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Effects of aqueous leaf extract of Tridax procumbens on contractile activity of corpus cavernosum in N-nitro-L-arginine methyl ester-induced hypertensive male rats

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Journal of Integrative Medicine 2018年第1期16卷 51-56页

作者： shakiru ademola salami Hussein Mofomosara Salahdeen Evangelshane Chukwudubem Ugbebor Babatunde Adekunle Murtala Yinusa Raji Department of Physiology Lagos State University College of Medicine Laboratory for Reproductive Physiology and Developmental Programming Department of Physiology University of Ibadan

Objective： This study investigated the effects of aqueous leaf extract of Tridax procumbens （ALETP） on con- tractile activity of corpus cavernosum in N-nitro-L-arginine methyl ester （L-NAME）-induced hypertensive male rats. Methods： Twenty normal, adult male rats （130-150 g） were divided into four groups of five rats each. Group I （control） was given normal saline （0.6 mL/kg） and group II was given L-NAME （40 mg/kg） for 6 weeks. Groups Ill and IV also received L-NAME （40 mg/kg） for 6 weeks but were further co-treated with 100 and 200 mg/kg of ALETP, respectively, from week 4 to week 6. All treatments were given orally. Strips of corpus cavernosum from each of the four groups were exposed to increasing concentrations of acetyl~ choline （ACh） and sodium nitroprusside （SNP）（10^-9-10^-5 tool/L） after contraction with phenylephrine （10^-7 mol/L） to test for a dose-response effect, Response to potassium and calcium was also measured after cumulatively adding potassium and calcium （10-50 mmol/L） to potassium- and calcium-free organ chamber. Isometric contractions were recorded through an Ugo Basile data capsule acquisition system. Results： Mean arterial blood pressure was significantly reduced in the ALETP co-treated group compared to the control and L-NAME-only groups （P 〈 0.05）. Cavernosa strips from ALETP co-treated rats exhibited significant inhibition of contraction in response to phenylephrine, potassium chloride, and calcium chlo- ride （P 〈 0.05）. Relaxation in response to Ach and SNP was also significantly impaired in cavernosa strips from the L-NAME-only treated group （P 〈 0.05）, while ALETP co-treated groups showed enhanced per- centage relaxation. Conclusion： ALETP treatment of L-NAME-induced hypertensive rats promotes a relaxant effect on isolated cavernosa strips. ALETP shows potential in correcting erectile dysfunction in hypertension.

关键词： N-Nitro-L-arginine methyl ester Hypertensive Tridax procumbens Corpus cavernosum Relaxation Sodium nitroprusside Acetylcholine

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Synthesis and Characterization of Nitrosonaphthol Dyes Based on 1-Naphthol and Their Dyeing Properties on Tanned Leather

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Open Journal of Applied Sciences 2014年第6期4卷 354-359页

作者： Umar salami Ameuru Mohammed Kabir Yakubu Kasali ademola Bello Department of Textile Science and Technology Ahmadu Bello University Zaria Nigeria

Nitrosonaphthol dyes and other corresponding analogues were synthesised from 1-Naphthol. The dyes were applied onto chrome and vegetable tanned leather upon characterization. The results indicate that the dye bath exhaustion was better on chrome tanned leather than on vegetable tanned leather. This may be attributed to the chelating effect of chrome on leather and the higher temperature of dyeing the chrome tanned leather compared with the vegetable tanned leather. The fastness properties of the dyes of washing ranging from (3 - 5), perspiration on acid (4 - 5), alkaline (4 - 5) and light (4 - 7) were impressive on both vegetable and chrome tanned leather respectively.

关键词： 2-Nitroso-1-Naphthol Tanned Leather Exhaustion Fastness

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