li Changjun Liu shan zhong Houfang Lu Hairong Yue Kui Ma Lei Song Siyang Tang Bin Liang Laboratory of Low-Carbon Technology and Chemical Reaction Engineering School of Chemical EngineeringSichuan UniversityChengdu 610065China Institute of New Energy and Low-Carbon Technology Sichuan UniversityChengdu 610207China

CO_(2)capture with a low energy consumption is of important application significance for reducing CO_(2)emission.The phase-change absorbent developed in recent years shows its potential for low-energy CO_(2)capture.The unclear phase-splitting rule hinders the efficient development of CO_(2)phase-change absorbents.To predict phase-splitting behaviors of mono/poly-amine-organic solvent-water system with various concentrations,a quasi-activity coefficient was developed based on Debye&Mc Aulay equation and some Density function theory descriptors.Six models based on Debye&Mc Aulay equation were developed with different ion radius,descriptors or poly-amine-CO_(2)products.The phase-splitting boundary was drawn on the model with the best predictability.This quasi-activity coefficient would provide guidance for the phase-splitting systems development,especially for polyamines.

关键词： CO_(2)absorption Polyamines Biphasic system Phase-splitting Salting-out effect

SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl^(-)concentration

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第4期9卷 1745-1759页

作者： Jian-Bang Xu Wei-Jie Guan Yi-Lin Zhang Zhuo-Er Qiu Lei Chen Xiao-Chun Hou Junqing Yue Yu-Yun Zhou Jie Sheng Lei Zhao Yun-Xin Zhu Jing Sun Jincun Zhao Wen-Liang Zhou Nan-shan zhong State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineDepartment of Respiratory and Critical Care MedicineGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Department of Thoracic Surgery Guangzhou Institute for Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Guangzhou National Laboratory GuangzhouP.R.China School of Life Sciences Sun Yat-sen UniversityGuangzhouP.R.China Guangdong Provincial Key Laboratory of Pharmaceutical Functional Genes School of Life SciencesSun Yat-sen UniversityGuangzhouP.R.China Department of Physiology School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhouP.R.China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection disrupts the epithelial barrier and triggers airway inflammation.The envelope(E)protein,a core virulence structural component of coronaviruses,may play a role in this process.Pathogens could interfere with transepithelial Cl^(-)transport via impairment of the cystic fibrosis transmembrane conductance regulator(CFTR),which modulates nuclear factor kB(NF-kB)signaling.However,the pathological effects of SARS-CoV-2 E protein on airway epithelial barrier function,Cl^(-)transport and the robust inflammatory response remain to be elucidated.Here,we have demonstrated that E protein down-regulated the expression of tight junctional proteins,leading to the disruption of the airway epithelial barrier.In addition,E protein triggered the activation of Toll-like receptor(TLR)2/4 and downstream c-Jun N-terminal kinase(JNK)signaling,resulting in an increased intracellular Cl^(-)concentration([Cl^(-)]_(i))via up-regulating phosphodiesterase 4D(PDE4D)expression in airway epithelial cells.This elevated[Cl^(-)]_(i);contributed to the heightened airway inflammation through promoting the phosphorylation of serum/glucocorticoid regulated kinase 1(SGK1).Moreover,blockade of SGK1 or PDE4 alleviated the robust inflammatory response induced by E protein.Overall,these findings provide novel insights into the pathogenic role of SARS-CoV-2 E protein in airway epithelial damage and the ongoing airway inflammation during SARS-CoV-2 infection.

关键词： airway inflammation elevated

点云空间与反射强度融合的非结构化道路可行驶区域检测

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

控制理论与应用 2024年第5期41卷 847-854页

作者：周越洋徐江钟珊龚声蓉东北石油大学计算机与信息技术学院黑龙江大庆163319 常熟理工学院计算机科学与工程学院江苏苏州215500

可行驶区域检测旨在检测和提取智能车辆在道路上可行进的区域,目前主流的检测方法主要基于三维激光雷达的空间特征实现,难以处理路面边缘无清晰空间特征的非结构化道路.为此,本文提出了一种基于点云空间和反射强度融合的非结构化道路可... 详细信息

可行驶区域检测旨在检测和提取智能车辆在道路上可行进的区域,目前主流的检测方法主要基于三维激光雷达的空间特征实现,难以处理路面边缘无清晰空间特征的非结构化道路.为此,本文提出了一种基于点云空间和反射强度融合的非结构化道路可行驶区域检测方法.首先,通过融合反射强度因子改进了基于空间特征的柱坐标系检测模型;然后,使用强度和降维空间检测对检测精度较低的环形检测模型进行优化,并将其与柱坐标系检测模型联合使用以提高方法检测准确率;最后,在自录实际道路数据集上进行对比实验.实验结果表明本文方法显著提高了非结构化道路可行驶区域检测的成功率与精确率,在结构化道路上也具有良好效果.

关键词：智能驾驶非结构化道路三维激光雷达反射强度空间分布区域检测

维普期刊数据库博看期刊

竟陵派传记散文的理论意涵与价值阐述——以钟惺、谭元春为中心

在线全文

学校读者我要写书评

暂无评论

中南民族大学学报（人文社会科学版） 2024年第4期44卷 197-205,224页

作者：张啸吕忠山广西民族大学文学院广西南宁530006

竟陵派传记散文的开拓性与创新性似更为显著,且这类散文的理论生成和文本撰写极有力地表现出性灵思潮对其思想的辐射与创作的规约。从传记散文的演进脉络溯源,明代是主体意识觉醒与古典传记的突破期,特别是晚明士林群体主体意识之强化... 详细信息

竟陵派传记散文的开拓性与创新性似更为显著,且这类散文的理论生成和文本撰写极有力地表现出性灵思潮对其思想的辐射与创作的规约。从传记散文的演进脉络溯源,明代是主体意识觉醒与古典传记的突破期,特别是晚明士林群体主体意识之强化的思想背景和历史基础,使得竟陵派传记散文表现出“性灵”的本质一面。具体而言,“细事小语点染着色”与“奇事当传”为竟陵派传记散文理论的重要两端,使传记散文在写作原则、艺术手法、题材择取等多方面凸显出自身的创作特色。从价值意义上来看,竟陵派传记散文在延续了性灵文学“求真”本质意涵的同时,又较为适时地将“求善”价值理念蕴含于创作之中,即针对公安派之任情而发、情性泛滥这一现实而采取反思与节制主体性建构的策略。竟陵派对“性灵”一脉的修正及纠偏于传记散文一体是理应予以重视且认同的。

关键词：竟陵派传记散文性灵主体性