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Persistent greening against drying in northeast Asian semiarid grasslands:Asymmetrical responses of direct and legacy effects to intensified drought

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Advances in Climate Change Research 2024年第1期15卷 9-20页

作者： Yu-Tong MA Hai-shan CHEN Yao-Ming SONG Bo-Tao ZHOU shan-Lei SUN Xin-guan DU Yue SUN Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment Change/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China School of Atmospheric Sciences Nanjing University of Information Science and TechnologyNanjing 210044China

Despite experiencing a decadal shift towards drought conditions at the end of the 2Oth century,semiarid grasslands in northeast Asia(NEA)exhibited an evident greening trend from 1982 to 2020.However,the mechanism behind this phenomenon remains unclear.Hence,we analysed the interdecadal changes in vegetation response to drought on the basis of the standardised precipitation evapotranspiration index(SPEI)and Global Inventory Modelling and Mapping Studies LAI4g datasets,with an emphasis on the differences between direct and legacy effects(as measured by resilience),to explore the mechanism of persistent grassland greening.Results revealed that during the post-drought shift period(2000-2020),the sudden decrease in the water content of the intermediate soil layer triggered an intensified vegetation response to drought.Specifically,although direct effects and resilience were amplified,they exhibited asymmetric changes.Resilience was stronger than direct effects,and this difference increased with increasing drought(drought recovery)levels.These combined effects may account for persistent greening against intensified drying in the semiarid grasslands in NEA.Given the projected exacerbation of future droughts,this study holds notable importance for comprehending the long-term change dynamics of dryland ecosystems.

关键词： Semiarid grassland Drought decadal shift Direct effect Legacy effect(resilience) Northeast Asia

IQGAP3 promotes the progression of glioma as an immune and prognostic marker

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Oncology Research 2024年第4期32卷 659-678页

作者： XIAOFENG GAO JUANJUAN GE XUZHENG GAO NA MEI YANTING SU SHIGANG shan WENBIN QIAN JIANGHENG guan ZHENWANG ZHANG LONG WANG Hubei Provincial Key Laboratory of Diabetic Cardiovascular Diseases Xianning Medical CollegeHubei University of Science and TechnologyXianning437100China School of Stomatology and Ophthalmology Xianning Medical CollegeHubei University of Science and TechnologyXianning437100China School of Basic Medical Sciences Xianning Medical CollegeHubei University of Science and TechnologyHubei University of Science and TechnologyXianning437100China School of Pharmacy Xianning Medical CollegeHubei University of Science and TechnologyXianning437100China Department of Neurosurgery The General Hospital of Chinese PLA Central Theater CommandWuhan430070China

Background:IQGAP3 plays a crucial role in regulating cell proliferation,division,and cytoskeletal organization.Abnormal expression of IQGAP3 has been linked to various tumors,but its function in glioma is not well understood.Methods:Various methods,including genetic differential analysis,single-cell analysis,ROC curve analysis,Cox regression,Kaplan-Meier analysis,and enrichment analysis,were employed to analyze the expression patterns,diagnostic potential,prognostic implications,and biological processes involving IQGAP3 in normal and tumor tissues.The impact of IQGAP3 on immune infiltration and the immune microenvironment in gliomas was evaluated using immunofluorescence.Additionally,the cBioPortal database was used to analyze copy number variations and mutation sites of IQGAP3.Experimental validation was also performed to assess the effects of IQGAP3 on glioma cells and explore underlying mechanisms.Results:High IQGAP3 expression in gliomas is associated with an unfavorable prognosis,particularly in wild-type IDH and 1p/19q non-codeleted gliomas.Enrichment analysis revealed that IQGAP3 is involved in regulating the cell cycle,PI3K/AKT signaling,p53 signaling,and PLK1-related pathways.Furthermore,IQGAP3 expression may be closely related to the immunosuppressive microenvironment of glioblastoma.BRD-K88742110 and LY-303511 are potential drugs for targeting IQGAP3 in anti-glioma therapy.In vitro experiments showed that downregulation of IQGAP3 inhibits the proliferation and migration of glioma cells,with the PLK1/PI3K/AKT pathway potentially playing a crucial role in IQGAP3-mediated glioma progression.Conclusion:IQGAP3 shows promise as a valuable biomarker for diagnosis,prognosis,and immunotherapeutic strategies in gliomas.

关键词： IQGAP3 Tumor immune infiltration Prognosis Glioma Biomarker

Efficacy of radiofrequency ablation combined with sorafenib for treating liver cancer complicated with portal hypertension and prognostic factors

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World Journal of Gastroenterology 2024年第11期30卷 1533-1544页

作者： Li-Min Yang Hong-Juan Wang shan-Lin Li guan-Hua Gan Wen-Wen Deng Yong-Sheng Chang Lian-Feng Zhang Department of Gastroenterology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Gastroenterology Zhoukou Central Hospital of Henan ProvinceZhoukou 466000Henan ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Xinxiang Medical CollegeXinxiang 453000Henan ProvinceChina

BACKGROUND Patients with liver cancer complicated by portal hypertension present complex challenges in treatment.AIM To evaluate the efficacy of radiofrequency ablation in combination with sorafenib for improving liver function and its impact on the prognosis of patients with this condition.METHODS Data from 100 patients with liver cancer complicated with portal hypertension from May 2014 to March 2019 were analyzed and divided into a study group(n=50)and a control group(n=50)according to the treatment regimen.The research group received radiofrequency ablation(RFA)in combination with sorafenib,and the control group only received RFA.The short-term efficacy of both the research and control groups was observed.Liver function and portal hypertension were compared before and after treatment.Alpha-fetoprotein(AFP),glypican-3(GPC-3),and AFP-L3 levels were compared between the two groups prior to and after treatment.The occurrence of adverse reactions in both groups was observed.The 3-year survival rate was compared between the two groups.Basic data were compared between the survival and non-surviving groups.To identify the independent risk factors for poor prognosis in patients with liver cancer complicated by portal hypertension,multivariate logistic regression analysis was employed.RESULTS When comparing the two groups,the research group's total effective rate(82.00%)was significantly greater than that of the control group(56.00%;P<0.05).Following treatment,alanine aminotransferase and aspartate aminotransferase levels increased,and portal vein pressure decreased in both groups.The degree of improvement for every index was substantially greater in the research group than in the control group(P<0.05).Following treatment,the AFP,GPC-3,and AFP-L3 levels in both groups decreased,with the research group having significantly lower levels than the control group(P<0.05).The incidence of diarrhea,rash,nausea and vomiting,and fatigue in the research group was significantly greater than that in the control group(P<0.05).The 1-

关键词： Radiofrequency ablation Sorafenib Liver cancer Portal hypertension Efficacy Prognosis analysis

Progress of hidden spin polarization in inversion-symmetric crystals

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Science China(Physics,Mechanics & Astronomy) 2022年第3期65卷 1-18页

作者： shan guan Jia-Xin Xiong Zhi Wang Jun-Wei Luo State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Beijing Academy of Quantum Information Sciences Beijing 100193China

Hidden spin polarization refers to that doubly degenerate bands protected by combined inversion and time-reversal symmetry in nonmagnetic inversion-symmetric crystals could have opposite non-zero local spin polarizations, which are spatially separated in two real-space sectors paired by the inversion symmetry. Since its first prediction from ab initio calculation, hidden spin polarization has inspired tremendous interest and has been observed experimentally due to its intriguing fundamental properties as well as the great potential for applications. Moving forward, the search for moment-dependent spin splitting has also been extended to antiferromagnets even without considering spin-orbit coupling. This paper systematically reviews recent works in this field with a focus on basic concepts and material realization. It also details several remaining bottlenecks and suggests possible avenues for future research.

关键词： spin-orbit coupling hidden spin polarization tight-binding model ab initio calculation

Clinical practice guideline for acupuncture and moxibustion:Allergic rhinitis

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Journal of Integrative Medicine 2024年第3期22卷 245-257页

作者： Shi-hao Du Sheng Chen shan-ze Wang guan-qun Wang Shuo Du Wei Guo Xiao-long Xie Bi-hui Peng Chao Yang Ji-ping Zhao Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijing 100700China Department of Acupuncture and Moxibustion Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Department of Acupuncture and Moxibustion Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Department of Traditional Chinese Medicine Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

Acupuncture is one of the most effective complementary therapies for allergic rhinitis(AR)and has been recommended by several clinical practice guidelines(CPGs)for AR.However,these CPGs mentioned acupuncture without making recommendations for clinical implementation and therapeutic protocols,therefore limiting the applicability of acupuncture therapies for AR.Hence,for the benefit of acupuncture practitioners around the world,the World Federation of Acupuncture-moxibustion Societies have initiated a project to develop the CPG for the use of acupuncture and moxibustion to treat AR.This CPG was developed according to the Grading of Recommendations Assessment,Development,and Evaluation(GRADE)methodology,referring to the principles of the World Health Organization Handbook for Guideline Development.During the development of the CPG,the guideline development group(GDG)played an important role.The clinical questions,recommendations and therapeutic protocols were all formulated by the GDG using the modified Delphi method.The CPG contains recommendations for 15 clinical questions about the use of acupuncture and moxibustion interventions.These include one strong recommendation for the intervention based on high-quality evidence,three conditional recommendations for either the intervention or standard care,and 11 conditional recommendations for the intervention based on very low quality of evidence.The CPG also provides one filiform needle acupuncture protocol and five moxibustion protocols extracted based on the protocols presented in randomized controlled trials reviewed by the GDG.

关键词： Clinical practice guideline Allergic rhinitis Acupuncture Moxibustion GRADE

Clinical practice guideline for acupuncture and moxibustion: Female urinary incontinence

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Journal of Integrative Medicine 2024年第3期22卷 258-269页

作者： Chao Yang shan-ze Wang Sheng Chen Shuo Du guan-qun Wang Wei Guo Xiao-long Xie Bi-hui Peng Shi-hao Du Ji-ping Zhao Department of Acupuncture and Moxibustion Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Department of Acupuncture and Moxibustion Guangdong provincial hospital of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina shanghai Ninth People’s Hospital Shanghai Jiao Tong University School of MedicineShanghai 200011China Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijing 100700China

Urinary incontinence (UI) is a common problem worldwide.It has a major impact on physical and social activities and interpersonal relationships.UI is common in women,but is under-reported and undertreated.It affects the quality of life of female patients severely.Acupuncture and moxibustion have been proposed as potentially effective interventions for female UI.Hence,for the benefit of acupuncture practitioners around the world,the World Federation of Acupuncture-moxibustion Societies initiated a project to develop a clinical practice guideline (CPG) for the use of acupuncture and moxibustion to treat female UI.This CPG was developed according to the Grading of Recommendations Assessment,Development,and Evaluation (GRADE) methodology,referring to the principles of the World Health Organization Handbook for Guideline Development.During the development of the CPG,the guideline development group (GDG) played an important role.The clinical questions,recommendations and therapeutic protocols were all formulated by GDG using the modified Delphi method.This CPG contains ten recommendations about the use of acupuncture and moxibustion interventions for ten clinical questions,which include nine conditional recommendations for the intervention and one conditional recommendation for either the intervention or the comparison.This CPG also provides one protocol for conventional filiform needle therapy,two therapy protocols for deep needling stimulation on lumbosacral acupoints,and four moxibustion therapy protocols,based on the protocols presented in randomized controlled trials reviewed by the GDG.

关键词： Acupuncture Clinical practice guideline Female urinary incontinence Moxibustion GRADE

Characterizing and predicting smoldering temperature variations based on non-linear mixed effects models

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Journal of Forestry Research 2022年第6期33卷 1829-1839页

作者： Sainan Yin Yanlong shan Bo Gao Shuyuan Tang Xiyue Han Guojiang Zhang Bo Yu shan guan Science and Technology Innovation Center of Wildland Fire Prevention and Control Beihua University3999 Binjiang East RoadJilin City 132013JilinPeople’s Republic of China Forestry College Beihua University3999 Binjiang East RoadJilin City 132013JilinPeople’s Republic of China

Underground fires are slow spreading,long-lasting and low temperature smoldering combustion without flames,mainly occurring in peatlands and wetlands with rich organic matter.The spread of the smoldering is maintained by heat released during combustion and monitoring this is an important approach to detect underground fires.The Daxing'an Mountains region is a hotspot for underground fires in northeast China.This study examined a L arix gmelinii plantation in the Tatou wetlands of the Daxing'an Mountains and determined the maximum temperature variation of humus of varying particle sizes,and the temperature rising process based on non-linear mixed effects models by an indoor combustion experiment.Maximum combustion temperatures up to 897.5°C,increased with humus depth;among the three models tested,Richard's equations were best for characterizing temperature variations;a non-linear equation with three parameters had the highest accuracy in fitting the combustion temperature variations with varying humus particle sizes.These results are informative for predicting temperature variations and provide technical support for underground fire monitoring.

关键词： Underground fire NLME modeling Smoldering temperature Daxing'an mountains

党建引领新型农村集体经济发展的实践逻辑与效能优化——基于鲁中典型村的历时性探讨

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中国农村观察 2024年第1期 146-160页

作者：管珊湖北经济学院马克思主义学院

党建引领新型农村集体经济发展是乡村振兴的重要路径。在新型农村集体经济发展过程中,党建何以引领、以何引领及其效能问题并没有得到系统研究。本文基于对山东省淄博市乐疃村党建引领新型农村集体经济发展的历时性研究发现:嵌入村庄治... 详细信息

党建引领新型农村集体经济发展是乡村振兴的重要路径。在新型农村集体经济发展过程中,党建何以引领、以何引领及其效能问题并没有得到系统研究。本文基于对山东省淄博市乐疃村党建引领新型农村集体经济发展的历时性研究发现:嵌入村庄治理过程的适应性党建形塑了村级党建与村庄治理的正向循环,促进了村级党组织政治功能发挥和引领力塑造,为新型农村集体经济发展提供了内生动力;新型农村集体经济发展过程中,村级党建通过“资源-主体-行动”的三维引领,以资源链接机制、主体整合机制和组织动员机制有效实现了发展项目落地和初步运营;这一发展过程逐渐形塑出“政社共建、有限共治、延迟共享”的治理格局,带来了后期新型农村集体经济的发展停滞,从而折射出党建引领的实践张力。乐疃村的案例展现了党建引领在促进国家与社会互补共进上的实践复杂性。新型农村集体经济作为一种创新性探索,需要基层党组织在权威、利益、价值层面耦合调适,以此构建共建共治共享的发展秩序,提升党建引领效能。

关键词：党建引领新型农村集体经济国家与社会治理效能共建共治共享

SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl^(-)concentration

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1745-1759页

作者： Jian-Bang Xu Wei-Jie guan Yi-Lin Zhang Zhuo-Er Qiu Lei Chen Xiao-Chun Hou Junqing Yue Yu-Yun Zhou Jie Sheng Lei Zhao Yun-Xin Zhu Jing Sun Jincun Zhao Wen-Liang Zhou Nan-shan Zhong State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineDepartment of Respiratory and Critical Care MedicineGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Department of Thoracic Surgery Guangzhou Institute for Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China guangzhou National Laboratory GuangzhouP.R.China School of Life Sciences Sun Yat-sen UniversityGuangzhouP.R.China guangdong Provincial Key Laboratory of Pharmaceutical Functional Genes School of Life SciencesSun Yat-sen UniversityGuangzhouP.R.China Department of Physiology School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhouP.R.China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection disrupts the epithelial barrier and triggers airway inflammation.The envelope(E)protein,a core virulence structural component of coronaviruses,may play a role in this process.Pathogens could interfere with transepithelial Cl^(-)transport via impairment of the cystic fibrosis transmembrane conductance regulator(CFTR),which modulates nuclear factor kB(NF-kB)signaling.However,the pathological effects of SARS-CoV-2 E protein on airway epithelial barrier function,Cl^(-)transport and the robust inflammatory response remain to be elucidated.Here,we have demonstrated that E protein down-regulated the expression of tight junctional proteins,leading to the disruption of the airway epithelial barrier.In addition,E protein triggered the activation of Toll-like receptor(TLR)2/4 and downstream c-Jun N-terminal kinase(JNK)signaling,resulting in an increased intracellular Cl^(-)concentration([Cl^(-)]_(i))via up-regulating phosphodiesterase 4D(PDE4D)expression in airway epithelial cells.This elevated[Cl^(-)]_(i);contributed to the heightened airway inflammation through promoting the phosphorylation of serum/glucocorticoid regulated kinase 1(SGK1).Moreover,blockade of SGK1 or PDE4 alleviated the robust inflammatory response induced by E protein.Overall,these findings provide novel insights into the pathogenic role of SARS-CoV-2 E protein in airway epithelial damage and the ongoing airway inflammation during SARS-CoV-2 infection.

关键词： airway inflammation elevated