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Cardiovascular risk burden,dementia risk and brain structural imaging markers:a study from UK Biobank

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General Psychiatry 2024年第1期37卷 94-102页

作者： Yaying Cao Gaohong Zhu Chengwu Feng Jing Chen Wei Gan Yuan ma Yonghua Hu Klodian Dhana Trudy Voortman Jie Shen Ting Li Yan Zheng Changzheng Yuan Geng Zong Department of Food Nutrition and Health School of Medicine and HealthHarbin Institute of TechnologyHarbinHeilongjiangChina CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghaiChina Department of Nuclear Medicine First Affiliated Hospital of Kunming Medical UniversityKunmingYunnanChina Neurology Department Zhongshan Hospital Affliated with Fudan UniversityShanghaiChina medical Research Council Population Health Research Unit University of OxfordOxfordUK Department of Genetics Novo Nordisk Research Centre OxfordOxfordUK Harvard university T H Chan school of Public Health BostonMassachusettsUSA Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijingChina Department of Internal Medicine Rush University Medical CenterChicagolinoisUSA Department of Epidemiology rasmus MCUniversity Medical Center RotterdamRotterdamThe Netherlands Division of Human Nutrition and Health Wageningen University&ResearchWageningenThe Netherlands school of Public Health the Second Afliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina First Afiliated Hospital of Kunming medical university KunmingYunnanChina State Key Laboratory of Genetic Engineering School f ife SCciencesFudan UniversityShanghaiChina Ministry of Education Key Laboratory of Public Health Safety School of Public HealthFudan UniversityShanghaiChina The Key Laboratory of Inteligent Preventive Medicine of Zhejang Province HangzhouZhejiangChina shanghai Jiao Tong university Affiliated Sixth People's Hospital ShanghaiChina

Background Cardiovascular risk burden is associated with dementia risk and neurodegeneration-related brain structure,while the role of genetics and incident cardiovascular disease(CVD)remains *** To examine the association of overall cardiovascular risk burden with the risk of major dementia subtypes and volumes of related brain regions in a large sample,and to explore the role of genetics and CVD *** A prospective study among 354 654 participants free of CVD and dementia(2006-2010,mean age 56.4 years)was conducted within the UK Biobank,with brain magnetic resonance imaging(MRl)measurement availablefor 15104participants since *** risk burden was evaluated by the Framingham General Cardiovascular Risk Score(FGCRS).Dementia diagnosis was ascertained from inpatient and death register *** Overamedian 12.0-yearfollow-up,3998 all-cause dementia cases were *** FGCRS was associated with increasedall-cause dementia risk after adjusting for demographic,major lifestyle,clinical factors and the polygenic risk score(PRS)of Alzheimer's *** the high versus low tertile of FGCRS,the odds ratios(ORs)and 95%confidence intervals(Cls)were 1.26(1.12 to 1.41)for all-cause dementia,1.67(1.33 to 2.09)for Alzheimer's disease and 1.53(1.07 to 2.16)for vascular dementia(all p_(treng)lumes,higher FGCRS was associated with greater log-transformed white matter hyperintensities,smaller cortical volume and smaller grey matter *** Our findings suggest that the positive association of cardiovascular risk burden with dementia risk also applies to major dementia subtypes.T

关键词： Cardiovascular diagnosis burden

Integrin-linked kinase overexpression promotes epithelial-mesenchymal transition via nuclear factor-κB signaling in colorectal cancer cells

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World Journal of Gastroenterology 2016年第15期22卷 3969-3977页

作者： Hong Shen Jun-Li ma Yan Zhang Gan-lu Deng Yan-Ling Qu Xiao-Ling Wu Jing-Xuan He Sai Zhang shan Zeng Department of Oncology Xiangya Hospital Central South University Institute of medical Sciences Xiangya Hospital Central South University

AIM: To investigate the effect of integrin-linked kinase (ILK) on proliferation, metastasis, and invasion of the colorectal cancer cell line ***: In this study, the colorectal cancer cell line SW480 was stably transfected with ILK plasmids, and small interfering RNA (siRNA) was used to knockdown expression of nuclear factor (NF)-κB/p65. Methylthiazole tetrazolium (MTT) assay was performed to measure proliferation, and the wound healing migration assay and matrigel invasion assay were used to test the metastasis and invasion ability of SW480 cells. To explore the epithelial-mesenchymal transition (EMT) process, embryonic development, and the invasion and metastasis of tumors, the protein level of E-cadherin, vimentin, snail, and slug was detected by western blot. Immunofluorescence was also used to detect E-cadherin expression. Western blot was used to determine the level of phosphorylated-inhibitor of kappa B (IκB)a, inhibitor of gamma B (IγB)a, and nuclear factor kappa B (NF-κB) expressions and to explore the ILK signaling ***: Western blot results revealed that ILK expression significantly increased when ILK was overexpressed in SW480 cells (P luorescence results revealed that E-cadherin fluorescence intensity decreased after ILK was overexpressed (P lug were upregulated when ILK was overexpressed in SW480 cells (P < 0.05). In order to determine the role of the NF-κB signaling pathway in ILK overexpression promoted EMT occurrence, we overexpressed ILK in SW480 cells and found that levels of NF-κB/p65 and cytoplasmic phosphorylated-IκBa were increased and that cytoplasmic IкBa levels were

关键词： Colorectal cancer Integrin-linked kinase Epithelial-mesenchymal transition Nuclear factor-κ B Overexpression

“AI+教育”时代背景下医学实践课程教学模式现状与改革趋势

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医学新知 2024年第8期34卷 950-956页

作者：程珊丛林胡文东熊凯文马进空军军医大学航空航天医学系航空航天医学装备教研室西安710032

随着人工智能(artificial intelligence,AI)与教育深度融合发展,传统医学教育模式发生了重大变革。鉴于目前以ChatGPT、机器学习等为代表的人工智能技术在临床医学方面的应用,医学实践课程教学也应积极寻求变革。本文从教学方法和效果... 详细信息

随着人工智能(artificial intelligence,AI)与教育深度融合发展,传统医学教育模式发生了重大变革。鉴于目前以ChatGPT、机器学习等为代表的人工智能技术在临床医学方面的应用,医学实践课程教学也应积极寻求变革。本文从教学方法和效果评价两方面,阐述了AI背景下医学实践课程教学模式的改革需求和研究现状;同时,在教学理念方法革新、教学精准评价和教师AI思维培养三方面,探讨了AI时代背景下临床实践课程教学模式改革趋势,为医学院校培养符合时代发展需求的高层次医学人才提供可行途径。

关键词：人工智能医学实践课程教学改革教学理念精准评价思维培养

两种常用压力性损伤大鼠模型的建立方法与效果评价

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中国比较医学杂志 2024年第3期34卷 93-101页

作者：刘艺李小雷梁新培王娜马姗张新平贾汝福张素李贤河北医科大学研究生院石家庄050000 河北省疾病预防控制中心石家庄050000 北京大学人民医院北京100000 河北省人民医院石家庄050000 沧州市中心医院河北沧州061000

目的通过比较两种不同的压力性损伤大鼠模型的建立方法,探索更合适的压力性损伤动物模型制备方法。方法将18只雄性SD大鼠随机分为对照组(n=6)、模型A组(n=6)和模型B组(n=6)。对照组对模拟造模部位脱毛后进行碘伏处理。模型A组采用单纯... 详细信息

目的通过比较两种不同的压力性损伤大鼠模型的建立方法,探索更合适的压力性损伤动物模型制备方法。方法将18只雄性SD大鼠随机分为对照组(n=6)、模型A组(n=6)和模型B组(n=6)。对照组对模拟造模部位脱毛后进行碘伏处理。模型A组采用单纯深部组织异物植入法进行纵向加压;模型B组使用磁铁加压法进行横向加压,记录制备各组大鼠产生压力性损伤模型的全程时间及各分期时间,观察大鼠的一般情况,并进行成模率、死亡率、感染率的比较。结果肉眼观察到模型A组和模型B组均逐渐出现受压部位红肿、溃烂,出现渗血、渗液并伴有坏死现象。模型A组与模型B组产生压力性损伤全程时间比较:两组之间差异有统计学意义(P0.05);Ⅱ期两组之间差异有统计学意义(P<0.05);Ⅲ期两组之间差异有统计学意义(P<0.05);Ⅳ期两组之间差异有统计学意义(P<0.05)。对照组大鼠精神、运动评分与模型A组、模型B组比较有显著性差异(P<0.05)。模型A组大鼠与模型B组大鼠一般状态有明显区别,均出现毛色黯淡、活跃度下降的现象。模型A组大鼠与模型B组成模率为100%。模型A组死亡率、感染率高于模型B组,分别为33.34%、16.70%。结论两种方式均可成功制备压力性损伤Ⅳ期模型,二者既有共性也有各自特点,磁铁加压法用时短,大鼠一般状态良好,死亡率和感染率低,适合短时间内干预性研究;单纯深部组织异物植入法用时长,需要大鼠有一定耐受性,感染率高,死亡率高,可运用于长期的观察类压力性损伤大鼠的研究。

关键词：压力性损伤大鼠模型方法

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脊髓型颈椎病发病机制及治疗措施的研究进展

中国临床研究 2024年第5期37卷 661-665页

作者：刘立俊高山马广斌李鹏贾梦龙杨扬刘铭于龙潭山东中医药大学第一临床医学院山东济南250199 潍坊市中医院山东潍坊261041

脊髓型颈椎病(CSM)是颈椎病中最严重的一个亚型,是造成中老年人群脊髓功能障碍的主要原因。本病发病机制复杂,主要包括退变老化、动态失稳、脊髓缺血、脊髓损伤、炎症、细胞凋亡等可能的机制。治疗方案主要包括保守治疗和手术治疗,保守... 详细信息

脊髓型颈椎病(CSM)是颈椎病中最严重的一个亚型,是造成中老年人群脊髓功能障碍的主要原因。本病发病机制复杂,主要包括退变老化、动态失稳、脊髓缺血、脊髓损伤、炎症、细胞凋亡等可能的机制。治疗方案主要包括保守治疗和手术治疗,保守治疗包括药物、针刺、艾灸、牵引、物理治疗和手法治疗等方式,手术治疗根据手术入路可分为前路手术、后路手术、前后联合手术。治疗方案的选择应结合患者症状、体征以及辅助检查的结果等多方面综合考量,但如何选择适宜的治疗方案仍是临床医生关注的焦点。本文着重探讨该病的发病机制及治疗方法的相关研究进展,为CSM的诊断、治疗提供参考。

关键词：脊髓型颈椎病椎管狭窄颈椎前路椎间盘切除融合术颈椎后路手术

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儿童呼吸道常见病原学检验项目相关性研究

中国药物滥用防治杂志 2024年第1期30卷 52-55页

作者：陈金凤王凯单慧亭马岿新疆医科大学第一附属医院药学部新疆乌鲁木齐830011 山东省济宁市妇女儿童医院药剂科山东济宁272000

目的:探讨血常规(WBC)、C反应蛋白(CRP)、血清降钙素原(PCT)及肺炎支原体核酸,呼吸道病毒核酸或抗原阳性在呼吸道感染类型中的相关性。方法:收集2019年4月—2021年12月于山东省济宁市妇女儿童医院因呼吸道感染入院的患儿共306例,采集患... 详细信息

目的:探讨血常规(WBC)、C反应蛋白(CRP)、血清降钙素原(PCT)及肺炎支原体核酸,呼吸道病毒核酸或抗原阳性在呼吸道感染类型中的相关性。方法:收集2019年4月—2021年12月于山东省济宁市妇女儿童医院因呼吸道感染入院的患儿共306例,采集患儿静脉血检测血常规、PCT及CRP等炎症指标并统计分析其相关性。结果:乙型流感病毒、甲型流感病毒、呼吸道合胞病毒、腺病毒间WBC、NE%、CRP比较,差异有统计学意义(P0.05)。支原体核酸阳性与病毒阳性患儿NE%、CRP、PCT3比较,差异无统计学意义(P>0.05);支原体阳性与病毒阳性患儿WBC比较,差异有统计学意义(P0.05)。结论:在病毒病原学检测方法中,可根据医院自身的检测条件,抗原检测或核酸检测任选其一即可,当检测结果为阴性时,应用WBC、NE%、CRP检测对于不同病毒及支原体感染的鉴别诊断也具有一定的参考价值。

关键词：病毒感染儿童支原体感染炎性指标

卵巢畸胎瘤相关抗N-甲基-D-天冬氨酸受体脑炎发病机制及诊疗研究进展

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中国全科医学 2024年第24期27卷 3038-3043,3050页

作者：张珊张萌徐欣廖丽鑫孙明军马海燕张海滨郭钰珍兰州大学第二临床医学院甘肃省兰州市730030 兰州大学第二医院妇科甘肃省兰州市730030

抗N-甲基-D-天冬氨酸受体(NmdAR)脑炎是一种自身免疫性脑炎,是卵巢畸胎瘤的罕见并发症之一,主要治疗方式为手术切除肿瘤联合免疫治疗,但卵巢畸胎瘤相关抗NmdAR脑炎的发病机制目前尚不明确,且患者临床表现多样,多以神经系统表现为主,易... 详细信息

抗N-甲基-D-天冬氨酸受体(NmdAR)脑炎是一种自身免疫性脑炎,是卵巢畸胎瘤的罕见并发症之一,主要治疗方式为手术切除肿瘤联合免疫治疗,但卵巢畸胎瘤相关抗NmdAR脑炎的发病机制目前尚不明确,且患者临床表现多样,多以神经系统表现为主,易误诊及漏诊,需妇科和神经内科医生共同诊断及治疗。本文综述了NmdAR的结构和功能,归纳了既往卵巢畸胎瘤相关抗NmdAR脑炎的相关研究成果,总结其发病机制、早期诊断、鉴别诊断、治疗、预后和复发的研究进展,为更好地诊断和治疗卵巢畸胎瘤相关抗NmdAR脑炎提供理论依据和思路。

关键词：抗N-甲基-D-天冬氨酸受体脑炎畸胎瘤抗NmdAR受体发病机制

维普期刊数据库博看期刊

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美沙拉嗪致急性胰腺炎的文献病例分析

中国医院药学杂志 2024年第16期44卷 1915-1919页

作者：马忠叶高采平唐静唐薇巫明毫李发靖杜姗凉山州第一人民医院药剂科四川西昌615000 四川省医学科学院·四川省人民医院消化内科四川成都610072 四川省医学科学院·四川省人民医院药学部四川成都610072 电子科技大学医学院个体化药物治疗四川省重点实验室四川成都610072

目的:探讨美沙拉嗪所致急性胰腺炎的特点和发生规律,为临床安全用药提供参考。方法:检索从建库至2022年12月收录在中国知网、万方、维普、PubMed、Web of Science数据库中美沙拉嗪所致的急性胰腺炎的病例文献,并对相关数据进行整理和统... 详细信息

目的:探讨美沙拉嗪所致急性胰腺炎的特点和发生规律,为临床安全用药提供参考。方法:检索从建库至2022年12月收录在中国知网、万方、维普、PubMed、Web of Science数据库中美沙拉嗪所致的急性胰腺炎的病例文献,并对相关数据进行整理和统计分析。结果:纳入27篇文献,共31例患者,其中男性17例、女性14例,平均年龄(26.45±11.54)岁。美沙拉嗪所致急性胰腺炎一般发生在用药早期,潜伏期从1 d至2年,其中64.52%的患者同时存在胰酶升高、腹痛、影像学改变,再次用药的患者有94%再发急性胰腺炎,但未出现更严重的胰腺炎。同时,美沙拉嗪所致急性胰腺炎的发生与剂量和合并用药无关。经停药后急性胰腺炎患者恢复快,酶学水平的恢复晚于症状的恢复。结论:在临床使用美沙拉嗪的过程中,急性胰腺炎可能短时间即出现,应注意早期监测和识别,并及早干预,特别是年轻患者。若用药后发生急性胰腺炎,应尽快停药,对症治疗,尽量避免再次使用。

关键词：美沙拉嗪急性胰腺炎文献病例分析

Surface and Volume Symmetry Energy Coefficients of a Neutron-Rich Nucleus

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Chinese Physics Letters 2012年第9期29卷 32-35页

作者： ma Chun-Wang YANG Ju-Bao YU Mian PU Jie WANG shan-shan WEI Hui-Ling Department of Physics Henan Normal UniversityXinxiang 453007 Department of Life Sciences and Technology Xinxiang Medical UniversityXinxiang 453003 Department of Nuclear Physics Shanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800

Using an isobaric method,the symmetry-energy coefficient(asym)of a neutron-rich nucleus is obtained from experimental binding *** shell effects are shown in a^(*)_(sym)/A≡4asym/A of nuclei.A(sub)magic neutron magic number N=40 is suggested in a very neutron-rich nucleus,and a^(*)_(sym)/A of a nucleus is found to decrease when its mass *** a^(*)_(sym)/A of a very neutron-rich nucleus with large mass *** volume-symmetry coefficients(b_(v))and surface-symmetry coefficients(b_(s))of a neutron-rich nucleus are extracted from a sym*/A by a correlation a^(*)_(sym)/A=bv/A-b s/A^(4/3).It is found that bv and bs decrease when the nucleus becomes more neutron-rich,and tend to saturate in the very neutron-rich nucleus.A linear correlation between b v and bs is obtained in nuclei with different neutron-excess I,and bv of I>7 nuclei is found to coincide with the results of infinite nuclear matter a sym=32±4 MeV,and bs/bv of the nucleus is found to coincide with the results of the finite-range liquid-drop model results.

关键词： symmetry infinite coincide