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Efficacy and dose response of Lactiplantibacillus plantarum in diarrhea-predominant irritable bowel syndrome

World Journal of Gastroenterology 2023年第28期29卷 4451-4465页

作者： Christopher J Martoni shalini srivastava Anders Damholt Gregory J Leyer Clinical Development Human HealthChr.Hansen A/SHoersholm 2970Denmark Clinical Development Vedic LifesciencesMumbai 400053India Scientific Affairs Human HealthChr.Hansen A/SHoersholm 2970Denmark

BACKGROUND Probiotics have shown promise in alleviating symptoms of diarrhea-predominant irritable bowel syndrome(IBS-D);however,the certainty of evidence is *** randomized controlled dose-ranging trials are warranted on promising single-strain *** To investigate the clinical efficacy of Lactiplantibacillus plantarum(***)Lpla33(DSM34428)in adults with *** This is a randomized,double-blind,placebo-controlled,multi-center,and doseranging *** hundred and seven adults,18-70 years of age,with IBS-D,according to Rome IV criteria,were allocated(1:1:1)to receive placebo or *** Lpla33 at 1×10^(9)(1B)or 1×10^(10)(10B)colony-forming units/d over an 8-wk intervention *** primary outcome was the change in IBS severity scoring system(IBS-SSS)total score after 8 wk,while secondary and exploratory outcomes included abdominal pain severity,IBS related quality of life,stool and microbial profile,and perceived *** IBS-SSS was significantly reduced,after 8 wk,in participants receiving *** 1B(-128.45±83.30;P<0.001)and *** 10B(-156.77±99.06;P<0.001),compared to placebo(-58.82±74.75).Further,a dose-ranging effect was observed,with a greater absolute reduction in the *** 10B group(P<0.05).A reduction in sub-scores related to abdominal pain,abdominal distension,bowel habits,and quality of life was observed in both *** groups compared to placebo(P<0.001).Further,62.5%and 88.4%of participants administered *** 1B and 10B,respectively,were classified as stool consistency responders based on a reduction in diarrheal stool form,as compared to 26.3%in the placebo group(P<0.001).In contrast,no significant shifts were observed in microbial *** *** Lpla33(DSM34428)is well tolerated and improves IBS symptom severity with a dose-ranging effect and a corresponding normalization of bowel habits in adults with IBS-D.

关键词： Randomized clinical trial Diarrhea-predominant irritable bowel syndrome Microbiome Probiotic Lactiplantibacillus plantarum

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Synthesis,characterization and application of Lagerstroemia speciosa embedded magnetic nanoparticle for Cr(Ⅵ)adsorption from aqueous solution

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Journal of Environmental Sciences 2017年第5期29卷 283-293页

作者： shalini srivastava Shashi Bhushan Agrawal Monoj Kumar Mondal Department of Botany Institute of Science Banaras Hindu University Varanasi 221005 India Department of Chemical Engineering and Technology Indian Institute of Technology Banaras Hindu University Varanasi 221005 Uttar Pradesh India

Lagerstroemia speciosa bark（LB） embedded magnetic nanoparticles were prepared by co-precipitation of Fe2＋ and Fe3＋ salt solution with ammonia and LB for Cr（Ⅵ） removal from aqueous *** native LB,magnetic nanoparticle（MNP）,*** embedded magnetic nanoparticle（MNPLB） and Cr（Ⅵ） adsorbed MNPLB particles were characterized by SEM-EDX,TEM,BET-surface area,FT-IR,XRD and TGA *** analysis confirmed nearly spherical shape of MNP with an average diameter of 8.76 nm and the surface modification did not result in the phase change of MNP as established by XRD analysis,while led to the formation of secondary particles of MNPLB with diameter of 18.54 *** results revealed covalent binding between the hydroxyl group of MNP and carboxyl group of LB particles and further confirmed its physico-chemical nature favorable for Cr（Ⅵ） *** Cr（Ⅵ） adsorption on to MNPLB particle as an adsorbent was tested under different contact time,initial Cr（Ⅵ） concentration,adsorbent dose,initial pH,temperature and agitation *** results of the equilibrium and kinetics of adsorption were well described by Langmuir isotherm and pseudo-second-order model,*** thermodynamic parameters suggest spontaneous and endothermic nature of Cr（Ⅵ）adsorption onto *** maximum adsorption capacity for MNPLB was calculated to be 434.78 mg/g and these particles even after Cr（Ⅵ） adsorption were collected effortlessly from the aqueous solution by a *** desorption of Cr（Ⅵ）-adsorbed MNPLB was found to be more than 93.72%with spent MNPLB depicting eleven successive adsorption-desorption cycles.

关键词： Lagerstroemia speciosa Magnetic nanoparticles Co-precipitation Cr(Ⅵ) ions Adsorption capacity

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Evaluation of Inhibitory Effect of the Plant Phyllanthus amarus Against Dermatophytic Fungi Microsporum gypseum

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Biomedical and Environmental Sciences 2004年第3期17卷 359-365页

作者： ANURAG AGRAWAL shalini srivastava J.N.srivastava M.M.SRIVASAVA Department of Chemistry Faculty of Science Dayalbagh Educational Institute Deemed University Agra-282 005 IndiaDepartment of Chemistry Faculty of Science Dayalbagh Educational Institute Deemed University Agra-282 005 IndiaDepartment of Botany Faculty of Science Dayalbagh Educational Institute Deemed University Agra-282 005 IndiaDepartment of Chemistry Faculty of Science Dayalbagh Educational Institute Deemed University Agra-282 005 India

Objective The antifungal activity of various solvent extracts (such as ether, chloroform, ethyl acetate and ethyl alcohol) of the plant Phyllanthus amarus against dermatophytic fungi Microsporum gypseum was observed. Method Antifungal bioassay in terms of reduction in weight, colony diameter and sporulation of the target fungal colony was carried out using Broth Dilution method. Results Root part of the plant, extracted in various organic solvents did not show any noticeable antifungal activity. The percentage inhibition observed in different solvent extracts of aerial part was found as reduction in weight: chloroform [50.3%], ethyl acetate [27.7%] and ethyl alcohol [12.1%], reduction in colony diameter: chloroform [53.4%], ethyl acetate [31.4%] and ethyl alcohol [15.0%] and reduction in sporulation: maximum inhibition in chloroform extract, at test concentration of 4000 ppm at incubation period of 8 days. Conclusion Chloroform fraction of the aerial part of the plant P. amarus shows significant inhibitory effect against dermatophytic fungi M. gypseum and requires chemical characterization for its bioactive principle.

关键词： Phyllanthus amarus Antifungal activity Microsporum gypseum Skin infections

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STUDIES ON LARVICIDAL ACTIVITY OF THE PLANT PHYLLANTHUS AMARUS AND CHEMICAL CHARACTERIZATION OF ITS BIOACTIVE PRINCIPLE

STUDIES ON LARVICIDAL ACTIVITY OF THE PLANT PHYLLANTHUS AMAR...

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The ⅩⅤth International Plant Protection Congress

作者： M.M.srivastava shalini KHANNA C.N.srivastava shalini srivastava Department of Chemistry Faculty of Science Dayalbagh Educational Institute Dayalbagh Agra.282005 India Department of Chemistry Faculty of Science Dayalbagh Educational Institute Dayalbagh Agra.282005 India Department of Zoology Faculty of Science Dayalbagh Educational Institute Dayalbagh Agra.282005 India Department of Chemistry Faculty of Science Dayalbagh Educational Institute Dayalbagh Agra.282005 India

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Artificial Neural Network Modeling for Sorption of Cadmium from Aqueous System by Shelled Moringa Oleifera Seed Powder as an Agricultural Waste

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Journal of Water Resource and Protection 2010年第4期2卷 339-344页

作者： Abhishek Kardam Kumar Rohit Raj Jyoti Kumar Arora Man Mohan srivastava shalini srivastava 不详

A two-layer Artificial Neural Network (ANN) model was developed to predict the removal efficiency of Cd(II) ions from aqueous solution using shelled Moringa Oleifera seed (SMOS) powder. Batch experiments re-sulted into standardization of optimum conditions: biomass dosage (4.0 g), Cd(II) concentration (25 mg/L) volume (200 mL) at pH 6.5. A time of forty minutes was found sufficient to achieve the equilibrium. The ANN model was designed to predict sorption efficiency of SMOS for target metal ion by combining back propagation (BP) with principle component analysis. A sigmoid axon was used as transfer function for input and output layer. The Levenberg-Marquardt algorithm (LMA) was applied, giving a minimum mean squared error (MSE) for training and cross validation at the ninth place of decimal.

关键词： Artificial Neural Network Biosorption SMOS Cd(II) Removal

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Neural Network Modeling for Ni(II) Removal from Aqueous System Using Shelled Moringa Oleifera Seed Powder as an Agricultural Waste

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Journal of Water Resource and Protection 2010年第4期2卷 331-338页

作者： Kumar Rohit Raj Abhishek Kardam Jyoti Kumar Arora Man Mohan srivastava shalini srivastava 不详

A single-layer Artificial Neural Network (ANN) model was developed to predict the removal efficiency of Ni(II) ions from aqueous solution using shelled Moringa Oleifera seed (SMOS) powder. Batch experiments resulted into standardization of optimum conditions: biomass dosage (4.0 g), Ni(II) concentration (25 mg/L) volume (200 mL) at pH 6.5. A time of forty minutes was found sufficient to achieve the equilibrium. The ANN model was designed to predict sorption efficiency of SMOS for target metal ion by combining back propagation (BP) with principle component analysis. A sigmoid axon was used as transfer function for input and output layers. The Levenberg–Marquardt Algorithm (LMA) was applied, giving a minimum mean squared error (MSE) for training and cross validation at the ninth place of decimal.

关键词： Artificial Neural Networks Biosorption Moringa Oleifera Ni(II) Removal

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Molecular Docking Studies of Myricetin and Its Analogues against Human PDK-1 Kinase as Candidate Drugs for Cancer

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Computational Molecular Bioscience 2015年第2期5卷 20-33页

作者： shalini Singh Pradeep srivastava School of Biochemical Engineering IIT (BHU) Varanasi India

Phosphoinositide-dependent protein kinase-1 (PDK1), the class of serine threonine kinase, is a master regulator of the AGC family of kinases. It is a main component of the PI3K pathway. As it is reported that this pathway is most commonly, and this pathway is the most commonly deregulated among many cancers. So designing a selective inhibitor of PDK1 may have the efficacy as an anticancer agent. Herein, we describe our work focused on the structure based on screening of 95% similar analogues of Myricetin deposited in PubChem database as earlier studies have been suggested that myricetin acts as an anti cancer agent. Further molecular docking as well as the in silico ADMET studies are incorporated on these compounds to evaluate the binding and pharmacokinetic properties of these compounds. Due to low oral bioavailability, clinical use of myricetin is limited. Therefore this study is an attempt towards screening of structurally similar better compounds as compare with myricetin which can act as better inhibitor against PDK-1.

关键词： Myricetin PDK-1 ADMET Docking Analogues

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