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An improved constrained steering law for SGCMGs with DPC

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Acta Mechanica Sinica 2009年第5期25卷 713-720页

作者： Lei Jin shijie xu Department of Guidance, Navigation and Control,school of astronautics, beihang university, 100191 beijing, china Department of Guidance Navigation and Control School of Astronautics Beihang University 100191 Beijing China

An improved constrained （IC） steering law for single gimbal control moment gyros （SGCMGs） with deformed pyramid configuration （DPC） is proposed, First of all, the original system with five pyramid configuration （FPC） whose two adjacent gyros are in failure state is reconfigured as a degraded system with DPC. Then, the singular angular momentum hypersurfaces of the original and the degraded systems are plotted via the singular angular momentum equa- tion of SGCMGs. Based on singular surfaces, the differences between FPC and DPC in singularity and momentum envelope are obtained directly, which provide an important reference for steering law design of DPC. Finally, an IC steering law is designed and applied to DPC. The simulation results demonstrate that the IC steering law has advantages in simplicity of calculation, avoidance of singularity and exactness of output torque, which endow the degraded system with fine controllability in a restricted workspace.

关键词： Single gimbal control moment gyros (SGCMGs) - Deformed pyramid configuration (DPC) Failure Singularity - Steering law

Xiangshao Granules Ameliorate Post-stroke Depression by Inhibiting Activation of Microglia and IDO1 Expression in Hippocampus and Prefrontal Cortex

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Chinese Journal of Integrative Medicine 2025年第1期31卷 28-38页

作者： LI Cheng-gang xu lu-shan SUN Liang xu Yu-hao CAO Xiang ZHAO Chen-chen XIA Sheng-nan ZHANG Qing-xiu xu Yun Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing210008China State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjing210008China Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjing210008China Nanjing Neurology Medical Center Nanjing210008China

Objective To investigate the therapeutic effect of Xiangshao Granules(XSG)on post-stroke depression(PSD)and explore the underlying *** Forty-three C57BL/6J mice were divided into 3 groups:sham(n=15),PSD+vehicle(n=14),and PSD+XSG(n=14)groups according to a random number *** PSD models were constructed using chronic unpredictable mild stress(CUMS)after middle cerebral artery occlusion(MCAO).The sham group only experienced the same surgical operation,but without MACO and CUMS *** XSG group received XSG(60 mg/kg per day)by gavage for 4 *** mice in the sham and vehicle groups were given the same volume of 0.9%saline at the same *** body weight and behavior tests including open field test,sucrose preference test,tail suspension test,and elevated plus-maze test,were used to validate the PSD mouse ***-time fluorescence quantitative polymerase chain reaction(RT-qPCR),enzyme-linked immunosorbent assay(ELISA),and immunofluorescence staining were used to evaluate the anti-inflammatory effects of *** potential molecular mechanisms were explored and verified through network pharmacology analysis,Nissl staining,Western blot,ELISA,and RT-qPCR,*** The body weight and behavior tests showed that MCAO combined with CUMS successfully established the PSD *** alleviated neuronal damage,reduced the expressions of pro-apoptotic proteins Caspase-3 and B-cell lymphoma-2(BCL-2)-associated X(BAX),and increased the expression of anti-apoptotic protein BCL-2 in PSD mice(Pluding tumor necrosis factor-α,interleukin(IL)-1β,and IL-6 via the toll-like receptor 4/nuclear factor kappa-B signaling pathway in PSD mice(Plusion XSG could reverse

关键词： post-stroke depression Xiangshao Granules indoleamine 2,3-dioxygenase 1 Chinese medicine

Establishing a new testing protocol of the electrochemical stability window for electric double-layer capacitors

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Science china Chemistry 2025年第1期68卷 217-225页

作者： Ruilin Hou Xiaoxi Zhao Tingting Liang Qingyun Dou shan xu Xingbin Yan school of Materials Science and Engineering Sun Yat-sen UniversityGuangzhou 510275China Laboratory of Clean Energy Chemistry and Materials Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Center of Industrial Analysis and Testing Guangdong Academy of ScienceGuangzhou 510651China College of Engineering and Applied Sciences Nanjing UniversityNanjing 210093China

The electrochemical stability window(ESW)is crucial for determining the energy density of electric double-layer capacitors(EDLCs).However,current ESW testing protocols of EDLCs are strongly affected by artificial factors,thereby leading to unreliable *** solve this problem,we first identify the key shortcomings of the traditional protocols by analyzing their test ***,taking an aqueous carbon-based EDLC as an example,we design a side reaction descriptor to represent the response difference in the charging capacitance to side reactions between the cyclic voltammetry and galvanostatic chargedischarge *** the aid of this descriptor,we propose a new ESW testing protocol,which is not only able to completely avoid the adverse influence of subjective factors but also fully consider the operating condition *** protocol can be extended from the single electrode to the full *** work proposes a more rigorous definition of ESW and provides a reliable protocol for evaluating the ESW of EDLCs.

关键词： electric double-layer capacitors electrochemical stability window testing protocol side reaction descriptor operating limitation

Interfacial Zn^(2+)-solvation regulator towards reversible and stable Zn anode

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Journal of Energy Chemistry 2025年第1期100卷 684-692页

作者： Miao Zhou Xiongbin luo Hang Li shan Guo Zhuang Tong Xiaotao Zhou xu Li Zhaohui Hou Shuquan Liang Guozhao Fang College of Mechanical Engineering Key Laboratory of Hunan Province for Advanced Carbon-based Functional MaterialsHunan Institute of Science and TechnologyYueyang 414006HunanChina school of Materials Science and Engineering Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan ProvinceCentral South UniversityChangsha 410083HunanChina College of Materials and Metallurgy Guizhou UniversityGuiyang 550000GuizhouChina National Energy Metal Resources and New Materials Key Laboratory Central South UniversityChangsha 410083HunanChina

Aqueous zinc-ion batteries (AZIBs) are fundamentally challenged by the instability of the electrode/electrolyte interface,predominantly due to irreversible zinc (Zn) deposition and hydrogen ***,the intricate mechanisms behind the electrochemical discrepancies induced by interfacial Zn^(2+)-solvation and deposition behavior demand comprehensive *** molecules endowed with special functional groups (such as hydroxyl,carboxyl,etc.) have the potential to significantly optimize the solvation structure of Zn^(2+)and regulate the interfacial electric double layer (EDL).By increasing nucleation overpotential and decreasing interfacial free energy,these functional groups facilitate a lower critical nucleation radius,thereby forming an asymptotic nucleation model to promote uniform Zn ***,this study presents a pioneering approach by introducing trace amounts of n-butanol as solvation regulators to engineer the homogenized Zn (H-Zn) anode with a uniform and dense *** interfacial reaction and structure evolution are explored by in/ex-situ experimental techniques,indicating that the H-Zn anode exhibits dendrite-free growth,no by-products,and weak hydrogen evolution,in sharp contrast to the bare ***,the H-Zn anode achieves a remarkable Zn utilization rate of approximately 20% and simultaneously sustains a prolonged cycle life exceeding 500 ***,the H-Zn//NH_(4)V_(4)O^(10)(NVO) full battery showcases exceptional cycle stability,retaining 95.04%capacity retention after 400 cycles at a large current density of 5 A g^(-1).This study enlightens solvation-regulated additives to develop Zn anode with superior utilization efficiency and extended operational lifespan.

关键词： Aqueous zinc-ion batteries Zn^(2+)-solvation structure Interfacial reaction Asymptotic nucleation model Reversible and stable Zn anode

Association between Per and Polyfluoroalkyl Substance and Abdominal Fat Distribution:A Trait Spectrum Exposure Pattern and Structure-Based Investigation

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Biomedical and Environmental Sciences 2025年第1期38卷 3-14页

作者： Zhi Li Shilin shan Chenyang Song Chengzhe Tao Hong Qian Qin Yuan Yan Zhang Qiaoqiao xu Yufeng Qin Yun Fan Chuncheng lu State Key Laboratory of Reproductive Medicine Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166JiangsuChina Key Laboratory of Modern Toxicology of Ministry of Education School of Public HealthNanjing Medical UniversityNanjing 211166JiangsuChina Department of Public Health Kangda College of Nanjing Medical UniversityLianyungang 222000JiangsuChina Department of Microbes and Infection School of Public HealthNanjing Medical UniversityNanjing 211166JiangsuChina

Objective To investigate the associations between eight serum per-and polyfluoroalkyl substances(PFASs)and regional fat depots,we analyzed the data from the National Health and Nutrition Examination Survey(NHANES)2011-2018 *** Multiple linear regression models were developed to explore the associations between serum PFAS concentrations and six fat compositions along with a fat distribution score created by summing the concentrations of the six fat *** associations between structurally grouped PFASs and fat distribution were assessed,and a prediction model was developed to estimate the ability of PFAS exposure to predict obesity *** Among females aged 39-59 years,trunk fat mass was positively associated with perfluorooctane sulfonate(PFOS).Higher concentrations of PFOS,perfluorohexane sulfonate(PFHxS),perfluorodecanoate(PFDeA),perfluorononanoate(PFNA),and n-perfluorooctanoate(n-PFOA)were linked to greater visceral adipose tissue in this *** men,exposure to total perfluoroalkane sulfonates(PFSAs)and long-chain PFSAs was associated with reductions in abdominal fat,while higher abdominal fat in women aged 39-59 years was associated with short-chain *** prediction model demonstrated high accuracy,with an area under the curve(AUC)of 0.9925 for predicting obesity *** PFAS exposure is associated with regional fat distribution,with varying effects based on age,sex,and PFAS *** findings highlight the potential role of PFAS exposure in influencing fat depots and obesity risk,with significant implications for public *** prediction model provides a highly accurate tool for assessing obesity risk related to PFAS exposure.

关键词： Per-and polyfluoroalkyl substances Regional fat depots Obesity Structure-based NHANES

Critical biomarkers for responsive deep brain stimulation and responsive focal cortex stimulation in epilepsy field

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Fundamental Research 2025年第1期5卷 103-114页

作者： Zhikai Yu Binghao Yang Penghu Wei Hang xu Yongzhi shan Xiaotong Fan Huaqiang Zhang Changming Wang a d Jingjing Wang shan Yu Guoguang Zhao Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China Laboratory of Brain Atlas and Brain Inspired Intelligence Institute of AutomationChinese Academy of ScienceBeijing 100190China Clinical Research Center for Epilepsy Capital Medical UniversityBeijing 100053China Laboratory of Brain Inspired Intelligence Capital Medical UniversityBeijing 100053China school of Future Technology University of Chinese Academy of ScienceBeijing 101408China

To derive critical signal features from intracranial electroencephalograms of epileptic patients in order to design instructions for feedback-type electrical stimulation *** Detrended Fluctuation Analysis(DFA)exponent is chosen as the classification exponent,and the disparities between indicators representing distinct seizure states and the classification efficacy of rudimentary machine learning models are *** DFA exponent exhibited a statistically significant variation among the pre-ictal,ictal period,and post-ictal *** Linear Discriminant Analysis model demonstrates the highest accuracy among the three basic machine learning models,whereas the Naive Bayesian model necessitates the least amount of computational and storage *** set of DFA exponents is employed as an intermediary variable in the machine learning *** resultant model possesses the capability to function as a feedback trigger program for electrical stimulation systems of the feedback variety,specifically within the domain of neural modulation in epilepsy.

关键词： Biomarker Critical state Feedback electrical stimulation Epilepsy Brain computer interface

微生物促进矿物相变及其改良膨胀土胀缩特性试验研究

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岩石力学与工程学报 2025年第1期44卷 209-220页

作者：李珍玉单世杰林坤朱航中南林业科技大学土木工程学院湖南长沙410004

为了研究微生物改良膨胀土胀缩特性的效果,采用元素微量分析、X射线衍射、傅里叶红外光谱和土的胀缩性试验,探讨微生物作用下膨胀土矿物成分、含量和结构的变化规律,研究微生物促进矿物相变作用对膨胀土胀缩特性的影响。试验结果表明,菌... 详细信息

为了研究微生物改良膨胀土胀缩特性的效果,采用元素微量分析、X射线衍射、傅里叶红外光谱和土的胀缩性试验,探讨微生物作用下膨胀土矿物成分、含量和结构的变化规律,研究微生物促进矿物相变作用对膨胀土胀缩特性的影响。试验结果表明,菌-土反应液中阳离子Si^(4+),Al^(3+),K^(+)和Mg^(2+)随时间的推移不断溶出,其中,K^(+)浓度呈现先增加后减少的趋势,在14 d时达到峰值,蒙脱石晶体中的Si-O键、Al-O键和-OH键均受到了影响,表明微生物作用下,K^(+)进入蒙脱石晶体层间,晶体结构受到了破坏。经过14 d的微生物作用,膨胀土试样在2θ=9.882°处出现了伊-蒙混层峰,28 d后在2θ=48.07°处出现了伊利石峰值。K值法计算结果表明,蒙脱石含量减少,而伊利石含量增加。膨胀土的自由膨胀率和有荷膨胀率的降幅率分别为69.01%和24.04%;线缩率和体缩率的降幅率分别为32.9%和30.98%。研究表明,胶质芽孢杆菌能够有效促进蒙脱石向伊利石的转化,降低膨胀土的胀缩性,为膨胀土的微生物改良提供新的技术途径。

关键词：土力学膨胀土蒙脱石胶质芽孢杆菌相变胀缩特性

Research Progress on Microfluidic Paper-based Analytical Devices for Point-of-care Testing

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激光生物学报 2025年第1期34卷 1-11页

作者： ZHANG Yuji xu Ruicheng shan Dan school of Environmental&Biological Engineering Nanjing University Science&TechnologyNanjing 210094China

Point-of-care testing(POCT)refers to a category of diagnostic tests that are performed at or near to the site of the patients(also called bedside testing)and is capable of obtaining accurate results in a short time by using portable diagnostic devices,avoiding sending samples to the medical *** has been extensively explored for diagnosing and monitoring patients’diseases and health conditions with the assistance of development in biochemistry and *** paper-based analytical devices(μPADs)have gained dramatic popularity in POCT because of their simplicity,user-friendly,fast and accurate result reading and low ***μPADs have been successfully commercialized and received excellent feedback during the past several *** review briefly discusses the main types ofμPADs,preparation methods and their detection principles,followed by a few representative *** future perspectives of the development inμPADs are also provided.

关键词： point-of-care testing microfluidic paper-based analytical devices sensor personalized medical treatment portable diagnostic equipment

Multi-channel microelectrode arrays for detection of single-cell level neural information in the hippocampus CA1 under general anesthesia induced by low-dose isoflurane

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Fundamental Research 2025年第1期5卷 72-81页

作者： Ruilin Hu Penghui Fan Yiding Wang Jin shan luyi Jing Wei xu Fan Mo Mixia Wang Yan luo Ying Wang Xinxia Cai Jinping luo State Key Laboratory of Transducer Technology Aerospace Information Research InstituteChinese Academy of ScienceBeijing 100190China university of Chinese Academy of Sciences Beijing 100049China Department of Anesthesiology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200020China

Timely monitoring of anesthesia status during surgery is important to prevent an overdose of isoflurane ***,in-depth studies of the neural mechanisms of anesthetics are *** CA1 plays an important role during ***,a high spatiotemporal resolution microdevice technology for the accurate detection of deep brain nuclei is *** this research,four-shank 32-channel implantable microelectrode arrays(MEAs)were developed for the real-time recording of single-cell level neural information in rat hippocampal *** nanoparticles were modified onto the microelectrodes to substantially enhance the electrical properties of the microelectrode *** modified MEAs exhibited low impedance(11.5±1 kΩ)and small phase delay(-18.5°±2.54°),which enabled the MEAs to record single-cell level neural information with a high signal-to-noise *** MEAs were implanted into the CA1 nuclei of the anesthetized rats,and the electrophysiological signals were recorded under different degrees of anesthesia mediated by low-dose concentrations of *** recorded signals were analyzed in *** caused an inhibition of spike firing rate in hippocampal CA1 neurons,while inducing low-frequency oscillations in CA1,thus enhancing the low-frequency power of local field *** this manner,the spike firing rate and the power of local field potentials in CA1 could characterize the degree of isoflurane *** present study provides a technical tool to study the neural mechanisms of isoflurane anesthesia and a research method for monitoring the depth of isoflurane anesthesia in clinical practice.

关键词： Micro electrode array Hippocampal CA1 Isoflurane anesthesia Spike Local field potentials