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Achieving room-temperature M_(2)-phase VO_(2) nanowires for superior thermal actuation

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Nano Research 2021年第11期14卷 4146-4153页

作者： Yong-Qiang Zhang Kai Chen Hao Shen Yue-Cun Wang Mohamed Nejib Hedhili Xixiang Zhang ju Li Zhi-Wei shan Center for Advancing Materials Performance from the Nanoscale State Key Laboratory for Mechanical Behavior of MaterialsXi’an Jiaotong UniversityXi’an710049China Physical Science and Engineering Division King Abdullah University of Science and Technology(KAUST)Thuwal23955-6900Saudi Arabia Departments of Nuclear Science and Engineering and Materials Science and Engineering Massachusetts Institute of TechnologyCambridgeMA02139USA

Vanadium dioxide (VO_(2)) has emerged as a promising micro-actuator material for its large amplitude and high work density across the transition between the insulating (M_(1) and M_(2)) and metallic (R) phase. Even though M_(2)–R transition offers about 70% higher transformation stress than M_(1)–R structural phase transition, the application of the M_(2) phase in the micro-actuators is hindered by the fact that previously, M_(2) phase can only stay stable under tensile stress. In this work, we propose and verify that by synthesizing the VO_(2) nanowires under optimized oxygen-rich conditions, stoichiometry change can be introduced into the nanowires (NWs) which in turn yield a large number free-standing single-crystalline M_(2)-phase NWs stable at room temperature. In addition, we demonstrate that the output stress of the M_(2)-phase NWs is about 65% higher than that of the M_(1)-phase NWs during their transition to R phase, quite close to the theoretical prediction. Our findings open new avenues towards enhancing the performance of VO_(2)-based actuators by using M_(2)–R transition.

关键词： single crystalline vanadium dioxide(VO_(2))nanowires metal-insulator transition room-temperature M_(2)phase micro-actuator martensitic transformation transformation strain

Myofiber development during embryonic to neonatal development in duck breeds differing in muscle growth rates

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Journal of Integrative Agriculture 2016年第2期15卷 403-413页

作者： LI Hui-fang SHU Jing-ting shan Yan-ju CHEN Wen-feng SONG Chi XU Wen-juan Key Laboratory for Poultry Genetics and Breeding of Jiangsu Province Institute of Poultry Science Chinese Academy of Agricultural Science Yangzhou 225125 P.R. China Jiangsu Tengdayuan Co. Ltd. Jiangyan 225538 P.R. China

Little is known about the muscle developmental patterns during embryonic to neonatal development in *** investigated the developmental patterns in the lateral gastrocnemius muscles of Gaoyou and Jinding ducks differing in their muscle growth rates during the final stages of egg incubation and the first week after *** of the MyoD gene was quantified by quantitative real-time PCR（qRT-PCR）.The average cross-sectional area and diameter of the fibers increased from embryonic day 21（E21）,peaking at E27,and then declining slightly 7 d after *** density of the fibers decreased initially but increased after hatching in both breeds and *** within-breed variation in muscle fiber-type composition was greater than the average variation between the ***,the percentage of type Ⅰ fibers increased and that of type lIb fibers decreased ***,the percentage of type lla fibers was almost constant as development proceeded in both duck *** profiles of MyoD mRNA expression were similar in both breeds,and a significantly positive relationship was observed between the expression of MyoD and the percentage of type lIb *** study firstly revealed the characteristics of duck muscle development and differences between the two breeds differing in growth ***,type lIb fibers might convert to type Ⅰ fibers in the lateral gastrocnemius,while MyoD may potentially function in controlling the muscle fiber phenotype during the secondary myogenesis of muscle development.

关键词： duck myofiber development MyoD gene gene expression

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羧甲基淀粉钠工艺对片剂崩解性能的影响

化工管理 2024年第2期 156-159页

作者：周晔王天瑶琚冬冬刘秀燕单艺璇江苏恒瑞医药股份有限公司江苏连云港222047

文章着重分析羧甲基淀粉钠在用于改善难溶性药物的片剂在高湿条件下崩解不佳时的效果。以难溶性药物来曲唑作为本次研究的模型药物,采用常规的口服片剂生产工艺制备药物片剂。结果显示使用无交联工艺的羧甲基淀粉钠的片剂,在高湿条件(92... 详细信息

文章着重分析羧甲基淀粉钠在用于改善难溶性药物的片剂在高湿条件下崩解不佳时的效果。以难溶性药物来曲唑作为本次研究的模型药物,采用常规的口服片剂生产工艺制备药物片剂。结果显示使用无交联工艺的羧甲基淀粉钠的片剂,在高湿条件(92.5%RH)出现崩解不佳或不崩解现象,使用经交联工艺的羧甲基淀粉钠的片剂在高湿条件(92.5%RH)下崩解良好。经交联化的羧甲基淀粉钠空间结构更强,在高湿条件下的凝胶化反应较弱,吸湿溶胀后仍有一定的空间间隙供水分进入片芯,故而合理控制反应过程中氢氧化钠浓度和交联剂用量可使难溶性药物在高湿条件下保持良好的崩解性能。

关键词：羧甲基淀粉钠难溶性药物崩解

Effect of an Arbitrary Dust Size Distribution Dust Particles for Vortex-Like Ion Distribution Dusty Plasma

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Communications in Theoretical Physics 2009年第9期52卷 517-522页

作者： WEI ju-Na SHI Yu-Ren HE Guang-jun JIANG Xin DUAN Wen-shan CHEN Jian-Min Department of Physics Northwest Normal University Lanzhou 730070 China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Science Lanzhou 720000 China

In order to investigate the effect of an arbitrary dust size distribution for vortex-like ion distributiondusty plasma,we use a reasonable polynomial-expressed function to represent an arbitrary dust size *** results of linear dispersion relation,nonlinear solitary wave amplitude,width and velocity for polynomialexpressed dust size distribution dusty plasma with vortex-like ion distribution have been studied.

关键词： vortex-like ion distribution linear dispersion relation solitary wave

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不同入药部位干药材石蜡制片方法的改良研究

西南民族大学学报（自然科学版） 2024年第4期50卷 408-417页

作者：安菊红朱婷婷邱伟珊杨月钟世红西南民族大学药学院四川成都610041

石蜡制片作为干药材显微鉴定的关键技术之一,在组织学中应用广泛.根据不同组织构造特点,选取有代表性的皮类、茎类、种子类、根类干药材为主要实验材料,主要从软化、脱水和透明等环节对传统制片方法进行改进,探索各药材专属性石蜡制片方... 详细信息

石蜡制片作为干药材显微鉴定的关键技术之一,在组织学中应用广泛.根据不同组织构造特点,选取有代表性的皮类、茎类、种子类、根类干药材为主要实验材料,主要从软化、脱水和透明等环节对传统制片方法进行改进,探索各药材专属性石蜡制片方法.结果表明,软化是制作石蜡切片的关键步骤,对不同种类干药材应区别处理.纤维、石细胞富集的皮类生药如厚朴,采用5%氢氟酸水浴浸透软化12 h;木质部纤维化严重的茎类生药如桂枝,采用甘油与氢氧化钠混合溶液软化14 h;内外硬度差异较大的种子类生药如芥子,5%甘油软化6 h;纤维性强和试剂不易渗透的根类生药如黄芪,5%盐酸软化6 h,能提高各干药材横切面的清晰度和完整度,获得组织完整、细胞结构清晰的高质量切片.经改良的石蜡切片技术专属性高,重复性好,避免了常规制片易出现的浸蜡不彻底、组织变硬变脆等问题.研究结果可为制作不同部位石蜡切片提供方法学参考.

关键词：石蜡切片干药材软化技术改进显微观察

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医疗器械临床评价改革研究和实践

中国药物评价 2024年第1期41卷 4-9页

作者：刘英慧卢红鞠珊滕颖影程玮璐国家药品监督管理局医疗器械技术审评中心北京100081

医疗器械临床评价是通过对临床数据进行分析评价从而证明产品安全有效性的活动。本文回顾自1990年逐步对医疗器械进行市场准入管理以来,医疗器械临床评价的发展历程。通过分析审评审批制度改革下,对于医疗器械临床评价关键性问题的研究... 详细信息

医疗器械临床评价是通过对临床数据进行分析评价从而证明产品安全有效性的活动。本文回顾自1990年逐步对医疗器械进行市场准入管理以来,医疗器械临床评价的发展历程。通过分析审评审批制度改革下,对于医疗器械临床评价关键性问题的研究情况和相应对策;总结中国药品监管机构牵头的国际医疗器械监管机构论坛临床评价工作组的研究成果;深入探讨新版《医疗器械监督管理条例》下临床评价的改革实践和相应成果,以及医疗器械临床评价的新工具——真实世界数据应用的研究情况与具体实践。

关键词：医疗器械临床评价临床试验真实世界数据

Monolayer Graphitic Carbon Nitride as Metal-Free Catalyst with Enhanced Performance in Photo- and Electro-Catalysis

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Nano-Micro Letters 2022年第3期14卷 308-321页

作者： Huiyan Piao Goeun Choi Xiaoyan Jin Seong‑ju Hwang Young Jae Song Sung‑Pyo Cho Jin‑ho Choy Intelligent Nanohybrid Materials Laboratory(INML) Institute of Tissue Regeneration Engineering(ITREN)Dankook UniversityCheonan 31116Republic of Korea College of Science and Technology Dankook UniversityCheonan 31116Republic of Korea Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonan 31116Republic of Korea Department of Materials Science and Engineering College of EngineeringYonsei UniversitySeoul 03722Republic of Korea SKKU Advanced Institute of Nanotechnology(SAINT) Sungkyunkwan University(SKKU)Suwon 440‑746Republic of Korea Department of Nano Engineering Sungkyunkwan University(SKKU)Suwon 440‑746Republic of Korea National Center for Inter‑University Research Facilities(NCIRF) Seoul National UniversitySeoul 08826Republic of Korea Graphene Research Center Advanced Institute of Convergence TechnologySuwon 16229Republic of Korea Department of Pre‑Medical Course College of MedicineDankook UniversityCheonan 31116Republic of Korea Tokyo Tech World Research Hub Initiative(WRHI) Institute of Innovative ResearchTokyo Institute of TechnologyYokohama 226‑8503Japan

The exfoliation of bulk graphitic carbon nitride(g-C_(3)N_(4))into monolayer has been intensively studied to induce maximum sur-face area for fundamental studies,but ended in failure to realize chemi-cally and physically well-defined monolayer of g-C_(3)N_(4)mostly due to the difficulty in reducing the layer thickness down to an atomic *** has,therefore,remained as a challenging issue in two-dimensional(2D)chemistry and physics *** this study,an“atomic monolayer of g-C_(3)N_(4)with perfect two-dimensional limit”was successfully prepared by the chemically well-defined two-step *** atomically resolved monolayer of g-C_(3)N_(4)was also confirmed by spectroscopic and micro-scopic *** addition,the experimental Cs-HRTEM image was collected,for the first time,which was in excellent agreement with the theoretically simulated;the evidence of monolayer of g-C_(3)N_(4)in the perfect 2D limit becomes now clear from the HRTEM image of orderly hexagonal symmetry with a cavity formed by encirclement of three adjacent heptazine *** to bulk g-C_(3)N_(4),the present g-C_(3)N_(4)monolayer showed significantly higher photocatalytic gen-eration of H2O2 and H2,and electrocatalytic oxygen reduction *** addition,its photocatalytic efficiency for H2O2 production was found to be the best for any known g-C_(3)N_(4)nanomaterials,underscoring the remarkable advantage of monolayer formation in optimizing the catalyst performance of g-C_(3)N_(4).

关键词： Graphitic carbon nitride Monolayer Atomic image Electro-and photo-catalysis

Aurora A Kinase Plays a Key Role in Mitosis Skip during Senescence Induced by Ionizing Radiation

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Biomedical and Environmental Sciences 2023年第10期36卷 903-916页

作者： ZHANG Xu Rui ZHANG Tong shan ZHANG Ya Nan HUA jun Rui WANG ju Fang HE Jin Peng Key Laboratory of Space Radiobiology of Gansu Province&CAS Key Laboratory of Heavy Ion Radiation Biology and Medicine Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000GansuChina National-Local Joint Engineering Research Center of Biodiagnostic&Biotherapy The Second Affiliated HospitalXi’an Jiaotong UniversityXi’an 710004ShaanxiChina University of Chinese Academy of Sciences Beijing 100049China

Objective To investigate the fate and underlying mechanisms of G2 phase arrest in cancer cells elicited by ionizing radiation(IR).Methods Human melanoma A375 and 92-1 cells were treated with X-rays radiation or Aurora A inhibitor MLN8237(MLN)and/or p21 depletion by small interfering RNA(si RNA).Cell cycle distribution was determined using flow cytometry and a fluorescent ubiquitin-based cell cycle indicator(FUCCI)system combined with histone H3 phosphorylation at Ser10(p S10 H3)*** was assessed using senescence-associated-β-galactosidase(SA-β-Gal),Ki67,andγH2AX *** expression levels were determined using western *** Tumor cells suffered severe DNA damage and underwent G2 arrest after IR *** damaged cells did not successfully enter M phase nor were they stably blocked at G2 phase but underwent mitotic skipping and entered G1 phase as tetraploid cells,ultimately leading to senescence in *** this process,the p53/p21 pathway is *** p21 accumulation,Aurora A kinase levels declined *** treatment confirmed that Aurora A kinase activity is essential for mitosis skipping and senescence *** Persistent p21 activation during IR-induced G2 phase blockade drives Aurora A kinase degradation,leading to senescence via mitotic skipping.

关键词： Ionizing radiation Senescence G2 arrest Tetraploid Mitosis skipping

Simulation on dissolute and dust dispersion in comprehensive mechanized heading face with forced-exhaust ventilation

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Journal of Coal Science & Engineering(China) 2011年第3期17卷 298-304页

作者： NIE Wen CHENG Wei-min HAN Li ZhoU Sheng-ju YU Yan-bin ZHAO shan-shan Key Lab of Mine Disaster Prevention and Control Shandong University of Science and Technology Qingdao 266510 China New julong Energy Resource Co. Ltd. Juye 274918 China Faculty of Safety Engineering China University of Minlng ＆ Technology Xuzhou 221008 China

According to the characteristics of comprehensive mechanized heading face, established the mathematical model of single-phase air flow with κ-ε two equations model, and have established κ-ε-θ-κp mathematic model to solve two-phase flow of gas and particles in dust space with eulerian-eulerian method and eulerian-lagrangian method. Numerical solution of gas-particle two-phase flow was put forward based on collocated grid SIMPLE algorithm. Moreover, numerical simulation of dust concentration in fully mechanized caving face was carded out by using Fluent software. Finally, when in forced-exhaust ventilation circumstance, drawer type fan drum have less dust absorption, and most of dust spread to the other site; the dust concentration is inversely proportional to the distance from tunneling head, and the dust concentration has already diffused to decrease below 102 mg/m3 at the position ofx=12 m. Dust are more focused on relative side（in the range about y from 0 to 2 meter） of roadway space of press-ventilated fan drum, especially between tunneling place and drawer type fan drum; the roadway with road header have a higher dust concentration. These conclusions provide reliable theory basis for the dust prevention in comprehensive mechanized heading face.

关键词： dissolute dust dispersion forced-exhaust ventilation circumstance κ-ε-θ-κp mathematical model comprehensive digging