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G protein controls stress readiness by modulating transcriptional and metabolic homeostasis in Arabidopsis thaliana and Marchantia polymorpha

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Molecular Plant 2022年第12期15卷 1889-1907页

作者： Ting-Ying Wu shalini krishnamoorthi Kulaporn Boonyaves Isam Al-Darabsah Richalynn Leong Alan M.Jones Kimitsune Ishizaki Kang-Ling Liao Daisuke Urano Temasek Life Sciences Laboratory SingaporeSingapore Department of Mathematics University of ManitobaWinnipegMBCanada Singapore-MIT Alliance for Research and Technology SingaporeSingapore Department of Biological Sciences National University of SingaporeSingapore 117558Singapore Departments of Biology and Pharmacology University of North CarolinaChapel HillNCUSA Graduate School of Science Kobe UniversityKobeHyogo 657-8501Japan

The core G protein signaling module,which consists of Gαand extra-large Gα(XLG)subunits coupled with the Gβγdimer,is a master regulator of various stress *** this study,we compared the basal and salt stress-induced transcriptomic,metabolomic and phenotypic profiles in Gα,Gβ,and XLG-null mutants of two plant species,Arabidopsis thaliana and Marchantia polymorpha,and showed that G protein mediates the shift of transcriptional and metabolic homeostasis to stress readiness *** demonstrated that such stress readiness serves as an intrinsic protection mechanism against further stressors through enhancing the phenylpropanoid pathway and abscisic acid ***,WRKY transcription factors were identified as key intermediates of G protein-mediated homeostatic *** and mathematical model comparisons between *** and *** revealed evolutionary conservation of transcriptional and metabolic networks over land plant evolution,whereas divergence has occurred in the function of plant-specific atypical XLG *** together,our results indicate that the shifts in transcriptional and metabolic homeostasis at least partially act as the mechanisms of G protein-coupled stress responses that are conserved between two distantly related plants.

关键词： homeostatic adjustments transcriptional regulation metabolic regulation heterotrimeric G protein evolutionary conservation

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Variegated Roles of and Relationships Between Private Tutoring and Schooling: Insights From the State of Maharashtra, India

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ECNU Review of Education 2024年第1期7卷 66-88页

作者： shalini Bhorkar University College London&St.Mary's University

Purpose:The relationship between private tutoring(PT)and mainstream education is among the complex themes characterizing PT discourses in the *** study examined the complications of practices and processes in tutoring and schooling to elucidate different roles played by PT and its relationship with mainstream ***/Approach/Methods:This study used qualitative data from a diverse set of 37 PT providers from the State of Maharashtra,India,to delineate their roles and explore their relationship with schooling in this ***:The classification of PT providers roles into complementary,accommodating,competing,and substitutive ones demonstrated a diverse range of relationships between PT and mainstream *** analysis showed that these relationships are dynamic in nature,and the boundaries between them are ***/Value:Research in the field of PT has been consistently pointing toward a perplexing mixture of positive and negative outcomes resulting from its relationship with mainstream *** study transcended the positive vis-a-vis negative binary approach by contributing to the deeper understanding of PT ***,it exemplified how future studies can disentangle the complexities of such relationships by deploying flexible,context-specific theoretical approaches.

关键词： Education inequalities educational privatization India private tutoring schooling-tutoring relationships shadoweducation

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Small activating RNA delivery in vivo:Challenges,prospects,and lessons learned from siRNA delivery

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Nano Research 2024年第10期17卷 8990-9002页

作者： shalini Pandey Patrick T.Bednarz Matthias A.Oberli Omid Veiseh Department of Bioengineering William Marsh Rice UniversityHouston 77030USA Xibus Systems 199 Dexter AveWatertown 02472USA

Over the last two decades,small activating RNAs(saRNAs)have quickly moved from discovery to clinical *** as 20 nucleotide long,double stranded RNA,saRNAs have the unique ability to increase gene transcription at the chromatin *** therapeutic modality has great potential as a safe and redosable alternative to gene therapy by increasing target protein expression without changing the genetic *** describe the successful in vivo saRNA delivery vectors and found that similar to small interfering RNA(siRNA)and mRNA targeting tissues outside the liver works best at the end of a *** highlight nanoparticle vectors and RNA-conjugates,where some success has been reported for non-hepatic delivery of saRNAaptamers.

关键词： small activating RNA hepatic bias lipid nanoparticles RNA-conjugates

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Overlap in oncogenic and pro-inflammatory pathways associated with areca nut and nicotine exposure

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Cancer Pathogenesis and Therapy 2024年第3期2卷 187-194页

作者： Krati Garg Anuj Kumar Vidisha Kizhakkethil Pramod Kumar shalini Singh Department of Biochemical Engineering and Biotechnology Indian Institute of Technology(IIT)DelhiDelhi 110016India Division of Molecular Biology ICMR-National Institute of Cancer Prevention and Research(ICMR-NICPR)Indian Council of Medical ResearchNoidaUttar Pradesh 201301India Department of Biotechnology Vellore Institute of Technology(VIT)VelloreTamil Nadu 632024India ICMR-National Institute of Cancer Prevention&Research(ICMR-NICPR) Indian Council of Medical ResearchNoidaUttar Pradesh 201301India

Background:Betel nut/areca nut/Areca catechu is one of the most commonly used psychoactive substance,and is also a major preventable cause of *** other psychoactive substances,such as nicotine,the mechanisms underlying addiction to areca nuts and related oncogenesis remain *** reports suggest a possible overlap in the mechanisms of action of nicotine and areca nuts in the human ***,this study aimed to investigate the interactome of human proteins associated with areca nut exposure and the intricate similarities and differences in the effects of the two psychoactive substances on ***:A list of proteins associated with areca nut use was obtained from the available literature using terms from Medical Subject Headings(MeSH).Protein-protein interaction(PPI)networks and functional enrichment were *** results obtained for both psychoactive substances were ***:Given the limited number of common proteins(36/226,16%)in the two sets,a substantial overlap(612/1176 nodes,52%)was observed in the PPI networks,as well as in Gene *** nuts mainly affect signaling pathways through three hub proteins(alpha serine/threonine-protein kinase,tumor protein 53,and interleukin-6),which are common to both psychoactive substances,as well as two unique hub proteins(epidermal growth factor receptor and master regulator of cell cycle entry and proliferative metabolism).Areca nut-related proteins are associated with unique pathways,such as extracellular matrix organization,lipid storage,and metabolism,which are not found in nicotine-associated ***:Areca nuts affect regulatory mechanisms,leading to systemic toxicity and *** nuts also affect unique pathways that can be studied as potential markers of exposure,as well as targets for anticancer therapeutic agents.

关键词： Cancer Areca nut Nicotine Interactome Cell signaling

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谷物和油料中甲酸乙酯和硫化羰本底水平评估

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粮油食品科技 2024年第3期32卷 16-29页

作者： Pushpendra KOLI shalini MAHAWAR Yu XIAO Yong-lin REN 李燕羽(译) 默多克大学环境和生命科学学院澳大利亚珀斯WA6150 ICAR印度草原与饲料研究所动植物关系部印度占西UP284003 国家粮食和物资储备局科学研究院粮食储运研究所

甲酸乙酯和硫化羰是潜在的储藏物熏蒸剂,广泛存在于大气、植物和土壤中。它们在新收获的谷物和储存的小麦、大麦、燕麦和油菜籽中的本底含量因商品、温度、含水量和储存期而异,其中甲酸乙酯含量为0.5~2.0 mg/kg,硫化羰含量为0.02~1.0 mg... 详细信息

甲酸乙酯和硫化羰是潜在的储藏物熏蒸剂,广泛存在于大气、植物和土壤中。它们在新收获的谷物和储存的小麦、大麦、燕麦和油菜籽中的本底含量因商品、温度、含水量和储存期而异,其中甲酸乙酯含量为0.5~2.0 mg/kg,硫化羰含量为0.02~1.0 mg/kg。两种成分含量在储存后的前4~5个月呈上升趋势,然后下降,在温度高于20℃,谷物和油菜籽含水量分别大于9.5%和5%时变化最明显。这些本底含量研究对开发甲酸乙酯和硫化羰作为储藏物熏蒸剂时制定最大残留限量(MRL)和市场接受度值有重要参考价值。

关键词：甲酸乙酯硫化羰熏蒸剂熏蒸剂本底水平谷物油料

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谷物和油料甲酸乙酯和硫化羰天然含量评估

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粮油食品科技 2024年

作者： Pushpendra KOLI shalini MAHAWAR Amy XIAO Yong-lin REN 李燕羽 ICAR印度草原与饲料研究所动植物关系部国家粮食和物资储备局科学研究院粮食储运研究所默多克大学环境和生命科学学院

甲酸乙酯和硫化羰是潜在的储藏物熏蒸剂，广泛存在于大气、植物和土壤中。它们在新收获的谷物和储存的小麦、大麦、燕麦和油菜籽中含量因商品、温度、含水量和储存期而异，其中甲酸乙酯含量为0.5～2.0 mg/kg，硫化羰含量为0.02～1.0 mg... 详细信息

甲酸乙酯和硫化羰是潜在的储藏物熏蒸剂，广泛存在于大气、植物和土壤中。它们在新收获的谷物和储存的小麦、大麦、燕麦和油菜籽中含量因商品、温度、含水量和储存期而异，其中甲酸乙酯含量为0.5～2.0 mg/kg，硫化羰含量为0.02～1.0 mg/kg。含量在前4～5个月呈上升趋势，然后下降，在温度高于20 ℃，谷物和油菜籽含水量分别大于9.5%和5%时变化最明显。这些本底含量研究对开发甲酸乙酯和硫化羰作为储藏物熏蒸剂时制定最大残留限量（MRL）和市场接受度值有重要参考价值。

关键词：甲酸乙酯硫化羰熏蒸剂熏蒸剂本底水平谷物油料

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Gasification kinetic studies of low volatile weakly caking coal

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International Journal of Coal Science & Technology 2023年第2期10卷 159-168页

作者： Akanksha Mishra shalini Gautam Tripurari Sharma Department of Mechanical Engineering Sharda School of Engineering and TechnologySharda UniversityG.NoidaIndia Department of Fuel Minerals and Metallurgical EngineeringIndian Institute of Technology(ISM)DhanbadIndia

Present investigation focuses on the fractional conversion of low volatile weakly caking coal(LVWC)under the standard set of operating conditions for *** this purpose,samples of LVWC of different ash content have been collected from Kusunda Area of Bharat Coking Coal *** results were validated using Homogenous and Shrinking Core kinetic models and the suitability of selected samples for gasification was assessed by estimating the activation *** values of activation energy for LVWC samples were obtained in the range of 25.17-44.09 kJ/***,empirical models were developed to correlate the response of interest with the input variables(temperature,residence time and CO_(2) flow rate).The significance of these developed empirical models was checked using analysis of variance(ANOVA).

关键词： LVWC Gasification CO_(2) Activation energy

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Assessing Anthropogenic Pressure and Its Impact on Hippophae salicifolia Pockets in Central Himalaya,Uttarakhand

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Journal of Mountain Science 2013年第3期10卷 464-471页

作者： Deepak DHYANI shalini DHYANI RK MAIKHURI G.B.Pant Institute of Himalayan Environment and Development Garhwal UnitSrinagar GarhwalUttarakhandIndia

Natural habitat ofHippophae salicifolia in Central Himalaya is continuously being degraded due to habitat destruction and harvesting. Although logging is prohibited, habitat destruction has increased because of regular road construction, repairing and broadening activities. In addition, Hippophae resources are continuously being harvested by lopping （both partial and complete） for fuelwood, fodder and fruits in higher Himalayan region. This paper presents a detailed analysis of relationship between density, demographic structure, and harvesting of H. salicifolia growing pockets in the five major valleys （Gangotri, Yamunotri, Niti, Mana and Bhyundhar） of Uttarakhand in Central Himalaya, India. A total of 12o quadrats were laid randomly to study population structure, regeneration, sex ratio and lopping using quadrats of lOO m2 （a4 in each valley） in Hippophae growing patches. Our study shows that the density, size distribution, and regeneration of Hippophae vary considerably among the major valleys. Trees in the Yamunotri valley have the highest density of large trees but the lowest density of seedlings. In contrast, there are few large trees but many seedlings in the Mana valley. The number and size of lopped trees also varied among the valleys. Lopping was greatest in Bhyundhar （11.4%） and Yamunotri （19.7%） and least in Niti （3.9%）. The size of lopped trees differed substantially as well. In Bhyundhar, the largest trees were taken while saplings were taken in Yamunotri. Our study revealed that unsustainable harvesting from plants for fuel, fencing and fruits along with road broadening activities in Central Himalaya are the main cause ofhabitat destruction. Our research highlights the urgent need for in-situ and ex-situ conservation of Hippophae salicifolia so that it＇s potential can be harnessed sustainably by rural hill societies for their socio-economic development.

关键词： Central Himalaya Seabuckthorn Dioecious Disturbance Habitat Conservation

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Synthesis,characterization and application of Lagerstroemia speciosa embedded magnetic nanoparticle for Cr(Ⅵ)adsorption from aqueous solution

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Journal of Environmental Sciences 2017年第5期29卷 283-293页

作者： shalini Srivastava Shashi Bhushan Agrawal Monoj Kumar Mondal Department of Botany Institute of Science Banaras Hindu University Varanasi 221005 India Department of Chemical Engineering and Technology Indian Institute of Technology Banaras Hindu University Varanasi 221005 Uttar Pradesh India

Lagerstroemia speciosa bark（LB） embedded magnetic nanoparticles were prepared by co-precipitation of Fe2＋ and Fe3＋ salt solution with ammonia and LB for Cr（Ⅵ） removal from aqueous *** native LB,magnetic nanoparticle（MNP）,*** embedded magnetic nanoparticle（MNPLB） and Cr（Ⅵ） adsorbed MNPLB particles were characterized by SEM-EDX,TEM,BET-surface area,FT-IR,XRD and TGA *** analysis confirmed nearly spherical shape of MNP with an average diameter of 8.76 nm and the surface modification did not result in the phase change of MNP as established by XRD analysis,while led to the formation of secondary particles of MNPLB with diameter of 18.54 *** results revealed covalent binding between the hydroxyl group of MNP and carboxyl group of LB particles and further confirmed its physico-chemical nature favorable for Cr（Ⅵ） *** Cr（Ⅵ） adsorption on to MNPLB particle as an adsorbent was tested under different contact time,initial Cr（Ⅵ） concentration,adsorbent dose,initial pH,temperature and agitation *** results of the equilibrium and kinetics of adsorption were well described by Langmuir isotherm and pseudo-second-order model,*** thermodynamic parameters suggest spontaneous and endothermic nature of Cr（Ⅵ）adsorption onto *** maximum adsorption capacity for MNPLB was calculated to be 434.78 mg/g and these particles even after Cr（Ⅵ） adsorption were collected effortlessly from the aqueous solution by a *** desorption of Cr（Ⅵ）-adsorbed MNPLB was found to be more than 93.72%with spent MNPLB depicting eleven successive adsorption-desorption cycles.

关键词： Lagerstroemia speciosa Magnetic nanoparticles Co-precipitation Cr(Ⅵ) ions Adsorption capacity

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The catalytic activity of transition metal oxide nanoparticles on thermal decomposition of ammonium perchlorate

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Defence Technology（防务技术） 2019年第4期15卷 629-635页

作者： Jalpa A. Vara Pragnesh N. Dave shalini Chaturvedi Department of Chemistry K S K V Kachchh University Mundra Road Bhuj 370 001 Gujarat India Department of Chemistry Sardar Patel University Vallabh Vidyangar 388 120 Gujarat India Samarpan Science and Commerce College Gandhinagar Gujarat India

The catalytic proficiency of three MONs for AP thermal decomposition was studied in this work.A chemical co-precipitation method was used for synthesis of MONs(CuZnO,CoZnO,and NiZnO)and their characterization carried out by utilizing XRD,FTIR,and *** TGA/DSC technique was employed for the investigation of the catalytic proficiency of MONs on the *** DSC data were used for measuring activation energy of catalyzed AP by using Ozawa,Kissinger,and Starink *** MONs were much sensitive for AP decomposition,and the performance of AP decomposition was further *** all the MONs,the CuZnO exhibits higher catalytic action than others and decomposition temperature of AP is descending around 117℃ by *** reduction in the activation energy was noticed after the incorporation of MONs in AP.

关键词： Metal oxide nanoparticles(MONs) Ammonium perchlorate(AP) Catalytic activity Activation energy

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