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Thermodynamic phase transition and winding number for the third-order Lovelock black hole

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Chinese Physics C 2024年第9期48卷 188-198页

作者： Yu-shan Wang Zhen-Ming Xu Bin wu School of Physics Northwest UniversityXi'an 710127China Shaanxi Key Laboratory for Theoretical Physics Frontiers Xi'an 710127China Peng Huanwu Center for Fundamental Theory Xi'an 710127China

Phase transition is important for understanding the nature and evolution of the black hole thermodynamic *** this study,we predicted the phase transition of the third-order Lovelock black hole using the winding number... 详细信息

关键词： black hole thermodynamics Lovelock black hole phase transition

Mitigation of Deane and Hamill phenomenon in gallium nitride high-voltage power supply for electric propulsion system application

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High Voltage 2024年第1期9卷 252-265页

作者： Minghai Dong Hui Li shan Yin Kye Yak See Yingzhe wu Xiong Xin School of Aeronautics&Astronautics University of Electronic Science and Technology of ChinaChengduChina School of Electrical&Electronic Engineering Nanyang Technological UniversitySingaporeSingapore School of Automation Engineering University of Electronic Science and Technology of ChinaChengduChina Innoscience(Shenzhen)Semiconductor Co.Ltd. ShenzhenChina

The step-up resonant converters are widely adopted to provide high voltage in kV-level for electric propulsion system due to their high efficiency,low mass,modularisation,and high-power *** bipolar Cockcroft-Walton voltage multiplier(BiCWVM)is a major circuit that steps up the voltage in the resonant ***,the diode nonlinearity in BiCWVM can introduce self-sustained quasi-periodic oscillations in the voltage and current waveforms,which is commonly known as the Deane and Hamill(DH)*** oscillation can lead to higher magnetic loss and control failure,and it is more likely to present in the gallium nitride-based converter due to the highfrequency *** authors aim to investigate and mitigate the DH phenomenon systematically so that proper mitigation can be *** facilitate the investigation,the circuit before the BiCWVM in the converter is derived and modelled as a voltage source v_(m)and a series inductor L_(sy).Also,the reverse recovery process of the diode in the BiCWVM can be represented by a piecewise-linear(PWL)model,with the simplified circuit and PWL model,the relationship between voltage and current under different operating conditions can be determined with *** relationship allows to understand the mechanism of diode reverse recovery in BiCWVM that leads to DH ***,a hybrid-/full-silicon carbide(SiC)design is proposed to mitigate the DH phenomenon,which is verified experimentally for a 300-kHz,5-W,20-V/1.5-kV GaN-based step-up resonant converter.

关键词： power resonant high

Histopathological characteristics of needle core biopsy and surgical specimens from patients with solitary hepatocellular carcinoma or intrahepatic cholangiocarcinoma

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World Journal of Gastrointestinal Oncology 2019年第5期11卷 404-415页

作者： Ju-shan wu Ji-Liang Feng Rui-Dong Zhu San-Guang Liu Da-Wei Zhao Ning Li General Surgical Center Beijing You-An Hospital Capital Medical University Clinical-Pathology Center Beijing You-An Hospital Capital Medical University Department of Hepatobiliary Surgery the Second Hospital Hebei Medical University Medical Imaging Department Beijing You-An Hospital Capital Medical University

BACKGROUND Pathological manifestations of hepatic tumours are often associated with prognosis. Although surgical specimens(SS) can provide more information,currently, pre-treatment needle core biopsy(NCB) is increasingly showing important value in understanding the nature of liver tumors and even in diagnosis and treatment decisions. However, the concordance of the clinicopathological characteristics and immunohistochemical(IHC) staining between NCB and SS from patients with hepatic tumours were less *** To introduce a more accurate method for interpreting the IHC staining results in order to improve the diagnostic value of hepatic malignancy in NCB *** A total of 208 patients who underwent both preoperative NCB and surgical resection for hepatocellular carcinoma(HCC) or intrahepatic cholangiocarcinomaRESULTS Morphologically, the presence of compact tumour nests or a cord-like structure in NCB was considered the primary cause of misdiagnosis of HCC from ICC. The kappa statistic showed a moderate agreement in histomorphology(k = 0.504) and histological grade(k = 0.488) between NCB and SS of the tumours. A 4-tier(+++,++, +, and-) scoring scheme that emphasized the focal neoplastic cell immunoreactivity of tumour cells revealed perfect concordance of CK19, GPC3 and HepPar1 between NCB and SS(k = 0.717; k = 0.768; k = 0.633). Furthermore,with the aid of a binary classification derived from the 4-tier score, a high concordance was achieved in interpreting the IHC staining of the three markers between NCB and final SS(k = 0.931; k = 0.907; k = 0.803), increasing the accuracy of NCB diagnosis C(k = 0.987; area under the curve = 0.997, 95%CI: 0.990-1.000; P< 0.001).CONCLUSION These findings imply that reasonable interpretation of IHC results in NCB is vital for improving the accuracy of tumour diagnosis. The simplified binary classification provides an easy and applicable approach.

关键词： Histopathological Needle core biopsy Surgical specimens Solitary hepatocellular carcinoma Intrahepatic cholangiocarcinoma

Effects of Incretin-based Therapies on Weight-related Indicators among Patients with Type 2 Diabetes: A Network Meta-analysis

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Biomedical and Environmental Sciences 2020年第1期33卷 37-47页

作者： XU Lu YU Shu Qing GAO Le HUANG Yi wu shan shan YANG Jun SUN Yi Xin YANG Zhi Rong CHAI San Bao ZHANG Yuan JI Li Nong SUN Feng ZHAN Si Yan Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Department of Mathematics and Statistics University of Maryland Baltimore CountyBaltimore MD 21250MarylandUSA National Clinical Research Center of Digestive Diseases Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China The Primary Care Unit School of Clinical MedicineUniversity of CambridgeCambridge CB21TNUK Department of Endocrinology and Metabolism Peking University International HospitalBeijing 102206China Department of Clinical Epidemiology and Biostatistics McMaster UniversityHamilton L8S 4L8OntarioCanada Department of Endocrinology and Metabolism Peking University People’s HospitalBeijing 100044China

Objective To evaluate the effects of incretin-based therapies on body weight as the primary outcome,as well as on body mass index(BMI)and waist circumference(WC)as secondary *** Databases including Medline,Embase,the Cochrane Library,and ***(***)were searched for randomized controlled trials(RCTs).Standard pairwise meta-analysis and network meta-analysis(NMA)were both carried *** risk of bias(ROB)tool recommended by the Cochrane handbook was used to assess the quality of *** analysis,sensitivity analysis,meta-regression,and quality evaluation based on the Grading of Recommendations Assessment,Development,and Evaluation(GRADE)were also *** A total of 292 trials were included in this *** with placebo,dipeptidyl-peptidase IV inhibitors(DPP-4 Is)increased weight slightly by 0.31 kg[95%confidence interval(CI):0.05,0.58]and had negligible effects on BMI and *** with placebo,glucagon-like peptide-1 receptor agonists(GLP-1 RAs)lowered weight,BMI,and WC by-1.34 kg(95%CI:-1.60,-1.09),-1.10 kg/m2(95%CI:-1.42,-0.78),and-1.28 cm(95%CI:-1.69,-0.86),*** GLP-1 RAs were more effective than DPP-4 Is in lowering the three ***,the effects of GLP-1 RAs on weight,BMI,and WC were favorable.

关键词： Body mass index Body weight Diabetes mellitus Dipeptidyl-peptidase IV inhibitors Glucagon-like peptide-1 receptor agonists Network meta-analysis Waist circumference

Numerical investigation of hydro-morphodynamic characteristics of a cascading failure of landslide dams

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Journal of Mountain Science 2024年第6期21卷 1868-1885页

作者： ZHONG Qiming CHEN Lingchun MEI Shengyao shan Yibo wu Hao ZHAO Kunpeng Department of Geotechnical Engineering Nanjing Hydraulic Research InstituteNanjing 210024China National Key Laboratory of Water Disaster Prevention Nanjing 210098China Key Laboratory of Reservoir and Dam Safety of the Ministry of Water Resources Nanjing 210029China

A cascading failure of landslide dams caused by strong earthquakes or torrential rains in mountainous river valleys can pose great threats to people’s lives,properties,and *** this study,based on the three-dimensional Reynoldsaveraged Navier-Stokes equations(RANS),the renormalization group(RNG)k-εturbulence model,suspended and bed load transport equations,and the instability discriminant formula of dam breach side slope,and the explicit finite volume method(FVM),a detailed numerical simulation model for calculating the hydro-morphodynamic characteristics of cascading dam breach process has been *** developed numerical model can simulate the breach hydrograph and the dam breach morphology evolution during the cascading failure process of landslide dams.A model test of the breaches of two cascading landslide dams has been used as the validation *** comparison of the calculated and measured results indicates that the breach hydrograph and the breach morphology evolution process of the upstream and downstream dams are generally consistent with each other,and the relative errors of the key breaching parameters,i.e.,the peak breach flow and the time to peak of each dam,are less than±5%.Further,the comparison of the breach hydrographs of the upstream and downstream dams shows that there is an amplification effect of the breach flood on the cascading landslide dam *** key parameters,i.e.,the distance between the upstream and the downstream dams,the river channel slope,and the downstream dam height,have been used to study the flood amplification *** parameter sensitivity analyses show that the peak breach flow at the downstream dam decreases with increasing distance between the upstream and the downstream dams,and the downstream dam ***,the peak breach flow at the downstream dam first increases and then decreases with steepening of the river channel *** the flood caused by the upstream dam failure flows to the

关键词： Cascading landslide dams Cascading dam failure process Detailed numerical simulation model Flood amplification effect Parameter sensitivity analyses

不同播种方式下高油酸花生生长性状及产量的表现

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湖北农业科学 2024年第9期63卷 6-9,27页

作者：蔡金兰康彦平孙付山李艳凡王文建吴山魏静李雄才襄阳市农业技术推广中心湖北襄阳441021 中国农业科学院油料作物研究所武汉430062 襄州区农业技术推广中心湖北襄阳441199

以高油酸花生(Arachis hypogaea L.)品种中花215、中花28和中花34为试验材料,采用小区试验对比的方法研究不同播种方式(单粒播种、双粒播种、单双粒间播)对高油酸花生生长性状及产量的影响。结果表明,不同播种方式对高油酸花生生长性状... 详细信息

以高油酸花生(Arachis hypogaea L.)品种中花215、中花28和中花34为试验材料,采用小区试验对比的方法研究不同播种方式(单粒播种、双粒播种、单双粒间播)对高油酸花生生长性状及产量的影响。结果表明,不同播种方式对高油酸花生生长性状及产量均产生一定影响,单粒播种更有利于花生单株生长发育,相比其他两种播种方式,能显著提高叶片SPAD值、单株结果数、单株生产力和干果产量;单双粒间播和双粒播种的干果产量无显著差异;3个高油酸品种单粒播种的经济效益最高,单双粒间播次之,双粒播种最低;相同播种方式下,中花215的产量和经济效益最高,中花34次之,中花28最低。

关键词：花生(Arachis hypogaea L.) 高油酸播种方式生长性状产量

Serum Amyloid A Protein: A Potential Biomarker Correlated With Clinical Stage of Lung Cancer

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Biomedical and Environmental Sciences 2007年第1期20卷 33-40页

作者： DAN-HUI LIU XIAO-MIN WANG LI-JUAN ZHANG SONG-WEI DAI LI-YUN LIU JI-FU LIU shan-shan wu SHUAN-YING YANG SAM FU XUE-YUAN XIAO DA-CHENG HE Key Laboratory of Cell Proliferation and Regulation of Ministry of Education Beijing Normal University Beijing 100875 China Department of Thoracic Surgery General Hospital of Beijing Command PLA Beijing 100700 China Department of Respiratory Medicine Second Hospital of Xi＇an Jiaotong University Xi＇an 710004 Shaanxi China Ciphergen Biosystems Inc. Fremont CA 94555 USA

Objective To identify serum diagnosis or progression biomarkers in patients with lung cancer using protein chip profiling analysis. Method Profiling analysis was performed on 450 sera collected from 213 patients with lung cancer, 19 with pneumonia, 16 with pulmonary tuberculosis, 65 with laryngeal carcinoma, 55 with laryngopharyngeal carcinoma patients, and 82 normal individuals. A new strategy was developed to identify the biomarkers on chip by trypsin pre-digestion. Results Profiling analysis demonstrated that an 11.6kDa protein was significandy elevated in lung cancer patients, compared with the control groups （P〈0.001）. The level and percentage of 11.6kDa protein progressively increased with the clinical stages Ⅰ-Ⅳ and were also higher in patients with squamous cell carcinoma than in other subtypes. This biomarker could be decreased after operation or chemotherapy. On the other hand, 11.6kDa protein was also increased in 50% benign diseases of lung and 13% of other cancer controls. After trypsin pre-digestion, a set of new peptide biomarkers was noticed to appear only in the samples containing a 11.6kDa peak. Further identification showed that 2177Da was a fragment of serum amyloid A （SAA, MW 11.6kDa）. Two of the new peaks, 1550Da and 1611Da, were defined from the same protein by database searching. This result was further confirmed by partial purification of 11.6kDa protein and MS analysis. Conclusion SAA is a useful biomarker to monitor the progression of lung cancer and can directly identify some biomarkers on chip.

关键词： Lung cancer Serum amyloid A On chip identification Surface enhanced laser desorption/ionization Biomarker

Synthesis and physiochemical property evaluation of carbamate derivatives of scutellarin methyl ester

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Chinese Chemical Letters 2013年第4期24卷 338-340页

作者： Feng-Jie Jiang Xiao-Zhong Fu shan-wu Wang Yong Huang Wen Zhou Ai-Min Wang Yong-Lin Wang School of Pharmacy Guiyang Medical College

A series of carbamate prodrugs of scutellarin methyl ester （4a-4e） were prepared in the presence of bis（trichloromethyl） carbonate （BTC） with scutellarin methyl esters and L-amino acid tert-butyl ester hydrochloride as starting materials. In vitro stability and aqueous solubility of target compounds were evaluated. The results indicated that compounds 4d and 4e have higher solubility and in vitro stability than scutellarin respectively.

关键词： ScutellarinBis(trichloromethyl) carbonatePhysiochemical property

Big Data Access Control Mechanism Based on Two-Layer Permission Decision Structure

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Computers, Materials & Continua 2024年第4期79卷 1705-1726页

作者： Aodi Liu Na Wang Xuehui Du Dibin shan Xiangyu wu Wenjuan Wang He’nan Province Key Laboratory of Information Security Information Engineering UniversityZhengzhou450000China

Big data resources are characterized by large scale, wide sources, and strong dynamics. Existing access controlmechanisms based on manual policy formulation by security experts suffer from drawbacks such as low policymanagement efficiency and difficulty in accurately describing the access control policy. To overcome theseproblems, this paper proposes a big data access control mechanism based on a two-layer permission decisionstructure. This mechanism extends the attribute-based access control (ABAC) model. Business attributes areintroduced in the ABAC model as business constraints between entities. The proposed mechanism implementsa two-layer permission decision structure composed of the inherent attributes of access control entities and thebusiness attributes, which constitute the general permission decision algorithm based on logical calculation andthe business permission decision algorithm based on a bi-directional long short-term memory (BiLSTM) neuralnetwork, respectively. The general permission decision algorithm is used to implement accurate policy decisions,while the business permission decision algorithm implements fuzzy decisions based on the business *** BiLSTM neural network is used to calculate the similarity of the business attributes to realize intelligent,adaptive, and efficient access control permission decisions. Through the two-layer permission decision structure,the complex and diverse big data access control management requirements can be satisfied by considering thesecurity and availability of resources. Experimental results show that the proposed mechanism is effective andreliable. In summary, it can efficiently support the secure sharing of big data resources.

关键词： Big data access control data security BiLSTM