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Acetylene/argon mixture plasma to build ultrathin carbon bridge of CF_(x)/C/MnO_(2) for high-rate lithium primary battery

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Rare Metals 2024年第6期43卷 2574-2584页

作者： Da-Wei Zou Xing-Guang Fu Gao-Bang Chen Yi-Fan Liu Bao-shan wu Xian Jian School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou 31300lChina

Forming an ultrathin conducting layer on a fluorinated carbon(CFx)surface for reducing severe electrochemical polarization in lithium/fluorinated carbon primary batteries(Li/CF_(x))remains a considerable challenge for achieving batteries with excellent rate ***,CFxwas modified by using acetylene/argon mixture plasma combined with MnO_(2)*** CF_(x)/C/MnO_(2)composite effectively reduced the voltage hysteresis and improved the electrochemical performance of Li/CF_(x).The excellent rate performance of CF_(x)/C/MnO_(2)was due to the high electrochemical activity provided by the atomicscale conductive carbon layer and ultrafine MnO_(2)*** with pristine CF_(x),the charge transfer resistance of the optimized CF_(x)/C/MnO_(2)decreased from 218.5 to 48.2Ω,the discharge rate increased from 2C to 10C,and the power density increased from 3.11 to 13.44 kW·g^(-1),The intrinsic reason for the enhanced rate performance was attributed to the fact that the ultrathin carbon layer acted as a conductive bridge to reduce the voltage hysteresis at the initial stage of the Li/CF_(x)discharge,and the high electrochemical activity of the ultrafine MnO_(2)particles provided a faster lithium-ion diffusion rate.

关键词： C_(2)H_(2)/Ar plasma Fluorinated carbon Lithium primary battery MnO_(2)

Investigating the Potential Mechanism of Huazhi Rougan Granules Against Alcoholic Liver Disease by Network Pharmacology and Experiment

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 191-203页

作者： Ying-Ying Tan Ying-Ying Liu Yi-Yan Zhai Yi-Xuan Wang Zhi-shan wu Antony Stalin Guo-Liang Cheng Bing Li Chao wu Zhi-Hong Huang shan Lu Xiao-Tian Fan Zheng Zhao Jia-Rui wu Department of Clinical Chinese Pharmacy School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijingChina Department of Bioinformatics Institute of Fundamental and Frontier SciencesUniversity of Electronic Science and Technology of ChinaChengduChina Department of Traditional Chinese Medicine State Key Laboratory of Generic Manufacture Technology of Chinese Traditional MedicineLinyiChina Department of Clinical Medicine Beijing Zest Bridge Medical Technology Inc.BeijingChina

Objective: Huazhi Rougan granules(HRGs) are a promising drug to improve alcoholic liver disease(ALD), but its mechanism remains unclear. Materials and Methods: Network pharmacology, molecular docking, and animal experiments were used to reveal the potential mechanism of HRG against ALD. Results: A total of 245 potential targets of HRG against ALD were obtained. Functional enrichment analysis suggests that HRG could synergistically regulate various biological pathways to exert therapeutic effects on ALD. Molecular docking showed that the key targets exhibited the good binding ability with the key compounds. The in vivo experiments showed that HRG can effectively alleviate pathological changes in liver tissue, improve blood lipid levels, antioxidant stress ability, and liver function, and reduce the release of inflammatory cytokines in the liver. Conclusions: This study reflects that HRG is an effective strategy for treating ALD, providing a basis for revealing the prevention and treatment mechanisms of ALD.

关键词： Alcoholic liver disease Huazhi Rougan granules inflammatory response network pharmacology

Research on Early Warning of Banking Crises from the Perspective of Credit Structures

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Contemporary Social Sciences 2024年第3期9卷 45-63页

作者： Zhou Yuqin Luo Zixuan wu shan Chongqing Normal University Nanjing University of Finance and Economics

The relationship between credit expansion and banking crises is complex and cannot be fully explained by total credit alone.A systematic analysis of the relationship between the amount and structure of total credit and banking crises is important for an objective prediction of the influence of potential financial *** paper,drawing on data from 15 selected countries,delves into the power of credit indicators in the early warning of banking crises from the perspectives of industrial structure,sector structure,and term structure of *** machine learning methods were used,including Logistic Regression,Random Forest,Decision Tree,Support Vector Machine(SVM),Bagging,and Boosting *** empirical findings indicate that credit expansion plays a crucial role in triggering banking ***,total credit is better suited for the early warning of short-term banking crises,whereas credit structure is more useful for the early warning of long-term banking ***,in an early warning system,identifying key early warning indicators is more meaningful than merely increasing the number of *** learning can somewhat enhance the early warning power,but it may not always be ***,more attention should be paid to potential systemic banking crises resulting from an imbalance in credit structure while regulating the total credit threshold.

关键词： banking crises credit expansion transnational empirical evidence structural perspective

High-fat diet impairs gut barrier through intestinal microbiota-derived reactive oxygen species

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Science China(Life Sciences) 2024年第5期67卷 879-891页

作者： Nianyi Zeng Fan wu Junqi Lu Xiang Li Shaomei Lin Lang Zhou Zhongwei Wang Guangyan wu Qingfa Huang Daowen Zheng Jie Gao shan wu Xiaojiao Chen Muxuan Chen Fanguo Meng Haitao shang Yan He Peng Chen Hong Wei Zhuang Li Hongwei Zhou Microbiome Medicine Center Department of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhou 510282China Department of Environmental Health Guangdong Provincial Key Laboratory of Tropical Disease ResearchSchool of Public Health and Tropical MedicineSouthern Medical UniversityGuangzhou 510515China Redox Medical Center for Public Health Soochow UniversitySuzhou 215301China Precision Medicine Institute The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Pathophysiology Guangdong Provincial Key Laboratory of ProteomicsSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China

Gut barrier disruption is a key event in bridging gut microbiota dysbiosis and high-fat diet(HFD)-associated metabolic ***,the underlying mechanism remains *** the present study,by comparing HFD-and normal diet(ND)-treated mice,we found that the HFD instantly altered the composition of the gut microbiota and subsequently damaged the integrity of the gut *** sequencing revealed that the HFD upregulates gut microbial functions related to redox reactions,as confirmed by the increased reactive oxygen species(ROS)levels in fecal microbiota incubation in vitro and in the lumen,which were detected using in vivo fluorescence *** microbial ROS-producing capability induced by HFD can be transferred through fecal microbiota transplantation(FMT)into germ-free(GF)mice,downregulating the gut barrier tight ***,mono-colonizing GF mice with an Enterococcus strain excelled in ROS production,damaged the gut barrier,induced mitochondrial malfunction and apoptosis of the intestinal epithelial cells,and exacerbated fatty liver,compared with other low-ROS-producing Enterococcus *** administration of recombinant high-stability-superoxide dismutase(SOD)significantly reduced intestinal ROS,protected the gut barrier,and improved fatty liver against the *** conclusion,our study suggests that extracellular ROS derived from gut microbiota play a pivotal role in HFD-induced gut barrier disruption and is a potential therapeutic target for HFD-associated metabolic diseases.

关键词： fatty liver disease gut microbiota gut barrier high-fat diet oxidative stress reactive oxygen species

Differentiation and immunosuppressive function of CD19^(+)CD24^(hi)CD27^(+) regulatory B cells are regulated through the miR-29a-3p/NFAT5 pathway

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 472-480页

作者： Jin-Yang Li Tian-Shuo Feng Ji Gao Xin-Xiang Yang Xiang-Cheng Li Zhen-Hua Deng Yong-Xiang Xia Zheng-shan wu Hepatobiliary Center the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Key Laboratory of Liver Transplantation Chinese Academy of Medical SciencesNanjing 210029China NHC Key Laboratory of Living Donor Liver Transplantation Nanjing Medical UniversityNanjing 210029China

Background: Regulatory B cells(Bregs) is an indispensable element in inducing immune tolerance after liver transplantation. As one of the microRNAs(miRNAs), mi R-29a-3p also inhibits translation by degrading the target mRNA, and yet the relationship between Bregs and mi R-29a-3p has not yet been fully explored. This study aimed to investigate the impact of miR-29a-3p on the regulation of differentiation and immunosuppressive functions of memory Bregs(m Bregs) and ultimately provide potentially effective therapies in inducing immune tolerance after liver transplantation. Methods: Flow cytometry was employed to determine the levels of Bregs in peripheral blood mononuclear cells. TaqMan low-density array miRNA assays were used to identify the expression of different miRNAs, electroporation transfection was used to induce mi R-29a-3p overexpression and knockdown, and dual luciferase reporter assay was used to verify the target gene of miR-29a-3p. Results: In patients experiencing acute rejection after liver transplantation, the proportions and immunosuppressive function of m Bregs in the circulating blood were significantly impaired. mi R-29a-3p was found to be a regulator of m Bregs differentiation. Inhibition of miR-29a-3p, which targeted nuclear factor of activated T cells 5(NFAT5), resulted in a conspicuous boost in the differentiation and immunosuppressive function of m Bregs. The inhibition of mi R-29a-3p in CD19~+ B cells was capable of raising the expression levels of NFAT5, thereby promoting B cells to differentiate into m Bregs. In addition, the observed enhancement of differentiation and immunosuppressive function of m Bregs upon mi R-29a-3p inhibition was abolished by the knockdown of NFAT5 in B cells. Conclusions: mi R-29a-3p was found to be a crucial regulator for m Bregs differentiation and immunosuppressive function. Silencing mi R-29a-3p could be a potentially effective therapeutic strategy for inducing immune tolerance after liver transplantation.

关键词： Regulatory B cells miR-29a-3p NFAT5 Liver transplantation

面具下的真容:以何遮蔽何以澄明——评约瑟夫·海顿的三幕喜歌剧《月亮的世界》的中国首演

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人民音乐 2024年第4期 37-41页

作者：吴姗湖南师范大学音乐学院

对于1737年间的意大利来说,歌剧早已从专享走向了民众,喜歌剧作为商业化的娱乐形式,如同威尼斯狂欢节那般为大众提供了私密且合法的放纵空间,彼时剧院的姿态就像今天的爵士吧。而对于2023年9月23日前往北京大华城市表演艺术中心的乐迷而... 详细信息

对于1737年间的意大利来说,歌剧早已从专享走向了民众,喜歌剧作为商业化的娱乐形式,如同威尼斯狂欢节那般为大众提供了私密且合法的放纵空间,彼时剧院的姿态就像今天的爵士吧。而对于2023年9月23日前往北京大华城市表演艺术中心的乐迷而言,观看海顿三幕喜歌剧《月亮的世界》的中国首演,同样只需推开一扇“没有阶梯”的门,便能从闹市踏足而入。

关键词：表演艺术中心喜歌剧娱乐形式狂欢节首演海顿爵士威尼斯

基于Kalman滤波的供水管网水力模型用水量动态估计

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清华大学学报（自然科学版） 2024年第2期64卷 271-281页

作者：吴珊吴雨晨侯本伟韩宏泉北京工业大学城市建设学部北京100124 北京市市政工程设计研究总院有限公司北京100082

节点用水量的动态估计是供水管网水力模型动态更新的主要工作,以扩展Kalman滤波(EKF)为代表的数据同化方法已被应用于管网水力模型参数动态校核和估计中,但现有研究未考虑用户节点24 h用水模式对节点用水量估计的影响。该文研究了节点... 详细信息

节点用水量的动态估计是供水管网水力模型动态更新的主要工作,以扩展Kalman滤波(EKF)为代表的数据同化方法已被应用于管网水力模型参数动态校核和估计中,但现有研究未考虑用户节点24 h用水模式对节点用水量估计的影响。该文研究了节点用水模式先验信息对EKF方法节点用水量动态估计结果的影响。根据用户24 h的用水模式和t时刻用水量估计值预测t+1时刻节点用水量,并采用t+1时刻管网测量数据校正t+1时刻节点用水量预测值。案例管网的应用结果表明:与现有研究中应用的EKF方法相比,考虑用水模式的扩展Kalman滤波(IEKF)方法对应的用水量估计平均绝对百分比误差降低了15.93%,节点用水量时变曲线的Nash-Sutcliffe效率(NSE)系数值提高了0.40,且2种方法的计算时间相近;与推断测量Kalman滤波(IMKF)相比,IEKF方法对应的用水量估计平均绝对百分比误差降低了12.20%,节点用水量时变曲线的NSE系数值提高了0.35,计算时间缩短了99.8%。在节点用水量估计问题中,考虑用水模式可以显著提高EKF方法的计算精度。

关键词：供水管网模型校核用水量估计用水模式扩展Kalman滤波(EKF)

Bovine and Goat Milk Fat Globule Membrane Supplementation Alleviates Autism-like Behavior by Modulating Lipid Metabolism and Gut Microbiota

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Food Science and Human Wellness 2024年

作者： Rui Guo Xiao Xiao Chuanchuan Wang Tian Yuan Qianhui Zou Tian Zhang Jiarui Liang Ying He Zhuo Liu Xuebo Liu shan wu Zhigang Liu Northwest A&F University Shenzhen Research Institute Shaanxi Precision Nutrition and Health Research Institute Research and Development Center Xi'an Yinqiao Dairy (Group) Co. Ltd Laboratory of Functional Chemistry and Nutrition of Food College of Food Science and Engineering Northwest A&F University Shaanxi Key Laboratory of Natural Products & Chemical Biology College of Chemistry & Pharmacy Northwest A&F University

ASD (autism spectrum disorder) is a neurodevelopmental disorder influenced by genes and the environment. This study investigated the protective effects of bovine MFGM (BMFGM) and goat MFGM (GMFGM) supplementation on ASD model mice. Analysis of phospholipid composition showed higher levels of phosphatidylcholine in BMFGM and phosphatidylethanolamine in GMFGM. Behavioral results indicated MFGMs ameliorated social deficits， with GMFGM being more effective. MFGMs mitigated neuroinflammation by suppressing microglial overactivation and proinflammatory cytokines expression， meanwhile GMFGM increased the anti-inflammatory factor IL-10. MFGMs also altered gut microbiota composition and maintained gut barrier integrity. Uniquely， GMFGM increased butyrate production. Correlation analysis revealed positive associations between social behavior， levels of phosphatidylcholine， sphingomyelin， and the abundance of Allobaculum， Clostridium＿sensu＿stricto， and Turicibacter. Overall， these findings revealed the protective effects of MFGMs on neurodevelopment in ASD animal models and the underlying mechanism could be partly explained by their regulation of gut microbiota by the phospholipid components in MFGMs.

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面向均匀损伤的RC框架结构抗震优化设计方法

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工程力学 2024年第4期41卷 210-221页

作者：吴山何浩祥兰炳稷北京工业大学工程抗震与结构诊治北京市重点实验室北京100124

RC框架结构在地震作用下多出现局部楼层损伤明显或抗力不足问题,通过对抗侧力构件性能的合理优化可实现各楼层损伤程度相近的设计效果,消除薄弱层,达到更为理想的均匀损伤分布模式。提出RC框架结构的均匀损伤设计方法,以各楼层损伤指数... 详细信息

RC框架结构在地震作用下多出现局部楼层损伤明显或抗力不足问题,通过对抗侧力构件性能的合理优化可实现各楼层损伤程度相近的设计效果,消除薄弱层,达到更为理想的均匀损伤分布模式。提出RC框架结构的均匀损伤设计方法,以各楼层损伤指数相等或相近为优化目标,各层框架柱配筋率为优化变量,通过智能算法与有限元平台协同计算技术,实现RC框架结构均匀损伤优化设计,并采用弹塑性时程分析和IDA方法对优化效果进行验证分析。结果表明,通过智能算法优化框架柱配筋方案可以有效调控结构各层损伤程度,不同地震波作用下结构最优配筋率分布是不完全相同的,并且框架柱的最优配筋率分布也未呈现明显的统计规律,但将不同地震波下优化结果的均值作为框架柱配筋方案可以提高结构抗震能力,该优化方法合理有效。

关键词：均匀损伤优化设计 RC框架智能算法易损性分析