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Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS-CoV-2 Omicron strain infection in china:A national multicenter survey of 35,566 individuals

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 113-120页

作者： Meng-Fan Liu Rui-Xia Ma Xian-Bao Cao Hua Zhang Shui-Hong Zhou Wei-Hong Jiang Yan Jiang Jing-Wu Sun Qin-Tai Yang xue-Zhong Li Ya-Nan Sun Li Shi Min Wang Xi-Cheng Song Fu-Quan Chen Xiao-Shu Zhang Hong-Quan Wei Shao-Qing Yu Dong-Dong Zhu luo Ba Zhi-Wei Cao xu-Ping Xiao Xin Wei Zhi-Hong Lin Feng-Hong Chen Chun-Guang shan Guang-Ke Wang Jing Ye Shen-Hong Qu Chang-Qing Zhao Zhen-Lin Wang Hua-Bin Li Feng Liu Xiao-Bo Cui Sheng-Nan Ye Zheng Liu Yu xu Xiao Cai Wei Huang Ru-Xin Zhang Yu-Lin Zhao Guo-Dong Yu Guang-Gang Shi Mei-Ping lu Yang Shen Yu-Tong Zhao Jia-Hong Pei Shao-Bing Xie Long-Gang Yu Ye-Hai Liu Shao-Wei Gu Yu-Cheng Yang Lei Cheng Jian-Feng liu Graduate school of beijing university of Chinese Medicine BeijingChina Department of Otorhinolaryngology Head and Neck Surgery China-Japan Friendship HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First People's Hospital of YinchuanYinchuanChina Department of Otorhinolaryngology The First People's Hospital of Yunnan ProvinceKunmingChina Department of Otorhinolaryngology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Xiangya Hospital Central South UniversityChangshaChina Department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Qingdao UniversityQingdaoChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of USTCHefeiChina Department of Otorhinolaryngology Head and Neck Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Qilu Hospital of Shandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Otolaryngology The Second Hospital of Shandong UniversityShandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery Peking University People's HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery Yantai Yuhuangding HospitalQingdao UniversityYantaiChina Department of Otorhinolaryngology Head and Neck Surgery Xijing HospitalThe Fourth Military Medical UniversityXi'anChina Gansu Provincial Center for Disease Control and Prevention LanzhouChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of China Medical UniversityShenyangChina Department of Otorhinolaryngology Head and Neck Surgery Tongji Hospit

Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in ***:This study was conducted by 45 tertiary Grade-A hospitals in *** and offline questionnaire data were obtained from patients infected with COVID-19 between December 28,2022,and February 21,*** collected information included basic demographics,medical history,smoking and drinking history,vaccination history,changes in olfactory and gustatory functions before and after infection,and other postinfection symptoms,as well as the duration and improvement status of olfactory and gustatory ***:Complete questionnaires were obtained from 35,566 *** overall incidence of olfactory and taste dysfunction was 67.75%.Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste *** received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such *** infection,the average olfactory and taste VAS scores were 8.41 and 8.51,respectively;after infection,they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the *** median duration of dysosmia and dysgeusia was 15 and 12 days,respectively,with 0.5%of patients having symptoms lasting for more than 28 *** overall self-reported improvement rate was 59.16%.Recovery was higher in males,never smokers,those who received two or three vaccine doses,and those that had never experienced dental health issues,or chronic accompanying ***:The incidence of dysosmia and dysgeusia following infection with the SARS-CoV-2 virus is high in *** and prognosis are influenced by several factors,including sex,SARS-CoV-2 vaccination,history of head-facial trauma,nasal and oral health status,smoking and drinking history,and the persistence of accompanying symptoms.

关键词： epidemiologic studies incidence olfactory disorders prognosis SARS-CoV-2 taste disorders

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基于冠状动脉CT血管造影的斑块特征指数对稳定性冠心病患者病变特异性心肌缺血的诊断价值

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中国临床医学 2024年第2期31卷 200-207页

作者：徐海嘉何玮过伟锋杨姗都业弘陆海锋复旦大学附属中山医院心内科上海200032 上海市心血管病研究所上海200032 复旦大学基础医学院上海200032 复旦大学附属中山医院血管外科上海200032 复旦大学附属中山医院放射科上海200032 上海市医学影像研究所上海200032 同济大学附属东方医院放射科上海200120

目的探讨基于冠状动脉CT血管造影(coronary CT angiography,CCTA)构建的斑块特征指数对稳定性冠心病(coronary artery disease,CAD)患者病变特异性心肌缺血的预测价值。方法前瞻性地纳入2020年10月至2022年3月于复旦大学附属中山医院收... 详细信息

目的探讨基于冠状动脉CT血管造影(coronary CT angiography,CCTA)构建的斑块特征指数对稳定性冠心病(coronary artery disease,CAD)患者病变特异性心肌缺血的预测价值。方法前瞻性地纳入2020年10月至2022年3月于复旦大学附属中山医院收治的稳定性CAD患者90例,包括狭窄程度在30%~90%的目标血管135支。所有患者2周内均接受了CCTA、侵入性冠脉造影和有创血流储备分数(fractional flow reserve,FFR)测量。根据有无血流动力学显著性狭窄,分为心肌缺血人群(FFR≤0.80,n=30)和非缺血人群(FFR>0.8,n=60),将135支目标血管分为病变特异性心肌缺血组(FFR≤0.8,n=36)和非病变特异性心肌缺血组(FFR>0.8,n=99)。采用单因素和多因素logistic回归分析诊断病变特异性心肌缺血的影响因素,并建立基于CCTA的斑块特征指数的回归模型。采用ROC曲线分析基于CCTA的斑块特征指数对稳定性CAD患者病变特异性心肌缺血的预测效能。结果心肌缺血人群与非缺血人群在年龄、体质量指数、性别、心血管危险因素、药物治疗史方面差异均无统计学意义。与非缺血组相比,心肌缺血组的斑块长度、斑块面积、面积狭窄百分比、动脉粥样硬化斑块总体积、血管体积、脂质斑块体积水平较高,点状钙化、正性重塑、餐巾环征的比例较高,而最小管腔面积较小(均P<0.05)。单因素和多因素logistic回归分析结果显示,最小管腔面积(OR=0.303,95%CI 0.178~0.517,P<0.001)和总动脉粥样硬化体积(OR=1.006,95%CI 1.002~1.010,P=0.003)为稳定性CAD患者病变特异性心肌缺血的独立预测因子。基于CCTA的斑块特征指数预测概率的回归方程为P=1/[1+e-(-1.19441×MLA+0.006058×TAV+0.600912)],其诊断病变特异性心肌缺血的AUC为0.879(95%CI 0.811~0.928),总体诊断准确度、灵敏度、特异度、PPV、NPV分别为80.0%、83.3%、78.8%、58.8%、92.9%。结论在稳定性CAD患者中,基于CCTA的斑块特征指数对病变特异性心肌缺血有较高的预测价值,具有良好的临床应用前景。

关键词：冠心病心肌缺血冠状动脉CT血管造影斑块特征指数诊断效能

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《药剂学》课程教学中思政元素的发掘与探讨

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海峡药学 2024年第1期36卷 75-77页

作者：洪怡曹艳符棘玉卢山郭瑜婕许汉林湖北中医药大学药学院湖北武汉430065

目的探讨《药剂学》课程教学中思政元素的发掘与应用。方法从人、课程、实践的角度发掘思政的元素,创新教学模式,在理论和实践课程中落到实处。结果《药剂学》课程教学内容与思政元素有机融入,紧密结合。结论通过在课程中加入思政元... 详细信息

目的探讨《药剂学》课程教学中思政元素的发掘与应用。方法从人、课程、实践的角度发掘思政的元素,创新教学模式,在理论和实践课程中落到实处。结果《药剂学》课程教学内容与思政元素有机融入,紧密结合。结论通过在课程中加入思政元素,达到全方位立体的育人目标。

关键词：课程思政《药剂学》思政元素

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Micropollutant removal and disinfection byproduct control by sequential peroxymonosulfate-UV treatment in water: A case study with sulfamethoxazole

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Journal of Environmental Sciences 2022年第7期34卷 141-150页

作者： Tian-Yang Zhang Yong-shan lu Zhen-Ning luo Wen-Jun Sun Bin xu Chen-Yan Hu Yu-Lin Tang Zheng-Yu Dong Xiao-Meng Ren State Key Laboratory of Pollution Control and Resource Reuse Key Laboratory of Yangtze Water EnvironmentMinistry of EducationCollege of Environmental Science and EngineeringTongji UniversityShanghai 200092China shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China school of Environment Tsinghua UniversityBeijing 100084China College of Environmental and Chemical Engineering Shanghai University of Electric PowerShanghai 200090China PLA Naval Medical Center Shanghai 200433China

UV/peroxymonosulfate(UV/PMS) advanced oxidation process has attracted significant attention for removal of micropollutants in water. However, during practical water treatment applications, the PMS treatment must be performed before the UV treatment to achieve full contact. In this study, sulfamethoxazole(SMX) was selected as the target micropollutant. Four different operational approaches, including UV alone, PMS alone, simultaneous UV/PMS and sequential PMS-UV, were compared for their differences in SMX removal and disinfection by-product(DBP) formation potentials during chlorine-driven disinfection. Among the four approaches, UV/PMS and PMS-UV achieved over 90% removal efficiencies for SMX without substantial differences. For raw water, the trichloronitromethane(TCNM) formation potential after treatment with PMS-UV was lower than that after UV/PMS treatment. The time interval over which the PMS-UV process was conducted had little effect on the final removal efficiency for SMX. However, a brief(5 min) pre-PMS treatment significantly reduced the TCNM formation potential and the genotoxicity from DBPs. The formation risk for TCNM during chlorination increased markedly with increasing PMS dosages, and the appropriate dosage under these experimental conditions was suggested to be 0.5–1.0 mmol/L. Under alkaline conditions, PMS-UV treatment can enhance SMX degradation as well as dramatically reduced the formation potentials for haloketones, haloacetonitriles and halonitromethanes. This study suggests that proper optimization of UV/PMS processes can remove SMX and reduce its DBP formation.

关键词： Peroxymonosulfate-UV(PMS-UV) Sulfamethoxazole(SMX) Disinfection by-products(DBPs) Operational approaches Water treatment

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油莎豆茎叶代谢物与块茎形态的关联研究

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中国油料作物学报 2024年第1期46卷 62-71页

作者：麻剑南单成彬冯旭马越王力伟张向前赵小庆路战远张德健马超美内蒙古大学生命科学学院牧草与特色作物生物学教育部重点实验室内蒙古呼和浩特010030 内蒙古医科大学药学院内蒙古呼和浩特010110 内蒙古自治区农牧业科学院内蒙古呼和浩特010031

为研究油莎豆表型差异与茎叶代谢物间的关联,比较分析了10份油莎豆样本的叶宽、块茎宽度、块茎厚度、块茎高度等表型参数,同时利用超高效液相色谱-串联质谱(UHPLC-MS/MS)技术定性定量分析其茎叶代谢物。10份油莎豆样本分为2个表型,即宽... 详细信息

为研究油莎豆表型差异与茎叶代谢物间的关联,比较分析了10份油莎豆样本的叶宽、块茎宽度、块茎厚度、块茎高度等表型参数,同时利用超高效液相色谱-串联质谱(UHPLC-MS/MS)技术定性定量分析其茎叶代谢物。10份油莎豆样本分为2个表型,即宽叶圆粒型和窄叶长粒型,其叶宽与块茎宽度和块茎厚度呈正相关。用UHPLC-MS/MS对油莎豆茎叶中28个主要代谢物,包括黄烷-3醇、咖啡酸衍生物和黄酮类成分的相对含量进行测定分析比较。结果表明,4个黄酮类化合物即木犀草素-7-二葡萄糖醛酸苷、荭草苷、木犀草素-7-葡萄糖醛酸苷和木犀草素在宽叶圆粒型油莎豆茎叶中的含量显著高于窄叶长粒型油莎豆茎叶。利用KEGG和PlantCyc推导绘制了4种差异黄酮代谢物在油莎豆茎叶中的生物合成途径,并预测宽叶圆粒型油莎豆相较于窄叶长粒型更具有耐旱性,可为油莎豆的品种鉴定、选育和茎叶资源利用提供依据。。

关键词：油莎豆表型二次代谢产物超高效液相色谱-串联质谱

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A highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases

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Acta Pharmaceutica Sinica B 2022年第4期12卷 1652-1661页

作者： Jie Zhou Wei xu Zezhong Liu Chao Wang Shuai Xia Qiaoshuai Lan Yanxing Cai shan Su Jing Pu Lixiao Xing Youhua Xie lu lu Shibo Jiang Qian Wang Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical Sciences and BSL-3 FacilityShanghai Institute of Infectious Diseases and BiosecurityFudan UniversityShanghai 200032China State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology and ToxicologyBeijing 100850China

The development of broad-spectrum antivirals against human coronaviruses(HCoVs)is critical to combat the current coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and its variants,as well as future outbreaks of emerging *** have previously identified a polyethylene glycol-conjugated(PEGylated)lipopeptide,EK1C4,with potent pan-CoV fusion inhibitory ***,PEG linkers in peptide or protein drugs may reduce stability or induce anti-PEG antibodies in ***,we herein report the design and synthesis of a series of dePEGylated lipopeptide-based pan-CoV fusion inhibitors featuring the replacement of the PEG linker with amino acids in the heptad repeat 2 C-terminal fragment(HR2-CF)of *** these lipopeptides,EKL1C showed the most potent inhibitory activity against infection by SARS-CoV-2 and its spike(S)mutants,as well as other HCoVs and some bat SARS-related coronaviruses(SARSr-CoVs)*** dePEGylated lipopeptide EKL1C exhibited significantly stronger resistance to proteolytic enzymes,better metabolic stability in mouse serum,higher thermostability than the PEGylated lipopeptide EK1C4,suggesting that EKL1C could be further developed as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases.

关键词： Coronavirus Lipopeptide SARS-CoV-2 Polyethylene glycol Fusion inhibitor

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Adipose-derived stem cell/FGF19-loaded microfluidic hydrogel microspheres for synergistic restoration of critical ischemic limb

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Bioactive Materials 2023年第9期27卷 394-408页

作者： Ruihan Wang Fangqian Wang shan lu Bin Gao Yuanqing Kan Tong Yuan Yisheng xu Chen Yuan Daqiao Guo Weiguo Fu Xiaohua Yu Yi Si Department of Vascular Surgery Zhongshan Hospital Fudan UniversityShanghai200032PR China Institute of Vascular Surgery Fudan UniversityShanghai200032PR China National Clinical Research Center for Interventional Medicine Shanghai200032PR China Department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou310009ZhejiangPR China Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province Hangzhou310000ZhejiangPR China State Key Laboratory of Chemical Engineering East China University of Science and TechnologyShanghai200237China

The efficacy of stem cell therapy is substantially compromised due to low cell survival rate and poor local retention post-delivery. These issues drastically limit the application of stem cells for ischemic limb therapy, which requires effective blood perfusion and skeletal muscle regeneration. Herein, based on microfluidic technology, an integrated stem cell and cytokine co-delivery system designed for functional ischemic limb salvage was constructed by first incorporating the myogenic cytokine, fibroblast growth factor 19 (FGF19), into microspheres composed of methacrylate gelatin (GelMA). Then adipose-derived stem cells (ADSCs) were highly absorbed into the porous structure of the microspheres, overcoming the insufficient loading efficiency and activities by conventional encapsulation strategy. The fabricated ADSCs/FGF19@μsphere system demonstrated a uniform size of about 180 μm and a highly porous structure with pore sizes between 20 and 40 μm. The resultant system allowed high doses of ADSCs to be precisely engrafted in the lesion and to survive, and achieved sustained FGF19 release in the ischemic region to facilitate myoblast recruitment and differentiation and myofibrils growth. Furthermore, the combination of ADSCs and FGF19 exhibited a positive synergistic effect which substantially improved the therapeutic benefit of angiogenesis and myogenesis, both in vitro and in vivo. In summary, a stem cell and cytokine co-delivery system with the properties of easy preparation and minimal invasiveness was designed to ensure highly efficient cell delivery, sustained cytokine release, and ultimately realizes effective treatment of ischemic limb regeneration.

关键词： Microfluidic technology Stem cell Cytokine Porous microspheres Ischemic limb salvage

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Fine root litter quality regulates soil carbon storage efficiency in subtropical forest soils

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Soil Ecology Letters 2023年第4期5卷 65-80页

作者： shan xu Fanglong Su Emma J.Sayer Shu Kee Lam Xiankai lu Chengshuai Liu Derrick Y.F.Lai Department of Geography and Resource Management The Chinese University of Hong KongShatinNew TerritoriesHong Kong SARChina South china Botanical Garden Chinese Academy of SciencesGuangzhou 510070China Lancaster Environment Centre Lancaster UniversityLancasterLA14YQUnited Kingdom Smithsonian Tropical Research Institute P.O.Box 0843-03092BalboaAnconPanamaRepublic of Panama school of Agriculture and Food The University of MelbourneVictoria 3010Australia Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control and Management Guangdong Institute of Eco-environmental Science&TechnologyGuangzhou 510650China State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China Centre for Environmental Policy and Resource Management The Chinese University of Hong KongShatinNew TerritoriesHong Kong SARChina

●High-quality and low-quality root litter had contrasting patterns of mass loss.●Greater litter-derived C was incorporated into soils under high-quality root litter.●Root litter decay rate or litter-derived C were related to soil microbial diversity.●Root litter quality had little effect on soil physicochemical properties.●High root litter quality was the main driver of enhanced soil C storage *** root litter is a major contributor to soil carbon(C)storage in forest *** decomposition,the quality of root litter could play a critical role in soil C ***,it is unclear whether root litter quality influences soil C storage *** conducted a two-year greenhouse decomposition experiment using 13C-labeled fine root litter of two tree species to investigate how root litter quality,represented by C to nitrogen(C/N)ratios,regulates decomposition and C storage efficiency in subtropical forest soils in china.‘High-quality’root litter(C/N ratio=26)decayed faster during the first year(0−410 days),whereas‘low-quality’root litter(C/N ratio=46)decomposed faster toward the end of the two-year period(598−767 days).However,over the two years of the study,mass loss from high-quality root litter(29.14±1.42%)was lower than‘low-quality’root litter(33.01±0.54%).Nonetheless,root litter C storage efficiency(i.e.,the ratio of new root litter-derived soil C to total mineralized root litter C)was significantly greater for high-quality root litter,with twice as much litter-derived C stored in soils compared to low-quality root litter at the end of the *** litter quality likely influenced soil C storage via changes in microbial diversity,as the decomposition of high-quality litter declined with increasing bacterial diversity,whereas the amount of litter-derived soil C from low-quality litter increased with fungal *** results thus reveal that root litter quality mediates decomposition and C storage in subtropical forest soils in Ch

关键词： fine root litter quality root litter decomposition litter carbon storage efficiency soil organic carbon accumulation subtropical forest

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Comparative Analysis of Telomerase Activity in CD117^＋CD34^＋ Cardiac Telocytes with Bone Mesenchymal Stem Cells, Cardiac Fibroblasts and Cardiomyocytes

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Chinese Medical Journal 2015年第14期128卷 1942-1947页

作者： Yuan-Yuan Li shan-shan lu Ting xu Hong-Qi Zhang Hua Li Neurointensive Care Unit Second Affiliated Hospital School of Medcine Zhejiang University Hangzhou 310009 Zhejiang China Department of Anatomy Histology and Embryology Shanghai Medical College of Fudan University Shanghai 200032 China State Key Laboratory of Cell Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China

Background： This study characterized the cardiac telocyte （TC） population both in vivo and in vitro, and investigated its telomerase activity related to mitosis. Methods： Using transmission electron microscopy and a phase contrast microscope, the typical morphological features of cardiac TCs were observed; by targeting the cell surface proteins CD1 17 and CD34, CD 117^＋CD34^＋ cardiac TCs wcrc sorted via flow cytomctry and validated by immunofluorescence based on the primary cell culture. Then the optimized basal nutrient medium for selected population was examined with the cell counting kit 8. Under this conditioned medium, the process of cell division was captured, and the telomerase activity of CD117^＋ CD34^＋ cardiac TCs was detected in comparison with bone mesenchymal stem cells （BMSCs）, cardiac fibroblasts （CFBs）, cardiomyocytes （CMs）. Results： Cardiac TCs projected characteristic telopodes with thin segments （podomers） in alternation with dilation （podoms）. In addition, 64% of the primary cultured cardiac TCs were composed of CD117^＋CD34^＋ cardiac TCs： which was verified by immunofluorescence. In a live cell imaging system, CD117^＋CD34^＋ cardiac TCs were observed to enter into cell division in a short time. followed by an significant invagination forming across the middle of the cell body. Using a real-time quantitative telomeric-repeat amplification assay, the telomerase concentration in CD117^＋CD34^＋ cardiac TCs was obviously lower than in BMSCs and CFBs, and significantly higher than in CMs. Conclusions： Cardiac TCs represent a unique cell population and CD11 7^＋CD34^＋ cardiac TCs have relative low telomerase activity that differs from BMSCs, CFBs and CMs and thus they might play an important role in maintaining cardiac homeostasis.

关键词： Cardiac Telocyte Cell Division Telomerase Activity Telopode

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Effect of Nb and Mo on the Microstructure, Mechanical Properties and Ductility-Dip Cracking of Ni–Cr–Fe Weld Metals

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Acta Metallurgica Sinica(English Letters) 2016年第10期29卷 928-939页

作者： xu Zhang Dian-Zhong Li Yi-Yi Li shan-Ping lu Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences school of Materials Science and Engineering University of Science and Technology of China Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal Research Chinese Academy of Sciences

A series of Ni-Cr-Fe welding wires with different Nb and Mo contents were designed to investigate the effect of Nb and Mo on the rnicrostructure, mechanical properties and the ductility-dip cracking susceptibility of the weld metals by optical microscopy （OM）, scanning electron microscopy, X-ray diffraction as well as the tensile and impact tests. Results showed that large Laves phases formed and distributed along the interdendritic regions with high Nb or Mo addition. The Cr-carbide （M23C6） was suppressed to precipitate at the grain boundaries with high Nb addition. Tensile testing indicates that the ultimate strength of weld metals increases with Nb or Mo addition. However, the voids formed easily around the large Laves phases in the interdendritic area during tensile testing for the weld metal with high Mo content. It is found that the tensile fractographs of high Mo weld metals show a typical feature of interdendritic fracture. The high Nb or Mo addition, which leads to the formation of large Laves phases, exposes a great weakening effect on the impact toughness of weld metals. In addition, the ductility-dip cracking was not found by OM in the selected cross sections of weld metals with different Nb additions. High Nb addition can eliminate the ductility-dip cracking from the Ni-Cr-Fe weld metals effectively.

关键词： Nb Mo Laves phase Microstructure Mechanical properties

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