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Study on the Synthesis Process of Adenosine Arabinoside by Immobilized Nucleoside Phosphorylase

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Study on the Synthesis Process of Adenosine Arabinoside by I...

Factorial study of moxibustion in treatment of diarrhea-predominant irritable bowel syndrome

河南省化学会2016年学术年会

作者： Li-Juan Guo shan-tao Xing tao Li Kai-Yue Zhuo Guo-Jie Yuan Gui-Rong Qu Xi-Ning Yang Xinke college Henan Institute of science and technology Xinxiang tuoxin biochemical CO. Ltd. Henan university of science and technology new academy of sciences

Nucleoside and their derivatives have been comprehensively applied in biology and medicine duo to their particular *** arabinoside is a kind of naturally-occurring antiviral compounds,which has activities against several enveloped viruses. Vidarabine phosphorylation transforms into vidarabine triphosphate within the cell, then competes with DNA adenosine triphosphate, which produces an negative effect on DNA polymerase and ribonucleotide reductase to inhibite the synthesis of *** bears multiple bioactivities including antibacterial and antiviral activity. Now it is currently being used in clinical trials for viral infections such as hepatitis B virus, herpes virus, etc. It has obvious curative effect, so it is of medical importance and social significance on the research of production methods of adenosine arabinoside. The synthesis methods of adenosine arabinoside were included chemical synthesis and biosynthesis, but the chemical synthesis method has many problems such as, the complicated steps, the low yield,the product of reaction is difficult to separate, and severe polluction the problems have seriously restricted mass production. Based on the research of our group about nucleoside phosphorylase,which was proposed to make use of the uracil arabinoside as substrate and immobilized the nucleoside phosphorylase as an enzyme source to synthetic adenosine arabinoside. To achieve the objectives such as low-cost, high yield, environmental and easier extraction.

关键词： Immobilized Nucleoside Phosphorylase Adenosine Arabinoside Uracil Arabinoside

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World Journal of Gastroenterology 2014年第37期20卷 13563-13572页

作者： Ji-Meng Zhao Lu-Yi Wu Hui-Rong Liu Hong-Yi Hu Jia-Ying Wang Ren-Jia Huang Yin Shi shan-Ping tao Qiang Gao Ci-Li Zhou Li Qi Xiao-Peng Ma Huan-Gan Wu shanghai University of Traditional Chinese Medicine Key Laboratory of Acupuncture-Moxibustion and Immunology Shanghai Research Institute of Acupuncture and Meridian Traditional Chinese Medicine Hospital of shanxi Province Jiading Hospital of Traditional Chinese Medicine Jiading District Central Hospital

AIM: To identify an appropriate therapeutic regimen for using aconite cake-separated moxibustion to treat diarrhea-predominant irritable bowel syndrome (D-IBS).

关键词： Diarrhea-predominant irritable bowel syndrome Aconite cake-separated moxibustion Factorial design Moxibustion quantity Clinical research

Study on the Synthesis Process of 5-Aza-2'-deoxycytidine by Immobilized Deoxynucleotidyl Transferase

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Study on the Synthesis Process of 5-Aza-2'-deoxycytidine by ...

Argon supper-cryosurgery for patients with middle and late stage liver cancer

河南省化学会2016年学术年会

作者： Li-Juan Guo tao Li Kai-Yue Zhuo Dong-Kun Wang Gui-Rong Qu shan-tao Xing Xi-Ning Yang Xinke college Henan Institute of science and technology Xinxiang tuoxin biochemical CO. Ltd. Henan university of science and technology new academy of sciences

Nucleoside and their derivatives have been comprehensively applied in biology and medicine duo to their particular activities.5-Aza-2’-deoxycytidine a kind of 2’-deoxidization cytidine analogues, which has a unique therapeutic mechanism of methylation transferase inhibitor. To inhibit DNA methylation transferase. making it as a more effective drugs in active demethylation of DNA and then prohibits the propagation of the cancer cells. Now it is currently being used in clinical trials for myelodysplastic syndrome, Thus the products can bring the enormous social benefit, so it so it is of medical importance and social significance on the research of production methods of decitabine. Besides, As raw materials mainly used in the production of other drugs which have higher *** synthesis methods of 5-Aza-2’-deoxycytidine were included chemical synthesis and biosynthesis, but the chemical synthesis method has many problems. such as, the complicated steps, the low yield and the product of reaction is difficult to separate, under considerable pressure to go green, the probiems have seriously restricted mass ***, how to develop innovative processes has become a serious problem to be soon studied and solved. Study on the Synthesis Process of 5-Aza-2’-deoxycytidine by Immobilized Deoxynucleotidyl Transferase. Optimize the synthetic process and in highly efficient way to make5-Aza-2’-deoxycytidine which was proposed to make ues of the thymidine and 5-Azacytosine as substrate and immobilized the deoxynucleotidyl Transferaseas an enzyme source to synthetic decitabine. To achieve the objectives such as low-cost, high yield,environmental and easier extraction,which indicated that the new technology were suitable for industrial application.

关键词： Immobilized Deoxynucleotidyl Transferase 5-Aza-2’-deoxycytidine

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Hepatobiliary & Pancreatic Diseases International 2003年第3期2卷 354-357页

作者： Ke-Feng Dou Shu-Qiang Yue Hai-Ming Li Yan-Ling Yang Kai-shan tao Wen-Xian Guan Yong Chen Kai Sun the Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China Department of Hepatobiliary Surgery Xijing Hospital Fourth Military Medical University Xi'an 710032 China. doukf@***

OBJECTIVE: To assess the value of argon supper-cryosurgery for 42 patients with middle and late stage liver cancer. METHODS: Forty-two patients who had received argon supper-cryosurgery were analyzed retrospectively in terms of their clinical characteristics as well as the performance of argon supper-cryosurgery. RESULTS: All patients were ameliorated in symptoms shortly after the operation, including pain alleviation, psyche straightening up, alpha-fetoprotein descending or recovery. Jaundice occurred in 1 patient and intraabdominal hemorrhage in 2. The levels of aspartate transaminase and alanine transaminase in all patients were elevated 1 month after the operation, and normalized after protective therapy of the liver. No operative death was noted. CONCLUSIONS: Cold and heat reversed therapy of argon supper-cryosurgery can drastically destroy tumor tissue, especially the tumors which are too large to resect or close to the large vessels. It is applicable to increase the operative rate, decrease the operative death rate, and enlarge the therapeutic scope.

关键词： liver cancer argon supper-cryosuygery operation complications

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基于EMD的井中雷达信号预处理

电子科技大学学报 2022年第6期51卷 875-883页

作者：邹宁金杨超郭成陶杉宋海中国石油化工集团公司碳酸盐岩缝洞型油藏提高采收率重点实验室乌鲁木齐830011 中国石油化工股份有限公司西北油田分公司乌鲁木齐830011 电子科技大学资源与环境学院成都611731

针对井中雷达数据因环境复杂易受到“污染”而很难提取出有效数据的问题,基于经验模态分解方法(EMD)提出了二维模态经验分解方法(BEMD),该方法对井中雷达信号预处理的时频域分解算法进行分析,将其拓展至高维进行信号处理。仿真结果表明... 详细信息

针对井中雷达数据因环境复杂易受到“污染”而很难提取出有效数据的问题,基于经验模态分解方法(EMD)提出了二维模态经验分解方法(BEMD),该方法对井中雷达信号预处理的时频域分解算法进行分析,将其拓展至高维进行信号处理。仿真结果表明,二维模态经验分解能够有效剔除高频、低频的干扰,较一维的模态经验分解有较大的改进,验证了该方法具备应用于井中雷达数据处理的潜力。

关键词：井中雷达 EMD算法时域有限差分信号预处理

中国人腰椎间盘结构与人工椎间盘置换相关的参数测量

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中国组织工程研究与临床康复 2011年第48期15卷 8973-8976页

作者：王子轩单涛青岛市市立医院介入放射科(本部) 山东省青岛市266011 青岛大学医学院基础学院人体形态学实验中心山东省青岛市266021

背景:全椎间盘置换已应用多年,但国内鲜见对人腰椎间盘结构测量的大样本系统研究。目的:为中国人腰椎间盘假体置换手术和设计提供参考数据。方法:选取中国成年尸体41具(男22例,女19例),解剖获得完整的腰椎标本。测量椎体软骨板断面厚度... 详细信息

背景:全椎间盘置换已应用多年,但国内鲜见对人腰椎间盘结构测量的大样本系统研究。目的:为中国人腰椎间盘假体置换手术和设计提供参考数据。方法:选取中国成年尸体41具(男22例,女19例),解剖获得完整的腰椎标本。测量椎体软骨板断面厚度。随机抽取正常成年人标准腰椎正侧位X射线片157例(男89例,女68例)。测量椎体上/下横径、上/下矢状径和椎间隙高度。结果与结论:成年尸体及正常成年人标准腰椎正侧位X射线片显示腰椎间盘软骨板厚度、椎体上/下横径、矢状径和椎间隙高度均不存在性别差异(P>0.05)。除L1/2相邻椎体矢状径、L3/4相邻椎体横径和L4/5相邻椎体矢状径外,其余椎间盘相邻椎体横径或矢状径的差异有显著性意义(P<0.05),但各径线实测数值之间差距均较小。腰椎间隙自L1/2至L4/5逐渐增宽,前缘高度大于后缘高度。L5/S1椎间隙与其他腰椎间隙存在较大差异,其相邻终板间夹角明显增大。

关键词：人工椎间盘置换腰椎椎间盘测量现代中国人

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肩胛骨的骨性测量及其临床意义

解剖学杂志 2014年第3期37卷 372-374页

作者：韩铭单涛尚超山东中医药大学附属医院骨科济南250014 青岛大学医学院人体解剖学教研室青岛266021

目的:研究肩胛骨的解剖学特点,为肩胛骨骨折临床治疗及内固定物的设计提供参考.方法:取国人101副(男49副,女52副)肩胛骨标本,分别测量其各项指标.结果:肩胛骨各测量值同性别间左右两侧比较无差异;肩胛骨上角处厚度男女分别为4.12±1.03(... 详细信息

目的:研究肩胛骨的解剖学特点,为肩胛骨骨折临床治疗及内固定物的设计提供参考.方法:取国人101副(男49副,女52副)肩胛骨标本,分别测量其各项指标.结果:肩胛骨各测量值同性别间左右两侧比较无差异;肩胛骨上角处厚度男女分别为4.12±1.03(2.16～7.05) mm和4.00±1.33(1.47～10.18) mm,肩胛冈与冈下窝夹角角度为136.71°±11.64°(101.9°～175.8°)和137.81°±11.78°(101.4°～166.0°),下角角度为50.08°±2.90°(42°～586)和49.37°±2.86°(42°～56°),以上测量值男女间比较差异无统计学意义;其余测量值男性均大于女性,差异均有统计学意义.结论:本次测量结果可为肩胛骨骨折手术过程中骨折复位以及肩胛骨内固定物的设计与制作提供参考,术前参照此数据对钢板预塑形可有效缩短手术时间,并降低反复弯折造成钢板韧性降低疲劳断裂的风险.本研究同时丰富了国人体质调查的资料.

关键词：肩胛骨测量解剖学骨折内固定

基于气动悬浮激光加热技术YAG熔体高温热物理性能评测

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无机材料学报 2018年第12期33卷 1297-1302页

作者：丰盛单志涛潘瑞琨徐博祖成奎陶海征武汉理工大学硅酸盐建筑材料国家重点实验室武汉430070 中国建筑材料科学研究总院有限公司北京100024

钇铝石榴石Y_3Al_5O_(12)(Yttrium Aluminum Garnet,简记为YAG)材料具有优异的光、热和电学性能,引起了广泛关注。但高熔点和冷却过程中复杂的相选择机制,使YAG熔体特别是熔点以下过冷区内的热物理性能参数获得困难。利用自主搭建的气... 详细信息

钇铝石榴石Y_3Al_5O_(12)(Yttrium Aluminum Garnet,简记为YAG)材料具有优异的光、热和电学性能,引起了广泛关注。但高熔点和冷却过程中复杂的相选择机制,使YAG熔体特别是熔点以下过冷区内的热物理性能参数获得困难。利用自主搭建的气动悬浮无容器激光加热装置,基于受迫振动和光学描影等原理,在1750~2650 K宽达900 K的温区内,评测了YAG熔体的黏度、表面张力和密度。研究表明,与Al_2O_3熔体相比,YAG熔体密度具有更高的温度敏感性,具有高约1倍的平均线膨胀系数;不同于表面张力随温度变化不敏感的Al_2O_3熔体,YAG熔体的表面张力随温度升高产生略微降低;与Al_2O_3熔体的黏温关系相比,在熔点以下的过冷区内发现YAG熔体具有更陡峭的黏温变化趋势。

关键词：高温热物理性质 YAG 气动悬浮技术过冷区

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外辐射源雷达高速加速微弱目标检测研究

现代雷达 2011年第5期33卷 30-35页

作者：杨金禄单涛陶然北京理工大学信息与电子学院北京100081

针对以模拟电视伴音信号为照射源的外辐射源雷达对高速加速运动微弱目标的探测问题,提出了将长时间相参积累和长时间非相参积累相结合的积累思想,以及一种基于短时分数阶傅里叶变换和动态规划的检测方法。从高速加速运动目标在外辐射源... 详细信息

针对以模拟电视伴音信号为照射源的外辐射源雷达对高速加速运动微弱目标的探测问题,提出了将长时间相参积累和长时间非相参积累相结合的积累思想,以及一种基于短时分数阶傅里叶变换和动态规划的检测方法。从高速加速运动目标在外辐射源雷达中的回波模型入手,推导出了该算法的原理和实现过程,分析了算法的虚警概率和检测概率,并给出了仿真结果。分析和仿真结果均表明此算法对高速加速运动的微弱目标具有较好的检测性能。

关键词：分数阶傅里叶变换动态规划微弱目标检测