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Antidiabetic Drugs in Combination with Hydroxychloroquine Improve Glycemic Control in Alloxan Induced Diabetic Rats

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Pharmacology & Pharmacy 2014年第7期5卷 725-735页

作者： Shaheda Zannah Md. Saiful Islam A. F. M. Towheedur Rahman Md. Asaduzzaman abdul Alim Al Bari Yusuf Ali Gazi Jahirul Islam A. H. M. Khurshid Alam Hazrat Ali Mamunur rashid Department of Chemistry Khulna University of Engineering and Technology Khulna Bangladesh Department of Pharmacy University of Rajshahi Rajshahi Bangladesh

Worldwide prevalence of diabetes mellitus has become an issue of great concern in current decades. This life threatening disease is associated with worsening of glycemic control and progressive metabolic dysfunctions. Objective: Current study aimed to investigate the effect of hydroxychloroquine (HCQ) as an adjunct to glibenclamide or metformin on glycemic control in alloxan induced diabetic rats. Methods: HCQ was combined separately with two conventional anti-diabetic drugs;glibenclamide and metformin. At first, alloxan (120 mg/kg) induced diabetic rats were treated with single dose of metformin (850 mg/70 kg BW), glibenclamide (10 mg/70 kg BW) and HCQ (300 mg/70 kg BW) intraperitoneally once daily for two weeks. Then non fixed dose combinations of glibenclamide (5 mg/70 kg BW) with HCQ (150 mg/70 kg BW) and metformin (425 mg/70 kg BW) with HCQ (150 mg/70 kg BW) were injected along with those of the three drugs alone once daily for four weeks. Results: In alloxan induced diabetic rats, glibenclamide, metformin and their combination therapies reduced blood glucose level significantly but combination therapies are the most effective. Glibenclamide or metformin in combination with HCQ also significantly (P < 0.05) reduced the elevated levels of total cholesterol, triglycerides, and low density lipoprotein cholesterol (LDL-C) level and increased high density lipoprotein cholesterol (HDL-C) level. Moreover, HCQ potentiates the liver glycogen synthesis of metformin or glibenclamide. Conclusion: Outcomes of this investigation indicate that combination of glibenclamide or metformin with HCQ improves glycemic control and provides additional metabolic benefits, not achieved with either glibenclamide or metformin alone.

关键词： Diabetes Mellitus Glycemic Control HCQ Glibenclamide Metformin

Assessment of Biochemical and Antioxidative Status in Patients Suffering from Dengue Fever

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2015年第3期35卷 411-418页

作者： Mahmood Rasool Arif Malik Khalid Mahmud Khan Muhammad Saeed Qureshi Beenish Shabbir Sara Zahid Muhammad Asif abdul Manan Sana rashid Saima Rubab Khan Hafiz Muhammad Arsalan Rabail Alam Mahwish Arooj Mahmood Husain Qazi Adeel Gulzar Ahmed Chaudhary Adel Mohammed Abuzenadah Mohammed Hussain Al-Qahtani Sajjad Karim Center of Excellence in Genomic Medicine Research Faculty of Applied Medical SciencesKing Abdulaziz University Institute of Molecular Biology and Biotechnology the University of Lahore Fatima Jinnah Medical College Sir Gangaram Hospital Lahore Institute of Molecular Biology and Biotechnology the University of Lahore Department of Biotechnology and Informatics BUITEMS Quetta 87300 Pakistan Center for Research in Molecular Medicine the University of Lahore KACST Technology Innovation Center in Personalized Medicine King Abdulaziz University Center of Excellence in Genomic Medicine Research Faculty of Applied Medical Sciences King Abdulaziz University

Summary：A multi-centred study was designed to collect dengue epidemiologic data from government and registered private hospitals/clinics and maintained archive of frozen specimens in bio-bank to be used for future dengue epidemic control program, and assess the epidemiology of dengue fever（DF） by evaluating biochemical and oxidative status of patients. ELISA Ig M antibodies test was done to confirm DF. From August 2010 to December 2011, 101 confirmed blood samples of DF patients referred to pathology lab of Jinnah Hospital Lahore were subjected to the epidemiologic assessment by evaluating the biochemical and physiological indices and alterations of circulating antioxidants. Clinical features of DF patients and effect of fever on blood components and serum proteins of liver were recorded. The hospital stay in DF, dengue hemorrhagic fever（DHF） and dengue shock syndrome（DSS） showed significant difference. Significant increases in serum alanine amino transferase（ALT）（P=0.000）, aspartate amino transferase（AST）（P=0.000）, alkaline phosphatase（ALP）（P=0.000）, malondialdehyde（MDA） along with significant decreases in total protein（TP）（P=0.000）, reduced glutathione（GSH）（P=0.000）, superoxide dismutase（SOD）, catalase（CAT）（P=0.000）, and sialic acid contents（P=0.016） were observed. A positive correlation existed between bound sialic acid levels, liver enzymes and circulating antioxidants（r=0.656, P=0.016）. In the present study, alterations of circulating antioxidants in DF suggest that DF might be a metabolic response to an acute, self-limiting tropical viral infection, and a consequence of the viral inflammatory process.

关键词： dengue fever alanine amino transferase aspartate amino transferase malondialdehyde superoxide dismutase catalase

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求解绝对值方程的两种广义超松弛方法

数学理论与应用 2020年第4期40卷 44-55页

作者： rashid Ali 潘克家 Asad Ali 中南大学数学与统计学院长沙410083 Department of Mathematics Abdul Wali Khan University Mardan 23200KPK Pakistan

绝对值方程广泛存在于运筹学、管理科学和工程领域中。对于给定的绝对值方程Ax-|x|=b,其中A为任意实矩阵,提出并分析了求解绝对值方程的广义超松弛(GSOR)方法和改进广义超松弛(MGSOR)方法.此外,研究了这两种方法的收敛性.最后,通过数值... 详细信息

绝对值方程广泛存在于运筹学、管理科学和工程领域中。对于给定的绝对值方程Ax-|x|=b,其中A为任意实矩阵,提出并分析了求解绝对值方程的广义超松弛(GSOR)方法和改进广义超松弛(MGSOR)方法.此外,研究了这两种方法的收敛性.最后,通过数值实验来验证所提方法的有效性.

关键词：绝对值方程广义超松弛(GSOR)方法改进广义超松弛(MGSOR)方法数值实验

A multi-purpose National Forest Inventory in Bangladesh:design,operationalisation and key results

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Forest Ecosystems 2021年第1期8卷 151-172页

作者： Matieu Henry Zaheer Iqbal Kristofer Johnson Mariam Akhter Liam Costello Charles Scott Rashed Jalal Md.Akhter Hossain Nikhil Chakma Olaf Kuegler Hossain Mahmood Rajib Mahamud Mohammad Raqibul Hasan Siddique Khaled Misbahuzzaman Mohammad Main Uddin Mohammed Al Amin Farid Uddin Ahmed Gael Sola Md.Baktiar Siddiqui Luca Birigazzi Mahmudur Rahman Ilias Animon Saimunnahar Ritu Laskar Muqsudur Rahman Aminul Islam Heather Hayden Frida Sidik Mondal Falgoonee Kumar Rakibul Hassan Mukul Hossain Nishad Ariful Hoque Belal Asif Reza Anik abdul Khaleque Md.Shaheduzzaman Syed Shahadat Hossain Tariq Aziz Md.Tauhidor Rahaman Ruhul Mohaiman Patrick Meyer Purnata Chakma A.Z.M.Manzoor rashid Sourav Das Shrabanti Hira Mohammed Jashimuddin Mohammad Mahfuzur Rahman Karl Wurster Sarder Nasir Uddin Abul Kalam Azad S.M.Zahirul Islam Laurent Saint-André Food and Agriculture Organization of the United Nations Viale delle Terme di Caracalla00153 RomeItaly Forest Department Ministry of EnvironmentForests and Climate ChangeBan BhabanShere Bangla NagarAgargaonDhaka 1207Bangladesh School of Ecosystem and Forest Sciences University of MelbourneParkville VictoriaMelbourne 3010Australia United States Forest Service(USFS)/SilvaCarbon WashingtonD.CUSA Institute of Forestry and Environmental Sciences(IFES) University of ChittagongChattogramBangladesh Department of Forestry and Environmental Science Rangamati Science and Technology UniversityRangamatiBangladesh Forestry and Wood Technology Discipline Khulna UniversityKhulnaBangladesh School of Biological Sciences The University of QueenslandQLDBrisbane 4072Australia Arannyak Foundation DhakaBangladesh United Nations Framework Convention on Climate Change(UNFCCC) BonnGermany Bangladesh Space Research and Remote Sensing Organization(SPARRSO) DhakaBangladesh Institute for Marine Research and Observation Ministry of Marine Affairs and FisheriesNegaraBaliIndonesia Department of Agricultural Economics Bangabandhu Sheikh Mujibur Rahman Agricultural University(BSMRAU)GazipurBangladesh Bangladesh Bureau of Statistics(BBS) DhakaBangladesh Institute of Statistical Research and Training University of DhakaDhakaBangladesh United States Agency for International Development(USAID) DhakaBangladesh Department of Forestry and Environmental Science Shahjalal University of Science and TechnologyKumargaonSylhetBangladesh Department of Biological Sciences Faculty of Science and EngineeringMacquarie UniversitySydneyAustralia Bangladesh National Herbarium(BNH) Zoo RoadMirpurDhakaBangladesh Bangladesh Forest Research Institute(BFRI) SholoshaharChottogramBangladesh National Research Institute for Agriculture Food and Environment(INRAE)ParisFrance

Background:National forest inventory and forest monitoring systems are more important than ever considering continued global degradation of trees and *** systems are especially important in a country like Bangladesh,which is characterised by a large population density,climate change vulnerability and dependence on natural *** the aim of supporting the Government’s actions towards sustainable forest management through reliable information,the Bangladesh Forest Inventory(BFI)was designed and implemented through three components:biophysical inventory,socio-economic survey and remote sensing-based land cover *** article documents the approach undertaken by the Forest Department under the Ministry of Environment,Forests and Climate Change to establish the BFI as a multipurpose,efficient,accurate and replicable national forest *** design,operationalization and some key results of the process are ***:The BFI takes advantage of the latest and most well-accepted technological and methodological ***,it was designed through a collaborative process which drew from the experience and knowledge of multiple national and international ***,1781 field plots were visited,6400 households were surveyed,and a national land cover map for the year 2015 was *** technological enhancements include a semi-automated segmentation approach for developing the wall-to-wall land cover map,an object-based national land characterisation system,consistent estimates between sample-based and mapped land cover areas,use of mobile apps for tree species identification and data collection,and use of differential global positioning system for referencing plot ***:Seven criteria,and multiple associated indicators,were developed for monitoring progress towards sustainable forest management goals,informing management decisions,and national and international reporting needs.A wide range of biophysica

关键词： South-Asia Forest monitoring Innovation Remote sensing Socio-economic Partnership Ecosystem services Carbon sequestration

Risk and predictors of severity and mortality in patients with type 2 diabetes and COVID-19 in Dubai

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World Journal of Diabetes 2023年第8期14卷 1259-1270页

作者： Fatheya Alawadi Alaaeldin Bashier Azza abdulaziz Bin Hussain Nada Al-Hashmi Fawzi Al Tayb Bachet Mohamed Mahmoud Aly Hassanein Marwan Abdelrahim Zidan Rania Soued Amar Hassan Khamis Debasmita Mukhopadhyay Fatima abdul Aya Osama Fatima Sulaiman Muhammad Hamed Farooqi Riad Abdel Latif Bayoumi Department of Endocrinology Dubai Academic Health CorporationDubaiUnited Arab Emirates Department of Medical Education and Research Dubai Academic Health CorporationDubaiUnited Arab Emirates Department of Radiology Mediclinic City HospitalDubaiUnited Arab Emirates College of Medicine Mohamed Bin Rashid University of Medicine and Health SciencesDubaiUnited Arab Emirates Dubai Diabetes Center Dubai Academic Health CorporationDubaiUnited Arab Emirates Basic Medical Sciences College of MedicineMohammed Bin Rashid University of Medicine and Health SciencesDubaiUnited Arab Emirates

BACKGROUND Globally,patients with diabetes suffer from increased disease severity and mortality due to coronavirus disease 2019(COVID-19).Old age,high body mass index(BMI),comorbidities,and complications of diabetes are recognized as major risk factors for infection severity and *** To investigate the risk and predictors of higher severity and mortality among inhospital patients with COVID-19 and type 2 diabetes(T2D)during the first wave of the pandemic in Dubai(March–September 2020).METHODS In this cross-sectional nested case-control study,a total of 1083 patients with COVID-19 were *** study included 890 men and 193 *** these,427 had T2D and 656 were *** clinical,radiographic,and laboratory data of the patients with and without T2D were *** predictors of mortality in COVID-19 non-survivors were identified in patients with and without *** T2D patients with COVID-19 were older and had higher BMI than those without *** had higher rates of comorbidities such as hypertension,ischemic heart disease,heart failure,and more life-threatening *** laboratory parameters of disease severity were significantly higher than in those without ***,these patients had a longer hospital stay and a significantly higher mortality *** died from COVID-19 at a rate three times higher than patients *** laboratory and radiographic severity indices in non-survivors were high in patients with and without *** the univariate analysis of the predictors of mortality among all COVID-19 non-survivors,significant associations were identified with old age,increased white blood cell count,lymphopenia,and elevated serum troponin *** multivariate analysis,only lymphopenia was identified as an independent predictor of mortality among T2D *** Patients with COVID-19 and T2D were older with higher BMI,more comorbidities,higher disease severity indices,more severe proinflamma

关键词： Type 2 diabetes COVID-19 Risk factors Mortality United Arab Emirates