检索结果-南通市图书馆

Analysis of SBLOCA on CPR1000 with a passive system

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2017年第1期28卷 64-73页

作者： Zi-Jiang Yang Jun-Li Gou Jian-qiang shan Pan Wu School of Nuclear Science and Technology Xi’an Jiaotong University Xi’an 710049 China

Since the Fukushima accident in 2011,more and more attention has been paid to nuclear reactor safety.A number of evolutionary passive systems have been developed to enhance the inherent safety of *** paper presents a passive safety system applied on CPR1000,which is a traditional generation II+ *** passive components selected are as follows:(1) the reactor makeup tanks(RMTs);(2) the advanced accumulators(A-ACCs);(3) the passive emergency feedwater system(PEFS);(4)the passive depressurization system(PDS);(5) the incontainment refueling water storage tank(IRWST).The model of the coolant system and the passive systems was established by utilizing a system code(RELAP5/MOD3.3).The SBLOCA(small-break loss of coolant) was analyzed to test the passive safety *** the SBLOCA occurred,the RMTs were *** water in the RMTs was then injected into the pressure *** RMTs' low water level triggered the PDS,which depressurized the coolant system *** the pressure of the coolant system decreased,the A-ACCs and the IRWST were put to work to prevent the uncovering of the *** results show that,after the small-break loss-of-coolant accident,the passive systems can prevent uncovering of the core and guarantee the safety of the plant.

关键词： Passive safety systems RELAP5/MOD3.3 CPR1000 SBLOCA

Discovery of super-silicic and super-titanic garnets in garnet-pyroxenite in Zhaheba and its geological significance

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2008年第14期53卷 2186-2191页

作者： NIU HeCai ZHANG HaiXiang shan qiang YU XueYuan Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640 China

Super-silicic garnet which exists stably at more than 5 GPa is a typical ultra-high pressure mineral. The super-silicic garnet and super-titanic garnet were discovered for the first time in garnet-pyroxenite of early Paleozoic Zhaheba-Aermantai orogenic belt in north Xinjiang. Our study indicates that these su- per-silicic garnets as well as super-titanic garnets were formed at a depth of at least 300 km. Their host rock―― garnet-pyroxenite is one kind of ultra-pressure metamorphic rocks which is related to the ul- tra-deep subduction of the oceanic crust. Thus, the early Paleozoic Zhaheba-Aermantai orogenic belt is related to the ultra-deep subduction of the Paleo-Asian oceanic crust.

关键词：蛇纹石辉岩石榴石变质作用

Uncertainty and sensitivity analysis of in-vessel phenomena under severe accident mitigation strategy based on ISAA-SAUP program

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第1期35卷 108-123页

作者： Hao Yang Ji-Shen Li Zhi-Ran Zhang Bin Zhang Jian-qiang shan School of Nuclear Science and Technology Xi’an Jiaotong UniversityXi’an 710049China State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong UniversityXi’an 710049China

The phenomenology involved in severe accidents in nuclear reactors is highly ***,integrated analysis programs used for severe accident analysis heavily rely on custom empirical parameters,which introduce considerable ***,in recent years,the field of severe accidents has shifted its focus toward applying uncertainty analysis methods to quantify uncertainty in safety assessment programs,known as“best estimate plus uncertainty(BEPU).”This approach aids in enhancing our comprehension of these programs and their further development and *** study concentrates on a third-generation pressurized water reactor equipped with advanced active and passive mitigation *** an Integrated Severe Accident Analysis Program(ISAA),numerical modeling and uncertainty analysis were conducted on severe accidents resulting from large break loss of coolant *** uncertainty parameters of the ISAA program were meticulously *** Wilks'formula,the developed uncertainty program code,SAUP,was employed to carry out Latin hypercube sampling,while ISAA was employed to execute batch *** analysis was then conducted on two figures of merit,namely hydrogen generation and the release of fission products within the pressure *** calculations revealed that hydrogen production and the fraction of fission product released exhibited a normal distribution,ranging from 182.784 to 330.664 kg and from 15.6 to 84.3%,*** ratio of hydrogen production to reactor thermal power fell within the range of 0.0578–0.105.A sensitivity analysis was performed for uncertain input parameters,revealing significant correlations between the failure temperature of the cladding oxide layer,maximum melt flow rate,size of the particulate debris,and porosity of the debris with both hydrogen generation and the release of fission products.

关键词： Gen-III PWR Severe accident mitigation Wilks’formula Hydrogen Fission products Uncertainty and sensitivity analysis

Simulation of chemical kinetics in sodium-concrete interactions

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2006年第1期17卷 53-60页

作者： ZHANG Bin ZHU Ji-Zhou shan Jian-qiang WANG Xue-Rong Nuclear Safety Group Nuclear Engineering Department Xi＇an Jiaotong University Xi＇an 710049 China

Sodium-concrete interaction is a key safety-related issue in safety analysis of liquid metal cooled fast breeder reactors (LMFBRs). The chemical kinetics model is a key component of the sodium-concrete interaction model. Conservation equations integrated in sodium-concrete interaction model cannot be solved without a set of re-lationships that couple the equations together, and this may be done by the chemical kinetics model. Simultaneously, simulation of chemical kinetics is difficult due to complexity of the mechanism of chemical reactions between sodium and concrete. This paper describes the chemical kinetics simulation under some hypotheses. The chemical kinetics model was integrated with the conservation equations to form a computer code. Penetration depth, penetration rate, hydrogen flux, reaction heat, etc. can be provided by this code. Theoretical models and computational procedure were recounted in detail. Good agreements of an overall transient behavior were obtained in a series of sodium-concrete interaction experiment analysis. Comparison between analytical and experimental results showed that the chemical kinetics model presented in this paper was creditable and reasonable for simulating the sodium-concrete interactions.

关键词：化学动力学钠凝固交互作用 LMFBRs

Modified calcination conditions of rare alkali metal Rb-containing muscovite(KAl_2[AlSi_3O_(10)](OH)_2)

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2013年第6期32卷 632-635页

作者： Zhi-qiang shan Xin-Qian Shu Ji-Fu Feng Wei-Ning Zhou School of Chemical and Environmental Engineering China University of Mining & Technology Comprehensive Utilization Research Institute of Resource Guilin Research Institute Geology for Mineral Resources

Muscovite mineral was roasted in different *** leaching rate was a standard to examine the impact of various factors on calcination effect,including the agent types,roasting time,mass ratio,and roasting *** results indicate that the best agent is the combination of sodium chloride and calcium chloride,and its mass ratio of muscovite/NaCl/CaCl2is1.00:0.25:*** at 850℃ for 30 min,the rubidium leaching rate is up to 90.12%.The reaction of muscovite ore with the chlorinating agent CaCl2was studied by TG/DSC,and the surface morphology before and after leaching was characterized by *** chloride products can be obtained using t-BAMBP extraction,hydrochloric acid re-extraction,and purification.

关键词： Modified calcination Muscovite ore Chlorinating agent

Lactobacillus rhamnosus GR-1 attenuates foodborne Bacillus cereus-induced NLRP3 inflammasome activity in bovine mammary epithelial cells by protecting intercellular tight junctions

在线全文

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2023年第1期14卷 307-321页

作者： qiang shan Ning Liu Xue Wang Yaohong Zhu Jinhua Yin Jiufeng Wang Department of Veterinary Clinical Sciences College of Veterinary MedicineChina Agricultural UniversityBeijing 100193China. College of Animal Science and Technology Tarim UniversityAlar 843300China.

Background:Bacillus cereus is an important pathogen that causes human food poisoning,specifically diarrhea and *** can also induce mastitis in dairy cows and has a strong survival ability in milk,as it cannot be inactivated by high-temperature short-time ***,*** can enter the market through pasteurized milk and other dairy products,imposing enormous hidden dangers on food safety and human ***:In this study,*** 2101(BC)was isolated from milk samples of cows with *** grew rapidly with strong hemolysis,making it difficult to prevent mastitis and ensure food ***-T cells were treated with BC and/or Lactobacillus rhamnosus GR-1(LGR-1).Pretreatment with LGR-1 protected the integrity of tight junctions and the expression of zonula occludens-1(ZO-1)and occludin destroyed by ***,LGR-1 pretreatment reduced the expression of NOD-like receptor family member pyrin domain-containing protein 3(NLRP3),caspase recruitment and activation domain(ASC),Caspase-1 p20,gasdermin D(GSDMD)p30,inflammatory factors(interleukin(IL)-1βand IL-18),and cell death induced by ***,LGR-1 pretreatment reduced NLRP3 inflammasome activity and increased expressions of ZO-1 and occludin induced by lipopolysaccharides(LPS)+ATP ***-T cells were transfected with NLRP3 si RNA or MCC950 and/or treated with BC and/or ***3-si RNA transfection and MCC950 attenuated BC-induced NLRP3 inflammasome *** of inflammatory cytokines and cell death suggested that the inflammatory pathway might play an important role in the induction of the NLRP3 inflammasome by BC and the protection of ***:These results suggest that LGR-1 might be a probiotic alternative to antibiotics and could be administered to prevent mastitis in dairy cows,thus ensuring food security.

关键词： Bacillus cereus Intercellular tight junctions Lactobacillus rhamnosus GR-1 NLRP3 inflammasome

Plasma metabolic profiling reveals that chromium yeast alleviates the negative effects of heat stress in mid-lactation dairy cows

在线全文

学校读者我要写书评

暂无评论

Animal Nutrition 2023年第2期13卷 401-410页

作者： Yeqianli Wo Fengtao Ma qiang shan Duo Gao Yuhang Jin Peng Sun State Key Laboratory of Animal Nutrition Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing100193China

Chromium yeast(CY)supplementation has the potential to alleviate the negative effects of heat stress in dairy cows,but the mechanism remains *** aimed to identify the metabolic mechanisms whereby CY supplementation alleviates the negative effects of heat stress in mid-lactation dairy *** Holstein dairy cows with similar milk yield(24.6±1.5 kg/d),parity(2 or 3)and days in milk(125±8 d)were fed the same basal diet containing 0.09 mg of Cr/kg *** were allocated randomly to 2 groups:a control group(CON,without CY supplementation)and a CY group(CY,administered 0.36 mg Cr/kg DM).The experiment was performed over 8 weeks during a hot summer,in which the mean temperature-humidity index was 79.0±3.13(>72),indicating that the dairy cows were exposed to heat *** yeast supplementation reduced rectal temperature(P=0.032),and increased the lactation performance by increasing the yield of milk(+2.6 kg/d),protein,lactose and total solid,and protein and lactose percentages in the milk of the heat-stressed dairy cows(P1.0,P<0.05),and found to be involved in 6 Kyoto Encyclopedia of Genes and Genomes pathways,including those involved in nicotinate and nicotinamide ***,plasma concentration of nicotinamide was higher after CY supplementation,which might also contribute to the reduction of rectal temperature,the regulation of glucose homeostasis,and an improvement in the lactation performance of heat-stressed dairy *** conclusion,CY supplementation reduces re

关键词： Chromium yeast Heat stress Metabolomics Nicotinamide Dairy cow

Tcf1 at the crossroads of CD4^＋ and CD8^＋ T cell identity

在线全文

学校读者我要写书评

暂无评论

Frontiers in Biology 2017年第2期12卷 83-93页

作者： Jodi A. Gullicksrud qiang shan Hai-Hui Xue Department of Microbiology Carver College of Medicine University of Iowa Iowa City IA 52242 USA Interdisciplinary Immunology Graduate Program Carver College of Medicine University of Iowa Iowa City IA 52242 USA

Transcription factors and DNA/histone modification enzymes work in concert to establish and maintain cell identity. CD4^＋ and CD8^＋ T cells are key players in cellular immunity with distinct functions. Recent studies offer novel insights into how their identities are established in the thymus and maintained in the periphery during immune responses. During thymic maturation, Thpok, HDAC1 and HDAC2 guard CD4^＋ T cells from activation of CD8^＋ cytotoxic genes, and Tcfl and Left utilize their intrinsic HDAC activity to shut down CD4^＋ lineage-associated genes in CD8^＋ T cells. In activated CD4＋ T cells, Tcfl and Left act upstream of the Bc16-Blimpl axis to direct differentiation of follicular helper T （Tfh） cells, and prevent diversion of Tfh to IL-17-producing cells. In parallel, T-bet, together with Eomes or Blimpl, ensures proper induction of the cytotoxic program in CD8^＋ effectors elicited by acute infection, and prevents generation of pathogenic, IL-17-producing CD8^＋ effector T cells. Antigen persistence due to chronic viral infection leads to CD8^＋ T cell exhaustion. A portion of exhausted CD8^＋ T cells has the capacity to activate the Tfh program in a Tcfl-dependent manner. Those Tfh-like CD8^＋ T cells exhibit enhanced proliferative capacity in response to PD-1 blockage therapy and are more effective in curtailing viral replication. Thus, dissecting the molecular aspects of T cell identity, during development and immune responses, may lead to new therapies for treating autoimmunity, tumors, and persistent infections.

关键词： Tcf1 Lef1 HDAC CD4^+ T cells CD8^+ T cells cell identity

Significantly reduced function of T cells in patients with acute arterial thrombosis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2015年第3期12卷 287-293页

作者： Wen-Wen YAN Kun-shan ZHANG qiang-Lin DUAN Le-Min WANG i University School of Medicine ShanghaL China

Objectives To explore the intrinsic factors related to the pathogenesis of acute arterial thrombosis （AAT） and to elucidate the patho- genesis of AAT on the basis of differentially expressed genes. Methods Patients with acute myocardial infarction （AMI）, stable angina （SA） and healthy controls （n = 20 per group） were recruited, and the whole human genome microarray analysis was performed to detect the differentially expressed genes among these subjects. Results Patients with AMI had disease-specific gene expression pattern. Biological functional analysis showed the function of T cells was significantly reduced, the mitochondrial metabolism significantly decreased, the ion metabolism was abnormal, the cell apoptosis and inflammatory reaction increased, the phagocytosis elevated, the neutrophil-mediated immunity increased and the post-traumatic repair of cells and tissues increased in AMI patients. The biological function in SA group and healthy controis remained stable and was comparable. Conclusions The reduced function ofT cell gene models in AAT showed the dysfunction of the immune system. The pathogenesis of AAT may be related to the inflammatory reaction after arterial intima infection caused by potential pathogenic microorganisms.

关键词： Acute arterial thrombosis Gene expression pattern Myocardial infarction Stable angina