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Multiple scenario simulation and optimization of an urban green infrastructure network based on complex network theory:a case study in Harbin City,China

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Ecological Processes 2022年第1期11卷 439-454页

作者： Shuang Song Shao‑Han Wang Meng‑Xi Shi shan‑shan hu Da‑Wei Xu College of Landscape Architecture Northeast Forestry UniversityHarbin 150000China Key Lab for Garden Plant Germplasm Development&Landscape Eco‑Restoration in Cold Regions of Heilongjiang Province Harbin 150000China

Background:Urban green infrastructure(GI)networks play a significant role in ensuring regional ecological security;however,they are highly vulnerable to the influence of urban development,and the optimization of GI networks with better connectivity and resilience under different development scenarios has become a practical problem that urgently needs to be *** Harbin,a megacity in Northeast China,as the case study,we set five simulation scenarios by adjusting the economic growth rate and extracted the GI network in multiple scenarios by integrating the minimal cumulative resistance model and the gravity *** low‑degree‑first(LDF)strategy of complex network theory was introduced to optimize the GI network,and the optimization effect was verified by robustness ***:The results showed that in the 5%economic growth scenario,the GI network structure was more complex,and the connectivity of the network was better,while in the other scenarios,the network structure gradually degraded with economic *** optimization by the LDF strategy,the average degree of the GI network in multiple scenarios increased from 2.368,2.651,2.189,1.972,and 1.847 to 2.783,3.125,2.643,2.414,and 2.322,respectively,and the GI network structure connectivity and resilience were significantly enhanced in all ***:Economic growth did not necessarily lead to degradation of the GI network;there was still room for economic development in the study area,but it was limited under existing GI conditions,and the LDF strategy was an effective method to optimize the GI *** research results provide a new perspective for the study of GI network protection with urban economic growth and serve as a methodological reference for urban GI network optimization.

关键词： GI network Simulation Complex network theory LDF strategy Robustness

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Application of transgenic mice to the molecular pathogenesis of cataract

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1929-1948页

作者： Yue Zhang Xiao-Ya Chen Yu-Zhu hu Xiao Zhang Shun-Fei Zheng shan-shan hu Mudanjiang Medical University Mudanjiang 157011Heilongjiang ProvinceChina Department of Ophthalmology Hongqi Hospital of Mudanjiang Medical UniversityMudanjiang 157011Heilongjiang ProvinceChina

One of the most prevalent disorders that cause blindness worldwide is cataract,and its essence is the visual disorder caused by the opacity of the *** significant degree of variation in cataracts and the fact that a variety of factors can impact a patient’s lens transparency make it especially crucial to investigate the pathogenesis of cataracts at the molecular *** has been found that more than 60 genes are linked to the formation of cataracts,and the construction of a transgenic mouse model of cataract similar to the selection of human lens clouding due to a variety of causes has become an important means of studying the pathogenesis of ***,the research on the application of transgenic mice to the molecular pathogenesis of cataracts will be the main topic of this review of the literature.

关键词： transgenic mice cataract lens

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Microstructure evolution and mechanical properties of high-boron steel with different ratios of boron and carbon

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China Foundry 2022年第2期19卷 169-176页

作者： Ming-chen Ma Chao-qing Luo Si-min Chen Hong-qun Tang shan-shan hu Yu-mei Zhou Jian-lin Liang Guangxi Key Laboratory of Processing for Nonferrous Metals and Featured Materials Center of Ecological Collaborative Innovation for Aluminium Industry in GuangxiSchool of ResourcesEnvironment and MaterialsGuangxi UniversityNanning 530004China School of Mechanical Engineering Guangxi UniversityNanning 530004China School of Mechatronic Engineering Guangdong Polytechnic Normal UniversityGuangzhou 510665China

Boron and carbon contents are the main factors influencing the properties of high-boron *** this study,experimental samples with different boron-to-carbon ratios(%B/%C)were *** microstructures of the different samples were observed,and their hardness,bending strength,and impact toughness were *** show that the main microstructures in the investigated high-boron steel samples are the eutectic Fe_(2)B structure with a fishbone shape and the ternary peritectic Fe_(3)(C,B)structure with a chrysanthemum *** the boron content is 2.5wt.%and the carbon content is 0.43wt.%(i.e.,%B/%C=5.82),the overall mechanical properties of the alloy are the *** alloy's hardness,bending strength and impact toughness reach their maximums,which are 67.3 HRC,1,267.36 MPa and 6.19 J·cm^(-2),*** optimized alloy is compared with conventional materials exhibiting excellent wear resistance(namely,high-manganese steel and high-chromium cast iron)through two-body and three-body abrasion *** wear resistance of this high-boron steelinvestigated in this work is found to be superior to those of the more common materials.

关键词： high-boron steel boron and carbon contents wear resistance microstructure mechanical properties

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Icariin Ameliorates D-galactose-induced Cell Injury in Neuron-like PC12 Cells by Inhibiting MPTP Opening

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Current Medical Science 2024年第4期44卷 748-758页

作者： shan-shan hu Tong-yao WANG Lu NI Fan-xin hu Bo-wen YUE Ying ZHENG Tian-lun WANG Abhishek KUMAR Yan-yan WANG Jin-e WANG Zhi-yong ZHOU Third-grade Pharmacological Laboratory of Traditional Chinese Medicine State Administration of Traditional Chinese MedicineChina Three Gorges UniversityYichang 443002China College of Medicine and Health Sciences China Three Gorges UniversityYichang 443002China College of Basic Medical Science China Three Gorges UniversityYichang 443002China

Objective Icariin(ICA)has a good neuroprotective effect and can upregulate neuronal basal autophagy in naturally aging *** dysfunction is associated with brain aging-related neurodegenerative *** opening of the mitochondrial permeability transition pore(mPTP)is a crucial factor in mitochondrial dysfunction and is associated with excessive *** study aimed to explore that ICA protects against neuronal injury by blocking the mPTP opening and down-regulating autophagy levels in a D-galactose(D-gal)-induced cell injury *** A cell model of neuronal injury was established in rat pheochromocytoma cells(PC12 cells)treated with 200 mmol/L D-gal for 48 *** this cell model,PC12 cells were pre-treated with different concentrations of ICA for 24 *** was used to detect cell *** associatedβ-galactosidase(SA-β-Gal)staining was used to observe cell *** blot analysis was performed to detect the expression levels of a senescence-related protein(p21),autophagy markers(LC3B,p62,Atg7,Atg5 and Beclin 1),mitochondrial fission and fusion-related proteins(Drp1,Mfn2 and Opa1),and mitophagy markers(Pink1 and Parkin).The changes of autophagic flow were detected by using mRFP-GFP-LC3 *** intracellular ultrastructure was observed by transmission electron *** was used to detect mPTP,mitochondrial membrane potential(MMP),mitochondrial reactive oxygen species(mtROS)and ROS *** and apoptosis levels were detected by flow *** D-gal treatment significantly decreased the viability of PC12 cells,and markedly increased the SA-β-Gal positive cells as compared to the control *** the D-gal stimulation,the expression of p21 was significantly ***,D-gal stimulation resulted in an elevated LC3B II/I ratio and decreased p62 ***,autophagosomes and autolysosomes were significantly increased,indicating abnormal activation of autophag

关键词： icariin neuronal injury mitochondrial dysfunction mitochondrial permeability transition pore autophagy

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Expression and significance of pigment epithelium-derived factor and vascular endothelial growth factor in colorectal adenoma and cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 670-686页

作者： Ye Yang Wu Wen Feng-Lin Chen Ying-Jie Zhang Xiao-Cong Liu Xiao-Yan Yang shan-shan hu Ye Jiang Jing Yuan Digestive Diseases Chengdu Qingbaijiang District People's HospitalChengdu 610300Sichuan ProvinceChina Digestive Diseases Chengdu Second People’s HospitalChengdu 610000Sichuan ProvinceChina Graduate School Chengdu Medical CollegeChengdu 610000Sichuan ProvinceChina

BACKGROUND The incidence and mortality of colorectal cancer(CRC)are among the highest in the world,and its occurrence and development are closely related to tumor *** the balance between pigment epithelium-derived factors(PEDF)that inhibit angiogenesis and vascular endothelial growth factors(VEGF)that stimulate angiogenesis is broken,angiogenesis is out of control,resulting in tumor ***,it is very necessary to find more therapeutic targets for CRC for early intervention and later *** To investigate the expression and significance of PEDF,VEGF,and CD31-stained microvessel density values(CD31-MVD)in normal colorectal mucosa,adenoma,and *** In this case-control study,we collected archived wax blocks of specimens from the Digestive Endoscopy Center and the General Surgery Department of Chengdu Second People's Hospital from April 2022 to October *** cases of specimen wax blocks were selected as normal intestinal mucosa confirmed by electronic colonoscopy and concurrent biopsy(normal control group),50 cases of specimen wax blocks were selected as colorectal adenoma confirmed by electronic colonoscopy and pathological biopsy(adenoma group),and 50 cases of specimen wax blocks were selected as CRC confirmed by postoperative pathological biopsy after inpatient operation of general surgery(CRC group).An immunohistochemical staining experiment was carried out to detect PEDF and VEGF expression in three groups of specimens,analyze their differences,study the relationship between the two and clinicopathological factors in CRC group,record CD31-MVD in the three groups,and analyze the correlation of PEDF,VEGF,and CD31-MVD in the colorectal adenoma group and the CRC *** F test or adjusted F test is used to analyze measurement data ***-Wallis rank sum test was used between groups for ranked *** chi-square test,adjusted chi-square test,or Fisher's exact test were used to compare the rates betwe

关键词： Pigment epithelium-derived factors Vascular endothelial growth factor Microvessel density Colorectal adenoma Colorectal cancer Targeted therapy

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Microbial hydrolysis of 17β-acetoxy steroidal compounds during aromatization by Arthrobacter simplex

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Acta Chimica Sinica(English Edition) 1983年第1期1卷 81-85页

作者： ZHOU Wei-shan(CHOU Wei-shan) hu Bo NI Yuan shanghai Institute of Organic Chemistry,Academia Sinica shanghai Institute of Organic Chemistry Academia Sinica

Steroidal compounds containing 17β-acetoxy group after aromatization by Arthrobactersimplex afforded 17β-hydroxy-,17-keto-or unhydrolyzed 17β-acetoxy-ring A-aromatic compou-nds.17-Keto-compounds were probably formed through the oxidation of the corresponding 17 β-hydroxyl group during fermentation with this *** of 17 β-acetoxy group isdependent upon other substituents present in the substrates.

关键词： OH acetoxy steroidal compounds during aromatization by Arthrobacter simplex Microbial hydrolysis of 17

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A Meta-analysis of Ginsenoside Rg3 for Non-small Cell Lung Cancer

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Clinical oncology and cancer researeh 2011年第3期8卷 175-180页

作者： shan-shan hu Li-kun ZHOU Yi BA Hong-li LI Cai-hua Zhu Department of Digestive Oncology Tianjin Medical University Cancer Institute ＆ Hospital Key Laboratory of Cancer Prevention and Therapy Tianjin 300060 China

OBJECTIVE Ginsenoside Rg3 （Rg3） has shown anti-tumor effects on various tumor cells. It has been widely used in China for non-small cell lung cancer （NSCLC）. However, there are only a few clinical trials to study the effectiveness of Rg3 on NSCLC, and almost them are small- samples, so we performed a meta-analysis on the results of the studies we collected in order to investigate the effectiveness of Rg3 on NSCLC. METHODS A meta-analysis was conducted in all the selected randomized controlled trials evaluating the effectiveness of Rg3 on NSCLC patients. All on-line databases regarding Rg3 from 1950 to 2011 were searched. Supplemental hand searching of the references of retrieved articles was performed. RESULTS Six trials met the inclusion criteria. Four of them compared chemotherapy plus Rg3 with chemotherapy alone, and the other 2 compared chemotherapy plus Rg3 with chemotherapy plus placebo. These trials are homogeneous. Two of the trials report overall survival, but the data are not suitable for a meta-analysis. After meta-analysis was conducted in the included studies comparing the effects of chemotherapy plus Rg3 with that of chemotherapy alone or chemotherapy plus placebo, it was suggested that chemotherapy plus Rg3 increased the response rate [odds ratio： 2.64 （95% Ch 1.70-4.11）, fixed effects model] and disease control rate [odds ratio： 3.34 （95% CI： 1.92-5.81）; fixed effects model] of the patients at stage II-IV, especially for the patients at stage Ill-IV. CONCLUSION Meta-analysis of the available evidence suggests that Rg3 plus chemotherapy improves the response rate of NSCLC patients, and well-designed RCTs with large sample size are needed.

关键词： Rg3 20 (R)-GS-Rg3 (Rg3) non-small cell lung cancer meta-analysis.

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Fast-track surgery in elderly patients undergoing colorectal cancer radical resection

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International Journal of Nursing Sciences 2014年第4期1卷 381-384页

作者： Hong-Yan Kong Ai-Ling Yang Cai-Ya Ying Zhen-Fang Kong Ling-Ling Yuan shan-shan hu Shun Zhang Department of Anorectal Surgery Ningbo No.2 HospitalNingboChina School of Medicine Ningbo UniversityNingboChina Laboratory of Stem Cell Ningbo No.2 HospitalNingboChina

Purpose:To investigate the efficacy of applying fast-track surgery(FTS)to elderly patients undergoing radical resection of colorectal ***:Elderly patients undergoing radical resection of colorectal cancer received FTS(n=31)or routine(n=31)nursing *** time to first anal exhaust,oral feeding and leaving the bed,duration of postoperative hospital stay and the incidence of complications were compared between the two ***:Patients receiving FTS nursing demonstrated significantly shorter times to exhaust,oral feeding and leaving the bed compared with those receiving routine nursing(all p<0.01).Furthermore,there were significantly fewer incidences of postoperative pulmonary and urinary tract infections and intestinal adhesion in patients receiving FTS nursing(all p<0.05).Conclusion:Application of FTS in elderly patients undergoing radical resection of colorectal cancer facilitates an early rehabilitation after surgery,but places higher demands on nursing care.

关键词： Aged Colorectal neoplasms Fast-track surgery Nursing care

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Wave effect of gravitational waves intersected with a microlens field Ⅱ:An adaptive hierarchical tree algorithm and population study

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 241-254页

作者： Xikai shan Guoliang Li Xuechun Chen Wen Zhao Bin hu Shude Mao Department of Astronomy Tsinghua University Purple Mountain Observatory Chinese Academy of Sciences Institute for Frontier in Astronomy and Astrophysics Beijing Normal University School of Physics and Astronomy Beijing Normal University School of Astronomy and Space Science University of Science and Technology of China CAS Key Laboratory for Researches in Galaxies and Cosmology Department of Astronomy University of Science and Technology of ChinaChinese Academy of Sciences

The gravitational lensing wave effect generated by a microlensing field embedded in a lens galaxy is an inevitable phenomenon in strong lensed gravitational waves （SLGWs）.This effect presents both challenges and opportunities for the detection and application of ***,investigating this wave effect requires computing a complete diffraction integral over each microlens in the *** is extremely time-consuming due to the large number of microlenses （10～3-10～6）.Therefore,simply adding all the microlenses is ***,the complexity of the time delay surface makes the lens plane resolution a crucial factor in controlling numerical *** this paper,we propose a trapezoid approximation-based adaptive hierarchical tree algorithm to meet the challenges of calculation speed and *** find that this algorithm accelerates the calculation by four orders of magnitude compared to the simple adding method and is one order of magnitude faster than the fixed hierarchical tree algorithm proposed for electromagnetic *** importantly,our algorithm ensures controllable numerical errors,increasing confidence in the *** with our previous work （***.66,239511,2023）,this paper addresses all numerical issues,including integral convergence,precision,and computational time1).Finally,we conducted a population study on the microlensing wave effect of SLGWs using this algorithm and found that the microlensing wave effect cannot be ignored,especially for Type II SLGWs （from saddle position of the time delay surface） due to their intrinsic geometric structures and their typical intersection with a denser microlensing ***,more than 33%（11%） of SLGWs have a mismatch larger than 1%（3%） compared to the unlensed ***,we found that the mismatch between signal pairs in a doubly imaged GW is generally larger than 10-3,and 61%（25%） of signal pairs have a mismatch larger than 1%（3%）.Therefo

关键词： gravitational lensing diffractional integral algorithm gravitational wave

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Low expression of β-arrestin2 correlated with hepatocellular carcinoma progression

Low expression of β-arrestin2 correlated with hepatocellula...

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安徽省药理学会2012年学术年会

作者： shan-shan hu Jing-jing Wu Wu-yi Sun Wei Wei Institute of Clinical Pharmacology Anhui Medical UniversityKey Laboratory of Anti-inflammatory and ImmunopharmacologyMinistry of Education

Aim β-arrestins are ubiquitous cytosolic proteins which initially be regarded as potential characters in G protein-coupled receptors(GPCR) desensitization,sequestration,and ***,it has been documented that β-arrestins play a vital role in many tumors growth and *** present study aimed to explore the function and prognostic role of β-arrestins in hepatocellular carcinoma(HCC).Methods The expression of B-arrestinl and β-arrestin2 in paraffin-embedded human liver tissues and in tumors from HCC patients who underwent surgery resection were detected by immunohistochemistry(IHC),reverse transcription polymerase chain reaction(RT-PCR) and Western blot,*** prognostic significance of β-arrestin2 was validated using the Kaplan-Meier survival estimates and the log-rank *** expression ofβ-arrestin1 and β-arrestin2 in stepwise metastatic human HCC cell lines(HCCLM3, MHCC97H,MHCC97L,SMMC-7721,HepG2) and normal liver cell line L-02 were measured by RT-PCR and Western blot ***3 expression plasmids encoding GFP-tagged β-arrestin2 will be further used to investigate the role of B-arrestin2 in the metastasis and invasion of *** IHC analysis showed that expression of β-arrestin2 was higher in paraffin-embedded normal liver tissues than in HCC tumor tissues,but the expression ofβ-arrestin1 was not significantly *** similar results were presented in tumors from HCC patients who underwent surgery *** and multivariate analysis revealed that β-arrestin2 was a significant predictor for overall *** vitro,the RT-PCR and Western blot analysis showed that β-arrestin2 was low expressed in the highly metastatic HCC cell lines and high expressed in normal liver cell line L02,but there was no difference of β-arrestin 1 expression among human HCC cell lines and ***,SMMC-7721 cells were transfected with plasmid pcDNA3/β-arrestin2-GFP and the results showed that the expression of β-arrestin

关键词： hepatocellular carcinoma β-arrestins invasion metastasis prognosis

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