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A database of modeled gridded dry deposition velocities for 45 gaseous species and three particle size ranges across North America

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Journal of Environmental Sciences 2023年第5期127卷 264-272页

作者： Leiming Zhang Zhuanshi He Zhiyong Wu Anne Marie Macdonald Jeffrey R.Brook shailesh Kharol Air Quality Research division Science and Technology BranchEnvironment and Climate Change CanadaTorontoON M3H 5T4Canada department of Chemical Engineering and Applied Chemistry University of TorontoTorontoON M5S 2E4Canada

The dry deposition process refers to the flux loss of an atmospheric pollutant due to uptake of the pollutant by the earth’s *** deposition flux of a chemical species is typically calculated as the product of its surface-layer concentration and its dry deposition velocity(V_(d)).Field measurement based V_(d) data are very scarce or do not exist for many chemical species considered in chemistry transport *** the present study,gaseous and particulate dry deposition schemes were applied to generate a database of hourly V_(d) for 45 gaseous species and three particle size ranges for two years(2016–2017)at a 15 kmby 15 km horizontal resolution across North *** V_(d) of the 45 gaseous species ranged fromdomain,with chemical species-dependentmedian(mean)values being in the range of 0.018–1.37 cm/sec(0.05–1.43 cm/sec).The spatial distributions of the two-year average V_(d) showed values higher than 1–3 cm/sec for those soluble and reactive species over certain land *** species have the highest V_(d) over water surfaces,while insoluble but reactive species have the highest V_(d) over *** V_(d) of PM_(2.5) across the whole domain ranged from 0.039 to 0.75 cm/sec with median(mean)value of 0.18(0.20)cm s^(−1),while the mean V_(d) for PM_(2.5)–10 is twice that of PM_(2.5).Uncertainties in the modeled V_(d) are typically on the order of a factor of 2.0 or larger,which needs to be considered when applying the dataset in other studies.

关键词： Air quality modeling Atmospheric pollutant Atmospheric deposition dry deposition velocity Spatiotemporal distribution

Advanced Endoscopic Palliation of Unresectable Periampullary Carcinoma: A Systematic Review

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Open Journal of Gastroenterology 2022年第10期12卷 249-262页

作者： shailesh Simkhada Shravana Aryal Albert d. Osei Ashik Pokharel Rami Matar Michael Maitar Springfield Memorial Hospital Springfield Illinois USA Southern Illinois University Springfield Illinois USA Medstar Health Internal Medicine Baltimore Maryland USA St. George’s University West Indies Grenada

Background and Aims: Periampullary malignancies often present at an advanced unresectable stage requiring palliation of symptoms for the better quality of life. Though they require multispecialty support;role of endoscopic interventions in palliation is paramount because of the advancement in technology and increase experience of Gastroenterologist. Methods: We did extensive review of articles regarding endoscopic advances in the management of Unresectable Periampullary Malignancies. Several systematic reviews, Meta analysis, and Randomized controlled trials published over the last 2 decades were thoroughly searched on PUBMEd and GOOGLE SCHOLAR. Results: Advanced Endoscopic procedures have been emerging as a superior modality than conventional measures because of minimal invasiveness and greater clinical and technical success. Conclusion: Periampullary malignancies often present at an advanced unresectable stage requiring palliation of symptoms for the better quality of life. Several endoscopic interventions have already been established as the standard of care in palliation of symptoms of unresectable periampullary malignancies, we can say with confidence that with growing advances in EUS, advancement in technologies and increasing experiences, the role of gastroenterologist will be pivotal in these groups of patients.

关键词： Periampullary Malignancies Endoscopic Ultrasound Celiac Plexus Neurolysis ERCP EUS-Bd EUS-GE

Borderline resectable pancreatic tumors:Is there a need for further refinement of this stage?

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Hepatobiliary & Pancreatic diseases International 2011年第3期10卷 319-324页

作者： shailesh V Shrikhande Supreeta Arya Savio George Barreto Sachin Ingle Melroy A d'Souza Rohini Hawaldar Parul J Shukla department of Hepato-Pancreato-Biliary Surgical Oncology department of Radiology Tata Memorial Hospital department of Surgery Royal Adelaide Hospital Clinical Research Secretariat

BACKGROUNd:The ideal treatment of patients with 'borderline resectable pancreatic tumors (BRTs)' needs to be *** protocols advise neoadjuvant chemo(radio)therapy,although some patients may appear to have BRT on preoperative imaging and a complete resection may be achieved without the need for vascular *** aim of the present study was to identify specific findings on preoperative imaging that could help predict in which patients with BRT a complete resection,with or without vascular resection (VR),could be ***:Twelve patients with BRTs were *** location,maximum degree of circumferential contact (CC),length of contact of the tumor with major vessels (LC),and luminal narrowing of vessels at the point of contact with the tumor (venous deformity,Vd) were graded on preoperatively acquired multidetector computed tomography (MdCT) images and then compared with the intraoperative findings and need for ***:A complete resection (R0) was achieved in 10 patients with 2 having microscopic positive margins (R1) on histopathology at the uncinate *** of the 10 patients required VR (40%).In 3 of the 4 patients whose tumors required VRs,CC was ≥grade III and Vd was grade *** did not influence the need for ***:It is possible to achieve a complete resection at the first instance in patients found to have BRTs on preoperative *** MdCT-based grading systems and our proposed criteria may help identify such patients,thus avoiding any delay in curative resections in such patients.

关键词： pancreatic head carcinoma pancreatic cancer pancreatic neoplasms resection

Valorisation of fruit waste for enhanced exopolysaccharide production by Xanthomonas campestries using statistical optimisation of medium and process

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Food Bioscience 2022年第2期46卷 1014-1019页

作者： Avni Vaishnav Kinjal Upadhyay Manoj Koradiya devayani Tipre shailesh dave department of Microbiology School of ScienceGujarat UniversityAhmedabad380009GujaratIndia department of Biochemistry and Biotechnology St.Xavier’s CollegeAhmedabad380009GujaratIndia department of Microbiology L.J.Institutes of Applied SciencesS.G.RoadAhmedabad382210GujaratIndia Xavier Research Foundation Loyola Centre for R&DSt.Xavier’s College CampusAhmedabad380009GujaratIndia

The aim of this research work was to enhance the fermentative production of exopolysaccharide(EPS)with mixed fruit waste as a key *** campestries was isolated from spoiled orange and its EPS production efficiency was determined using EPS *** to optimisation,the production was 3.4 g/L,upon optimizing the medium the production improved to 9.2 g/*** medium formulation was studied by sequential addition of medium components and replacement of sugar with mixed fruit *** formulated medium,the production enhanced to 11.1 g/*** further optimisation,the response surface methodology was used,which resulted in the enhancement of production to 14.5 g/*** scale-up study was undertaken in a 10 L shake flask and *** 10 L flask EPS,production was 14.45 g/L in 100 h,whereas in 10 L fermenter it was 21.10 g/L in 60h *** optimisation studies gave nearly 500%(6.2fold)enhanced EPS production and dwindle in fermentation *** of sucrose with fruit waste extract made the process environment-friendly;omission of L-cystine and use of 50%reduced amount of sodium acetate in the medium lowered the production cost of *** developed process resulted in the utilization of fruit waste and was also useful in solving the fruit waste disposal problem.

关键词： Exopolysaccharide Mixed fruits waste Formulated medium Scale up Response surface methodology

Pancreatic fistula after pancreatectomy:Evolving definitions,preventive strategies and modern management

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World Journal of Gastroenterology 2008年第38期14卷 5789-5796页

作者： shailesh V Shrikhande Melroy A d'Souza department of GI and HPB Surgical Oncology Tata Memorial HospitalMumbai 400-012 India

Pancreatic resection is the treatment of choice for pancreatic malignancy and certain benign pancreatic disorders. However, pancreatic resection is technically a demanding procedure and whereas mortality after a pancreaticoduodenectomy is currently d high-volume centers, post-operative morbidity is considerable, about 30%-50%. At present, the single most significant cause of morbidity and mortality after pancreatectomy is the development of pancreatic leakage and fistula (PF). The occurrence of a PF increases the length of hospital stay and the cost of treatment, requires additional investigations and procedures, and can result in life-threatening complications. There is no universally accepted definition of PF that would allow standardized reporting and proper comparison of outcomes between different centers. However, early recognition of a PF and prompt institution of appropriate treatment is critical to the prevention of potentially devastating consequences. The present article, reviews the evolution of post resection pancreatic fistula as a concept, and discusses evolving definitions, the current preventive strategies and the management of this problem.

关键词：胰切除术胰腺瘘并发症胰腺吻合术

Quality of life and oral potentially malignant disorders: Critical appraisal and prospects

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World Journal of Clinical Oncology 2018年第4期9卷 56-59页

作者： shailesh M Gondivkar Rahul R Bhowate Amol R Gadbail Sachin C Sarode Shankargouda Patil department of Oral Medicine and Radiology Government Dental College and Hospital department of Oral Medicine and Radiology Sharad Pawar Dental College and Hospital department of dentistry Indira Gandhi Government Medical College and Hospital department of Oral Pathology and Microbiology Dr. D.Y. Patil Dental College and Hospital department of Maxillofacial Surgery and diagnostic Sciences Division of Oral Pathology College of Dentistry Jazan University

Quality of life(QoL) is a vital and often required health outcome measure that is relevant to patient care. A healthy oral cavity enables person to perform daily activities without any limitations. However, any disturbance may result in impaired QoL. The oral health-remains an essential element of people's health and well-being. In recent years, the tradition of clinical practice and research has been changed by incorporating QoL assessment, as it helps in assessment of patients' needs and monitoring treatment responses. Oral potentially malignant disorders(OPMds) are a group of chronic disorders including oral leukoplakia(OL), oral lichen planus and oral submucous fibrosis(OSF). It is evident that patients with OPMds experience significant health-related symptoms, functional limitations and psycho-social impairment, compromising their Qo L. Moreover, the worsening of Qo L has been associated with advanced stages of OPMds. despite of increasing number of OPMd cases in recent decades, limited literature is available regarding QoL in this population. Although, there is higher prevalence of habit-related OPMds, particularly OSF and OL in Southern Asian countries, only a few studies have been performed in these populations. Moreover, these studies administered generic Qo L instruments, which offer less sensitivity to clinical changes. However, condition-specific instruments are more sensitive and allows better measurement of QoL. As the impacts of different conditions on OHRQoL may vary, the development and validation of a QoL instrument specific to each clinical entity of OPMds is currently needed.

关键词： Quality of life Oral potentially malignant disorders Oral submucous fibrosis Oral lichen planus Oral leukoplakia

Appendiceal tie syndrome:A very rare complication of a common disease

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World Journal of Gastrointestinal Surgery 2015年第4期7卷 67-70页

作者： Laligen Awale Brikh Raj Joshi Saroj Rajbanshi shailesh Adhikary department of Surgery Gastrointestinal Surgery DivisionBP Koirala Institute of Health Sciences department of Surgery General Surgery DivisionB.P Koirala Institute of Health Sciences

Acute appendicitis is the most common surgical emergency that we encounter. Adynamic Intestinal obstruction due to appendicitis or its complication may be seen time and often. Mechanical obstruction because of appendicitis is uncommon and even rarer for a closed loop obstruction to occur. Although it was described as early as 1901, very few cases have been reported. We report the case of a 20 years male who presented with generalized colicky pain abdomen, abdominal distension, vomiting and obstipation for three to four days. Vital signs were stable. His abdomen was distended and peritonitic, especially in the right iliac fossa. Rest of the physical examination was unremarkable. Blood tests were normal except for leucocytosis with neutrophilia. An abdominal X-ray finding was indicating a small bowel obstruction. A midline laparotomy was performed. On intraoperative examination, distended loops of small bowel from the jejunum to the distal ileum was observed, and a constricting ring around the terminal ileum created by a phlegmonous appendicitis with its tip adherent to the root of mesentery was found, obstructing an edematous loop of small bowel without signs of ischemia. As the bowel was viable simple appendectomy was done. Postoperatively, he had an uneventful recovery and was discharged after 3 d.

关键词： Appendicitis Appendicular band Intestinalobstruction Mechanical small bowel obstruction Closedloop obstruction

Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification

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Bone Research 2019年第4期7卷 371-387页

作者： Charles Hwang Simone Marini Amanda KHuber david MStepien Michael Sorkin Shawn Loder Chase APagani John Li Noelle dVisser Kaetlin Vasquez Mohamed AGarada Shuli Li Jiajia Xu Ching-Yun Hsu Paul BYu Aaron WJames Yuji Mishina shailesh Agarwal Jun Li Benjamin Levi department of Surgery University of MichiganAnn ArborMI 48109USA department of Computational Medicine and Bioinformatics University of MichiganAnn ArborMI 48109USA department of Pathology Johns Hopkins UniversityBaltimoreMD 21218USA division of Cardiovascular Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA department of Biologic and Materials Sciences&Prosthodontics School of DentistryUniversity of MichiganAnn ArborMI 48109USA

Heterotopic ossification(HO)is a debilitating condition characterized by the pathologic formation of ectopic *** occurs commonly following orthopedic surgeries,burns,and neurologic *** surgical excision may provide palliation,the procedure is often burdened with significant intra-operative blood loss due to a more robust contribution of blood supply to the pathologic bone than to native *** on these clinical observations,we set out to examine the role of vascular signaling in *** endothelial growth factor A(VEGFA)has previously been shown to be a crucial pro-angiogenic and pro-osteogenic cue during normal bone development and *** findings,using a validated mouse model of HO,demonstrate that HO lesions are highly vascular,and that VEGFA is critical to ectopic bone formation,despite lacking a contribution of endothelial cells within the developing anlagen.

关键词： VEGFA injuries ossification

APE/Ref-1激活Akt通路保护HUVECs免于去血清培养诱导的细胞凋亡

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APE/Ref-1激活Akt通路保护HUVECs免于去血清培养诱导的细胞凋亡