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Hyperkalemia:Major but still understudied complication among heart transplant recipients

World Journal of Transplantation 2021年第6期11卷 203-211页

作者： Jagmeet Singh Asim Kichloo Navya Vipparla Michael Aljadah Michael Albosta shakeel jamal Sindhura Ananthaneni Sandesh Parajuli Department of Nephrology Guthrie Robert Packer HospitalSayrePA 18840United States Department of Internal Medicine Central Michigan University College of MedicineSaginawMI 48602United States Department of Internal Medicine Medical College of WisconsinMilwaukeeWI 53226United States Department of Nephrology University of Wisconsin School of Medicine and Public HealthMadisonWI 53706United States

Hyperkalemia is a recognized and potentially life-threatening complication ofheart transplantation. In the complex biosystem created by transplantation,recipients are susceptible to multiple mechanisms for hyperkalemia which arediscussed in detail in this manuscript. Hyperkalemia in heart transplantationcould occur pre-transplant, during the transplant period, or post-transplant. Pretransplantcauses of hyperkalemia include hypothermia, donor heart preservationsolutions, conventional cardioplegia, normokalemic cardioplegia, continuouswarm reperfusion technique, and ex-vivo heart perfusion. Intra-transplant causesof hyperkalemia include anesthetic medications used during the procedure,heparinization, blood transfusions, and a low output state. Finally, post-transplantcauses of hyperkalemia include hemostasis and drug-induced *** has been studied in kidney and liver transplant recipients, butthere is limited data on the incidence, causes, management, and prevention inheart transplant recipients. Hyperkalemia is associated with an increased risk ofhospital mortality and readmission in these patients. This review describes thecurrent literature pertaining to the causes, pathophysiology, and treatment ofhyperkalemia in patients undergoing heart transplantation and focuses primarilyon post-heart transplantation.

关键词： Transplantation Cardiovascular Hyperkalemia Heart transplant Medication Management

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Emerging therapeutics in the management of COVID-19

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World Journal of Virology 2021年第1期10卷 1-29页

作者： Asim Kichloo Michael Albosta Akshay Kumar Michael Aljadah Mohamed Mohamed Zain El-Amir Farah Wani shakeel jamal Jagmeet Singh Akif Kichloo Department of Internal Medicine Samaritan Medical CenterWatertownNY 13601United States Department of Internal Medicine Central Michigan UniversitySaginawMI 48602United States Department of Cardiothoracic Surgery University of PittsburghPittsburghPA 15260United States Deparment of Internal Medicine Medical College of WisconsinMilwaukeeWI 53226United States Department of Family Medicine Samaritan Medical CenterWatertownNY 13601United States Department of Transplant Nephrology Geisinger Commonwealth School of MedicineSayrePA 18510United States Department of Anesthesiology and Critical Care Saraswathi Institue of Medical SciencesUttar Pradesh 245304India

Abstract The severe acute respiratory syndrome coronavirus 2(coronavirus disease 2019,COVID-19)pandemic has placed a tremendous burden on healthcare systems *** for treatment of the virus are extremely inconsistent due to the lack of time evaluating drug efficacy in clinical ***,there is a deficiency of published literature that comprehensively discusses all therapeutics being considered for the treatment of COVID-19.A review of the literature was performed for articles related to therapeutics and clinical trials in the context of the current COVID-19 *** used PubMed,Google Scholar,and *** to search for articles relative to the topic of *** used the following keywords:“COVID-19”,“therapeutics”,“clinical trials”,“treatment”,“FDA”,“ICU”,“mortality”,and“management”.In addition,searches through the references of retrieved articles was also *** this paper,we have elaborated on the therapeutic strategies that have been hypothesized or trialed todate,the mechanism of action of each therapeutic,the clinical trials finished or inprocess that support the use of each therapeutic,and the adverse effects associated with each ***,there is no treatment that has been proven to provide significant benefit in reducing morbidity and *** are many clinical trials for numerous different therapeutic agents currently *** looking back and measuring successful strategies from previous pandemics in addition to carrying out ongoing research,we provide ourselves with the greatest opportunity to find treatments that are beneficial.

关键词： COVID-19 Therapeutics Infectious disease SARS-CoV-2 Pharmacology Virology

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Utilization of extracorporeal membrane oxygenation during the COVID-19 pandemic

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World Journal of Critical Care Medicine 2021年第1期10卷 1-11页

作者： Asim Kichloo Akshay Kumar Rawan Amir Michael Aljadah Najiha Farooqi Michael Albosta Jagmeet Singh shakeel jamal Zain El-Amir Akif Kichloo Nazir Lone Department of Internal Medicine Central Michigan UniversitySaginawMI 48603United States Department of Cardiothoracic Surgery University of PittsburghPittsburghPA 15260United States Department of Internal Medicine University of MarylandBaltimoreMD 20742United States Department of Internal Medicine Medical College of WisconsinMilwaukeeWI 53226United States Department of Surgery Central Michigan UniversitySaginawMI 48603United States Department of Nephrology and Transplant Nephrology Guthrie Robert Packer HospitalSayrePA 18840United States Department of Anesthesiology and Critical Care Saraswathi Institute of Medical SciencesUttar Pradesh 245304India Department of Pulmonology and Critical Care Northwell HealthRiverheadNY 11901United States

The ongoing outbreak of severe acute respiratory syndrome coronavirus-2[SARSCoV-2,or coronavirus disease 2019(COVID-19)]was declared a pandemic by the World Health Organization on March 11,***,more than 65 million people have been infected with this SARS-CoV-2 virus,and over 1.5 million people have died due to the viral *** a tremendous amount of medical progress has been made since its inception,there continues to be ongoing research regarding the pathophysiology,treatments,and *** a vast majority of those infected develop only mild to moderate symptoms,about 5%of people have severe forms of infection resulting in respiratory failure,myocarditis,septic shock,or multi-organ *** maximal cardiopulmonary support and invasive mechanical ventilation,mortality remains *** membrane oxygenation(ECMO)remains a valid treatment option when maximal conventional strategies *** of ECMO in the pandemic is challenging from both resource allocation and ethical *** article reviews the rationale behind its use,current status of utilization,and future considerations for ECMO in critically ill COVID-19 patients.

关键词： Extracorporeal membrane oxygenation COVID-19 Critical care Acute respiratory distress syndrome Shock Research

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Spectrum of Upper GI Endoscopy in Pediatric Population at a Tertiary Care Centre in Pakistan

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Open Journal of Pediatrics 2014年第3期4卷 180-184页

作者： Muhammad Rehan Khan shakeel Ahmed Syed Rehan Ali Prem Kumar Maheshwari Muhammad Saad jamal Department of Pediatrics and Child Health The Aga Khan University Hospital Karachi Pakistan

Although upper GI endoscopy is considered to be a gold standard in diagnosis of many pediatric gastrointestinal disorders, there is limited data about its utility from developing countries. We carried out this retrospective study at Aga khan University Hospital, Karachi, Pakistan from 2008-2012. During the study period, a total of 200 procedures were performed. Mean age of patients was 8.5 years. 66% of patients received general anesthesia for the procedure. Failure to thrive with suspected coeliac disease was the most common indication for the procedure, seen in 31% of patients. Gastritis was the most common abnormal endoscopic finding, seen in 14.5% of patients. Gastritis was the most common histopathological finding on biopsy, seen in 31% of the patients (n = 62). Findings?were consistent with coeliac disease in 18% (n = 36), duodenitis, 10.5% (n = 21) and esophagitis, 4%?(n = 8) of patients. No immediate post procedure complication was noted in our study.

关键词： Upper GI Endoscopy Children Indications

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