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赭曲霉毒素A的健康危害评估

毒理学杂志 2024年第3期38卷 185-192页

作者：杜宏举宁钧宇高珊李国君北京市疾病预防控制中心食物中毒诊断溯源技术北京市重点实验室北京100013 首都医科大学公共卫生学院北京100069

目的赭曲霉毒素A(ochratoxin A,OTA)是谷物等食物中常见的真菌毒素,可对人体健康产生多种不良作用。本文基于OTA毒性效应进行健康危害评估,旨在确定其安全的暴露水平,为食品安全暴露风险评估提供科学依据。方法本文基于系统性文献检索,... 详细信息

目的赭曲霉毒素A(ochratoxin A,OTA)是谷物等食物中常见的真菌毒素,可对人体健康产生多种不良作用。本文基于OTA毒性效应进行健康危害评估,旨在确定其安全的暴露水平,为食品安全暴露风险评估提供科学依据。方法本文基于系统性文献检索,对OTA进行危害识别和危害特征描述,依据现有毒理学数据确定其安全的暴露水平。结果OTA具有肝肾毒性、遗传毒性、生殖发育毒性和致癌性等多种毒性效应,以暴露边界值(margin of exposure,MOE)法进行OTA毒性的危害特征描述,以定性反映人群暴露的健康危害。结论表征非肿瘤效应时,OTA的MOE取值为200;表征肿瘤效应时,MOE取值为10000。该研究结果可为今后OTA的食品安全风险评估提供参考。

关键词：赭曲霉毒素A 食品安全危害评估暴露边界值

Surface and Volume Symmetry Energy Coefficients of a Neutron-Rich Nucleus

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Chinese Physics Letters 2012年第9期29卷 32-35页

作者： MA Chun-Wang YANG ju-Bao YU Mian PU Jie WANG shan-shan WEI Hui-Ling Department of Physics Henan Normal UniversityXinxiang 453007 Department of Life Sciences and Technology Xinxiang Medical UniversityXinxiang 453003 Department of Nuclear Physics Shanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800

Using an isobaric method,the symmetry-energy coefficient(asym)of a neutron-rich nucleus is obtained from experimental binding *** shell effects are shown in a^(*)_(sym)/A≡4asym/A of nuclei.A(sub)magic neutron magic number N=40 is suggested in a very neutron-rich nucleus,and a^(*)_(sym)/A of a nucleus is found to decrease when its mass *** a^(*)_(sym)/A of a very neutron-rich nucleus with large mass *** volume-symmetry coefficients(b_(v))and surface-symmetry coefficients(b_(s))of a neutron-rich nucleus are extracted from a sym*/A by a correlation a^(*)_(sym)/A=bv/A-b s/A^(4/3).It is found that bv and bs decrease when the nucleus becomes more neutron-rich,and tend to saturate in the very neutron-rich nucleus.A linear correlation between b v and bs is obtained in nuclei with different neutron-excess I,and bv of I>7 nuclei is found to coincide with the results of infinite nuclear matter a sym=32±4 MeV,and bs/bv of the nucleus is found to coincide with the results of the finite-range liquid-drop model results.

关键词： symmetry infinite coincide

积极老龄化视域下数智素养对老年人社会参与影响分析

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现代预防医学 2024年第15期51卷 2785-2790页

作者：王广通陈星韩志鹏于贞杰井淇胡善菊于颖荣山东第二医科大学管理学院山东第二医科大学护理学院

目的分析老年人口社会参与现状及影响因素，探索数智素养对老年人社会参与的影响。方法选取《2021年中国家庭健康指数调查》中1 123名60岁及以上老年人作为研究对象，运用构成比、率进行描述性分析，采用χ2检验、二分类logistic回归... 详细信息

目的分析老年人口社会参与现状及影响因素，探索数智素养对老年人社会参与的影响。方法选取《2021年中国家庭健康指数调查》中1 123名60岁及以上老年人作为研究对象，运用构成比、率进行描述性分析，采用χ2检验、二分类logistic回归分析数智素养对社会参与的影响情况。结果老年人社会、家庭和个人层面社会参与率分别为73.9%、81.2%、87.4%。回归分析结果显示，男性（OR=1.646,95%CI:1.230～2.202）、大专及以上（OR=2.127,95%CI:1.201～3.766）、经常使用智能手机（OR=2.459,95%CI:1.441～4.194）、经常使用平板电脑（OR=3.953,95%CI:1.637～9.548）的老年人更倾向于社会层面社会参与。男性（OR=1.720,95%CI:1.250～2.368）、无债务（OR=0.495,95%CI:0.334～0.733）、经常使用智能手机（OR=2.545,95%CI:1.448～4.473）、有时使用平板电脑（OR=3.532,95%CI:1.607～7.764）的老年人更倾向于家庭层面社会参与。有配偶（OR=2.877,95%CI:1.389～5.961）、有时使用智能手机（OR=3.533,95%CI:1.871～6.674）的老年人更倾向于个人层面社会参与。结论老年人口社会参与水平较高，各层面社会参与影响因素存在差异性，数智素养对老年人社会参与具有显著正向作用。建议加强适老化改造和防沉迷建设，拓宽及简化数字技术服务的获取途径，释放代际支持的数字反哺隐藏优势。

关键词：积极老龄化数智素养社会参与影响因素

End-to-End Paired Ambisonic-Binaural Audio Rendering

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Effects of specimen size on flow stress of micro rod specimen

自动化学报（英文版） 2024年第2期

作者： Yin Zhu Qiuqiang Kong junjie Shi Shilei Liu Xuzhou Ye ju-Chiang Wang hongming shan junping Zhang

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Transactions of Nonferrous Metals Society of China 2009年第S02期19卷 511-515页

作者： WANG Chun-ju GUO Bin shan De-bin SUN Li-ning School of Materials Science and Engineering Harbin Institute of technologyHarbin 150001China Robot Institute of Technology Harbin Institute of TechnologyHarbin 150001China

With the miniaturization of parts,size effects occur in the micro-forming *** investigate the effects of the specimen size on the flow stress,a series of upsetting deformation experiments were carried out at room temperature for specimens with different *** the grain size of billets was changed by anneal processes to analyze the grain size effects on the size dependence of flow *** deviation of stress was *** results show that the flow stress decreases with decreasing billet *** the dislocation accumulation in free surface layer is slight,the reduction degree of flow stress becomes larger when the plastic deformation goes *** flow stress is enlarged by grain size,which can be analyzed by the grain boundary length per *** deviation increases with decreasing specimen *** can be explained by the effects of grain orientation stochastic distribution according to the Schmid *** a result,the micro-forming process must be considered from the viewpoint of polycrystalline structure,and the single grains of micro-billet dominate the deformation.

关键词： micro-forming size effects free surface effects deviation flow stress

Evaluation of latest TMPA and CMORPH satellite precipitation products over Yellow River Basin

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Water Science and Engineering 2016年第2期9卷 87-96页

作者： shan-hu Jiang Meng Zhou Li-liang Ren Xue-rong Cheng Peng-ju Zhang State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai University College of Hydrology and Water Resources Hohai University

The main objective of this study was to evaluate four latest global high-resolution satellite precipitation products(TMPA 3B42 RT, CMORPH,TMPA 3B42V7, and CMORPH_adj) against gauge observations of the Yellow River Basin from March 2000 to December 2012. The assessment was conducted with several commonly used statistical indices at daily and monthly scales. Results indicate that 3B42V7 and CMORPH_adj perform better than the near real-time products(3B42RT and CMORPH), particularly the 3B42V7 product. The adjustment by gauge data significantly reduces the systematic biases in the research products. Regarding the near real-time datasets, 3B42 RT overestimates rainfall over the whole basin, while CMORPH presents a mixed pattern with negative and positive values of relative bias in low- and high-latitude regions,respectively, and CMORPH performs better than 3B42 RT on the whole. According to the spatial distribution of statistical indices, these values are optimized in the southeast and decrease toward the northwest, and the trend is similar for the spatial distribution of the mean annual precipitation during the period from 2000 to 2012. This study also reveals that all the four products can effectively detect rainfall events. This study provides useful information about four mainstream satellite products in the Yellow River Basin, and the findings can facilitate the use of global precipitation measurement(GPM) data in the future.

关键词： Satellite precipitation TMPA CMORPH Yellow River Basin

泰和乌鸡蛋营养价值和小分子代谢物成分的综合分析

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食品科学 2024年第15期45卷 139-147页

作者：巨晓军章明姬改革单艳菊屠云洁刘一帆邹剑敏赵伟东郑国庆束婧婷江苏省家禽科学研究所江苏省家禽遗传育种重点实验室江苏扬州225125 泰和凤升农牧科技有限公司江西吉安343700

为了探究泰和乌鸡蛋的营养价值和小分子代谢物成分,通过与同批生产的麻黄鸡蛋进行比较,首先对泰和乌鸡蛋的外观、蛋品质和水解氨基酸含量进行分析,然后运用全局精准非靶向代谢组学方法对泰和乌鸡蛋蛋白和蛋黄的代谢物分别进行综合表征,... 详细信息

为了探究泰和乌鸡蛋的营养价值和小分子代谢物成分,通过与同批生产的麻黄鸡蛋进行比较,首先对泰和乌鸡蛋的外观、蛋品质和水解氨基酸含量进行分析,然后运用全局精准非靶向代谢组学方法对泰和乌鸡蛋蛋白和蛋黄的代谢物分别进行综合表征,筛选泰和乌鸡蛋的标志性代谢物。结果显示,泰和乌鸡蛋外型小于麻黄鸡蛋,小头尖,大部分蛋壳表面有黑斑沉积。泰和乌鸡蛋质量、蛋黄色泽、蛋黄质量、蛋黄比率显著低于麻黄鸡蛋(P1),其中有32个代谢物相对含量高于麻黄鸡蛋,19个代谢物相对含量低于麻黄鸡蛋,这些差异物质主要富集在氨基酸代谢途径,其中丙氨酸、天冬氨酸和谷氨酸代谢途径的富集程度最显著且影响因子最大;蛋白中含量差异较大、影响较大的代谢物有硬脂酰胺、花生四烯酸、L-赖氨酸、L-天冬氨酸等,它们可作为鉴别泰和乌鸡蛋潜在的标志性代谢物。泰和乌鸡蛋黄中差异代谢物相对较少,仅有33个且在代谢物分类中比较分散,蛋黄中含量差异较大、影响较大的代谢物有3-氨基-4-甲基戊酸、亚氨基精氨酸、D-葡萄糖,可作为鉴别泰和乌鸡蛋潜在的标志性代谢物。本研究结果可为泰和乌鸡蛋的推广和食品开发提供基础数据支持。

关键词：泰和乌鸡蛋蛋品质水解氨基酸全局精准非靶向代谢组学

Two-Terminal Lithium-Mediated Artificial Synapses with Enhanced Weight Modulation for Feasible Hardware Neural Networks

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Nano-Micro Letters 2023年第5期15卷 236-253页

作者： Ji Hyun Baek Kyung ju Kwak Seung ju Kim Jaehyun Kim Jae Young Kim In Hyuk Im Sunyoung Lee Kisuk Kang ho Won Jang Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoul 08826Republic of Korea Advanced Institute of Convergence Technology Seoul National UniversitySuwon 16229Korea

Recently,artificial synapses involving an electrochemical reaction of Li-ion have been attributed to have remarkable synaptic ***-terminal synaptic transistors utilizing Li-ion intercalation exhibits reliable synaptic characteristics by exploiting the advantage of nondistributed weight updates owing to stable ion ***,the three-terminal configurations with large and complex structures impede the crossbar array implementation required for hardware neuromorphic ***,achieving adequate synaptic performances through effective Li-ion intercalation in vertical two-terminal synaptic devices for array integration remains ***,two-terminal Au/LixCoO_(2)/Pt artificial synapses are proposed with the potential for practical implementation of hardware neural *** Au/LixCoO_(2)/Pt devices demonstrated extraordinary neuromorphic behaviors based on a progressive dearth of Li in LixCoO_(2)*** intercalation and deintercalation of Li-ion inside the films are precisely controlled over the weight control spike,resulting in improved weight control *** types of synaptic plasticity were imitated and assessed in terms of key factors such as nonlinearity,symmetricity,and dynamic ***,the LixCoO_(2)-based neuromorphic system outperformed three-terminal synaptic transistors in simulations of convolutional neural networks and multilayer perceptrons due to the high linearity and low programming *** impressive performances suggest the vertical two-terminal Au/LixCoO_(2)/Pt artificial synapses as promising candidates for hardware neural networks.

关键词： Artificial synapse Neuromorphic Li-based Two-terminal Synaptic plasticity

笼养密度对公母分饲黄羽肉鸡生长性能、免疫器官发育、抗氧化能力、肠道组织形态及免疫相关基因mRNA表达的影响

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动物营养学报 2024年第4期36卷 2277-2291页

作者：姬改革巨晓军单艳菊章明邹剑敏屠云洁刘一帆束婧婷庞立川范晨宇江苏省家禽科学研究所江苏省家禽遗传育种重点实验室扬州225125 湖南农业大学动物科技学院长沙410128

本试验旨在探讨笼养密度对公母分饲黄羽肉鸡生长性能、免疫器官发育、抗氧化能力、肠道组织形态及免疫相关基因mRNA表达的影响。选用21日龄黄脚麻鸡720只,3层层叠式笼内饲喂,鸡笼规格为长×宽×高=1.2 m×0.8 m×0.4 m,公鸡和母鸡分开饲... 详细信息

本试验旨在探讨笼养密度对公母分饲黄羽肉鸡生长性能、免疫器官发育、抗氧化能力、肠道组织形态及免疫相关基因mRNA表达的影响。选用21日龄黄脚麻鸡720只,3层层叠式笼内饲喂,鸡笼规格为长×宽×高=1.2 m×0.8 m×0.4 m,公鸡和母鸡分开饲养,均随机分为4组(每组5个重复),笼养密度分别为15(低密度组)、17(中密度组)、19(中高密度组)和21只/m 2(高密度组)。试验期42 d。结果表明:1)对于公鸡,21~42日龄时,高密度组平均日采食量显著低于低密度组和中密度组(P<0.05);43~63日龄时,中高密度组和高密度组平均日采食量显著低于低密度组和中密度组(P<0.05),中高密度组和高密度组平均日增重显著低于低密度组(P<0.05)。对于母鸡,21~42日龄时,中高密度组和高密度组平均日采食量显著低于低密度组(P<0.05),高密度组平均日增重显著低于低密度组(P<0.05);43~63日龄时,高密度组平均日采食量显著低于低密度组和中密度组(P<0.05),中高密度组平均日增重显著低于低密度组(P<0.05)。2)对于公鸡,低密度组肝脏重量显著低于其他各组(P<0.05),肝脏指数显著低于高密度组(P<0.05)。3)对于母鸡,中密度组血清超氧化物歧化酶活性显著高于高密度组(P<0.05),中高密度组血清丙二醛含量显著高于高密度组(P<0.05)。4)对于公鸡,中密度组空肠绒毛高度/隐窝深度显著高于高密度组(P<0.05)。对于母鸡,高密度组十二指肠隐窝深度显著高于中高密度组(P<0.05),中高密度组十二指肠绒毛高度/隐窝深度显著高于高密度组(P<0.05);高密度组空肠绒毛高度显著低于中密度组和中高密度组(P<0.05),高密度组空肠绒毛高度/隐窝深度显著低于低密度组(P<0.05);高密度组回肠隐窝深度显著高于其他各组(P<0.05)。5)对于公鸡,中高密度组空肠肿瘤坏死因子-α(TNF-α)mRNA相对表达量显著高于其他各组(P<0.05)。对于母鸡,中高密度组空肠核因子E2相关因子2(Nrf2)和Toll样受体4(TLR4)mRNA相对表达量显著高于低密度组(P<0.05)。由此可见,高笼养密度会对黄羽肉鸡生长性能、抗氧化能力、肠道组织形态等相关指标产生影响;笼养密度可能通过影响肠道抗氧化和免疫相关基因表达影响黄羽肉鸡肠道免疫功能。

关键词：黄羽肉鸡笼养密度生长性能免疫肠道形态抗氧化基因表达