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Chinese Chemical Letters 2023年第3期34卷 279-282页

作者： shan-Xiu ni Yan-Lin Li Hui-Qi ni Yu-Xiang Bi Jie Sheng Xi-Sheng Wang Department of Chemistry University of Science and Technology of ChinaHefei 230026China

A nickel-catalyzed direct hydromonofluoromethylation of unactivated olefins with industrial raw fluoroiodomethane is developed,furnishing various primary alkyl fluorides in a step-economic *** key factor to success is the use of pyridine-oxazoline as ligand and(MeO)_(2)MeSiH as the hydrogen *** transformation demonstrates high efficiency,mild conditions,good functional-group compatibility and great potential in the drug discovery.

关键词： Hydromonofluoromethylation Unactivated alkenes nickel-catalysis Primary fluorides ni-H species

Ligand-Promoted,Enantioconvergent Synthesis of Aliphatic Alkanes Bearing Trifluoromethylated Stereocenters via Hydrotrifluoroalkylation of Unactivated Alkenes

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Chinese Journal of Chemistry 2022年第13期40卷 1531-1536,I0002页

作者： Yan He Kang-Jie Bian Bing-Bing Wu Peng Liu shan-Xiu ni Xi-Sheng Wang Department of Chemistry University of Science and Technology of ChinaHefeiAnhui 230026China

While drug chirality remains one of the most important themes in medicinal chemistry and fluorine-containing drugs have comprised large portion of global pharmaceutical market,the synthesis of fluorine-containing compounds featuring a trifluoromethylated stereogenic carbon center is still *** strategy of enantioconvergent cross-coupling of trifluoromethylated alkyl halide has significantly updated previous toolbox that is dependent on additional functional group to achieve desired bond formation and highly enantioselective ***,evident limitations were present in specific coupling candidate(sp?carbon)and/or prerequisite heteroatom in trifluoroalkyl source for inducing effective stereoconvergent *** novel design of sterically hindered bisoxazoline ligand and drastic increase of molecular complexity of in situ generated sp3 coupling partner via metal-hydride atom transfer,herein,we report a nickel-catalyzed,highly enantioselective hydrotrifluoroalkylation of unactivated alkenes for diverse synthesis of enantioenriched aliphatic alkanes featuring trifluoromehylated stereogenic *** stereochemical control(mostly>95:5 er),high catalytic reactivity,mild conditions,and broad substrate scope(40+examples),enable convenient late-stage asymmetric trifluoroalkylation of various biologically active complexmolecules.

关键词： Trifluoromethylated stereocenters Hydrotrifluoroalkylation C-Ccoupling Unactivated alkenes Chemoselectivity

INTRACRAniAL ARTERIAL OCCLUSIVE LESION IN PATIENTS WITH GRAVES DISEASE

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Chinese Medical Sciences Journal 2006年第3期21卷 140-144页

作者： Jun ni shan Gao Li-ying Cui Shun-wei Li Department of Neurology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730

Objective To investigate the distribution and clinical manifestations of intracranial arterial occlusive lesions （IA- OLs）, and their correlation with thyroid function. Methods We enrolled 7 patients who had Graves＇ disease （GD） with IAOLs screened and evidenced by transcranial Doppler, then further confirmed with digital substract angiography in 2 patients and magnetic resonance angiography in 5 patients. Brain magnetic resonance imaging （MRI） was performed in all 7 patients. Three patients were followed up. Results Among 7 patients, 1 was male and 6 were females. The mean age was 32.0 ± 5.5 （ range from 11 to 49） years old. Six of them had symptoms of GD but one was asymptomatic with abnormality of I3, T4, and thyroid stimulating hormone. The lesions of intracranial arteries were symmetrical bilaterally in the intemal carotid artery system in 6 patients, as well as asymmetrical in 1 patient. Terminal internal carotid artery （TICA） were involved in all 7 patients. Middle cerebral artery （MCA） were involved in 3, anterior cerebral artery in 2, and basilar artery in 1 patient. Net-like collateral vessels and mimic moyamoya disease were observed in the vicinity of the occlusive arteries in 2 patients. All patients presented symptoms of ischemic stroke including transient ischemic attack and/or infarction while IA- OLs were found. Three patients had obvious involuntary movements. Brain MRI revealed infarctions located in the cortex, basal ganglion, or hemiovular center in 5 patients. The remaining 2 patients had normal brain MRI. The neurological symptoms were improved concomitant with relief of the thyroid function in 2 patients, while IAOLs were aggravated with deterioration of the thyroid function in 1 patient. Conclusion IAOLs in patients with GD mainly involve intracranial arteries, especially the TICA and MCA, which is similar to moyamoya disease. The neurological symptoms and severity of involved arteries may relieve while the hyperthyroidism is gradually

关键词： Graves'disease transcranial Doppler intracranial arterial stenosis occlusive disease

Novel magnetic carbon supported molybdenum disulfide catalyst and its application in residue upgrading

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Green Energy & Environment 2021年第6期6卷 952-960页

作者： Xiangyang Zhu Dong Qiao Liangrong Yang Qinling Bi Huifang Xing shan ni Menglei Yuan Huizhou Liu Luhai Wang An Ma CAS Key Laboratory of Green Process and Engineering State Key Laboratory of Biochemical EngineeringInstitute of Process EngineeringChinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China c China University of Petroleum Beijing102249China Petrochemical Research Institute PetrochinaBeijing102206China

A novel hybrid material consisted of carbon covered Fe_(3)O_(4)nanoparticles and MoS_(2)nanoflower(FCM)was designed and prepared by micelle-assisted hydrothermal *** techniques,including X-Ray diffraction(XRD),high-resolution transmission electron microscopy(HRTEM)and X-ray photoelectron spectroscopy(XPS)were employed to characterize *** results show that FCM has a flower-like morphology with a 330 nm Fe_(3)O_(4)core as well as 70 nm highly crystalline MoS_(2)*** is superparamagnetic with a saturation magnetization of 35 emu *** hydrocracking of Canadian bitumen residue(CBR)was applied to estimate its catalytic *** results show that FCM exhibits superior catalytic hydrocracking activity compared to bulk MoS_(2)and commercial oil-dispersed Mo(CO)6 by the same Mo *** measurement by elemental analysis,XPS and XRD reveals that the MoS_(2)nanoflower with abundant catalytic active sites and covered carbon layer with anti-coke ability donate to the superior upgrading ***,the catalysts can be easily recovered by the external magnetic *** work provides a novel kind magnetic nanocatalyst which is potential for slurry-phase hydrocracking applications.■2020,Institute of Process Engineering,Chinese Academy of *** services by Elsevier *** behalf of KeAi Communications Co.,*** is an open access article under the CC BY-NC-ND license(http://***/licenses/by-nc-nd/4.0/).

关键词： Magnetic Carbon MoS_(2) Catalyst Heavy oil

Neurological Manifestations of Takayasu Arteritis

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Chinese Medical Sciences Journal 2011年第4期26卷 227-230页

作者： Li-xin Zhou Jun ni shan Gao Bin Peng Li-ying Cui Department of Neurology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

Objective To investigate the clinical neurological manifestations of Takayasu arteritis (TA). Methods A retrospective study was conducted with 63 consecutive TA cases admitted to Peking Union Medical College Hospital from January 2009 to May 2010. All the patients fulfilled the diagnostic criteria of TA by the American College of Rheumatology. Among the 63 TA patients, 27 with neurological manifestations were included in the present study. All the patients were evaluated using standardized neurological examination, sonography, computed tomography (CT) angiography, and cerebral CT or magnetic resonance imaging. Results Dizziness and visual disturbance were the most common symptoms, which occurred in 20 (74.1%) and 16 (59.3%) patients respectively. Another common symptom was headache, observed in 15 (55.6%) patients. Six (22.2%) patients had suffered from ischemic stroke; 7 (25.9%) patients had epileptic seizures. Two (7.4%) patients were diagnosed as reversible posterior encephalopathy syndrome (RPES) based on typical clinical and imaging manifestations. Conclusions Neurological manifestations are common symptoms in TA patients in the chronic phase, including dizziness, visual disturbance, headache, ischemic stroke, seizures, and some unusual ones such as RPES. We suggested RPES be included into the differential diagnosis of acute neurological changes in TA.

关键词： Takayasu arteritis neurological manifestation epileptic seizures reversible posterior encephalopathy syndrome

Microbial hydrolysis of 17β-acetoxy steroidal compounds during aromatization by Arthrobacter simplex

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Acta Chimica Sinica(English Edition) 1983年第1期1卷 81-85页

作者： ZHOU Wei-shan(CHOU Wei-shan) HU Bo ni Yuan shanghai Institute of Organic Chemistry,Academia Sinica shanghai Institute of Organic Chemistry Academia Sinica

Steroidal compounds containing 17β-acetoxy group after aromatization by Arthrobactersimplex afforded 17β-hydroxy-,17-keto-or unhydrolyzed 17β-acetoxy-ring A-aromatic compou-nds.17-Keto-compounds were probably formed through the oxidation of the corresponding 17 β-hydroxyl group during fermentation with this *** of 17 β-acetoxy group isdependent upon other substituents present in the substrates.

关键词： OH acetoxy steroidal compounds during aromatization by Arthrobacter simplex Microbial hydrolysis of 17

Interfacial engineering of transition-metal sulfides heterostructures with built-in electric-field effects for enhanced oxygen evolution reaction

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Chinese Journal of Chemical Engineering 2022年第1期35卷 320-328页

作者： shan ni Hongnan Qu Huifang Xing Zihao Xu Xiangyang Zhu Menglei Yuan Meng Rong Li Wang Jiemiao Yu Yanqing Li Liangrong Yang Huizhou Liu CAS Key Laboratory of Green Process and Engineering State Key Laboratory of Biochemical EngineeringInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of SciencesQingdao 266061China

Developing highly efficient,durable,and non-noble electrocatalysts for the sluggish anodic oxygen evolution reaction(OER)is the pivotal for meeting the practical demand in water ***,the current transition-metal electrocatalysts still suffer from low activity and durability on account of poor interfacial reaction *** this work,a facile solid-state synthesis strategy is developed to construct transition-metal sulfides heterostructures(denoted as MS_(2)/niS_(2),M=Mo or W)for boosting OER *** a result,MoS2/niS2 and WS2/niS2 show lower overpotentials of 300 mV and 320 mV to achieve the current density of 10 mA·cm^(-2),and smaller Tafel slopes of 60 ***^(-1) and 83 ***^(-1)in 1 mol·L^(-1) KOH,respectively,in comparison with the single MoS2,WS2,niS2,as well as even the benchmark *** experiments reveal that the designed heterostructures have strong electronic interactions and spontaneously develop a built-in electric field at the heterointerface with uneven charge distribution based on the difference of band structures,which promote interfacial charge transfer,improve absorptivity of OH-,and modulate the energy level more comparable to the ***,the designed transition-metal sulfides heterostructures exhibit a remarkably high electrocatalytic activity for *** study provides a simple strategy to manipulate the heterostructure interface via an energy level engineering method for OER and can be extended to fabricate other heterostructures for various energy-related applications.

关键词： Oxygen evolution reaction Transition-metal sulfides heterostructures Heterointerface Built-in electric field

超高压、辐照杀菌对镇江肴肉贮藏期间品质的影响

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食品工业科技 2023年第15期44卷 362-369页

作者：倪珊扬州大学食品科学与工程学院江苏扬州225127

本文研究了超高压、辐照杀菌方式对肴肉贮藏期间的品质特性的影响,肴肉分别以550 MPa,600 s超高压和6 kGy剂量辐照处理,以未杀菌肴肉作为对照组,于4℃冷藏条件下,以1、10、20、30、40 d为取样点,测定各组样品的pH、硫代巴比妥酸反应物... 详细信息

本文研究了超高压、辐照杀菌方式对肴肉贮藏期间的品质特性的影响,肴肉分别以550 MPa,600 s超高压和6 kGy剂量辐照处理,以未杀菌肴肉作为对照组,于4℃冷藏条件下,以1、10、20、30、40 d为取样点,测定各组样品的pH、硫代巴比妥酸反应物、总挥发性盐基氮、菌落总数、挥发性物质等指标的变化。结果表明:在贮藏期内,各处理组的p H均呈下降趋势,对照组(CK组)下降幅度最大,40 d时降至最低点6.48;各组TBARS值、TVB-N值、菌落总数均呈上升趋势,辐照组的TBARS值始终显著高于另外两组(P<0.05),30 d时,对照组(CK组)菌落总数为6.36 lg CFU/g明显超出国标限值;高压组和辐照组的挥发性物质种类高于对照组(CK组),高压组的醛类、芳香族类、烃类物质的总含量和占比随着贮藏时间的增加呈上升趋势,且高于对照组(CK组)的总含量;而辐照组的醇类、醛类、芳香族类等物质含量及占比均呈下降趋势,超高压处理对肴肉的挥发性风味物质变化有积极影响。超高压处理肴肉能够有效延长肴肉的货架期,并保持食品品质特性。

关键词：镇江肴肉超高压辐照品质杀菌方式

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SYNTHESIS　AND　PROPERTIES　OF　THERMOTROPIC　LIQUID　CRYSTALLINE　COPOLYESTERS　CONTAIniNG　BIS（4－HYDROXYPHENYL）METHANONE（Ⅵ）

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Chinese Chemical Letters 1995年第11期6卷 339-342页

作者： De Wen DONG Ping HAN Zhen Guo CHI Yu shan ni(Changchun Institute of Applied Chemistry, Academia Sinica, Changchun,130022) Acad Sinica Changchun Inst Appl Chem Changchun 130022 Peoples R China

A series of thermotropic liquid crystalline copolyesters were synthesized by thermal polycondensation of p-hydroxybenzoic acid, terephthalic acid, bis (4-hydroxyphenyl )methanone and diols. The resulting copolyesters ... 详细信息

关键词： BIS AND CONTAIniNG

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Application of Inflammatory Markers in Induced Sputum in Stable Chronic Obstructive Pulmonary Disease Patients with Positive Bronchodilation Tests

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Current Medical Science 2019年第4期39卷 560-567页

作者： Xu-xue GUO ni-shan DENG Qian-hui CHEN Hong-ying YU Xu-hong DING Su-ping HU Han-xiang niE Department of Respiratory Diseases Renmin Hospital of Wuhan UniversityWuhan 430060China

Positive bronchodilation (BD) tests can be noticed in some stable chronic obstructive pulmonary disease (COPD) *** characteristics of airway inflammation in this entity remain *** study aimed to identify the characteristics of airway inflammation in stable COPD patients with positive BD *** airway inflammation was assessed in 88 patients with stable COPD using the examination of induced sputum in the aftermath of lung function and BD *** counts and the levels of molecular markers including eosinophil cationic protein (ECP),myeloperoxidase (MPO),interleukin-5 (IL-5),and IL-8 were assayed by Wright's stain,Immuno-CAP system,and ELISA,*** the 88 patients with stable COPD,20 (22.7%) showed positive BD *** values of eosinophils (4.7%±3.4%) and ECP (90.1±41.6 ng/mL) in induced sputum in stable COPD patients with positive BD tests were markedly elevated as compared with those in stable COPD patients with negative BD tests or in healthy controls (all Pnificantly lower than those in asthmatic patients (all Pnificantly decreased in stable COPD patients with positive BD tests as compared with the patients with asthma (12.5±7.8 vs.48.2±26.0 ng/mL;P0.05).Moreover,the values of neutrophils (61.8%±15.1%),MPO (574.0±111.8 ng/mL),and IL-8 (32.6±13.4 ng/mL) in induced sputum in stable COPD patients with positive BD tests were significantly higher than those in asthmatics or normal controls (all P0.05).The stable COPD patients with positive BD tests may present not only eosinophilic airway inflammation but also neutrophilic airway inflammation.

关键词： airway inflammation bronchodilation tests chronic obstructive pulmonary disease induced sputum