检索结果-南通市图书馆

Oleanolic acid improved intestinal immune function by activating and potentiating bile acids receptor signaling in E. coli-challenged piglets

引用

Journal of Animal Science and Biotechnology 2024年第5期15卷 2137-2155页

作者： Chenyu Xue Hongpeng Jia Rujing Cao Wenjie Cai Weichen Hong Jianing Tu Songtao Wang Qianzhi Jiang Chongpeng Bi anshan shan Na Dong The Laboratory of Molecular Nutrition and Immunity College of Animal Science and TechnologyNortheast Agricultural UniversityHarbinP.R.China

Background Infection with pathogenic bacteria during nonantibiotic breeding is one of the main causes of animal intestinal *** acid(OA)is a pentacyclic triterpene that is ubiquitous in *** previous work demonstrated the protective effect of OA on intestinal health,but the underlying molecular mechanisms remain *** study investigated whether dietary supplementation with OA can prevent diarrhea and intestinal immune dysregulation caused by enterotoxigenic Escherichia coli(ETEC)in *** key molecular role of bile acid receptor signaling in this process has also been *** Our results demonstrated that OA supplementation alleviated the disturbance of bile acid metabolism in ETEC-infected piglets(P<0.05).OA supplementation stabilized the composition of the bile acid pool in piglets by regulating the enterohepatic circulation of bile acids and significantly increased the contents of UDCA and CDCA in the ileum and cecum(P<0.05).This may also explain why OA can maintain the stability of the intestinal microbiota structure in ETEC-challenged *** addition,as a natural ligand of bile acid receptors,OA can reduce the severity of intestinal inflammation and enhance the strength of intestinal epithelial cell antimicrobial programs through the bile acid receptors TGR5 and FXR(P<0.05).Specifically,OA inhibited NF-κB-mediated intestinal inflammation by directly activating TGR5 and its downstream c AMP-PKA-CREB signaling pathway(P<0.05).Furthermore,OA enhanced CDCA-mediated MEK-ERK signaling in intestinal epithelial cells by upregulating the expression of FXR(P<0.05),thereby upregulating the expression of endogenous defense molecules in intestinal epithelial *** In conclusion,our findings suggest that OA-mediated regulation of bile acid metabolism plays an important role in the innate immune response,which provides a new diet-based intervention for intestinal diseases caused by pathogenic bacterial infections in pig

关键词： Bile acid receptors Enterotoxigenic Escherichia coli Intestinal innate immunity Oleanolic acid

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

猪源抗菌肽分子改造与应用进展

引用

动物营养学报 2024年第6期36卷 3413-3424页

作者：邵长轩庞佳楠关红蕊单安山东北农业大学动物科学技术学院哈尔滨150030

抗菌肽(AMPs)是动植物、微生物中普遍存在的一种小肽类物质,多数具有广谱抗菌活性,已逐渐发展为替代抗生素的有力候选者之一。猪源AMPs是第一批从哺乳动物中分离得到的AMPs,已发现有30多种,主要包括Cathelicidins家族和防御素(defensins... 详细信息

抗菌肽(AMPs)是动植物、微生物中普遍存在的一种小肽类物质,多数具有广谱抗菌活性,已逐渐发展为替代抗生素的有力候选者之一。猪源AMPs是第一批从哺乳动物中分离得到的AMPs,已发现有30多种,主要包括Cathelicidins家族和防御素(defensins)家族。这些猪源AMPs抗菌机制与抗生素不尽相同,其可以与细菌细胞膜相互作用破坏膜的完整性,最终导致细菌细胞内容物泄漏并杀死细菌,因此不易产生耐药性。但天然猪源AMPs还存在稳定性差、细胞毒性高及规模生产成本高等问题,目前的研究在于先后开发了氨基酸替换、序列截断、杂合、结构优化和/或脂肪酸修饰等方法,以期获得兼具高效和低毒的短序列AMPs。本文根据猪源AMPs的来源家族进行分类,并对其二级结构、抑菌机制及现阶段的改造和应用状况进行了综述。

关键词：猪源抗菌肽抑菌机制分子改造应用

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Biological function of resveratrol and its application in animal production:a review

引用

Journal of Animal Science and Biotechnology 2023年第3期14卷 864-886页

作者： Qingwei Meng Jiawei Li Chunsheng Wang anshan shan College of Animal Science and Technology Northeast Agricultural UniversityHarbin150030China

With the prohibition of antibiotics in feed,plant functional substances have been widely studied as feed ***,a natural stilbene,and a non-flavonoid polyphenol found in plants,possesses antioxidant,anti-inflammatory,and metabolic regulatory *** generated intense scientific and public interest,primarily due to its widely reported ability to prevent cancer,delay aging and alleviate related metabolic ***,resveratrol has been studied and applied as a feed additive in animal *** review focuses on the outline of the absorption and metabolism and biological functions of resveratrol and summarizes the application of dietary resveratrol in animal production up to the present,including pigs,poultry,and *** pigs,dietary resveratrol improved intestinal health,mitochondrial function,meat quality,and *** poultry,studies have shown that dietary resveratrol improves growth performance and meat and egg quality and alleviates heat stress induced adverse *** are few studies on dietary resveratrol in ruminants;however previous studies have indicated that dietary resveratrol increases nutrient digestibility and reduces methane emissions in *** is hoped that this review could provide a specific theoretical basis and research ideas for the research and application of resveratrol.

关键词： Animal production Biological function Health Pigs Poultry Resveratrol Ruminants

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Lactobacillus rhamnosus GG ameliorates DON-induced intestinal damage depending on the enrichment of beneficial bacteria in weaned piglets

引用

Journal of Animal Science and Biotechnology 2022年第6期13卷 1840-1856页

作者： Yongsong Bai Kaidi Ma Jibo Li Zhongshuai Ren Jing Zhang anshan shan Institute of Animal Nutrition Northeast Agricultural UniversityHarbin 150030P.R.China College of Animal Sciences Jilin UniversityKey Laboratory of Zoonosis ResearchMinistry of EducationChangchun 130062P.R.China

Background: Deoxynivalenol(DON) is one of the most common environmental pollutants that induces intestinal inflammation and microbiota dysbiosis. Lactobacillus rhamnosus GG(LGG) is a probiotic that not only has anti-inflammatory effects, but also shows protective effect on the intestinal barrier. However, it is still unknown whether LGG exerts beneficial effects against DON-induced intestinal damage in piglets. In this work, a total of 36 weaned piglets were randomized to one of four treatment groups for 21 d. The treatment groups were CON(basal diet);LGG(basal diet supplemented with 1.77 × 10^(11)CFU/kg LGG);DON(DON-contaminated diet) and LGG + DON(DON-contaminated diet supplemented with 1.77 × 10^(11)CFU/kg LGG).Result: Supplementation of LGG can enhance growth performance of piglets exposed to DON by improving intestinal barrier function. LGG has a mitigating effect on intestinal inflammation induced by DON exposure, largely through repression of the TLR4/NF-κB signaling pathway. Furthermore, supplementation of LGG increased the relative abundances of beneficial bacteria(e.g., Collinsella, Lactobacillus, Ruminococcus_torques_group and Anaerofustis), and decreased the relative abundances of harmful bacteria(e.g., Parabacteroides and Ruminiclostridium_6), and also promoted the production of ***: LGG ameliorates DON-induced intestinal damage, which may provide theoretical support for the application of LGG to alleviate the adverse effects induced by DON exposure.

关键词： Deoxynivalenol Gut microbiota Intestinal infammation Lactobacillus rhamnosus GG Piglets

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Exopolysaccharides of Lactobacillus rhamnosus GG ameliorate Salmonella typhimurium-induced intestinal inflammation via the TLR4/NF-κB/MAPK pathway

引用

Journal of Animal Science and Biotechnology 2023年第4期14卷 1501-1513页

作者： Jinze Li Qiuke Li Qianhui Wu Nan Gao Zhihua Wang Yang Yang anshan shan Institute of Animal Nutrition Northeast Agricultural UniversityHarbin 150030P.R.China

Background Salmonella typhimurium(S.T),as an important foodborne bacterial pathogen,can cause diarrhea and gastroenteritis in humans and *** studies have confirmed that exopolysaccharides(EPSs)have various biological functions,but the mechanism through which EPSs improve the immunity of animals against the invasion of pathogenic bacteria is ***,we explored the protective effect of EPSs of Lactobacillus rhamnosus GG(LGG)on the S.T-infected *** Mice received adequate food and drinking water for one week before the start of the *** 7 d of prefeeding,2×108 CFU/mL S.T solution and an equivalent volume of saline(control group)were given orally for 1 *** the fourth day,the mice were treated with 0.5 mg/mL EPSs,1.0 mg/mL EPSs,2.0 mg/mL EPSs,or 2.0 mg/mL penicillin for 7 ***,the body and relative organ weight,histological staining,and the levels of antioxidant enzyme activity and inflammatory cytokines were *** The S.T-infected mice exhibited symptoms of decreased appetite,somnolence,diarrhea and flagging *** with EPSs and penicillin improved the weight loss of the mice,and the high dose of EPSs showed the best therapeutic *** significantly ameliorated S.T-induced ileal injury in ***-dose EPSs were more effective than penicillin for alleviating ileal oxidative damage induced by *** mRNA levels of inflammatory cytokines in the ileum of mice showed that the regulatory effects of EPSs on inflammatory cytokines were better than those of *** could inhibit the expression and activation of key proteins of the TLR4/NF-κB/MAPK pathway and thereby suppress the level of S.T-induced ileal *** EPSs attenuate S.T-induced immune responses by inhibiting the expression of key proteins in the TLR4/NF-κB/MAPK signaling ***,EPSs could promote bacterial aggregation into clusters,which may be a potential strategy for reducing the bacterial invasion of

关键词： Exopolysaccharides Lactobacillus rhamnosus Salmonella typhimurium TLR4/NF-κB/MAPK

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Transcriptome analysis of the effect of pyrroloquinoline quinone disodium（PQQ·Na2） on reproductive performance in sows during gestation and lactation

引用

Journal of Animal Science and Biotechnology 2019年第4期10卷 1022-1036页

作者： Boru Zhang Chenxi Wang Wei Yang Hongyun Zhang Qingwei Meng Baoming Shi anshan shan Institute of Animal Nutrition Northeast Agricultural University

Background: Pyrroloquinoline quinone(PQQ), which is a water soluble, thermo-stable triglyceride-quinone, is widely distributed in nature and characterized as a mammalian vitamin-like redox cofactor. The objective of this study was to investigate the effects of pyrroloquinoline quinone disodium(PQQ·Na2) on reproductive performance in ***: Dietary supplementation with PQQ·Na2 significantly increased the total number of piglets born, the number of piglets born alive and the born alive litter weight. It also increased the antioxidant status in the placenta, plasma and milk. The concentration of NO was significantly increased in the plasma and placenta. RNA-seq analysis showed that462 unigenes were differentially expressed between the control(Con) treatment and PQQ treatment *** these unigenes, 199 were upregulated, while 263 unigenes were downregulated. The assigned functions of the unigenes covered a broad range of GO categories. Reproduction(27, 7.03%) and the reproduction process(27, 7.03%) were assigned to the biological process category. By matching DEGs to the KEGG database, we identified 29 ***: In conclusion, dietary supplementation with PQQ·Na2 in gestating and lactating sows had positive effects on their reproductive performance.

关键词： Oxidative stress Pyrroloquinoline quinone Pyrroloquinoline quinone disodium Reproductive performance,RNA-seq Sow

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Manipulation of Animal Production by Biotechnology

引用

Journal of Northeast Agricultural University(English Edition) 1997年第2期4卷 137-159页

作者： shan anshan (Northeast Agricultural University, Harbin 150030, P R China)

Basal level of Animal Production is maintained with regulation of endocrine to concert genetic potential and environmental conditions. This balance can be moved to dramatical imporvements in rate and efficiency of production as well as composition of the products by biotechnological methods. In this paper, several novel achievements in the last decade are briefly reviewed for refference to further research and application of biotedchnology in animal production.

关键词： biotechnology animal production manipulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Modified halloysite nanotubes reduce the toxic effects of zearalenone in gestating sows on growth and muscle development of their offsprings

引用

Journal of Animal Science and Biotechnology 2016年第4期7卷 570-578页

作者： Rui Gao Qingwei Meng Jianan Li Min Liu Yuanyuan Zhang Chongpeng Bi anshan shan Institute of Animal Nutrition Northeast Agricultural University

Background： Zearalenone （ZEN） is an estrogenic mycotoxin that is primarily produced by Fusarium fungi and has been proven to affect the reproductive capacity of many species to varying degrees. The present experiment was designed to study the maternal persistent effects of zearalenone toxicity in gestating sows on growth and muscle development of their offsprings, and the alleviation of zearalenone toxicity by modified halloysite nanotubes （MHNTs）. Methods： Eighteen sows were fed with one of three dietary treatments that included the following：（1） a control diet, （2） a contaminated grain diet （with 50 % moldy corn, 2.77 mg/kg ZEN）, and （3） a contaminated grain diet （with 50 % moldy corn, 2.76 mg/kg ZEN）＋ 1% MHNTs. Each sow was exclusively fed its experimental diets from 35 to 70 d of gestation at a total of 2 kg daily. Muscle samples were collected from six piglets per treatment at birth, weaning and finishing. Results： The results showed that feeding the sows with the ZEN-contaminated diets from 35 to 70 d of gestation decreased the ADG, ADFI and G：F of their offsprings （P 〈 0.05）. The muscle fiber numbers in the newborn, weaning and growing-finishing pigs and the muscle fiber diameters at birth and weaning were also decreased by maternal ZEN exposure （P 〈 0.05）. The expressions of IGF-I, IGF-II, Myf-5 and Mstn at birth and IGF-II, Pax7, Myf-5 and MyoD1 at weaning were altered by feeding gestating sows with ZEN-contaminated diets （P 〈 0.05）. The MHNTs reduced most of the ZEN-induced toxic effects： the ADG and ADFI on growth performance, the muscle fiber numbers at weaning and finishing and the muscle fiber diameters at weaning （P 〈 0.05）. The expression levels of IGF-II and Mstn in newborn piglets and IGF-II and Myf-5 in weaning piglets were also prevented by adding 1% MHNTs （P 〈 0.05）. Conclusions： The present study demonstrated that the offsprings of sows fed with ZEN-contaminated diets from 35 to 70 day of gestation exhibited weakening on growth performance, p

关键词： Growth MHNTs Muscle development Offsprings Sows Zearalenone

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

饲料资源创制与利用课程建设初探

引用

黑龙江农业科学 2024年第10期 91-94页

作者：毕重朋董娜窦秀静吕银凤单安山东北农业大学动物科学技术学院黑龙江哈尔滨150030

饲料资源创制与利用课程是动物营养与饲料科学专业硕士研究生的专业必修课。该课程的教学目标是让学生掌握动物营养与饲料科学及相关领域的研究进展、行业发展状态、饲料资源创制与利用的基本理论和方法,培养学生确立研究课题的创造性... 详细信息

饲料资源创制与利用课程是动物营养与饲料科学专业硕士研究生的专业必修课。该课程的教学目标是让学生掌握动物营养与饲料科学及相关领域的研究进展、行业发展状态、饲料资源创制与利用的基本理论和方法,培养学生确立研究课题的创造性思维方式和取得创新性研究成果的独立与协作工作能力。本文从课程教学内容、教学方法、考核指标等方面进行了初步探索,在教学内容上引入国内外研究热点、在教学方法上引入互动和任务驱动法、在考核指标上重点考核创新思维能力,提升课程的教学效果,切实提高研究生专业素养和科研创新能力,为我国现代农业建设培养出更多具有创新精神和创新能力的高素质人才。

关键词：饲料资源创制与利用课程建设动物营养与饲料科学科研创新能力教学效果

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Recent Research Interests on Monogastric Nutrition in China

引用

Journal of Northeast Agricultural University(English Edition) 1998年第1期5卷 65-80页

作者： shan anshan, Song Jincai, Wang Lijuan and Sun Haixia (Northeast Agricultural University, Harbin 150030 PRC)

In recent years research interest of Chinese nutritionists has been switched to dietary application of β-agomists, feeding enzymes, antibiotics, probiotics, organic arsenic acids, high closes of copper and zinc, Chinese herbs and microelement Ccelates in monogastric Aninak. The Publications in this area were briefly reviewed for tle provsion of refferences to those who are working in this field.

关键词： Non-nutritional active substances monogastric nutrition China

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：