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Correlations between serum kidney injury molecule-1,cystatin C and immunosuppressants:A cross-sectional study of renal transplant patients in Bahrain

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Journal of Biomedical Research 2024年第3期38卷 269-277页

作者： Kannan Sridharan shamik shah Mona Al Hammad Fatima Ali Mohammed Sindhan Veeramuthu Mona Abdulla Taher Mustafa Mohamed Hammad Lamees Jawad Eman Farid Department of Pharmacology and Therapeutics College of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain Department of Nephrology Salmaniya Medical ComplexManamaKingdom of Bahrain Department of Internal Medicine College of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain Salmaniya Medical Complex ManamaKingdom of Bahrain Department of Laboratory Medicine Salmaniya Medical ComplexManamaKingdom of Bahrain Department of Microbiology Immunologyand Infectious DiseasesCollege of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain

Renal transplant patients receive several immunosuppressive drug regimens that are potentially nephrotoxic for *** creatinine is the standard for monitoring kidney function;however,cystatin C(Cys C)and kidney injury molecule-1(KIM-1)have been found to indicate kidney injury earlier than serum creatinine and provide a better reflection of kidney ***,we assessed Cys C and KIM-1 serum levels in renal transplant patients receiving mycophenolate mofetil,tacrolimus,sirolimus,everolimus,or cyclosporine to evaluate kidney *** used both the Chronic Kidney Disease Epidemiology Collaboration(CKD-EPI)2021 equation,which is based on creatinine and combined creatinine with Cys C,and the CKD-EPI 2012 equation,which is based on Cys C alone,to estimate glomerular filtration rate(GFR).Then,we assessed the association between serum KIM-1 and GFR<90 mL per minute per 1.73 *** observed significantly higher serum Cys C levels in patients with the elevated serum creatinine,compared with those with normal serum *** estimated GFRs based on creatinine were significantly higher than those based on the other equations,while a significant positive correlation was observed among all *** KIM-1 levels were negatively correlated with the estimated GFRs by the CKD-EPI Cys C and the combined creatinine with Cys C equations.A serum KIM-1 level above 0.71 ng/mL is likely to indicate GFR<90 mL per minute per 1.73 *** observed a significant correlation between serum creatinine and Cys C in our renal transplant ***,serum KIM-1 may be used to monitor renal function when using potentially nephrotoxic drugs in renal transplants.

关键词： KIM-1 cystatin C mycophenolate mofetil tacrolimus everolimus sirolimus cyclosporine

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Alternative Strategy for Development of Dielectric Calcium Copper Titanate‑Based Electrolytes for Low‑Temperature Solid Oxide Fuel Cells

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Nano-Micro Letters 2025年第1期17卷 310-332页

作者： Sajid Rauf Muhammad Bilal Hanif Zuhra Tayyab Matej Veis MAKYousaf shah Naveed Mushtaq Dmitry Medvedev Yibin Tian Chen Xia Martin Motola Bin Zhu College of Mechatronics and Control Engineering Shenzhen UniversityShenzhen 518060People’s Republic of China Department of Inorganic Chemistry Faculty of Natural SciencesComenius University BratislavaIlkovicova684215 BratislavaSlovakia Energy Storage Joint Research Center School of Energy and EnvironmentSoutheast UniversityNanjing 210096People’s Republic of China Hydrogen Energy Laboratory Ural Federal University620002 EkaterinburgRussia Laboratory of Electrochemical Devices Based on Solid Oxide Proton Electrolytes Institute of High Temperature Electrochemistry620066 EkaterinburgRussia School of Microelectronics Hubei UniversityWuhan 430062People’s Republic of China

The development of low-temperature solid oxide fuel cells(LT-SOFCs)is of significant importance for realizing the widespread application of *** has stimulated a substantial materials research effort in developing high oxide-ion conductivity in the electrolyte layer of *** this context,for the first time,a dielectric material,CaCu_(3)Ti_(4)O_(12)(CCTO)is designed for LT-SOFCs electrolyte application in this *** individual CCTO and its heterostructure materials with a p-type Ni_(0.8)Co_(0.15)Al_(0.05)LiO_(2−δ)(NCAL)semiconductor are evaluated as alternative electrolytes in LT-SOFC at 450–550℃.The single cell with the individual CCTO electrolyte exhibits a power output of approximately 263 mW cm^(-2) and an open-circuit voltage(OCV)of 0.95 V at 550℃,while the cell with the CCTO–NCAL heterostructure electrolyte capably delivers an improved power output of approximately 605 mW cm^(-2) along with a higher OCV over 1.0 V,which indicates the introduction of high hole-conducting NCAL into the CCTO could enhance the cell performance rather than inducing any potential short-circuiting *** is found that these promising outcomes are due to the interplay of the dielectric material,its structure,and overall properties that led to improve electrochemical mechanism in CCTO–***,density functional theory calculations provide the detailed information about the electronic and structural properties of the CCTO and NCAL and their heterostructure CCTO–*** study thus provides a new approach for developing new advanced electrolytes for LT-SOFCs.

关键词： LT-SOFCs Dielectric CaCu_(3)Ti_(4)O_(12) Semiconductor Ni_(0.8)Co_(0.15)Al_(0.05)LiO_(2−δ) Ionic conductivity Heterostructure electrolyte

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Restless head syndrome:A retrospective study

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World Journal of Methodology 2025年第1期15卷 51-59页

作者： Sanjay Prakash Varoon Vadodaria Niraj Chawda Chetsi S shah Anurag Prakash Department of Neurology Smt.B.K.Shah Medical Institute and Research CentreSumandeep VidyapeethVadodara 391760GujarātIndia Department of Medicine Smt.B.K.Shah Medical Institute and Research CentreSumandeep VidyapeethVadodara 391760GujarātIndia Department of Medicine Parul Institute of Medical Sciences and Research CentreParul University WaghodiaVadodara 391760India

BACKGROUND Restless legs syndrome(RLS)is characterized by an urge to move with an unpleasant sensation in the lower *** typically affects the ***,it can also affect several other body regions,such as the arms,abdomen,face,neck,head,and genital *** are only a few reports of the RLS variant affecting the *** To assess the epidemiological,clinical,and other aspects of the RLS variant affecting the *** We conducted a retrospective study of 17 adult patients(>18 years)who met the RLS criteria and simultaneously experienced RLS-like symptoms in the *** The median age at which symptoms appeared was 41.6 *** and females were equally affected(1.1:1).All 17 patients had uncomfortable sensations in the lower *** or disturbed sleep was the most common comorbidity(n=16,88.2%).However,headache was the most common presenting or primary symptom(n=10,70.5%).Dizziness or an abnormal sensation in the head was the second most common presenting symptom(5 patients,29.4%).Other presenting features were leg pain,backache,and generalized body *** patients responded favorably to dopaminergic *** If RLS-related unpleasant sensations and pain are felt in the head,they may be misinterpreted as headache,dizziness,or psychosomatic *** and headaches in a subset of patients may be two phenotypic manifestations of the same disorder.

关键词： Restless legs syndrome Restless head syndrome Dopamine Headache Migraine Tension-type headache

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Macular microvascular and structural changes on optical coherence tomography angiography in atypical optic neuritis

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World Journal of Methodology 2025年第1期15卷 88-94页

作者： Chinmay Mahatme Madhurima Kaushik Veerappan Rathinasabapathy Saravanan Karthik Kumar Virna M shah Department of General Ophthalmology Aravind Eye HospitalCoimbatore 641014Tamil NāduIndia Department of Neuro-ophthalmology Aravind Eye HospitalCoimbatore 641014Tamil NāduIndia Department of Vitreoretina Aravind Eye HospitalCoimbatore 641014Tamil NāduIndia

BACKGROUND Atypical optic neuritis,consisting of neuromyelitis optica spectrum disorders(NMOSD)or myelin oligodendrocyte glycoprotein antibody disease(MOGAD),has a very similar presentation but different prognostic implications and longterm management *** and metabolic factors are being thought to play a role in such autoimmune neuro-inflammatory disorders,apart from the obvious immune mediated *** the advent of optical coherence tomography angiography(OCTA),it is easy to pick up on these subclinical macular microvascular and structural *** To study the macular microvascular and structural changes on OCTA in atypical optic *** This observational cross-sectional study involved 8 NMOSD and 17 MOGAD patients,diagnosed serologically,as well as 10 healthy *** vascular density(MVD)and ganglion cell+inner plexiform layer thickness(GCIPL)were studied using *** There was a significant reduction in MVD in NMOSD and MOGAD affected as well as unaffected eyes when compared with healthy *** and MOGAD affected eyes had significant GCIPL thinning compared with healthy *** unaffected eyes did not show significant GCIPL thinning compared to healthy controls in contrast to MOGAD unaffected *** comparing NMOSD with MOGAD,there was no significant difference in terms of MVD or GCIPL in the affected or unaffected *** Although significant microvascular and structural changes are present on OCTA between atypical optic neuritis and normal patients,they could not help in differentiating between NMOSD and MOGAD cases.

关键词： Optical coherence tomography angiography Atypical optic neuritis Macular microvascular changes Neuromyelitis optica spectrum disorders Myelin oligodendrocyte glycoprotein antibody disorder

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Self-Coexistence Among Cognitive Radio Networks Using Risk-Motivated Channel Selection Based Deference Structure

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Tsinghua Science and Technology 2013年第3期18卷 242-249页

作者： Kenneth Ezirim shamik Sengupta Department of Computer Science Graduate Center Department of Math. and Comp. Sci. John Jay College

Among cognitive radio networks there is a persistent trend of competition to acquire under-utilized and idle channels for data transmission. The competition for spectrum resources often results in the misuse of the spectrum resources as networks experience contention in attempt to access unoccupied spectrum bands. The competitive scenario causes cognitive radio networks to incur a huge amount of loss, which constitutes a major problem of self-coexistence among networks. As a way to minimize these losses we present a self-coexistence mechanism that allows cognitive radio networks to coexist with each other by implementing a risk-motivated channel selection based on deference structure. Cognitive radio networks form deference structure community to have more efficient access to a channel of interest and can defer transmission to one another on that channel, thereby minimizing the chances of conflicts. As part of the decision making process to become a member of a deference structure community, cognitive radio networks rely on a risk-motivated channel selection scheme to evaluate the tentative deference structure channel. We provide numerical and simulation results that demonstrates the benefits of the proposed self-coexistence mechanism and show how it helps networks to coordinate their spectrum activities, minimize contention experienced and improve their utility. We also emphasize on the importance of the deference structure community size with regards to the average performance of member networks.

关键词： dynamic spectrum access cognitive radio self-coexistence deference deference structure

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Model Predictive Control of Resonant Systems Using Kautz Model

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International Journal of Automation and computing 2016年第5期13卷 501-515页

作者： shamik Misra Rajasekhara Reddy Prabirkumar Saha Department of Chemical Engineering Indian Institute of Technology Guwahati

The scope of this paper broadly spans in two areas： system identification of resonant system and design of an efficient control scheme suitable for resonant systems. Use of filters based on orthogonal basis functions （OBF） have been advocated for modelling of resonant process. Kautz filter has been identified as best suited OBF for this purpose. A state space based system identification technique using Kautz filters, viz. Kautz model, has been demonstrated. Model based controllers are believed to be more efficient than classical controllers because explicit use of process model is essential with these modelling techniques. Extensive literature search concludes that very few reports are available which explore use of the model based control studies on resonant system. Two such model based controllers are considered in this work, viz. model predictive controller and internal model controller. A model predictive control algorithm has been developed using the Kautz model. The efficacy of the model and the controller has been verified by two case studies, viz. linear second order underdamped process and a mildly nonlinear magnetic ball suspension system. Comparative assessment of performances of these controllers in those case studies have been carried out.

关键词： Model predictive control resonant systems Kautz model orthonormal basis function internal model control

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Structural, microstructural, and thermal characterizations of a chalcopyrite concentrate from the Singhbhum shear zone, India

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International Journal of Minerals,Metallurgy and Materials 2015年第3期22卷 225-232页

作者： Ritayan Chatterjee shamik Chaudhuri Saikat Kumar Kuila Dinabandhu Ghosh Department of Metallurgical and Materials Engineering Jadavpur University Division of Materials Engineering Lund University

The structural and morphological characterizations of a chalcopyrite concentrate, collected from the Indian Copper Complex, Ghatshila, India, were carried out by X-ray diffraction, scanning electron microscopy, and energy-dispersive X-ray spectroscopy. The con- centmte powder was composed mainly of free chalcopyrite and low quartz in about 3：1 weight ratio. The particle size was about 100 μm. Spectroscopic studies （FTIR, Raman, UV-visible） of the concentrate supported the XRD findings, and also revealed a marginal oxidation of the sulfide phase. The energy band gap of the sulfide was found to be 3.4 eV. Differential thermal analysis and thermogravimetry of the con- centrate showed a decomposition of chalcopyrite at 658 K with an activation energy of 208 kJ-mol 1, and two successive structural changes of silica at 848 K and 1145 K.

关键词： chalcopyrite structural properties microstructure thermal characteristics

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Biochar-mediated removal of pharmaceutical compounds from aqueous matrices via adsorption

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Waste Disposal and Sustainable Energy 2023年第1期5卷 37-62页

作者： Sahil Chauhan Tajamul Shafi Brajesh Kumar Dubey shamik Chowdhury School of Environmental Science and Engineering Indian Institute of Technology KharagpurKharagpurWest Bengal721302India Department of Civil Engineering Indian Institute of Technology KharagpurKharagpurWest Bengal721302India

Pharmaceutical is one of the noteworthy classes of emerging contaminants. These biologically active compounds pose a range of deleterious impacts on human health and the environment. This is attributed to their refractory behavior, poor biodegradability, and pseudopersistent nature. Their large-scale production by pharmaceutical industries and subsequent widespread utilization in hospitals, community health centers, and veterinary facilities, among others, have significantly increased the occurrence of pharmaceutical residues in various environmental compartments. Several technologies are currently being evaluated to eliminate pharmaceutical compounds (PCs) from aqueous environments. Among them, adsorption appears as the most viable treatment option because of its operational simplicity and low cost. Intensive research and development efforts are, therefore, currently underway to develop inexpensive adsorbents for the effective abatement of PCs. Although numerous adsorbents have been investigated for the removal of PCs in recent years, biochar-based adsorbents have garnered tremendous scientific attention to eliminate PCs from aqueous matrices because of their decent specific surface area, tunable surface chemistry, scalable production, and environmentally benign nature. This review, therefore, attempts to provide an overview of the latest progress in the application of biochar for the removal of PCs from wastewater. Additionally, the fundamental knowledge gaps in the domain knowledge are identified and novel strategic research guidelines are laid out to make further advances in this promising approach towards sustainable development.

关键词： Pharmaceuticals Adsorption Adsorbents Biochar Wastewater treatment

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IoT & AI Enabled Three-Phase Secure and Non-Invasive COVID 19 Diagnosis System

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Computers, Materials & Continua 2022年第4期71卷 423-438页

作者： Anurag Jain Kusum Yadav Hadeel Fahad Alharbi shamik Tiwari Virtualization Department School of Computer ScienceUniversity of Petroleum and Energy StudiesDehradun248007UttarakhandIndia College of Computer Science and Engineering University of Ha’ilHa’ilKingdom of Saudi Arabia

Corona is a viral disease that has taken the form of an epidemic and is causing havoc worldwide after its first appearance in the Wuhan state of China in December *** to the similarity in initial symptoms with viral fever,it is challenging to identify this virus ***-detection of this virus at the early stage results in the death of the *** and densely populated countries face a scarcity of resources like hospitals,ventilators,oxygen,and healthcare *** like the Internet of Things(IoT)and artificial intelligence can play a vital role in diagnosing the COVID-19 virus at an early *** minimize the spread of the pandemic,IoT-enabled devices can be used to collect patient’s data remotely in a secure *** data can be analyzed through a deep learning model to detect the presence of the COVID-19 *** this work,the authors have proposed a three-phase model to diagnose covid-19 by incorporating a chatbot,IoT,and deep learning *** phase one,an artificially assisted chatbot can guide an individual by asking about some common *** case of detection of even a single sign,the second phase of diagnosis can be considered,consisting of using a thermal scanner and pulse *** case of high temperature and low oxygen saturation levels,the third phase of diagnosis will be recommended,where chest radiography images can be analyzed through an AI-based model to diagnose the presence of the COVID-19 virus in the human *** proposed model reduces human intervention through chatbot-based initial screening,sensor-based IoT devices,and deep learning-based X-ray *** also helps in reducing the mortality rate by detecting the presence of the COVID-19 virus at an early stage.

关键词： COVID-19 internet of things deep learning chatbot X-ray capsule network convolutional neural network

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Comparative assessment of mechanical and chemical fluid diversion techniques during hydraulic fracturing in horizontal wells

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Petroleum Science 2023年第6期20卷 3582-3597页

作者： Maunish S.shah Subhash N.shah Drilling Cementingand Stimulation Research CenterDepartment of Petroleum EngineeringSchool of Energy TechnologyPandit Deendayal Energy UniversityRaisanGandhinagarGujaratIndia Mewbourne School of Petroleum and Geological Engineering The University of OklahomaNormanOKUSA

The application of fluid diversion during hydraulic fracturing is an evolving technology and has become popular amongst E&P operators over the past few *** primary objective of the fluid diversion is to improve hydraulic fracturing treatment by increasing stimulated reservoir volume and improving hydrocarbon *** is possible by achieving any of the following objectives:creating uniform distribution of treatment slurry within the target zone;treating unstimulated and under-stimulated zones;or by increasing fracture density by creating a complex fracture *** fluid diversion application is also helpful in decreasing the number of stages(by increasing stage length)for multi-stage plug-n-perf(PnP)fracturing *** is also applied to prevent fracture-driven interactions between adjacent wells,which is currently a major issue,especially in *** addition,for successful refracturing treatment,the diverter application is essential for isolating the existing fractures and redirecting the treatment slurry to the desired unstimulated *** diversion methods can be broadly categorized into the mechanical and chemical *** established mechanical diversion techniques are frac plugs,expandable casing patches,expandable liners,swellable packers,straddle packer assembly,sand plugs,frac sleeves,perforation ball sealers,and limited entry *** different chemical diversion techniques are particulates,fibers,gels,surfactants,perforation pods,and composite *** paper describes the current status of established mechanical and chemical diverter technologies and examines their comparative advantages and *** techniques are suitable for diverter application,but the technique is selected based on the desired objective and conditions of the wellbore and *** general guidelines for selecting diversion techniques and operational considerations are also provided in the *** diagnosis of diversion treatme

关键词： Fluid diversion Diverter Diverting agents Multi-stage fracturing Hydraulic fracturing Horizontal well

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