检索结果-南通市图书馆

Protective Effect of Liraglutide on Early Renal Fibrosis in Diabetes Mice

Journal of Biosciences and Medicines 2025年第1期13卷 84-91页

作者： Xiaolan Ke te’an Ma Department of Nephrology The First Affiliated Hospital of Yangtze University Jingzhou China

Background: In recent years, studies have shown that liraglutide may delay the progression of renal fibrosis by inhibiting renal fibrosis signaling pathways and reducing collagen deposition. TGF-β1 and E-Cadherin play crucial roles in renal fibrosis. Objective: To explore the protective effect of liraglutide on early renal fibrosis in diabetes mice. Methods: Twenty-four 8-week-old healthy male C57BL/6J mice were randomly divided into a normal diet feeding group (NG, n = 8) and a high-fat diet feeding group (HG, n = 16) using a simple random sampling method. Four weeks later, the high-fat diet feeding group received a one-time intraperitoneal injection of STZ diluted with 0.1 mol/L sodium citrate buffer (50 mg/Kg). The diabetes model was established after 7 days of continuous injection. The diabetes model mice were randomly divided into 2 groups, each containing 8 mice. One group received liraglutide (400 ug per kilogram per day, subcutaneous injection), named Liraglutide Intervention Group (LDG);the other group received an equal dose of saline subcutaneously, named the Diabetes Model Non-intervention Group (NDG). NG also received an equal dose of saline subcutaneously, named Normal Control Group (NCG). Renal tissue pathological changes were observed by HE and Masson staining;TGF-βl and E-Cadherin protein expressions were detected by immunohistochemistry;E-Cadherin protein expression was detected by Western blotting. Results: The degree of kidney tissue damage and fibrosis in liraglutide intervention group was milder than that in non-intervention group, and the expression of TGF-β1 and E-Cadherin protein tended to be similar to that in normal control group. Conclusion: Liraglutide can significantly reduce early renal fibrosis in diabetes mice, and its mechanism may be related to the reduction of TGF-β1 expression to induce EMT changes in epithelial cells (for example, up regulation of E-Cadherin).

关键词： Liraglutide Diabetes Renal fibrosis TGF-β1 E-Cadherin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sub-Atom Particles and Magnetic Monopoles Spin Ice Condensed in Higgs-Field Portals

引用

Journal of Applied Mathematics and Physics 2025年第1期13卷 348-364页

作者： Hung-te Henry Su Po-Han Lee Department of Physics Taiwan Chung Cheng University Chiayi Department of Electro-Optical Engineering Taipei University of Technology Taipei City The Affiliated Senior High School of Taiwan Normal University Taipei City

The study of magnetic monopoles continues to be a prominent and captivating topic in physics, particularly within the realm of physical materials. Recently, K. C. Tan, Hariom Jani, Michael Högen, and their collaborators (2023) reported groundbreaking discoveries, marking significant progress in this field. However, a sense of dissatisfaction persists among researchers regarding the current state of advancement. To address this, we propose a novel theoretical framework that explores magnetic monopoles through the lens of Higgs field portals. Our findings indicate that the spin of the magnetic monopole, s = 1, is intrinsically linked to the fundamental expression governing its behavior, with the two aspects being inseparable in practical terms. This theory offers a deeper understanding of the inherent nature of magnetic monopoles and provides a foundation for further exploration.

关键词： Magnetic Monopoles Higgs-Field Magnetic Spin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

核用钛合金辐照效应的研究现状与展望

引用

稀有金属材料与工程 2025年第1期54卷 232-242页

作者：胡爽万明攀朱特曹兴忠贵州大学材料与冶金学院贵州贵阳550025 贵州省材料结构与强度重点实验室贵州贵阳550025 中国科学院高能物理研究所北京100049

钛合金因具有高比强度、低密度、耐腐蚀性、抗氧化性、高温稳定性以及低中子截面等特点,逐渐被用作船舶和空间核动力装置的关键部件。为提高钛合金抗辐照性能,推进钛合金在核工程领域广泛应用,不少研究人员在钛合金辐照效应等关键问题... 详细信息

钛合金因具有高比强度、低密度、耐腐蚀性、抗氧化性、高温稳定性以及低中子截面等特点,逐渐被用作船舶和空间核动力装置的关键部件。为提高钛合金抗辐照性能,推进钛合金在核工程领域广泛应用,不少研究人员在钛合金辐照效应等关键问题研究上做出了很大努力。本文回顾了钛及钛合金在核领域的发展与辐照效应研究,全面综述了不同粒子辐照(中子、离子等)下,多种先进钛合金中辐照缺陷演变及相互作用机制,还总结了服役条件(温度、应力、辐照)对钛合金的硬度、拉伸、疲劳以及蠕变等力学性能的影响规律。最后,基于目前核用钛合金研究现状,展望了未来钛合金辐照效应的研究方向和改善抗辐照性能的发展趋势。

关键词：核用钛合金辐照效应微观结构力学性能

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

PBAT全生物降解地膜降解特征

引用

环境科学 2025年第1期46卷 551-559页

作者：金安妮余奋霞王玉林杜特贺婧宁夏大学生态环境学院银川750021 宁夏大学省部共建煤炭高效利用与绿色化工国家重点实验室银川750021 平罗县农业机械化综合服务中心平罗753400 西北退化生态系统恢复与重建教育部重点实验室银川750021 省部共建西北土地退化与生态恢复国家重点实验室培育基地银川750021

全生物降解地膜代替传统塑料地膜是解决“白色污染”的重要研究方向,但其是否能够真正实现生物降解仍是众多学者研究的焦点.以聚己二酸/对苯二甲酸丁二醇酯(PBAT)全生物降解地膜和普通聚乙烯地膜(PE)为研究对象,以不覆膜(CK)为对照,在... 详细信息

全生物降解地膜代替传统塑料地膜是解决“白色污染”的重要研究方向,但其是否能够真正实现生物降解仍是众多学者研究的焦点.以聚己二酸/对苯二甲酸丁二醇酯(PBAT)全生物降解地膜和普通聚乙烯地膜(PE)为研究对象,以不覆膜(CK)为对照,在宁夏回族自治区平罗县开展田间试验和室内试验,观察地膜表观开裂程度、地膜面积损失以及失重率等宏观特征,结合扫描电镜(SEM)、傅里叶红外光谱(FTIR)、热重分析(TG)和CO_(2)释放量等微观特征,综合探究PBAT在银北灌区的降解特征,为其大面积推广提供数据支撑.结果表明,宏观上,PBAT地膜覆盖60 d已经开始破裂,PBAT处理110 d后地膜面积损失率为27.92%,质量损失率(失重率)达到19.04%,均远大于PE地膜.微观上,综合SEM、FTIR图谱以及热重分析,在包埋110 d后,PE地膜无明显变化,而PBAT表面结构发生很大变化,层状结构更加明显,酯基结构发生改变,热稳定性变差.室内模拟试验发现,培养90 d后,PBAT地膜的矿化率为18.30%,接近树叶的矿化率,而PE地膜几乎无矿化.

关键词：聚己二酸/对苯二甲酸丁二醇酯(PBAT) 宏观微观 CO_(2) 降解特征地膜

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Rolling route for refining grains of super light Mg-Li alloys containing Sc and Be

引用

Transactions of Nonferrous Metals Society of China 2010年第8期20卷 1374-1379页

作者： CHIANG Chih-te LEE Shyong Department of Mechanical Engineering National Central University

Pioneering work on Sc or/and Be added Mg-Li alloys with refined grains was initiated. Various rolling-based thermo-mechanical treatments on these Mg-Li alloys were carried out. Four Mg-Li alloys were prepared by vacuum melting process. A unique route for producing fine grains was applied which concluded solution treatment at 350 ℃, cold rolling with 60% thickness reduction and 250 ℃ annealing, successively.

关键词： Mg-Li alloy beryllium scandium solid solution strengthening

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Compaction-induced stress in geosynthetic-reinforced granular base course--A discrete element model

引用

Journal of Rock Mechanics and Geotechnical Engineering 2018年第4期10卷 669-677页

作者： te Pei Xiaoming Yang School of Civil and Environmental Engineering Oklahoma State UniversityStillwaterUSA

A discrete element method(DEM) model was used to simulate the development of compaction-induced stress in a granular base course, with and without geogrid reinforcement. The granular base course was modeled as a mixture of uniformly sized triangular particles. The geogrid was modeled as a series of equally spaced balls that interact with each other through long-range interaction contacts. The longrange interaction contact was also used to simulate a deformable subgrade. The compactor was modeled as a solid cylinder rolling at a constant speed. The DEM model shows that the geogridreinforced granular base course gains additional compaction-induced stress due to the residual tensile stress developed in the geogrid. The residual tensile stress in the geogrid increases with the number of compaction passes. Parametric analyses were also conducted to assess the effects of geogrid stiffness and subgrade modulus on the compaction-induced stress.

关键词： Compaction Geosynthetics Granular soils Numerical analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Variational Calculation of Lattice SU(N) Gauge System

引用

Chinese Physics Letters 1996年第5期13卷 337-339页

作者： ZHENG Xi-te Shahram Alavian Department of Applied Physics Sichuan Union University(Chengdu University of Science and Technology)Chengdu 610065 Saskatchewan Accelerator Laboratory University of SaskatchewanSaskatoonSaskatchewanCanadaS7N5C6(present address)

A general method for an analytical calculation of SU(N)lattice gauge theories with finite N≥3 *** an example,the order parameter(E)of lattice SU(4)gauge systetn is *** result is in good agree^nent with Monte Carlo si... 详细信息

关键词： gauge lattice finite

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Large time behaviour for the Fokker-Planck equation with general potential

引用

Science China Mathematics 2018年第1期61卷 137-150页

作者： te Li Zhifei Zhang School of Mathematical Sciences Peking University

In this paper, we study the large time behaviour of the solution of the Fokker-Planck equation with general potential. For the long range potential, we prove the polynomial decay estimate in time of the solution. For ... 详细信息

关键词： Fokker-Planck equation large time behavior hypocoercivity method

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

强暴雨环境棒—板短空气间隙雨柱断裂特性研究

引用

高压电器 2025年第2期61卷 189-196页

作者：董冰冰宋家乐李特文韬蒋兴良合肥工业大学电气与自动化工程学院合肥230009 国网浙江省电力有限公司电力科学研究院杭州310014 重庆大学输配电装备及系统安全与新技术国家重点实验室重庆400044

强暴雨的发生会短接输电线路、杆塔、绝缘子串空气间隙绝缘距离,致使其发生雨闪事故,危害电网安全运行。为了研究强暴雨条件下空气间隙雨柱断裂特性及其对放电特性的影响规律,文中针对棒—板短空气间隙采用仿真结合试验的方式开展了雨... 详细信息

强暴雨的发生会短接输电线路、杆塔、绝缘子串空气间隙绝缘距离,致使其发生雨闪事故,危害电网安全运行。为了研究强暴雨条件下空气间隙雨柱断裂特性及其对放电特性的影响规律,文中针对棒—板短空气间隙采用仿真结合试验的方式开展了雨柱断裂特性研究。结果表明:在不同流速条件下,雨柱断裂长度均随外施电压的增加而降低,但降低的趋势与流速呈负相关;雨柱临界长度随流速的增加而增大,且随雨水电导率的增大而减小,但降低的趋势随之增大;雨柱断裂的直径和断裂时刻均随外施电压的增大而减小,两者变化率均与雨柱直径正相关。比较仿真计算与试验结果发现,断裂直径、断裂长度随降雨强度、电压变化趋势近似,断裂直径的数据结果偏差约10%,断裂长度偏差约15%以内。研究结果将为输电线路设计与绝缘选择提供理论支撑。

关键词：强暴雨环境直流放电短空气间隙雨柱断裂特性有限元仿真模拟试验

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nanomaterials incorporated ultrasound contrast agents for cancer theranostics

引用

Cancer Biology & Medicine 2016年第3期13卷 313-324页

作者： Lei Fu Heng-te Ke College of Pharmaceutical Sciences Soochow University Center of Systems Medicine Chinese Academy of Medical Sciences Suzhou Institute of Systems Medicine

Nanotechnology provides various nanomaterials with tremendous functionalities for cancer diagnostics and ***, theranostics has been developed as an alternative strategy for efficient cancer treatment through combination of imaging diagnosis and therapeutic interventions under the guidance of diagnostic results. Ultrasound(US) imaging shows unique advantages with excellent features of real-time imaging, low cost, high safety and portability, making US contrast agents(UCAs)an ideal platform for construction of cancer theranostic agents. This review focuses on the development of nanomaterials incorporated multifunctional UCAs serving as theranostic agents for cancer diagnostics and therapeutics, via conjugation of superparamagnetic iron oxide nanoparticles(SPIOs), Cu S nanoparticles, DNA, si RNA, gold nanoparticles(GNPs), gold nanorods(GNRs), gold nanoshell(GNS), graphene oxides(GOs), polypyrrole(PPy) nanocapsules, Prussian blue(PB) nanoparticles and so on to different types of UCAs. The cancer treatment could be more effectively and accurately carried out under the guidance and monitoring with the help of the achieved theranostic agents. Furthermore, nanomaterials incorporated theranostic agents based on UCAs can be designed and constructed by demand for personalized and accurate treatment of cancer, demonstrating their great potential to address the challenges of cancer heterogeneity and adaptation, which can provide alternative strategies for cancer diagnosis and therapeutics.

关键词： Cancer theranostics ultrasound contrast agents nanomaterials nanomedicine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：