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An assessment of racial differences in epidemiological, clinical and psychosocial factors among head and neck cancer patients at the time of surgery

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World journal of Otorhinolaryngology-Head and Neck Surgery 2020年第1期6卷 41-48页

作者： Anvesh Kompelli Kathleen B.Cartmell Katherine R.Sterba Anthony j.Alberg Christopher C.Xiao Amit j.Sood Elizabeth Garrett-Mayer shai j.white-gilbertson Steven A.Rosenzweig Terry A.Day Department of Otoloryngology-Head and Neck Surgery Medical University of South Carolina(MUSC)CharlestonSC29425USA College of Nursing MUSCCharlestonSC29425USA Hollings Cancer Center MUSCCharlestonSC29425USA Department of Public Health Sciences MUSCCharlestonSC29425USA Cancer Resistry Hollings Cancer CenterMUSCCharlestonSC29425USA Department of Pharmacology MUSCCharlestonSC29425USA

Objective:Racial disparities have been well characterized and African American(AA)patients have 30%lower 5-year survival rates than European Americans(EAs)for head and neck squamous carcinoma(HNSCC).This poorer survival can be attributed to a myriad of different *** purpose of this study was to characterize AA-EA similarities and differences in sociodemographic,lifestyle,clinical,and psychosocial characteristics in HNSCC patients near the time of ***:Setting:Single tertiary care ***:Thirty-nine newly diagnosed,untreated HNSCC patients(n=24 EAs,n=15 AAs)who were to undergo surgery were *** Design:Cross-sectional study Sociodemographic,lifestyle factors,and disease factors(cancer site,AjCC clinical and pathologic stage,and HPV status)were *** factors,leisure time,quality of life and social support were also assessed using validated ***:EA and AA patients were similar in the majority of sociodemographic factors *** had a higher trend toward pathologically later stage disease compared to EAs and significantly increased time to ***:EA and AA patients were similar in the majority of sociodemographic factors *** had a higher trend toward pathologically later stage disease compared to *** also had significantly increased time to treatment(P=0.05).The majority of AA patients(62%)had later stage pathologic *** were less likely to complete high school or college(P=0.01)than their EA ***,AAs were more likely to report having a gap in health insurance during the past decade(37%vs.15%).Conclusions:This preliminary study demonstrates a similar profile of demographics,clinical and psychosocial characteristics preoperatively for AAs and *** differences were AAs tending to have later pathologic stage disease,educational status,delays in treatment initiation,and gaps in health insurance.

关键词： Head and neck cancer Healthcare disparities Treatment delay Health services Quality care HPV

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First isolation of glutinol and a bioactive fraction with good antiinflammatory activity from n-hexane fraction of Peltophorum africanum leaf

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Asian Pacific journal of Tropical Medicine 2017年第1期10卷 42-46页

作者： Salmon A Adebayo Leshweni j shai jacobus N Eloff Phytomedicine Programme Department of Paraclinical SciencesUniversity of Pretoria Department of Biomedical Sciences Faculty of ScienceTshwane University of Technology

Objective: To investigate the anti-inflammatory activity of different fractions and glutinol(isolated compound),using nitric oxide synthase and cyclooxygenase(COX) inhibition as an indication of anti-inflammatory activity,Methods: Anti-inflammatory activity was evaluated using an in vitro assay determining the inhibition of the activity of pro-inflammatory enzyme model,Cyclooxygenases and inducible nitric oxide synthase are crucial enzymes involved in the pathogenesis of many chronic inflammatory conditions,Results: Sub-fraction F3.3 that was derived from n-hexane fraction of PA leaves significantly inhibited(P = 0.01) the catalytic activity of COX-2(IC50 = 0.67 μg/m L) better than isolated compound,glutinol(IC50 = 1.22 μg/m L),compound 2(CP2)(IC50 = 1.71 μg/m L) and sub-fraction F3.3.0(IC50 = 1.30 μg/m L),A similar trend was observed in investigation of the inhibition of nitric oxide synthesis in RAW 264.7 cells by F3.3,glutinol,CP2 and F3.3.0,Inducible COX-2 and inducible nitric oxide synthase are among potent signalling enzymes that exacerbate inflammation,Conclusions: Bioactive sub-fractions(F3.3 and F3.3.0) derived from the n-hexane fraction of PA had good anti-inflammatory activity,and the isolated compound,and glutinol may be useful as a template for the development of new anti-inflammatory drugs.

关键词： Peltophorum africanum COX-1/COX-2 iNOS Nitric oxide Anti-inflammatory

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Multicenter evaluation of recurrence in endoscopic submucosal dissection and endoscopic mucosal resection in the colon:A Western perspective

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World journal of Gastrointestinal Endoscopy 2023年第6期15卷 458-468页

作者： Mike T Wei Margaret j Zhou Andrew A Li Andrew Ofosu joo Ha Hwang shai Friedland Department of Gastroenterology and Hepatology Stanford University Medical CenterPalo AltoCA 94306United States Department of Gastroenterology University of Cincinnati College of MedicineCincinnatiOH 45267United States

BACKGROUND While colon endoscopic mucosal resection(EMR)is an effective technique,removal of larger polyps often requires piecemeal resection,which can increase recurrence *** submucosal dissection(ESD)in the colon offers the ability for en bloc resection and is well-described in Asia,but there are limited studies comparing ESD vs EMR in the *** To evaluate different techniques in endoscopic resection of large polyps in the colon and to identify factors for *** The study is a retrospective comparison of ESD,EMR and knife-assisted endoscopic resection performed at Stanford University Medical Center and Veterans Affairs Palo Alto Health Care System between 2016 and ***-assisted endoscopic resection was defined as use of electrosurgical knife to facilitate snare resection,such as for circumferential ***≥18 years of age undergoing colonoscopy with removal of polyp(s)≥20 mm were *** primary outcome was recurrence on *** A total of 376 patients and 428 polyps were *** polyp size was greatest in the ESD group(35.8 mm),followed by knife-assisted endoscopic resection(33.3 mm)and EMR(30.5 mm)(Pjusted for polyp size was found to significantly reduce risk of recurrence[adjusted hazard ratio 0.06(95%CI:0.01-0.57,P=0.014)].CONCLUSION In our study,EMR had significantly higher recurrence compared to ESD and knife-assisted endoscopic *** found factors including resection by ESD,en bloc removal,and use of circumferentia

关键词： Endoscopic mucosal resection Endoscopic submucosal dissection Recurrence Colonoscopy Polypectomy

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中国肥胖及代谢疾病外科治疗指南(2024版)

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中国实用外科杂志 2024年第8期44卷 841-849页

作者：中华医学会外科学分会甲状腺及代谢外科学组中国医师协会外科医师分会肥胖和代谢病外科专家工作组王勇梁辉张频杨景哥朱利勇刘金钢王存川朱晒红张忠涛不详

自2000年郑成竹完成国内首例腹腔镜垂直胃绑带术,减重代谢手术引入中国已有24年,目前国内手术术式历经变迁已基本与国际接轨,手术适应证及相关围手术期问题处理也已形成体系。在国内减重代谢外科专家的共同努力下,已发布《中国肥胖和2... 详细信息

自2000年郑成竹完成国内首例腹腔镜垂直胃绑带术,减重代谢手术引入中国已有24年,目前国内手术术式历经变迁已基本与国际接轨,手术适应证及相关围手术期问题处理也已形成体系。在国内减重代谢外科专家的共同努力下,已发布《中国肥胖和2型糖尿病外科治疗指南(2014)》[1]和《中国肥胖及2型糖尿病外科治疗指南(2019版)》[2],其内容和证据愈加完善,已成为国内减重代谢外科临床实践及科学研究的重要参考。

关键词：肥胖代谢疾病减重代谢手术 Roux-en-Y胃旁路术胃袖状切除术并发症

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宁夏40年灾害性冰雹天气分析

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自然灾害学报 2007年第3期16卷 24-28页

作者：纪晓玲马筛艳丁永红林莉裴晓蓉兰州大学大气科学学院甘肃兰州730000 宁夏气象防灾减灾重点实验室宁夏银川750002

利用1961-2000年5-9月常规地面观测资料及相应时段的NCEP/NCAR逐日全球再分析资料,分析了宁夏灾害性冰雹天气的时空分布和环流特征,然后对74次有灾情记录的冰雹天气过程的环流背景、影响系统等进行了合成对比分析。结果表明:宁夏冰雹主... 详细信息

利用1961-2000年5-9月常规地面观测资料及相应时段的NCEP/NCAR逐日全球再分析资料,分析了宁夏灾害性冰雹天气的时空分布和环流特征,然后对74次有灾情记录的冰雹天气过程的环流背景、影响系统等进行了合成对比分析。结果表明:宁夏冰雹主要分布在南部六盘山区和北部贺兰山区,集中出现在6-7月;冰雹发生于"西高东低"环流背景下;产生冰雹天气主要有平直气流、两槽一脊、一槽一脊和一脊一槽等4种环流形势;影响系统主要有切变线、低涡和冷槽,这几种系统往往是共同作用、共同影响的;同时也表明,在不同的环流背景下,不同影响系统造成的冰雹天气落区有较大的差异。

关键词：灾害冰雹时空分布环流宁夏

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H1N1流感早期胸部X线表现对预后评估意义的相关研究

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国际医学放射学杂志 2010年第3期 286-287页

作者：沈晶 G. Aciram A. Bar-shai j. Sosna O. Rogowski G. Rosen I. Weinstein Departments of Radiology Internal Medicine 'D' and Pulmonology Tel Aviv University

摘要目的回顾性研究A型流感(H1NI)病人早期胸部X线表现对临床预后评估的意义。材料与方法此项研究通过伦理委员会的

关键词：胸部躯干线表现 H1N1 流感流行性感冒预后评估

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禽白血病髓细胞样瘤细胞的鉴别与误诊分析

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中国兽医学报 2023年第4期43卷 687-692页

作者：何书海张晒邢一科成子强信阳农林学院动物科技学院河南信阳464000 山东农业大学动物科技学院山东泰安271018

j亚型禽白血病病毒(subtype j avian leukemia virus,ALV-j)诱导的髓细胞样瘤细胞在形态上与正常髓系细胞很相似,为明确两者的形态差异和减少对禽髓细胞性白血病的误诊,对ALV-j人工感染病例和自然感染病例中的髓细胞样瘤细胞的形态特征... 详细信息

j亚型禽白血病病毒(subtype j avian leukemia virus,ALV-j)诱导的髓细胞样瘤细胞在形态上与正常髓系细胞很相似,为明确两者的形态差异和减少对禽髓细胞性白血病的误诊,对ALV-j人工感染病例和自然感染病例中的髓细胞样瘤细胞的形态特征进行了系统观察,并将其与正常鸡髓系细胞进行了鉴别和分析。结果表明,ALV-j感染鸡的血液、肝脏、脾脏和法氏囊等器官中髓细胞样瘤细胞主要是含有粗大嗜酸颗粒的中幼粒细胞和晚幼粒细胞,胞核约占细胞体积的1/2,胞核偏在、未分叶,可见病理核分裂象,其在石蜡组织切片中直径为8~10μm,在血涂片中直径12~14μm;正常幼龄鸡的肝脏、肾脏、法氏囊等器官中也有数量不等的晚幼粒细胞,这些细胞在形态上与髓细胞样瘤细胞很相似,胞浆中含有较多细小的嗜酸颗粒,但细胞体积较小,核浆比小,胞核约占细胞体积的1/3;其在石蜡组织切片中直径为5~8μm,血涂片中未见。研究结果提示,临床中应依据细胞大小、核型以及胞浆成分等特征对髓细胞样瘤细胞进行鉴别,同时应结合病毒核酸检测结果来确诊j亚型禽白血病。

关键词：禽白血病 j亚群禽白血病髓细胞样瘤细胞鉴别误诊

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Evaluation of computer aided detection during colonoscopy among Veterans:Randomized clinical trial

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Artificial Intelligence in Medical Imaging 2023年第1期4卷 1-9页

作者： Mike T Wei Yu Chen Susan Y Quan jennifer Y Pan Robert j Wong shai Friedland Department of Gastroenterology and Hepatology Stanford University Medical CenterPalo AltoCA 94305United States Department of Gastroenterology and Hepatology Veterans Affairs Palo Alto Health Care SystemPalo AltoCA 94305United States

BACKGROUND There has been significant interest in use of computer aided detection(CADe)devices in colonoscopy to improve polyp detection and reduce miss *** To investigate the use of CADe amongst *** Between September 2020 and December 2021,we performed a randomized controlled trial to evaluate the impact of *** at Veterans Affairs Palo Alto Health Care System presenting for screening or low-risk surveillance were randomized to colonoscopy performed with or without *** outcomes of interest included adenoma detection rate(ADR),adenomas per colonoscopy(APC),and adenomas per *** addition,we measured serrated polyps per colonoscopy,non-adenomatous,non-serrated polyps per colonoscopy,serrated polyp detection rate,and procedural *** A total of 244 patients were enrolled(124 with CADe),with similar patient characteristics(age,sex,body mass index,indication)between the two *** of CADe was found to have decreased number of adenomas(1.79 vs 2.53,P=0.030)per colonoscopy compared to without *** was no significant difference in number of serrated polyps or non-adenomatous non-serrated polyps per colonoscopy between the two ***,use of CADe was found to have lower ADR(68.5%vs 80.0%,P=0.041)compared to without use of *** polyp detection rate was lower with CADe(3.2%vs 7.5%)compared to without CADe,but this was not statistically significant(P=0.137).There was no significant difference in withdrawal and procedure times between the two groups or in detection of adenomas per extraction(71.4%vs 73.1%,P=0.613).No adverse events were *** While several randomized controlled trials have demonstrated improved ADR and APC with use of CADe,in this RCT performed at a center with high ADR,use of CADe was found to have decreased APC and *** studies are needed to understand the true impact of CADe on performance quality among endoscopists as well as determine criteria for endoscopis

关键词： Colonoscopy Colorectal cancer prevention Artificial intelligence Computer aided detection Adenoma detection rate

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近45a宁夏气温、降水及植被指数的变化分析

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自然资源学报 2008年第4期23卷 626-634页

作者：陈豫英陈楠郑广芬穆建华马筛艳纳丽邵建宁夏气象防灾减灾重点实验室银川750002 宁夏气象台银川750002

利用1961—2005年宁夏气温、降水资料，并结合1982～2003年植被指数（NDVI）数据，分析了宁夏气温、降水和NDVI的时空变化特征。结果表明：近45a来，宁夏气温明显升高，降水总体呈减少趋势；冬季和引黄灌区升温最明显，冬季降水增加，... 详细信息

利用1961—2005年宁夏气温、降水资料，并结合1982～2003年植被指数（NDVI）数据，分析了宁夏气温、降水和NDVI的时空变化特征。结果表明：近45a来，宁夏气温明显升高，降水总体呈减少趋势；冬季和引黄灌区升温最明显，冬季降水增加，其它季节及各地区降水减少，其中秋季和宁夏南部山区减少最明显；秋冬季降水在1968年前后发生了突变，突变后，冬季降水增多，秋季降水减少；1985—1996年间发生了气温突变，突变后各季及各地区气温明显升高，冬春季和引黄灌区降水增多，其它季节和地区降水减少，极端气候事件较突变前发生更为频繁；近20a宁夏区域内NDVI值呈增加趋势，荒漠化面积整体得到控制。进一步分析表明，前一年气温偏高、夏季降水增加时，有利于当年NDVI值增加。

关键词：宁夏气温降水 NDVI 时空变化特征

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生活方式干预对脂肪储存库动员的影响

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中华高血压杂志 2017年第12期25卷 1199-1199页

作者： Gepner Y Shelef I Schwarzfuchs D Zelicha H Tene L Yas-kolka Meir A Tsaban G Cohen N Bril N Rein M Serfaty D Kenigsbuch S Komy O Wolak A Chassidim Y Golan R Avni-Hassid H Bilitzky A Sarusi B Goshen E Shemesh E Henkin Y Stumvoll M Blüher M Thiery j Ceglarek U Ru-dich A Stampfer Mj shai I 黄洁叶鹏

该研究的目的是评估不同的生活方式干预能否对身体的脂质储存部位产生不同的影响。方法：研究者在278名腹型肥胖（209名，占75％）或脂质代谢紊乱的成年人中进行了一项为期18个月的随机对照研究，提供午餐并对用餐情况进行监督。

关键词：生活方式干预储存脂质代谢紊乱脂肪随机对照研究腹型肥胖成年人

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