PURPOSE: To evaluate the role of optical coherence tomography (OCT) in determining choroidal neovascularization (CNV) activity before and after photodynamic therapy (PDT)-in patients with age-related macular degenerat...
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PURPOSE: To evaluate the role of optical coherence tomography (OCT) in determining choroidal neovascularization (CNV) activity before and after photodynamic therapy (PDT)-in patients with age-related macular degeneration (ARMD). DESIGN: Prospective observational case series. METHODS: setting: Institutional study. patient population: Fiftythree patients (62 eyes) with ARMD. observation procedure: Prospective observational case study. main outcome measures: Presence or absence of leakage on fluorescein angiography, presence of intraretinal or sub-retinal fluid on OCT, and macular and choroidal neovascular complex thickness on OCT. RESULTS: The macular thickness decreased significantly after PDT (P=.001). However, no significant changes in CNVthickness were measured after PDT (P=.567). Once the diagnosis of ARMD was established before treatment, OCT had a sensitivity of 96.77% for detecting CNV activity. After treatment, OCT had a good sensitivity (95.65% ) and a moderate specificity (59.01% ) in determining CNV activity, which resulted in a diagnostic efficiency (proportion of correct results) of 82.95% . CONCLUSIONS:OCT appears to be useful for indicating CNV activity. Therefore, it may serve as a complementary technique for deciding the need for PDT and re-treatment in patients with ARMD.
Aim:To evaluate the role of optical coherence tomography(OCT)in determining choroidal neovascularisation(CNV)activity before and after photodynamic therapy(PDT)in patients with pathological ***:33 patients(33 eyes)wit...
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Aim:To evaluate the role of optical coherence tomography(OCT)in determining choroidal neovascularisation(CNV)activity before and after photodynamic therapy(PDT)in patients with pathological ***:33 patients(33 eyes)with pathological myopia and being treated with PDT were *** 3 months all patients were evaluated and presence or absence of leakage on fluorescein angiography,presence of intraretinal or subretinal fluid on OCT,and macular and choroidal neovascular complex thickness on OCT,were determined at each ***:The macular thickness decreased significantly after PDT at 6 months(p=0.001)and at 12 months follow up(p=0.01).However,no significant changes in CNV thickness were measured after PDT at 6 months of follow up(p=0.418)and at 12 months of follow up(p=0.521).Once the diagnosis of CNV associated with pathological myopia was established,before treatment,OCT had a sensitivity of 96.96% for detecting CNV *** treatment,OCT had a good sensitivity(95.23%)and a moderate specificity(69,69%)in determining CNV activity,which resulted in a diagnostic efficiency(proportion of correct results)of 79.62%.Conclusions:OCT appears to be useful for indicating CNV ***,it may serve as a complementary technique for deciding the need for PDT and re-treatment in patients with pathological myopia.
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