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Prevalence of Cerebral Atherosclerosis among Patients with Metabolic Syndrome: A Case Control Study on Egyptian Subjects

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World Journal of Cardiovascular Diseases 2016年第1期6卷 8-13页

作者： Sherif elwan Tarek Zoheir Tawfik Heba Sayed Assal shaimaa el-jaafary Montasser Mohamed Hegazy Salwa Tawfik Alshaimaa Mahmoud Aboulfotooh Foad Abd-Allah Department of Internal Medicine National Research Institute Cairo Egypt Department of Neurology Cairo University Cairo Egypt

Background: The metabolic syndrome (MetS) is a clustering of vascular risk factors that tend to increase the risk of occurrence of diabetes mellitus type 2 (DMT2), cardiovascular and cerebro-vascular ischemic events. The aim of the present study is to investigate the association of extra-cranial and intracranial arterial atherosclerosis as well as silent brain infarction (SBI) with MetS, thereby determining the potential cerebrovascular atherosclerotic risk of MetS in the Egyptian population. Methods: A case control study was conducted on 50 Egyptian subjects with MetS and 30 without with age range from 40 - 60 years old. All participants were free from cerebrovascular ischemic events [stroke or transient ischemic attack (TIA)]. All participants underwent complete neurological examination, assessment of the diagnostic criteria for MetS, carotid and transcranial duplex ultrasonography (U/S) and brain MRI. Results: Preclinical carotid atherosclerosis (athero-sclerotic plaques with ely, there was a highly significant association between MetS and SBI even after adjustment for age and other confounders (P value = 0.001). Conclusion: Metabolic syndrome is an important factor associated with mild to moderate atherosclerosis (<50% stenosis) and silent brain infarcts among asymptomatic individuals. Interventions to reduce MetS are important for prevention of subclinical and clinical cerebral atherosclerotic disease.

关键词： Metabolic Syndrome Preclinical Atherosclerosis Silent Brain Infarction Neurovascular Ultrasound Brain MRI Egyptian Population

Petrology and Geochemistry of Some Ophiolitic Metaperidotites from the Eastern Desert of Egypt:Insights into Geodynamic Evolution and Metasomatic Processes

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Acta Geologica Sinica(English Edition) 2021年第4期95卷 1139-1157页

作者： Abdel-Aal M.ABDel-KARIM Mokhles K.AZER shaimaa A.el-SHAFEI Geology Department Faculty of ScienceZagazig UniversityZagazig 44519Egypt Geological Sciences Department National Research Centre12622-DokkiCairoEgypt

Ophiolitic peridotites exposed in the Eastern Desert(ED)of Egypt record multiple stages of evolution,including different degrees of partial melting and melt extraction,serpentinization,carbonatization and *** present study deals with metaperidotites at two selected localities in the central and southern ED,namely Wadi el-Nabáand Wadi Ghadir,*** represent residual mantle sections of a Neoproterozoic dismembered ophiolite that tectonically emplaced over a volcano-sedimentary succession that represents island–arc *** studied metaperidotites are serpentinized,with the development of talc-carbonate and quartz-carbonate rocks,especially along shear and fault *** relics of primary minerals(olivine,orthopyroxene and Cr-spinel)are preserved in a few samples of partiallyserpentinized *** of the Cr-spinel crystals have fresh cores followed by outer zones of ferritchromite and Crmagnetite,which indicates that melt extraction from the mantle protolith took place under oxidizing *** protoliths of the studied metaperidotites were dominated by harzburgites,which is supported by the abundance of mesh and bastite textures in addition to some evidence from mineral and whole-rock chemical *** high Cr#(0.62–0.69;Av.0.66)and low TiO_(2)(els,the higher Fo(89–92;Av.91)and NiO(0.24–0.54 wt%,Av.0.40)contents of the primary olivine relics,together with the high Mg#(0.91–0.93;Av.91)and low CaO,Al2 O3 and TiO_(2)of the orthopyroxene relics,are all comparable with depleted to highly depleted forearc harzburgite from a suprasubduction zone *** investigated peridotites have suffered subsequent phases of metasomatism,from oceanfloor hydrothermal alteration(serpentinization)to magmatic hydrothermal *** enrichment of the studied samples in light rare earth elements(LREEs)relative to the heavy ones(HREEs)is attributed to most probably be due to the contamination

关键词： ophiolitic metaperidotites partial melting melt extraction geodynamic evolution Eastern Desert Egypt

Phosphoric Acid Pretreatment and Saccharification of Paper Sludge as a Renewable Material for Cellulosic Fibers

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Journal of Renewable Materials 2024年第9期12卷 1573-1591页

作者： Samar el-Mekkawi Wafaa Abou-elseoud shaimaa Fadel Enas Hassan Mohammad Hassan Chemical Engineering and Pilot Plant Department National Research CentreDokkiGiza12622Egypt Cellulose and Paper Department National Research CentreDokkiGiza12622Egypt

Recycling of paper sludge waste is crucial for establishing a sustainable green *** waste contains valuable sugars that can be converted into important chemicals such as ethanol,poly hydroxybutyrate,and lactic ***,the main challenge in obtaining sugars in high yield from paper sludge is the high crystallinity of cellulose,which hinders *** address this,pretreatment using phosphoric acid was optimized using response surface methodology to facilitate cellulose hydrolysis with minimal energy and *** created prediction model using the response surface method considered factors such as acid concentration(ranging from 60%to 85%),consistency(ranging from 4%to 10%),temperature(ranging from 25℃to 80℃),and time(ranging from 0.5 to 4 h).The results revealed that the model’s significant factors affecting the yield were acid concentration,reaction time,temperature,and the product of acid concentration and temperature,while the model’s significant factors affecting the crystallinity were the consistency,the temperature,and their *** results showed that the optimum conditions for pretreatment were using an acid concentration of 64%,temperature of 25℃,consistency of 10%,and time of 30 *** hydrolysis of the conditionally pretreated paper sludge resulted in a weight loss of 42%,compared to only 18%weight loss in non-pretreated paper ***,the optimized conditions led to low levels of furfurals and acetic acid,which are undesirable by-products that can interfere with sugar *** total sugar obtained under the optimized conditions was 0.43 g glucose/g sample(10.46 g/L),while the contents of methyl furfural,furfural,and acetic acid were 21.65,235.7,and 4.57 mg/L,*** study demonstrates the potential of phosphoric acid for pretreatment and hydrolysis of paper sludge,enabling efficient saccharification and the production of sugars with minimal undesired by-products.

关键词： Waste valorization fermentable sugars response surface methodology acid hydrolysis cellulose crystallinity

Real time endoscopic ultrasound elastography and strain ratio in the diagnosis of solid pancreatic lesions

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World Journal of Gastroenterology 2017年第32期23卷 5962-5968页

作者： Hussein Okasha shaimaa elkholy Ramy el-Sayed Mohamed-Naguib Wifi Mohamed el-Nady Walid el-Nabawi Waleed A el-Dayem Mohamed I Radwan Ali Farag Yahya el-sherif Emad Al-Gemeie Ahmed Salman Mohamed el-Sherbiny Ahmed el-Mazny Reem E Mahdy Internal Medicine Department Cairo University Department of Tropical Medicine Zagazig University Internal Medicine Department Beni Suef University Tropical Medicine Department El Manial Specialized Hospital Pathology Department National Cancer InstituteCairo University Internal Medicine Department Assiut University

AIM To evaluate the accuracy of the elastography score combined to the strain ratio in the diagnosis of solid pancreatic lesions(SPL). METHODS A total of 172 patients with SPL identified by endoscopic ultrasound were enrolled in the study to evaluate the efficacy of elastography and strain ratio in differentiating malignant from benign lesions. The semi quantitative score of elastography was represented by the strain ratio method. Two areas were selected, area(A) representing the region of interest and area(B) representing the normal area. Area(B) was then divided by area(A). Sensitivity, specificity, positive predictive value(PPV), negative predictive value(NPV), and accuracy were calculated by comparing diagnoses made by elastography, strain ratio and final *** SPL were shown to be benign in 49 patients and malignant in 123 patients. elastography alone had a sensitivity of 99%, a specificity of 63%, and an accuracy of 88%, a PPV of 87% and an NPV of 96%. The best cut-off level of strain ratio to obtain the maximal area under the curve was 7.8 with a sensitivity of 92%, specificity of 77%, PPV of 91%, NPV of 80% and an accuracy of 88%. Another estimated cut off strain ratio level of 3.8 had a higher sensitivity of 99% and NPV of 96%, but with less specificity, PPV and accuracy 53%, 84% and 86%, respectively. Adding both elastography to strain ratio resulted in a sensitivity of 98%, specificity of 77%, PPV of 91%, NPV of 95% and accuracy of 92% for the diagnosis of SPL. CONCLUSION Combining elastography to strain ratio increases the accuracy of the differentiation of benign from malignant SPL.

关键词： Endoscopic Ultrasound elastography Strain Ratio Real Time Pancreatic lesions

Evaluation of the nutritional value of Artemia nauplii for European seabass(Dicentrarchus labrax L.)larvae

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Aquaculture and Fisheries 2024年第1期9卷 78-84页

作者： Alaa A.el-Dahhar Rashwan S.Rashwan Samy Y.el-Zaeem shaimaa A.Shahin Mona M.Mourad Mohammed F.el Basuini Animal and Fish Production Department Faculty of Agriculture-Saba BashaAlexandria UniversityAlexandria21526Egypt National Institute of Oceanography and Fisheries(NIOF) Cairo11562Egypt Department of Animal Production Faculty of AgricultureTanta UniversityTanta31527Egypt Faculty of Desert Agriculture King Salman International UniversitySouth Sinai46618Egypt

Adapted European seabass(Dicentrarchus labrax L.)larvae at 25 days post-hatching(dph)with a primary weight and length of 23 mg and 9.92 mm,start the weaning up to 46 dph using the weaning micro-diet(54%crude protein from fish meal,powder milk,and poultry egg)concurrently with Artemia enriched with fortification emulsions(0.6 g/L)of DHA selco®as a control group(DHAS)or Fish oil+20%Vitamin C(FOVC),or Fish oil+20%Vitamin E(FOVE),or Fish oil+10%Vit.C+10%Vit.E(FOCE),or Fish oil only(FO).At 46 dph,groups of larvae fed enriched Artemia with DHAS and FOVE exhibited the highest final body weight,weight gain,average daily gain,specific growth rate,feed intake,protein efficiency ratio,and survival%as well as the lowest feed conversion ***,larvae in FOVC displayed the lowest final body weight,total length,weight gain,average daily gain,specific growth rate,feed intake,protein efficiency ratio,and survival%as well as the highest feed conversion *** histological assessment exhibited no pathological alteration as well as an improvement in the structure with DHAS,FOVE,FOVC,and FOCE co-additives compared to *** peroxidase enzyme(GPx)recorded the highest rates(P<0.05)in groups fed Artemia supplemented with DHAS and FOVE followed by FOCE and *** the lowest record for GPx activity was noted in the FO *** conclusion,Using augmented Artemia nauplii with fish oil+vitamin E in single or in companion with vitamin C as cheap antioxidants support *** larval growth,survival,and antioxidant efficacy during the critical weaning period.

关键词： European seabass Gastrointestinal histology Antioxidants Vitamin C Vitamin E DHA

Investigation of the antioxidant defensive role of both AD-MSCs and BM-MSCs in modulating the alteration in the oxidative stress status in various STZ-diabetic rats’tissues

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BIOCelL 2021年第6期45卷 1561-1568页

作者： SHADY G.el-SAWAH FAYEZ ALTHOBAITI ADIL ALDHAHRANI EMAN FAYAD MARWA A.ABDel-DAYEM REHAB M.AMEN el shaimaa SHABANA EHAB I.el-HALLOUS HANAN M.RASHWAN Zoology Department Faculty of ScienceArish UniversityNorth SinaiEgypt Biotechnology Department Faculty of ScienceTaif UniversityTaif21944Saudi Arabia Clinical Laboratory Science Department Turabah University CollegeTaif UniversityTaif21995Saudi Arabia Department of Pharmacology and Biochemistry Faculty of PharmacyHorus University-EgyptNew Damietta34518Egypt Biology Department College of ScienceUniversity of BishaBisha61922Saudi Arabia Fellow of Biochemistry Genetic UnitChildren HospitalFaculty of MedicineMansoura UniversityMansouraEgypt Biology Department Faculty of ScienceTaif UniversityTaifSaudi Arabia

Diabetes mellitus(DM)could negatively affect patients’health via inducing a lot of serious functional hazards in many tissues’cells at molecular ***,many scientists had proposed stem cell therapy being an appropriate alternative treatment protocol for numerous health threatening issues including ***,the current study was designed to investigate the antioxidant potentiality of two MSCs types in alleviating tissues’oxidative stress dramatic elevation resulting as a consequence of Type 1 DM *** our 4 weeks study,animals were divided into four groups:control group,STZ-diabetic group(D),D+AD-MSCs group and D+BM-MSCs *** reported that diabetic rats treated with either AD-MSCs or BM-MSCs exhibited a marvelous body tissues(Pancreas,Liver and Kidney)enhancing capabilities in attenuating the oxidative stress status;as evidenced by XO,ROS,and MDA levels down-regulation;with a general concomitant elevation in the antioxidants’content;evidenced by many enzymatic and non-enzymatic antioxidants up-regulation;relative to the diabetic untreated ***,comparing both treatments with each other and to control group,most of the measured parameters were reverted back to near normal levels after AD-MSCs injection;which clearly point out their stunning health benefits and superiority as anti-diabetic agent in overcoming different tissues’complications;owing to their marked cytoprotective and regenerative potentialities.

关键词： Antioxidants Diabetes Mesenchymal stem cells Oxidative stress

Anti-inflammatory and antioxidant potential capacities of AD-MSCs and BM-MSCs in suppressing pancreaticβ-cells auto-immunity and apoptosis in rats with T1DM induced model

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BIOCelL 2022年第3期46卷 745-757页

作者： SHADY G.el-SAWAH FAYEZ ALTHOBAITI HANAN M.RASHWAN ADIL ALDHAHRANI MARWA A.ABDel-DAYEM EMAN FAYAD REHAB M.AMEN el shaimaa SHABANA EHAB I.el-HALLOUS Zoology Department Faculty of ScienceArish UniversityNorth SinaiEgypt Biotechnology Department Faculty of ScienceTaif UniversityTaifSaudi Arabia Clinical Laboratory Science Department Turabah University CollegeTaif UniversityTaifSaudi Arabia Department of Pharmacology and Biochemistry Faculty of PharmacyHorus University-EgyptNew DamiettaEgypt Biology Department College of ScienceUniversity of BishaBishaSaudi Arabia Fellow of Biochemistry Genetic UnitChildren HospitalFaculty of MedicineMansoura UniversityDakahlia GovernorateEgypt Biology Department Faculty of ScienceTaif UniversityTaifSaudi Arabia

Since Type 1 diabetes(T1DM)occurs whenβ-cells mass is reduced to less than 20%of the normal level due to autoimmune destruction of cells resulting in the inability to secrete insulin,preservation or replenishment of the functionalβ-cells mass has become a major therapeutic focus for this diabetic type ***,this 4-week work plan was designed to determine which mesenchymal stem cells(MSCs)type is more appropriate to alleviate pancreatic hazards resulting from diabetes induction;via tracking a comparative study between MSCs derived from adipose tissue(AD-MSCs)and from bone marrow(BM-MSCs)in management of T1DM considering their immunomodulatory,anti-apoptotic and antioxidative *** were divided randomly into 4 groups;control,STZdiabetic(D),D+AD-MSCs,and D+BM-MSCs *** stem cells types in this study were ***,both oxidative stress and antioxidant markers were evaluated using colorimetric analysis,while inflammatory,immune and apoptotic markers were assessed through flow cytometric *** showed that diabetic rats treated with either AD-MSCs or BM-MSCs exhibited marked pancreatic antioxidant and anti-inflammatory activities that were able to initiate pancreatic immunomodulation and reducingβ-cells apoptotic death,thus,help to restore their normal insulin secretion and hypoglycemic ***,AD-MSCs injection was shown to be superior as a pancreatic regenerative tool in overcoming diabetes;owing to their marked antioxidant,anti-inflammatory,immunomodulatory,and anti-apoptotic characteristics over BM-MSCs treatment.

关键词： Antioxidants Apoptosis Diabetes Inflammation Stem cells

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橄榄渣基活性炭活化工艺的优化（英文）

新型炭材料 2016年第5期31卷 492-500页

作者： Nour T.Abdel-Ghani Ghadir A.el-Chaghaby Mohamed H.elGammal el-shaimaa A.Rawash Chemistry Department Faculty of ScienceCairo University RCFF Agriculture Research Center

采用KOH对橄榄渣进行活化得到活性炭。设计2~3正交试验来优化制备工艺条件,水平和因子包括活化温度(600,900℃)、活化时间(1,3 h)和浸渍比(1∶2,1∶4)。活性炭的比表面积作为优化的评价指标。通过氮吸附仪、红外光谱仪和扫描电镜等手段... 详细信息

采用KOH对橄榄渣进行活化得到活性炭。设计2~3正交试验来优化制备工艺条件,水平和因子包括活化温度(600,900℃)、活化时间(1,3 h)和浸渍比(1∶2,1∶4)。活性炭的比表面积作为优化的评价指标。通过氮吸附仪、红外光谱仪和扫描电镜等手段对活性炭的表面化学和孔结构进行表征。结果表明,所有因子及其交互水平都非常显著(p<0.05)。活性炭的比表面积和制备条件的相关系数为99.2%。在最条件下制备的活性炭,比表面积为672 m^2/g、平均孔径为2.05 nm,微孔和介孔率分别为81.36%和18.37%。

关键词：橄榄渣活性炭 KOH 渴望函数孔隙率

Determination of delta-9-tetrahydrocannabinol content of cannabis seizures in Egypt

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Asian Pacific Journal of Tropical Medicine 2017年第3期10卷 291-294页

作者： Ahmed M.A.Souleman Alaa el-Din M.Gaafar Omar M.Abdel-Salam shaimaa A.elShebiney Department of Phytochemistry and Plant Systematic National Research CentreCairoEgypt Department of Photochemistry National Research CentreCairoEgypt Department of Toxicology and Narcotics National Research CentreCairoEgypt

Objective:To determine the delta-9-tetrahydrocannabinol(THC)content of cannabis seizures in ***:Unheated and heated extracts of cannabis seizures were prepared from the dried flowering tops and leaves(marijuana)or from the resin(hashish)and subjected to analysis using high performance liquid chromatography(HPLC).Results:The heated resin extract had the peak of THC in a relative ratio of 31.34%,while extracting the resin directly without heating contained only 18.34%of *** the other hand,marijuana showed minimum percentage of THC at 11.188% on heating and 9.55% without ***:These results indicate the high potency of the abused cannabis plant in the illicit Egyptian market.

关键词： Cannabis Hashish Marijuana THC High performance liquid chromatography