检索结果-南通市图书馆

Systemic Amyloidosis Secondary to Psoriasis: A Rare, Autoimmune and Genetically-Determined Disorder That Is Amenable to Treatment with Cyclosporin A—Cyclosporin A for Psoriasis-Induced Amyloidosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Nephrology 2024年第2期14卷 226-232页

作者： Kamel El-Reshaid shaima al-bader John Patrick Madda Department of Medicine Faculty of Medicine Kuwait University Kuwait City Kuwait Asad al-Hamad Dermatology Center Kuwait City Kuwait Department of Pathology Amiri Hospital Kuwait City Kuwait

Background: Systemic secondary amyloidosis (SSA) is associated with chronic inflammatory disorders and/or chronic infections. Patients and Methods: Over the past 10 years;a total of 21 patients, with long-term (17 months) and extensive psoriasis (P) with psoriasis area severity index (PASI) >29, were evaluated. Results: Two patients had nephrotic syndrome (proteinuria 3.9 and 3.6 g/day) and decrease creatinine clearance (46 and 62 ml/minute). Their renal biopsy revealed Congo-red (+) nodular glomerulosclerosis that lacked immune-deposits and resisted wash with K-permanganate wash indicating SSA. Three months subsequent to Cyclosporin A (CyA) therapy with 100 mg twice daily;psoriasis improved in all patients with decrease in (PASI) from 29.5 to 3.5 1. In the 2 patients with SSA;proteinuria decreased to 2.1 and 1.8 g/day and creatinine clearance improved to 51 and 69 ml/minute. Such improvement persisted up to 2 years of follow up and up to 78 months in patients with SSA. Conclusion: psoriasis-induced SSA is an autoimmune disease, with genetic predisposition that is amenable to CyA therapy.

关键词： Amyloidosis Psoriasis Nephrotic Syndrome Cyclosporin A

Hydroxychloroquine: A Safe, Effective and Inexpensive Maintenance Therapy for Chronic Spontaneous Urticaria

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rituximab Therapy for Persistent, Severe and Extensive Idiopathic Bullous Pemphigoid

International Journal of Clinical Medicine（临床医学国际期刊） 2024年第6期 225页

作者： Kamel El-Reshaid shaima al-bader Abdulla al-Refaee

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论

Journal of Cosmetics, Dermatological Sciences and Applications 2023年第1期13卷 76-83页

作者： shaima al-bader Kamel El-Reshaid Asad al-Hamad Dermatology Center Kuwait Department of Medicine Faculty of Medicine Kuwait University Kuwait

Background: Idiopathic Bullous Pemphigoid (IBP) is a rare blistering autoimmune disease. Its morbidity and mortality have remained high owing to complications of extensive skin involvement as well as its conventional steroid therapy. We reviewed the medical literature and found indicators of an autoimmune etiology for its pathogenesis triggering genetically predisposed patients. Objective: to evaluate, prospectively, the role of Rituximab (R) therapy in its persistent, severe and extensive form. Patients and methods: A total of 12 patients, with disease duration of 6 ± 1 months, were treated with yearly R infusions (1 g followed by 1 g 2 weeks later). Results: Significant clinical improvement was achieved as documented by decrease in total score of Bullous Pemphigoid Disease Area Index from 60 ± 3 to 6 ± 2 that persisted for 26 ± 11 months of follow up. Moreover, IBP autoantibodies (anti-BP 180 and anti-320 IgG) levels fell from to 91 ± 3 and 81 ± 2 to 8 ± 2 and 9 ± 2, respectively. Conclusions: R is a safe and effective treatment for severe IBP and such response further confirms its autoimmune pathogenesis.

关键词： Bullous Pemphigoid Rituximab Treatment BP Autoantibodies Bullous Pemphigoid Disease Area Index

Limits of Depth: Over-Smoothing and Over-Squashing in GNNs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Big Data Mining and Analytics 2024年第1期7卷 205-216页

作者： Aafaq Mohi ud din shaima Qureshi Department of Computer Science and Engineering National Institute of Technology SrinagarSrinagar 190006India

Graph Neural Networks(GNNs)have become a widely used tool for learning and analyzing data on graph structures,largely due to their ability to preserve graph structure and properties via graph representation ***,the effect of depth on the performance of GNNs,particularly isotropic and anisotropic models,remains an active area of *** study presents a comprehensive exploration of the impact of depth on GNNs,with a focus on the phenomena of over-smoothing and the bottleneck effect in deep graph neural *** research investigates the tradeoff between depth and performance,revealing that increasing depth can lead to over-smoothing and a decrease in performance due to the bottleneck *** also examine the impact of node degrees on classification accuracy,finding that nodes with low degrees can pose challenges for accurate *** experiments use several benchmark datasets and a range of evaluation metrics to compare isotropic and anisotropic GNNs of varying depths,also explore the scalability of these *** findings provide valuable insights into the design of deep GNNs and offer potential avenues for future research to improve their performance.

关键词： Graph Neural Networks(GNNs) learning on graphs over-smoothing over-squashing isotropic-GNNs anisotropic-GNNs

Rituximab Therapy for Persistent, Severe and Extensive Idiopathic Bullous Pemphigoid

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Des-gamma-carboxy prothrombin and alpha-fetoprotein levels as biomarkers for hepatocellular carcinoma and their correlation with radiological characteristics

Journal of Cosmetics, Dermatological Sciences and Applications（化妆品、皮肤病及应用期刊） 2023年第1期

作者： shaima al-bader Kamel El-Reshaid

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Pathophysiology 2024年第1期15卷 37-43页

作者： Muhammad ali Qadeer Zaigham Abbas shaima Amjad Bushra Shahid Abeer altaf Mehreen Siyal Department of Hepatogastroenterology Dr.Ziauddin University Hospital CliftonKarachi 75600Pakistan Medicine Dr.Ziauddin University Hospital CliftonKarachi 75600Pakistan Internal Medicine Dr.Ziauddin University Hospital CliftonKarachi 75600Pakistan

BACKGROUND alpha-fetoprotein(AFP),a commonly used biomarker for hepatocellular carcinoma(HCC),is normal in up to one-third of *** To evaluate the diagnostic performance of des-gamma-carboxy-prothrombin(DCP)alone and in combination with *** In this study,202 patients with radiologically proven HCC were enrolled,and their DCP and AFP levels were evaluated for their diagnostic *** The mean age of the enrolled patients was 58.5 years;72.0%were *** was elevated in 86.6%(n=175)of all patients,100.0%(n=74)of patients with portal vein thrombus,and 87.4%(n=111)of patients with multicentric *** was elevated in 64.3%(n=130)of all the patients,74%(n=55)of the patients with portal vein thrombus,and 71.6%(n=91)of the patients with multicentric HCC(P=0.030,0.001,and 0.015,respectively).In tumors less than 2 cm in size(n=46),DCP was increased in 32(69.5%)patients,and AFP was increased in 25(54.3%)patients(P=0.801).There was good pairing between DCP and AFP for HCCs of 2 cm size or larger(Palone in 57/202(28.2%)of all patients,and AFP alone was elevated in 12/202(5.9%)of the *** areas under receiver operating characteristic curves(AUROC)for tumors>2 cm was 0.74 for DCP and 0.59 for AFP;combining both markers resulted in an AUROC of *** tumorsal marker,had a better diagnostic performance in many cases of ***,DCP may replace AFP as the primary HCC biomarker.

关键词： Des-gamma-carboxy prothrombin Protein induced by vitamin K absence-II Cirrhosis alpha-fetoprotein Biomarkers Hepatocellular carcinoma Portal vein thrombus

Machine Learning-Based Channel State Estimators for 5G Wireless Communication Systems

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

工程与科学中的计算机建模（英文） 2023年第4期135卷 755-778页

作者： Mohamed Hassan Essai ali Fahad alraddady Mo’ath Y.al-Thunaibat shaima Elnazer Department of Electrical Engineering Faculty of EngineeringAl-Azhar UniversityQena83513Egypt Department of Computer Engineering College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia Department of Management Information Systems Taif UniversityTaif21944Saudi Arabia

For a 5G wireless communication system,a convolutional deep neural network(CNN)is employed to synthesize a robust channel state estimator(CSE).The proposed CSE extracts channel information from transmit-and-receive pairs through offline training to estimate the channel state ***,it utilizes pilots to offer more helpful information about the communication *** proposedCNN-CSE performance is compared with previously published results for Bidirectional/long short-term memory(BiLSTM/LSTM)NNs-based *** CNN-CSE achieves outstanding performance using sufficient pilots only and loses its functionality at limited pilots compared with BiLSTM and LSTM-based *** three different loss function-based classification layers and the Adam optimization algorithm,a comparative study was conducted to assess the performance of the presented DNNs-based *** BiLSTM-CSE outperforms LSTM,CNN,conventional least squares(LS),and minimum mean square error(MMSE)*** addition,the computational and learning time complexities for DNN-CSEs are *** estimators are promising for 5G and future communication systems because they can analyze large amounts of data,discover statistical dependencies,learn correlations between features,and generalize the gotten knowledge.

关键词： DLNNs channel state estimator 5G and beyond communication systems robust loss functions

Idea plagiarism detection with recurrent neural networks and vector space model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Intelligent Computing and Cybernetics 2021年第3期14卷 321-332页

作者： Azra Nazir Roohie Naaz Mir shaima Qureshi Department of Computer Science and Engineering National Institute of Technology SrinagarSrinagarIndia

Purpose-Natural languages have a fundamental quality of suppleness that makes it possible to present a single idea in plenty of different *** feature is often exploited in the academic world,leading to the theft of work referred to as *** approaches have been put forward to detect such cases based on various text features and grammatical structures of ***,there is a huge scope of improvement for detecting intelligent ***/methodology/approach-To realize this,the paper introduces a hybrid model to detect intelligent plagiarism by breaking the entire process into three stages:(1)clustering,(2)vector formulation in each cluster based on semantic roles,normalization and similarity index calculation and(3)Summary generation using *** effective weighing scheme has been introduced to select terms used to build vectors based on K-means,which is calculated on the synonym set for the said *** the value calculated in the last stage lies above a predefined threshold,only then the next semantic argument is *** the similarity score for two documents is beyond the threshold,a short summary for plagiarized documents is ***-Experimental results show that this method is able to detect connotation and concealment used in idea plagiarism besides detecting literal ***/value-The proposed model can help academics stay updated by providing summaries of relevant *** would eliminate the practice of plagiarism infesting the academic community at an unprecedented *** model will also accelerate the process of reviewing academic documents,aiding in the speedy publishing of research articles.

关键词： Natural language processing Vector space model Recurrent neural networks Plagiarism detection

Exploring compression and parallelization techniques for distribution of deep neural networks over Edge-Fog continuum-a review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Intelligent Computing and Cybernetics 2020年第3期13卷 331-364页

作者： Azra Nazir Roohie Naaz Mir shaima Qureshi Department of Computer Science and Engineering National Institute of Technology SrinagarSrinagarIndia

Purpose-The trend of“Deep Learning for Internet of Things(IoT)”has gained fresh momentum with enormous upcoming applications employing these models as their processing engine and Cloud as their resource *** this picture leads to underutilization of ever-increasing device pool of IoT that has already passed 15 billion mark in ***,it is high time to explore a different approach to tackle this issue,keeping in view the characteristics and needs of the two *** at the Edge can boost applications with realtime deadlines while complementing ***/methodology/approach-This review paper contributes towards three cardinal directions of research in the field of DL for *** first section covers the categories of IoT devices and how Fog can aid in overcoming the underutilization of millions of devices,forming the realm of the things for *** second direction handles the issue of immense computational requirements of DL models by uncovering specific compression *** appropriate combination of these techniques,including regularization,quantization,and pruning,can aid in building an effective compression pipeline for establishing DL models for IoT *** third direction incorporates both these views and introduces a novel approach of parallelization for setting up a distributed systems view of DL for ***-DL models are growing deeper with every passing ***-coordinated distributed execution of such models using Fog displays a promising future for the IoT application *** is realized that a vertically partitioned compressed deep model can handle the trade-off between size,accuracy,communication overhead,bandwidth utilization,and latency but at the expense of an additionally considerable memory *** reduce the memory budget,we propose to exploit Hashed Nets as potentially favorable candidates for distributed ***,the critical point between accuracy and size for such models needs further i

关键词： Distributed deep neural networks Fog Internet of things Compression Parallelization Paper type Research paper