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Unusual presentation of glomus tympanicum tumour: New bone formation in the middle ear

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World Journal of Clinical Cases 2014年第9期2卷 463-465页

作者： gaurav Kumar Zenon Andreou Jagdeep singh Virk Anthony Owa ENT Department Queen’s Hospital Romford Essex RM7 0AG United Kingdom

The objective of this study is to increase awareness of the rare presentation, diagnostic difficulties and management of glomus tympanicum of the middle ear. A 49 years old male, with a background of hypertension and epilepsy, presented with a two month history of left sided conductive hearing loss, pulsatile tinnitus and headache. Clinically and radiologically a diagnosis of glomus tympanicum was made. Intraoperatively, extensive osteogenesis of the middle ear resulting in ossicular fixation and erosion was found. This patient required a two stage operation for full clearance of disease. A stapedectomy drill was used to drill off the bony overgrowth surrounding the ossicles resulting in improved hearing thresholds and full clearance of the disease at two year follow up. Glomus tympanicum can result in new bone formation in the middle ear with resultant ossicular fixation and conductive hearing loss. This can be effectively treated surgically with restoration of hearing.

关键词： Glomus Tympanicum Osteogenesis conductive hearing loss

Photoluminescence behavior and visible light photocatalytic activity of ZnO,ZnO/ZnS and ZnO/ZnS/α-Fe_2O_3 nanocomposites

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Transactions of Nonferrous Metals Society of China 2018年第7期28卷 1387-1397页

作者： gaurav HITKARI Sandhya singh Gajanan PANDEY Sophisticated Instrumentation Laboratory Department of Applied Chemistry School for Physical Science Babasaheb Bhimrao Ambedkar University

In order to achieve effective, economic, and easily achievable photocatalyst for the degradation of dye methyl orange（MeO）, ZnO, ZnO/ZnS and ZnO/ZnS/α-Fe2O3 nanocomposites were prepared by simple chemical synthetic route in the aqueous medium. Phase, crystallinity, surface structure and surface behavior of the synthesized materials were determined by X-ray diffraction（XRD） and Brunauer-Emmett-Teller analysis（BET） techniques. XRD study established formation of good crystalline ZnO, ZnO/ZnS and ZnO/ZnS/α-Fe2O3 nanomaterials. By using intensity of constituent peaks in the XRD pattern, the compositions of nanocomposites were determined. From the BET analysis, the prepared materials show mesoporous behavior, type Ⅳ curves along with H4 hysteresis. The ZnO/ZnS/α-Fe2O3 composite shows the largest surface area among three materials. From the UV-visible spectra, the band gap energy of the materials was determined. Photoluminescence spectra（PL） were used to determine the emission behavior and surface defects in the materials. In PL spectra, the intensity of UV peak of ZnO/ZnS is lowered than that of ZnO while in case of ZnO/ZnS/α-Fe2O3, the intensity further decreased. The visible emission spectra of ZnO/ZnS increased compared with ZnO while in ZnO/ZnS/α-Fe2O3 it is further increased compared with ZnO/ZnS. The as-synthesized materials were used as photocatalysts for the degradation of dye MeO. The photo-degradation data revealed that the ZnO/ZnS/α-Fe2O3 is the best photocatalyst among three specimens for the degradation of dye MeO. The decrease of intensity of UV emission peak and the increase of intensity of visible emission cause the decrease of recombination of electrons and holes which are ultimately responsible for the highest photocatalytic activity of ZnO/ZnS/α-Fe2O3.

关键词： nanocomposite ZnO ZnS α-Fe2O3 calcination optical properties photocatalytic activity

Novel CMS lines in pigeonpea[Cajanus cajan(L.)Millspaugh]derived from cytoplasmic substitutions,and their effective restoration and deployment in hybrid breeding

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The Crop Journal 2017年第1期5卷 89-94页

作者： Abhishek Bohra Rintu Jha Indra Prakash singh gaurav Pandey Shalini Pareek Partha Sarathi Basu Sushil Kumar Chaturvedi Narendra Pratap singh ICAR Indian Institute of Pulses Research(IIPR)Kanpur 208024India

The availability of stable cytoplasmic male sterile(CMS or A) lines coupled with a robust restoration system(R lines) is an essential prerequisite for efficient hybrid ***-enabled hybrid technology holds immense potential to enhance the long-stagnant productivity of pigeonpea. In the present investigation, cytoplasmic substitutions were made in the nuclear backgrounds of early-maturing pigeonpea varieties or lines. Three new CMS lines(ICPL 88039 A, Pusa 992 A, and DPP 3-2A) resulted from genetic crosses involving cytoplasmic donors from A2(GT 288A) and A4(ICPA 2089) categories. In addition to visual inspection of anthers, pollen-staining techniques and scanning electron microscopy(SEM)analysis were used to confirm pollen sterility. Further, given the relevance of the plant mitochondrial genome to CMS manifestation, 25 mitochondrion-specific DNA markers were assayed on these newly developed A lines and isogenic maintainer(B) lines. DNA polymorphism between Pusa 992 A and Pusa 992 B as revealed by the nad7a_del marker confirmed the successful combination of sterilizing cytoplasm(A4) and nonrestoring nuclear background(Pusa 992). Such cytoplasm-specific DNA markers are required for A2-CMS as well. Further, to assess restoration ability, potential restorers were crossed with these CMS lines, and as a consequence, promising A × R combinations exhibiting 100%pollen fertility could be identified. In parallel, we also analyzed the inheritance patterns underlying fertility restoration using ICPL 88039A-derived F2 and BC1F1populations,and established a monogenic dominant model to explain the phenomenon of A2-CMS restoration. In summary, we report the successful development of new CMS lines and describe their effective deployment in hybrid breeding of pigeonpea.

关键词： Cytoplasm Hybrid Mitochondria Pigeonpea Restorer Sterility

Identification,development,and application of cross-species intron-spanning markers in lentil(Lens culinaris Medik.)

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The Crop Journal 2018年第3期6卷 299-305页

作者： Debjyoti Sen Gupta Jitendra Kumara Sunanda Gupta Sonali Dubey Priyanka Gupta Narendra Pratap singh gaurav Sablok Division of Crop Improvement ICAR-Institute of Pulses ResearchKanpur 208024UPIndia Division of Plant Biotechnology ICAR-Institute of Pulses ResearchKanpur 208024UPIndia Department of Biodiversity and Molecular Ecology Research and Innovation CentreFondazione Edmund MachVia E.Mach 138010 San Michele all'AdigeTrentoItaly

Lentil(Lens culinaris Medik) is one of the most important food legumes in the world. The use in lentil of molecular marker-assisted breeding is limited, owing to the low availability of polymorphic markers. In the present study, we developed a set of polymorphic intron-spanning markers(ISMs) using a cross-species mapping approach. In this approach, putative unique transcripts(PUTs) of L. culinaris were mapped onto the Medicago truncatula genome, exploiting its closeness with the lentil genome. Spliced alignment of the PUTs resulted in a total of 25,717 alignments, allowing the development of 1703 ISMs. From these, a subset of 105 ISMs were synthesized and validated with a 51% amplification success rate in 32 lentil genotypes. Of these ISMs, 40(74%) were polymorphic and generated 2–11 alleles per locus in a genetically diverse panel of 32 lentil genotypes including wild *** set of polymorphic ISMs along with their functional annotation data will be useful in lentil breeding.

关键词： Allele diversity Cross-species Genotypes Introns Lentil Molecular markers

An Intelligent Fine-Tuned Forecasting Technique for Covid-19 Prediction Using Neuralprophet Model

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Computers, Materials & Continua 2022年第4期71卷 629-649页

作者： Savita Khurana gaurav Sharma Neha Miglani Aman singh Abdullah Alharbi Wael Alosaimi Hashem Alyami Nitin Goyal Information Technology Department Seth Jai Parkash Mukand Lal Institute of Engineering and TechnologyRadaurHaryanaIndia Computer Science&Engineering Department Seth Jai Parkash Mukand Lal Institute of Engineering and TechnologyRadaurHaryanaIndia Computer Engineering Department National Institute of TechnologyKurukshetraHaryanaIndia Computer Science&Engineering Department Lovely Professional UniversityJalandharPunjabIndia Department of Information Technology College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia Department of Computer Science College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia Chitkara University Institute of Engineering and Technology Chitkara UniversityPunjabIndia

COVID-19,being the virus of fear and anxiety,is one of the most recent and emergent of various respiratory *** is similar to the MERS-COV and SARS-COV,the viruses that affected a large population of different countries in the year 2012 and 2002,*** standard models have been used for COVID-19 epidemic prediction but they suffered from low accuracy due to lesser data availability and a high level of *** proposed approach used a machine learning-based time-series Facebook NeuralProphet model for prediction of the number of death as well as confirmed cases and compared it with Poisson Distribution,and Random Forest *** analysis upon dataset has been performed considering the time duration from January 1st 2020 to16th July *** model has been developed to obtain the forecast values till September *** study aimed to determine the pandemic prediction of COVID-19 in the second wave of coronavirus in India using the latest Time-Series model to observe and predict the coronavirus pandemic situation across the *** India,the cases are rapidly increasing day-by-day since mid of Feb *** prediction of death rate using the proposed model has a good ability to forecast the COVID-19 dataset essentially in the second *** empower the prediction for future validation,the proposed model works effectively.

关键词： Covid-19 machine learning neuralprophet model poisson distribution prediction random forest model

Risk of pancreatic cancer in individuals with celiac disease in the United States:A population-based matched cohort study

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World Journal of Gastrointestinal Oncology 2023年第3期15卷 523-532页

作者： Arunkumar Krishnan Yousaf Bashir Hadi Sarah Shabih Diptasree Mukherjee Ruhee A Patel Rushik Patel shailendra singh Shyam Thakkar Section of Gastroenterology&Hepatology West Virginia University School of MedicineMorgantownWV 26505United States Department of Medicine Apex Institute of Medical ScienceKolkata 700075West BengalIndia

BACKGROUND Celiac disease(CD)has been associated with gastrointestinal ***,the magnitude of the risk of pancreatic cancer(PC)associated with CD is much less clear,and risks have not been estimated from large *** To assess the risk of PC in CD *** We conducted a population-based,multicenter,propensity score-matched cohort study with consecutive patients diagnosed with CD using the TriNeTx research network *** examined the incidence of PC in patients with CD compared with a matched cohort of patients without CD(non-CD,controls).Each patient in the main group(CD)was matched to a patient in the control group using 1:1 propensity score matching to reduce confounding *** incidence of PC was estimated using a Cox proportional hazards model with a hazard ratio(HR)and 95%confidence interval(CI).RESULTS A total of 389980 patients were included in this *** them,155877 patients had a diagnosis of CD,and the remaining 234103 individuals without CD were considered a control *** mean duration of follow-up for patients in the CD and control cohorts was 5.8±1.8 and 5.9±1.1 years,*** the follow-up,309 patients with CD developed PC,whereas 240 patients developed PC in the control group(HR=1.29;95%CI:1.09-1.53).In the secondary analyses in the first year after diagnosis of CD,patients with CD were at a significant increase in risk for PC;151 patients with CD had an incidence of PC compared with 96 incidences of PC among the patients in the non-CD control group(HR=1.56;95%CI:1.20-2.01)and sensitivity analysis showed similar magnitude to the one generated in the primary and secondary *** Patients with CD are at increased risk of *** elevation persists beyond the first year after diagnosis to reference individuals without CD from the general population.

关键词： Celiac disease Cancer Epidemiology Pancreas Pancreatic cancer Malignancy Carcinoma

A transient shift in equatorial hydrology and vegetation during the Eocene Thermal Maximum 2

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Geoscience Frontiers 2024年第5期15卷 174-181页

作者： gaurav Srivastava Harshita Bhatia Poonam Verma Yogesh P.singh Shailesh Agrawal Torsten Utescher R.C.Mehrotra Birbal Sahni Institute of Palaeosciences 53 University RoadLucknow 226007India Academy of Scientific and Innovative Research(AcSIR) Ghaziabad 201002India Senckenberg Research Institute and Natural History Museum Frankfurt/M.Senckenberg Research Station of Quaternary PalaeontologyWeimerGermany Institute for Geosciences University of BonnNussallee 853115 BonnGermany

The equatorial evergreen forests nourish the world’s biodiversity hotspots and are considered the lungs of the ***,their future survival is uncertain,due to anthropogenically increased carbon emissions and changes in the hydrological *** the changes in the hydrological cycle in the equatorial region due to an increase in carbon emission is of prime *** early Paleogene hyperthermal events are potential analogs to understand the consequences of high carbon emission on the hydrological *** this communication,we quantify the terrestrial seasonal climate using the plant proxy and infer that during the Eocene Thermal Maximum 2 when atmospheric carbon dioxide concentration was>1000 ppmv near the palaeo-equator(~0.6°N),the rainfall decreased significantly,leading to the expansion of deciduous *** study raises important questions about the future survival of equatorial rainforests and biodiversity hotspots under increased carbon emissions.

关键词： Coexistence approach Climate ETM-2 Global warming Hyperthermal Paleogene

Experimental and Finite Element Analysis of Corroded High-Pressure Pipeline Repaired by Laminated Composite

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1783-1806页

作者： Seyed Mohammad Reza Abtahi Saeid Ansari Sadrabadi Gholam Hosein Rahimi gaurav singh Hamid Abyar Daniele Amato Luigi Federico Faculty of Mechanical Engineering Tarbiat Modares UniversityTehran***Iran A.Leon Linton Department of Mechanical Robotics and Industrial EngineeringLawrence Technological UniversitySouthfieldMI48075USA Department of Mechanical Engineering Faculty of EngineeringMeybod UniversityYazd***Iran Department of Industrial Engineering University of SalernoVia Giovanni PaoloⅡFiscianoItaly Italian Aerospace Research Center(C.I.R.A.) Via MaioriseCapuaCE81043Italy

Repairs of corroded high-pressure pipelines are essential for fluids transportation under high *** of the methods used in their repairs is the use of layered *** composite used must have the necessary ***,the experiments and analytical solutions presented in this paper are performed according to the relevant standards and codes,including ASME PCC-2,ASME B31.8S,ASME B31.4,ISO 24817 and ASME *** addition,the experimental tests are replicated numerically using the finite element *** the strain gauges at different distances from the defect location,can reduce the nonlinear effects,deformation,and fluctuations due to the high *** direct relationship between the depth of an axial defect and the stress concentration is observed at the inner side edges of the *** reparation reduces the non-linearities related to the sharp variation of the geometry and a more reliable numerical simulation could be performed.

关键词： High-pressure pipeline composite repair ASME PCC-2 ISO 24817

Complexities of practicing architectural regionalism in India:An interview study

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Frontiers of Architectural Research 2020年第3期9卷 568-578页

作者： Sanyam Bahga gaurav Raheja Department of Architecture and Planning Indian Institute of Technolosy RoorkeeRoorkeeIndia

This paper presents the results and analysis from an interview study conducted with practitioners of architectural regionalism in *** interviews sought to gain indepth understanding of the strategies,mechanisms,and tools they employ to realize contextualized architecture that responds to local needs and potential.A sample composed of nine eminent Indian architects who regularly integrate the ideas of critical regionalism in their designs is selected and subsequently interviewed with regard to the varied aspects of their architectural *** are useful for practitioners and scholars of contemporary architecture in India for understanding the means employed by leading regionalist architects,while placing their work in the context of local building traditions,urban landscape,sociocultural conditions,technology,and climate.

关键词： Architectural regionalism Critical regionalism Indian architecture Architects’interviews Semi-structured interviews Architecture practice