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固本防哮饮对支气管哮喘缓解期模型小鼠肺组织氧化应激与AMPK/Nrf2/ho-1通路的影响

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中医杂志 2024年第2期65卷 205-212页

作者：代晓寒赵霞严花单祎文南京中医药大学附属医院江苏省南京市210029 南京中医药大学中医儿科学研究所/江苏省儿童呼吸疾病(中医药)重点实验室

目的探讨固本防哮饮防治支气管哮喘缓解期慢性气道炎症的可能作用机制。方法36只雌性Balb/c小鼠随机分为正常组,模型组,固本防哮饮低、中、高剂量组,孟鲁司特钠组,每组6只。除正常组外,其余各组小鼠采用卵白蛋白联合呼吸道合胞病毒诱导... 详细信息

目的探讨固本防哮饮防治支气管哮喘缓解期慢性气道炎症的可能作用机制。方法36只雌性Balb/c小鼠随机分为正常组,模型组,固本防哮饮低、中、高剂量组,孟鲁司特钠组,每组6只。除正常组外,其余各组小鼠采用卵白蛋白联合呼吸道合胞病毒诱导建立支气管哮喘缓解期小鼠模型。造模后固本防哮饮低、中、高剂量组分别给予固本防哮饮12、24、36 g/(kg·d)灌胃,孟鲁司特钠组给予孟鲁司特钠颗粒2.6 mg/(kg·d)灌胃,正常组、模型组小鼠给予双蒸水20 ml/(kg·d)灌胃,均每天1次,共28天。检测小鼠肺组织白细胞介素4(IL-4)、白细胞介素5(IL-5)水平;HE染色观察肺组织病理并进行炎症评分;DHE染色观察肺组织活性氧(ROS)水平;检测肺组织线粒体呼吸链复合物Ⅰ、Ⅱ、Ⅲ、Ⅳ、Ⅴ活性;检测血清超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、丙二醛(MDA)及三磷酸腺苷(ATP)水平;Western blot法检测小鼠肺组织中磷酸化腺苷单磷酸活化蛋白激酶(p-AMPK)、核因子E2相关因子2(Nrf2)、血红素加氧酶1(ho-1)及cAMP应答元件结合蛋白(CREB)蛋白表达水平。结果与正常组比较,模型组小鼠肺组织病理结果显示气道周围炎症细胞增多,炎症评分升高;DHE染色显示ROS水平升高,肺组织IL-4、IL-5水平升高;血清SOD、CAT及ATP水平降低,MDA水平升高;肺组织线粒体呼吸链复合物Ⅰ、Ⅱ、Ⅲ、Ⅳ、Ⅴ活性降低,p-AMPK、Nrf2、CREB蛋白表达降低(Pho-1信号通路有关。

关键词：支气管哮喘缓解期固本防哮饮氧化应激线粒体功能腺苷单磷酸活化蛋白激酶核因子E2相关因子2 血红素加氧酶1

Distribution Atlas of COVID-19 Pneumonia on Computed Tomography:A Deep Learning Based Description

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Phenomics 2021年第2期1卷 62-72页

作者： shan Huang Yuancheng Wang Zhen Zhou Qian Yu Yizhou Yu Yi Yang Shenghong ju Jiangsu Key Laboratory of Molecular and Functional Imaging Department of RadiologyZhongda HospitalMedical School of Southeast University87 Ding Jia Qiao RoadNanjing 210009JiangsuChina School of Electronics Engineering and Computer Science Peking UniversityBeijingChina Department of Computer Science The University of Hong KongHong KongChina Department of Critical Care Medicine Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingChina

Objectives To construct a distribution atlas of coronavirus disease 2019(COVID-19)pneumonia on computed tomography(CT)and further explore the difference in distribution by location and disease severity through a retrospective study of 484 cases in Jiangsu,*** All patients diagnosed with COVID-19 from January 10 to February 18 in Jiangsu Province,China,were enrolled in our *** patients were further divided into asymptomatic/mild,moderate,and severe/critically ill groups.A deep learning algorithm was applied to the anatomic pulmonary segmentation and pneumonia lesion *** frequency of opacity on CT was calculated,and a color-coded distribution atlas was built.A further comparison was made between the upper and lower lungs,between bilateral lungs,and between various severity *** lesion-based radiomics analysis was performed to ascertain the features associated with the disease *** A total of 484 laboratory-confirmed patients with 945 repeated CT scans were *** opacity was mainly distributed in the subpleural and peripheral *** distances from the opacity to the nearest parietal/visceral pleura were shortest in the asymptomatic/mild *** diffused lesions were found in the severe/critically ill *** frequency of opacity increased with increased severity and peaked at about 3-4 or 7-8 o’clock direction in the upper lungs,as opposed to the 5 or 6 o’clock direction in the lower *** with greater energy,more circle-like,and greater surface area were more likely found in severe/critically ill cases than the *** This study constructed a detailed distribution atlas of COVID-19 pneumonia and compared specific patterns in different parts of the lungs at various *** radiomics features most associated with the severity were also *** results may be valuable in determining the COVID-19 sub-phenotype.

关键词： COVID-19 Computed tomography Deep learning Distribution atlas Radiomics

Effects of Bacillus subtilis CSL2 on the composition and functional diversity of the faecal microbiota of broiler chickens challenged with Salmonella Gallinarum

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Journal of Animal Science and Biotechnology 2017年第2期8卷 450-458页

作者： ju Kyoung Oh Edward Alain B.Pajarillo Jong Pyo Chae In ho Kim Dong Soo Yang Dae-Kyung Kang Department of Animal Resources Science Dankook University119 Dandae-roCheonan 31116Republic of Korea Abson BioChem Inc10-1 Yangjimaeul-gilSangrok-guAnsan 15524Republic of Korea

Background： The chicken gastrointestinal tract contains a diverse microbiota whose composition and structure play important roles in gut functionality. In this study, microbial shifts resulting from feed supplementation with Bacillus subtilis CSL2 were evaluated in broilers challenged and unchallenged with Salmonella Gallinarum. To analyse bacterial community composition and functionality, 454 GS-FLX pyrosequencing of 16 S r RNA gene amplicons was ***： The Quantitative Insights into Microbial Ecology（QIIME） pipeline was used to analyse changes in the faecal microbiota over a 24-h period. A total of 718,204 sequences from broiler chickens were recorded and analysed. At the phylum level, Firmicutes, Bacteroidetes, and Proteobacteria were the predominant bacterial taxa. In Salmonellainfected chickens（SC）, Bacteroidetes were more highly abundant compared to control（NC） and Bacillus-treated（BT）chickens. At the genus level, in the NC and BT groups, Lactobacil us was present at high abundance, and the abundance of Turicibacter, unclassified Enterobacteriaceae, and Bacteroides increased in SC broilers. Furthermore, taxon-independent analysis showed that the SC and BT groups were compositional y distinct at the end of the 24-h period. Further analysis of functional properties showed that B. subtilis CSL2 administration increased gut-associated energy supply mechanisms（i.e. carbohydrate transport and metabolism） to maintain a stable microbiota and protect gut ***： This study demonstrated that S. Gallinarum infection and B. subtilis CSL2 supplementation in the diet of broiler chickens influenced the diversity, composition, and functional diversity of the faecal microbiota. Moreover, the findings offer significant insights to understand potential mechanisms of Salmonel a infection and the mode of action of probiotics in broiler chickens.

关键词： Bacillus subtilis Broiler chicken Microbiome Salmonel a Gallinarum 16S rRNA gene

Excellent response of severe aplastic anemia to treatment of gut inflammation: A case report and review of the literature

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World Journal of Clinical Cases 2020年第2期8卷 425-435页

作者： Xi-Chen Zhao Li Zhao Xiao-Yun Sun Zeng-shan Xu Bo ju Fan-jun Meng hong-Guo Zhao Department of Hematology The Central Hospital of Qingdao West Coast New AreaQingdao 266555Shandong ProvinceChina Department of Hematology The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Cumulative evidence suggests that the aberrant immune responses in acquired aplastic anemia(AA) are sustained by active chronic infections in genetically susceptible individuals. Recently, the constant source to trigger and sustain the pathophysiology has been proposed to come from the altered gut microbiota and chronic intestinal inflammation. In this case, our serendipitous finding provides convincing evidence that the persistently dysregulated autoimmunity may be generated, at least in a significant proposition of AA patients, by the altered gut microbiota and compromised intestinal *** SUMMARY A 30-year-old Chinese male patient with refractory severe AA experienced a 3-month-long febrile episode, and his fever was refractory to many kinds of injected broad-spectrum antibiotics. When presenting with abdominal cramps, he was prescribed oral mannitol and gentamycin to get rid of the gut infection. This treatment resulted in a quick resolution of the fever. Unanticipatedly, it also produced an excellent hematological response. He had undergone three episodes of recurrence within the one-year treatment, with each recurrence occurring 7-8 wk from the gastrointestinal inflammation eliminating preparations. however,subsequent treatments were able to produce subsequent remissions and consecutive treatments were successful in achieving durative hematological improvements, strongly indicating an etiological association between chronic gut inflammation and the development of AA. Interestingly, comorbid diseases superimposed on this patient(namely, psychiatric disorders, hypertension,insulin resistance, and renal dysfunction) were ameliorated together with the hematological *** Chronic gut inflammation may be responsible for AA pathogenesis. The comorbidities and AA may share a common etiological association.

关键词： Case report Severe aplastic anemia Hematological response Chronic gut inflammation Comorbid disease Etiological association

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多模态深层次高置信度融合跟踪算法

计算机系统应用 2024年第9期33卷 153-163页

作者：高伟薛杉胡秋霞李嘉琦田杰饶晔杨举西安航空学院计算机学院西安710077 中国电子科技集团第十五研究所西安研发中心西安710005

为解决单目标跟踪中因目标外观及环境变化导致的跟踪失败问题,提出一种多模态深层次高置信度融合跟踪算法.首先构建目标颜色模型和基于双线性插值hoG特征形状模型的高维度多模态模型,之后对候选目标利用粒子滤波进行搜索.针对模型融合... 详细信息

为解决单目标跟踪中因目标外观及环境变化导致的跟踪失败问题,提出一种多模态深层次高置信度融合跟踪算法.首先构建目标颜色模型和基于双线性插值hoG特征形状模型的高维度多模态模型,之后对候选目标利用粒子滤波进行搜索.针对模型融合的难点,通过准确量化形状和颜色模型多种置信度并设计高置信度融合准则,以实现该多模态模型中不同置信度的深层次自适应加权平衡融合.最后针对模型更新参数固定的问题,设计非线性分级平衡更新策略.经过在OTB-2015数据集上的测试,发现该算法的平均CLE和OS在所有参照算法表现中均表现最佳,其值分别为30.57和0.609.此外,其FPS为15.67,满足了跟踪算法在一般情况下的实时性要求.在某些常见的特定场景中,其精确率、成功率指标在多数情况下的表现也超过了同类顶尖算法.

关键词：视觉目标跟踪多模态置信度融合深层次加权分级平衡更新

Comments on“Adsorption behavior of heavy metal ions by carbon nanotubes grown on microsized Al_2O_3 particles”

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Journal of University of Science and Technology Beijing 2008年第3期15卷 366-366页

作者： Yuh-shan ho Department of Environmental Sciences College of Environmental Science and Engineering Peking University

Recently, Hsieh and horng [1] published the paper entitled as above. In section 3 results and discussion, the authors mentioned the first and the second order kinetic models without any quotations. In fact these two kinetic models have been published [2-5]. In order to distinguish a kinetics model based on the ad- sorption capacity of a solid from the one based on the concentration of a solution, Lagergren＇s first-order rate equation has been called pseudo-first-order [6-7]. The Lagergren＇s equation has been widely cited, but there are far more mistakes made in the quotation and in the reference section of papers, including the title, the author＇s name, journal title, year of publishing, volume, and page number [3]. In addition, the second order kinetic expression for the adsorption systems of divalent metal ions using sphagnum moss peat has been reported by ho [8].

关键词： Adsorption behavior of heavy metal ions by carbon nanotubes grown on microsized Al2O3 particles ho rate Comments on

Highly efficient and stable solid-state fiber dye-sensitized solar cells with Ag-decorated SiO_(2) nanoparticles

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Nano Research 2021年第8期14卷 2728-2734页

作者： Jae ho Kim Seok-ju Yoo Daseul Lee Jin Woo Choi Sang-Cheol Han Tae In Ryu Hyung Woo Lee Myunghun Shin Myungkwan Song Materials Center for Energy Convergence Korea Institute of Materials Science(KIMS)797Changwon-daeroSungsan-guChangwonGyeongsangnam-do51508Republic of Korea CEN Nano.Co.Ltd. Nano Convergence CenterMuan-roBuduk-myeonMiryang-siGyeongsangnam-do50404Republic of Korea Accident Coordination and Training Division National Institute of Chemical Safety(NICS)90Gajeongbuk-roYuseong-guDaejeon34114Republic of Korea Department of Nanoenergy Engineering and Research Center of Energy Convergence Technology Pusan National UniversityBusandaehak-ro 63-2Geumjeong-guBusan 46241Republic of Korea School of Electronics and Information Engineering Korea Aerospace University Goyang-cityGyeonggi-do10540Republic of Korea

Fiber-shaped dye-sensitized solar cells(FDSSCs)represent promising futuristic flexible or wearable power sources,owing to their simple fabrication process,light weight,weavability,and *** with strategies on changing the properties of semiconductor materials,the effects of incorporating silver-embedded SiO_(2) nanoparticles(Ag@SiO_(2)NPs)on the photoanodes of solid-state FDSSCs(SS-FDSSCs)are *** power conversion efficiency(PCE)of SS-FDSSCs with Ag@SiO_(2) NPs reaches 5.38%,which is comparable to the reference(3.98%).The PCEs remain at 95%between-16.9 and 91.7℃,indicating the operational stability of SS-FDSSCs within this temperature *** fabricated SS-FDSSCs,whose radii were 2 mm,maintains more than 90%of their efficiency over 500 bending cycles and 10 washing cycles.

关键词： dye-sensitized solar cells fiber-shaped solar cells SiO_(2)nanoparticles plasmonic effect solid-state electrolyte

Flavor supplementation during late gestation and lactation periods increases the reproductive performance and alters fecal microbiota of the sows

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Animal Nutrition 2021年第3期7卷 679-687页

作者： Renjie Wang Ning Liu Yuchen Yang Yan Lei Jirong Lyu Zhaolai Dai In ho Kim ju Li Zhenlong Wu Defa Li State Key Laboratory of Animal Nutrition China Agricultural UniversityBeijing100193China Department of Nutrition and Health China Agricultural UniversityBeijing100193China DadHank Biotechnology Corporation Chengdu611130China Department of Animal Resource&Science Dankook UniversityCheonan330-714South Korea Henan Yinfa Animal Husbandry Co.Ltd. Zhengzhou451100China

This study was conducted to evaluate the effect of flavor on reproductive performance and fecal microbiota of sows during late gestation and lactation.A total of 20 healthy Yorkshire sows were fed a corn-soybean basal diet unsupplemented or supplemented with 0.1%flavor compound from d 90 of gestation to 25 d post-farrowing,and then the piglets were *** reproductive performance and the fecal microbiota of sows were *** with the controls,flavor supplementation in maternal diets increased(P0.05).The 16S rRNA analysis showed that flavor supplementation signifi-cantly increased the abundance of Phascolarctobacterium(Phowed that Phascolarctobacterum was positively correlated with the average daily feed intake of sows(Phogenic bacteria in the sows.

关键词： Correlation Flavor Fecal microbiota Reproductive performance

Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma

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World Journal of Gastroenterology 2013年第47期19卷 8873-8879页

作者： De-Leung Gu Yen-Hsieh Chen Jou-ho Shih Chi-Hung Lin Yuh-shan Jou Chian-Feng Chen Institute of Biomedical Sciences Academia Sinica Institute of Microbiology and Immunology School of Life ScienceNational Yang-Ming University Bioinformatics Program Taiwan International Graduate ProgramAcademia Sinica Genome and Systems Biology Degree Program National Taiwan University VYM Genome Research Center National Yang-Ming University

High-throughput short-read sequencing of exomes and whole cancer genomes in multiple human hepatocellular carcinoma(HCC)cohorts confirmed previously identified frequently mutated somatic genes,such as TP53,CTNNB1 and AXIN1,and identified several novel genes with moderate mutation frequencies,including ARID1A,ARID2,MLL,MLL2,MLL3,MLL4,IRF2,ATM,CDKN2A,FGF19,PIK3CA,RPS6KA3,JAK1,KEAP1,NFE2L2,C16orf62,LEPR,RAC2,and *** classification of these mutated genes suggested that alterations in pathways participating in chromatin remodeling,Wnt/β-catenin signaling,JAK/STAT signaling,and oxidative stress play critical roles in HCC ***,because there are few druggable genes used in HCC therapy,the identification of new therapeutic targets through integrated genomic approaches remains an important *** a large amount of HCC genomic data genotyped by high density single nucleotide polymorphism arrays is deposited in the public domain,copy number alteration(CNA)analyses of these arrays is a cost-effective way to reveal target genes through profiling of recurrent and overlapping amplicons,homozygous deletions and potentially unbalanced chromosomal translocations accumulated during HCC ***,integration of CNAs with other high-throughput genomic data,such as aberrantly coding transcriptomes and non-coding gene expression in human HCC tissues and rodent HCC models,provides lines of evidence that can be used to facilitate the identification of novel HCC target genes with the potential of improving the survival of HCC patients.

关键词： Copy number alteration High-density single nucleotide polymorphism arrays Driver genes Hepatocellular carcinoma