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Assessment of the Bemisia tabaci C YP6CM l vQ transcript and protein levels in laboratory and field-derived imidacloprid-resistant insects and cross-metabolism potential of the recombinant enzyme

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Insect Science 2011年第1期18卷 23-29页

作者： Emmanouil Roditakis Evangelia Morou Anastasia Tsagkarakou Maria Riga Ralf Nauen Mark Paine shai morin John Vontas Laboratory of Entomology and Agricultural Zoology Plant Protection Institute of Heraklion National Agricultural Research Foundation Heraklion (N.AG.RE.F.) Heraklio Greece Faculty of Applied Biology and Biotechnology Department of Biology University of Crete Heraklion Greece Vector Group Liverpool School of Tropical Medicine Liverpool UK Bayer CropScience AG Research Insecticides Insect Toxicology and Resistance Monheim Germany Department of Entomology Faculty of Agricultural Food and Environmental Quality Sciences Hebrew University of Jerusalem Rehovot Israel

Over-expression of the cytochrome P450 CYP6CM1 gene has been associated with imidacloprid resistance in a number of Q and B biotype Bemisia tabaci laboratory strains from distinct geographical origins worldwide. We recently demonstrated that the Q biotype version of the CYP6CM 1 protein （CYP6CMlvQ） is capable of metabolizing imida- cloprid. Here, we show that the levels of BtCYP6CMlvQ were also elevated in laboratory- resistant strains and field-derived populations, with variable imidacloprid resistance levels, collected in Crete. High levels of CYP6CMlvQ transcripts were also determined in survivors of a heterogeneous field population, after exposure to discriminating imidacloprid dosage. Using peptide antibody-based detection assays, we demonstrated that in line with transcriptional data, the CYP6CMlvQ protein levels were higher in imidacloprid-resistant insects, which further implicates the gene as the causal factor of resistance. Finally, assess- ment of the cross-metabolism potential of CYP6CMlvQ against additional neonicotinoid molecules used for B. tabaci control revealed that clothianidin and thiacloprid, but not acetamiprid or thiamethoxam, are metabolized by the recombinant enzyme in vitro.

关键词： detoxification neonicotinoids peptide antibodies P450

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Sexual size dimorphism in lizards:Rensch’s rule,reproductive mode,clutch size,and line fitting method effects

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Integrative Zoology 2022年第5期17卷 787-803页

作者： Tao LIANG shai MEIRI Lei SHI College of Animal Science Xinjiang Agricultural UniversityUrumqiXinjiangChina College of Forestry Nanjing Forestry UniversityNanjingJiangsuChina School of Zoology&the Steinhardt Museum of Natural History Tel Aviv UniversityTel AvivIsrael

Rensch’s rule relates to a pattern whereby sexual size dimorphism is more female-biased in small-sized species and more male-biased in large-sized *** collected literature and museum data on the body size of males and females belonging to 4032 lizard species,as well as data on their reproductive modes and clutch *** used phylogenetic comparative analyses,and general linear mixed models,to test Rensch’s rule and examined how re-productive mode and clutch size affect sexual size *** size dimorphism was independent of clutch size in lizard species with variable clutch sizes and in oviparous *** litters were associated with female-biased sexual dimorphism in viviparous and in scincomorph *** regarding Rensch’s rule depended on the analytical method used to identify *** widely used,but less conservative,reduced major axis regression usually support Rensch’s rule while ordinary least squares regressions mostly show isometric *** rule tended to apply more to oviparous than to viviparous *** infer that Rensch’s rule is,at best,a weak pattern in *** is especially true in viviparous lineages where females reproduce infrequently and therefore evolve large sizes to maximise fecundity,resulting in female-biased dimorphism.

关键词： fecundity selection reduced major axis regression sexual selection sexual size dimorphism viviparity

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Small caliber overtube-assisted colonoscopy

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World Journal of Gastroenterology 2007年第44期13卷 5933-5937页

作者： shai Friedland Roy M Soetikno Stanford University School of Medicine and VA Palo Alto Health Care System United States

AIM: To combine the benefits of a new thin flexible scope with elimination of excessive looping through the use of an overtube. METHODS: Three separate retrospective series. Series 1: 25 consecutive male patients undergoing unsedated colonoscopy using the new device at a Veteran's hospital in the United States. Series 2: 75 male patients undergoing routine colonoscopy using an adult colonoscope, pediatric colonoscope, or the new device. Series 3: 35 patients who had incomplete colonoscopies using standard instruments. RESULTS: Complete colonoscopy was achieved in all 25 patients in the unsedated series with a median cecal intubation time of 6 min and a median maximal pain score of 3 on a 0-10 scale. In the 75 routine cases, there was significantly less pain with the thin scope compared to standard adult and pediatric colonoscopes. Of the 35 patients in the previously incomplete colonoscopy series, 33 were completed with the new system. CONCLUSION: Small caliber overtube-assisted colonoscopy is less painful than colonoscopy with standard adult and pediatric colonoscopes. Male patients could undergo unsedated colonoscopy with the new system with relatively little pain. The new device is also useful for most patients in whom colonoscopy cannot be completed with standard instruments.

关键词： Colonoscopy Endoscopy Colon Cancer Colon cancer screening

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A comparison of stick and slip contact conditions for a coated sphere compressed by a rigid flat

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Friction 2017年第3期5卷 326-338页

作者： shai RONEN Roman GOLTSBERG Izhak ETSION Department of Mechanical Engineering Technion Haifa 32000 Israel

A finite element analysis is used to study the elastic-plastic contact of a coated sphere compressed by a rigid flat under the stick contact *** was done for a wide range of hard coating material properties and coating thicknesses.A comparison with the slip contact condition is presented in terms of the critical contact parameters (at yield inception) and plasticity *** expressions are provided for critical interferences of the first and second yield inceptions,in the coating and on the substrate side of the interface,*** expression is also provided for the dimensionless coating thickness for optimal resistance to plasticity under the stick contact ***,the relations between different contact parameters in the elastic-plastic regime are *** general,it was found that the contact condition has a negligible effect on the contact parameters,except for phenomena occurring close to the contact area.

关键词： contact mechanics coatings stick elastic-plastic

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Yaw stability control for a rear double-driven electric vehicle using LPV-H∞ methods

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Science China(Information Sciences) 2018年第7期61卷 82-94页

作者： Yonathan WEISS Liron I.ALLERHAND shai AROGETI Department of Mechanical Engineering Ben-Gurion University of the Negev Bio Catch

This paper presents a new yaw stability controller for a rear double-driven electric vehicle. A linear parameter varying(LPV) model of the vehicle is formulated using longitudinal speed measurement and tire cornering stiffness estimation. The LPV model is then utilized to design a gain-scheduled H∞controller with guaranteed stability. Results from simulations, performed with Car Sim, show that the new controller improves the vehicle performance and handling even in extreme maneuvers and that it is robust to model parameter uncertainties.

关键词： yaw stability control electric vehicle torque vectoring H_∞ control gain-scheduling

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Hyperbaric oxygen therapy as a new treatment approach for Alzheimer's disease

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Neural Regeneration Research 2018年第5期13卷 817-818页

作者： Ronit Shapira shai Efrati Uri Ashery Department of Neurobiology the George S. Wise Faculty of Life Sciences Tel Aviv University Sackler School of Medicine Tel Aviv University Sagol Center for Hyperbaric Medicine & Research Assaf Harofeh Medical Center Sagol School of Neuroscience Tel Aviv University

Hyperbaric oxygen therapy as a new treatment approach for Alzheimer’s disease（AD）：Alongside the increase in life expectancy,the prevalence of age-related disorders,such as neurodegenerative diseases,is on the *** ... 详细信息

关键词： Hyperbaric oxygen therapy as a new treatment approach for Alzheimer’s disease AD

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Colonoscopic polypectomy in anticoagulated patients

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World Journal of Gastroenterology 2009年第16期15卷 1973-1976页

作者： shai Friedland Daniel Sedehi Roy Soetikno Division of Gastroenterology GI-111VA Palo Alto and Stanford University

AIM:To review our experience performing polypectomy in anticoagulated patients without interruption of ***: Retrospective chart review at the Veterans Affairs Palo Alto Health Care System. Two hundred and twenty five polypectomies were performed in 123 patients. Patients followed a standardized protocol that included stopping warfarin for 36 h to avoid supratherapeutic anticoagulation from the bowel preparation. Patients with lesions larger than 1 cm were generally rescheduled for polypectomy off warfarin. Endoscopic clips were routinely applied prophylactically. RESULTS: One patient (0.8%, 95% CI: 0.1%-4.5%) developed major post-polypectomy bleeding that required transfusion. Two others (1.6%, 95% CI: 0.5%-5.7%) had self-limited hematochezia at home and did not seek medical attention. The average polyp size was 5.1 ± 2.2 mm. CONCLUSION: Polypectomy can be performed in therapeutically anticoagulated patients with lesions up to 1 cm in size with an acceptable bleeding rate.

关键词： Colon cancer Colonic polyps Colonoscopy Early detection of cancer Endoscopy Hemorrhage Thrombosis Warfarin

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Comparison of conbercept and ranibizumab for the treatment efficacy of diabetic macular edema: a Metaanalysis and systematic review

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International Journal of Ophthalmology(English edition) 2019年第9期12卷 1479-1486页

作者： Wei-shai Liu Yan-Jie Li Department of Ophthalmology the First Hospital of Shanxi Medical University

AIM: To evaluate the efficacy of intravitreal injection of conbercept(IVC) and ranibizumab(IVR) in patients with diabetic macular ***: Reviewers have searched 12 databases, including PubMed, Medline, EMBASE, Web of Science, Springer, ScienceDirect, OVID, Cochrane Library, Clinical ***, cqVIP, WanFangdata and China National Knowledge Infrastructure(CNKI), up to December 28, 2018. Rev Man 5.3(Cochrane Library Software, Oxford, UK) was employed for statistical analysis. Fixed and random effects models were applied to assess heterogeneity. Odds ratio(OR) was applied for dichotomous variables;weighted mean difference(WMD) was applied for continuous variables. The confidence interval(CI) was set at 95%. Central macular thickness(CMT) and best-corrected visual acuity(BCVA) were employed to analyze the improvement of DME patients. Inclusion criteria for picking out studies were retrospective studies and randomized controlled trials(RCTs) that compared IVC and IVR for the treatment of diabetic macular ***: Four retrospective studies and five RCTs were included with a total of 609 patients. No statistically significant difference was observed in mean CMT and mean BCVA in the baseline parameters [BCVA(WMD:-0.48;95%CI:-1.06 to 0.10;P=0.1), CMT(WMD:-0.83;95%CI:-15.15 to 13.49;P=0.91). No significant difference was found in the improvement of BCVA and adverse event(AE) in IVC group, compared with IVR group after treatment of loading dosage [the 1 st month BCVA(WMD: 0.01;95%CI:-0.26 to 0.27;P=0.96), the 3 rd month BCVA(WMD:-0.04;95%CI:-0.14 to 0.06;P=0.46);the 6 th month BCVA(WMD:-0.24;95%CI:-1.62 to 1.14;P=0.73)], AE(OR: 0.84;95%CI: 0.38 to 1.84;P=0.66)]. A slight difference was found in the effectiveness rate(OR: 1.70;95%CI: 0.97 to 2.96;P=0.06), There were statistically significant differences between IVC and IVR treatment in terms of CMT (1 st month CMT(WMD:-19.88;95%CI:-27.94 to-11.82;P<0.001), 3 rd month CMT(WMD:-23.31;95%CI:-43.30 to-3.33;P=0.02),

关键词： diabetic macular edema central macular thickness best-corrected visual acuity conbercept ranibizumab

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Does the Application of Deep Brain Stimulation to Modulate Memory and Neural Circuity in AD Hold Substantial Promise?

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Neuroscience Bulletin 2022年第5期38卷 553-557页

作者： Abdalla Bowirrat shai Ashkenazi Aia Bowirrat Albert Pinhasov Adelson School of Medicine and Department of Molecular Biology Ariel University40700 ArielIsrael Adelson School of Medicine Ariel University40700 ArielIsrael Department of Orthopedic Surgery Hasharon HospitalRabin Medical CenterTel Aviv University4941492 Petah-TikvaIsrael

Alzheimer's disease(AD)is known to be a progressive neurodegenerative illness that attacks the brain,causing alterations in synaptic transmission,dystrophic neurites,and neuronal death brought on by the accumulation of neurofibrillary tangles in neuronsand neuritic amyloidbeta(Aβ)plaques in the extracellular space resulting in brain shrinkage and misshapen architecture[1].

关键词： alterations Aβ Alzheimer

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The miR166-SIHB15A regulatory module controls ovule development and parthenocarpic fruit set under adverse temperatures in tomato

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Molecular Plant 2021年第7期14卷 1185-1198页

作者： Christian Clepet Ravi Sureshbhai Devani Rachid Boumlik Yanwei Hao Halima morin Fabien Marcel Marion Verdenaud Brahim Mania Gwilherm Brisou Sylvie Citerne Gregory Mouille Jean-Christophe Lepeltier shai Koussevitzky Adnane Boualem Abdelhafid Bendahmane Institute of Plant Sciences Paris-Saclay INRAECNRSUniversite Paris-SaclayOrsay 91405France HM Clause Mas Saint-PierreQuartier La GalineSaint-Remy de Provence 13210France Hazera Seeds Ltd Berurim M.P.Shikmim 7983700Israel lnstitut Jean-Pierre Bourgin INRAEVersaillesFrance Present address:Key Laboratory of Horticultural Crop Biology and Germplasm Innovation in South China College of HorticultureSouth China Agricultural UniversityGuangzhou 510642China

Fruit set is inhibited by adverse temperatures,with consequences on *** isolated a tomato mutant producing fruits under non-permissive hot temperatures and identified the causal gene as SIHB15A,belonging to classⅢhomeodomain leucine-zipper transcription ***15A,loss-of-function mu-tants display aberrant ovule development that mimics transcriptional changes occurring in fertilized ovules and leads to parthenocarpic fruit set under optimal and non-permissive temperatures,in field and greenhouse *** cold growing conditions,SIHB15A is subjected to conditional haploinsufficiency and recessive dosage sensitivity controlled by microRNA 166(miR166).Knockdown of SIHB15A alleles by miR166 leads to a continuum of aberrant ovules correlating with parthenocarpic fruit *** with this,plants harboring an Slhb15a-miRNA166-resisiant allele developed normal ovules and were unable to set parthenocarpic fruit under cold *** affinity purification sequencing and RNA-sequencing analyses revealed that SIHB15A is a bifunctional transcription factor expressed in the ovule ***15A binds to the promoters of auxin-related genes to repress auxin signaling and to the promoters of ethylene-related genes to activate their expression.A survey of tomato genetic biodiversity identified pat and pat-1,two historical parthenocarpic mutants,as alleles of *** together,our findings demonstrate the role of SIHB15A as a sentinel to prevent fruit set in the absence of fertilization and provide a mean to enhance fruiting under extreme temperatures.

关键词： parthenocarpy dosage sensitivity HD-Ziplll miRNA166 heat stress cold stress

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