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Predictive value of a constructed artificial neural network model for microvascular invasion in hepatocellular carcinoma:A retrospective study

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 88-100页

作者： Hai-Yang Nong Yong-Yi Cen shan-Jin lu Rui-Sui Huang Qiong Chen Li-Feng Huang Jian-Ning Huang Xue Wei Man-Rong Liu Lin Li Ke Ding Department of Radiology The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Radiology Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Guangxi Clinical Medical Research Center for Hepatobiliary Diseases Affiliated Hospital of Youiiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Ultrasound The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Hepatobiliary Surgery The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina

BACKGROUND Microvascular invasion(MVI)is a significant risk factor for recurrence and metastasis following hepatocellular carcinoma(HCC)***,there is a paucity of preoperative evaluation approaches for *** To investigate the predictive value of texture features and radiological signs based on multiparametric magnetic resonance imaging in the non-invasive preoperative prediction of MVI in *** Clinical data from 97 HCC patients were retrospectively collected from January 2019 to July 2022 at our *** were classified into two groups:MVI-positive(n=57)and MVI-negative(n=40),based on postoperative pathological *** correlation between relevant radiological signs and MVI status was ***4.6 software and the mutual information method were employed to identify the top 10 dominant texture features,which were combined with radiological signs to construct artificial neural network(ANN)models for MVI *** predictive performance of the ANN models was evaluated using area under the curve,sensitivity,and *** models with relatively high predictive performance were screened using the DeLong test,and the regression model of multilayer feedforward ANN with backpropagation and error backpropagation learning method was used to evaluate the models’*** The absence of a pseudocapsule,an incomplete pseudocapsule,and the presence of tumor blood vessels were identified as independent predictors of HCC *** ANN model constructed using the dominant features of the combined group(pseudocapsule status+tumor blood vessels+arterial phase+venous phase)demonstrated the best predictive performance for MVI status and was found to be automated,highly operable,and very *** The ANN model constructed using the dominant features of the combined group can be recommended as a noninvasive method for preoperative prediction of HCC MVI status.

关键词： Hepatocellular carcinoma Texture analysis Magnetic resonance imaging Microvascular invasion Pseudocapsule Tumor blood vessels

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Carotenoid Metabolism:Biosynthesis,Regulation,and Beyond

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Journal of Integrative Plant Biology 2008年第7期50卷 778-785页

作者： shan lu Li Li State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University Nanjing 210093 China US Department of Agriculture-Agricultural Research Service Plant Soil and Nutrition Laboratory Department of Plant Breeding and Genetics Cornell University Ithaca New York 14853 USA

Carotenoids are indispensable to plants and play a critical role in human nutrition and health. Significant progress has been made in our understanding of carotenoid metabolism in plants. The biosynthetic pathway has been extensively studied. Nearly all the genes encoding the biosynthetic enzymes have been isolated and characterized from various organisms. In recent years, there is an increasing body of work on the signaling pathways and plastid development, which might provide global control of carotenoid biosynthesis and accumulation. Herein, we will highlight recent progress on the biosynthesis, regulation, and metabolic engineering of carotenoids in plants, as well as the future research towards elucidating the regulatory mechanisms and metabolic network that control carotenoid metabolism.

关键词： carotenoids isoprenoids metabolism metabolic engineering plastid regulation.

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Enhanced Fatigue Property of Welded S355J2W Steel by Forming a Gradient Nanostructured Surface Layer

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Acta Metallurgica Sinica(English Letters) 2020年第9期33卷 1252-1258页

作者： lu An Yan-Tao Sun shan-Ping lu Zhen-Bo Wang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

Welded joints are usually characterized by microstructural and compositional inhomogeneities, which may significantly degrade their fatigue properties and result in unpredictable failures. The present work demonstrates a novel and simple method to effectively optimize the microstructure in the surface layer and promote the fatigue properties of welded specimens. By a recently developed approach—surface mechanical rolling treatment(SMRT), a gradient nanostructured surface layer is formed on welded S355 J2 W steel specimens. The mean grain size is refined to nanometer scale, and the hardness is significantly enhanced in the SMRT surface layer. Independent of the initially inhomogeneous microstructure and hardness distributions, the microstructure and hardness distributions in the surface layers are comparable on different zones of a welded specimen after SMRT with the same procedure. Consequently, fatigue property of the SMRT specimens is significantly enhanced relative to that of the as-welded specimens within the high cycle fatigue regime.

关键词： Gradient nanostructured Surface mechanical rolling treatment S355J2W steel Welded Fatigue

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Pseudo-Differential Operators on Sobolev and Lipschitz Spaces

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Acta Mathematica Sinica,English Series 2010年第1期26卷 131-142页

作者： Yan LIN shan Zhen lu Department of Mathematics China University of Mining and Technology Beijing 100083 P. R. China School of Mathematical Sciences Beijing Normal University Beijing 100875 P. R. China

In this paper, by discovering a new fact that the Lebesgue boundedness of a class of pseudo- differential operators implies the Sobolev boundedness of another related class of pseudo-differential operators, the authors establish the boundedness of pseudo-differential operators with symbols in Sρ,δ^m on Sobolev spaces, where ∈ R, ρ≤ 1 and δ≤ 1. As its applications, the boundedness of commutators generated by pseudo-differential operators on Sobolev and Bessel potential spaces is deduced. Moreover, the boundedness of pseudo-differential operators on Lipschitz spaces is also obtained.

关键词： pseudo-differential operator Sobolev space Bessel potential space Lipschitz space

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Weighted Estimates for Iterated Commutators of Multilinear Fractional Operators

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Acta Mathematica Sinica,English Series 2012年第9期28卷 1769-1778页

作者： Zeng Yan SI shan Zhen lu School of Mathematics and Information Science He'nan Polytechnic University School of Mathematical Science Beijing Normal University

The author establishes weighted strong type estimates for iterated commutators of multi- linear fractional operators.

关键词： Multilinear fractional operators commutators weighted norm inequalities

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Fatigue-crack-initiation numerical modelling of a Ni-base powder metallurgy alloy

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航空动力学报 2012年第12期27卷 2778-2785页

作者： Mu, Yuan-Wei lu, shan Zhang, Hong School of Power and Energy Northwestern Polytechnical University Xi'an 710072 China

A simplified three-dimensional numerical model was presented to simulate the micro-crack nucleation and growth to some predefined dimension(approximately 0.38 mm) on the throat surface of a Ni-base powder metallurgy(PM) *** numerical simulation of micro-crack initiation was based on the Tanaka-Mura micro-crack initiation models,where individual grains of the mesoscopic model were simulated using the Voronoi *** improvements were made in the model.(1) Considering crack initiation along with 12 principal slip systems on octahedral slip planes of face centered cubic(FCC) crystal in three-dimensional(3-D) models.(2) Considering the effect of secondary phase precipitate due to impinging slip and dislocation pileup.(3) The Tanaka-Mura theory of fatigue-crack-initiation from notches was applied to simulate the crack initiation from another crack tip.(4) The coalescence of random initiated micro-cracks was simulated once they intersected with each other and a macro-crack was finally *** calculated results were in good agreement with the experimental data which verified the rationality of the simulation *** applicability of the proposed model for treating fatigue-crack-initiation life in engineering structures was preliminarily achieved.

关键词：信号模拟动力系统数字化 3D模型

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An artificial intelligence diabetes management architecture based on 5G

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Digital Communications and Networks 2024年第1期10卷 75-82页

作者： Ruochen Huang Wei Feng shan lu Tao shan Changwei Zhang Yun Liu Department of Geriatrics The First Affiliated Hospital of Nanjing Medical UniversityNanjing210096China Department of Information The First Afliated Hospital of Nanjing Medical UniversityNanjing210096China Department of Medical Informatics School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjing211166China Department of Outpatient The First Affiliated Hospital of Nanjing Medical UniversityNanjing210096China Jiangsu Key Laboratory of Wireless Communications Nanjing University of Posts and TelecommunicationsNanjing210003China

Along with the development of 5G network and Internet of Things technologies,there has been an explosion in personalized healthcare *** the 5G and Artificial Intelligence(Al)is introduced into diabetes management architecture,it can increase the efficiency of existing systems and complications of diabetes can be handled more effectively by taking advantage of *** this article,we propose a 5G-based Artificial Intelligence Diabetes Management architecture(AIDM),which can help physicians and patients to manage both acute complications and chronic *** AIDM contains five layers:the sensing layer,the transmission layer,the storage layer,the computing layer,and the application *** build a test bed for the transmission and application ***,we apply a delay-aware RA optimization based on a double-queue model to improve access efficiency in smart hospital wards in the transmission *** application layer,we build a prediction model using a deep forest *** on real-world data show that our AIDM can enhance the efficiency of diabetes management and improve the screening rate of diabetes as well.

关键词： Diabetes 5G Artificial intelligence Deep forest Smart hospital ward

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Modeling the Spatial-temporal Characteristics of Mutual Funds’Herd Behavior

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Journal of Systems Science and Systems Engineering 2021年第6期30卷 748-778页

作者： Rong Guan Hongjia Chen shan lu School of Statistics and Mathematics Central University of Finance and EconomicsBeijing 100081China

Herd behavior in financial markets often leads to unjustified macroscopic ***,despite existing studies on modeling herd behavior,how it varies across individual agents and over time remains *** show that herd behavior in mutual fund companies can be understood from the functional networks representing interactions inferred from investment ***,in this paper,the spatial characteristics of herd behavior stand for the topology relationships of observations in *** analyze the collective dynamics of mutual fund investment from 2003 to 2019 in China using the language of network science and show that herding behavior accompanies this industry's development but dwindles after the 2015 Chinese market *** integrating community detection analysis,we found an increased degree of coherence in the collective herding behavior of the system,even though the localization of herding behavior decreases for clusters of mutual fund companies when the systemic risk builds *** analysis showed that herding behavior impacts the payoff of individual fund companies differently across *** spatial-temporal changes of herding behavior between mutual funds presented in this paper shed light on the debate of individual versus systemic risk and,thus,could interest regulators and investors.

关键词： Mutual funds herding behavior complex network community detection

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Accurate 3D geometry measurement for non-cooperative spacecraft with an unfocused light-field camera

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Journal of Systems Engineering and Electronics 2022年第1期33卷 11-21页

作者： XU Shengming lu shan HOU Yueyang SHI Shengxian School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China shanghai Key Laboratory of Space Intelligent Control Technology Shanghai Aerospace Control Technology InstituteShanghai 201109China

This work explores an alternative 3D geometry measurement method for non-cooperative spacecraft guiding navigation and proximity *** one snapshot of an unfocused light-field camera, the 3D point cloud of a non-cooperative spacecraft can be calculated from sub-aperture images with the epipolar plane image(EPI) based light-field rendering algorithm.A Chang'e-3 model(7.2 cm×5.6 cm×7.0 cm) is tested to validate the proposed *** measurement distances(1.0 m, 1.2 m, 1.5 m) are considered to simulate different approaching *** errors are quantified by comparing the light-field camera data with a high precision commercial laser *** mean error distance for the three cases are 0.837 mm, 0.743 mm, and 0.973 mm respectively, indicating that the method can well reconstruct 3D geometry of a non-cooperative spacecraft with a densely distributed 3D point cloud and is thus promising in space-related missions.

关键词： 3D geometry measurement non-cooperative spacecraft unfocused light-field camera

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From golden rice to a STARice, more than just two steps forward in a pathway

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Science China(Life Sciences) 2019年第2期62卷 280-281页

作者： Wei-Cai Chen shan lu State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University

Carotenoids are widely distributed in higher plants, algae and some bacteria and fungi. For human beings, they are essential phytonutrients that serve not only as precursors of vitamin A.

关键词： From golden rice to a STARice more than just two steps forward in a pathway

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