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Syringic acid induces cancer cell death in the presence of Cu(Ⅱ)ions via pro-oxidant activity

Asian Pacific Journal of Tropical Biomedicine 2022年第6期12卷 270-278页

作者： Marzieh Rashedinia Azita Nasrollahi Marzieh Shafaghat shahrzad momeni Forough Iranpak Jamileh Saberzadeh Rita Arabsolghar Zahra Sabahi Medicinal Plants Processing Research Center Shiraz University of Medical SciencesShirazIran Department of Pharmacology and Toxicology Faculty of PharmacyShiraz University of Medical SciencesShirazIran Diagnostic Laboratory Sciences and Technology Research Center School of Paramedical SciencesShiraz University of Medical SciencesShirazIran Department of Biochemistry Islamic Azad University of ShirazShirazIran Department of Medical Laboratory Sciences School of Paramedical SciencesShiraz University of Medical SciencesShirazIran

Objective:To investigate the effects of syringic acid on HEK 293 and HepG2 cells in the absence and presence of exogenous Cu(Ⅱ)and Fe(Ⅱ)***:The antiproliferative effects of syringic acid on HEK 293 and HepG2 cells in the absence and presence of exogenous Cu(Ⅱ)and Fe(Ⅱ)ions were examined by MTT ***,colony-forming,reactive oxidative species(ROS)generation,apoptosis induction,autophagy,mitochondrial membrane potential,and mitochondrial mass were ***:At 24 and 72 h,no significant differences were observed in the viability of HepG2 cells between the control and syringic acid+Fe(Ⅱ)***,exposure of HepG2 cells to syringic acid+Cu(Ⅱ)for 72 h reduced the cell viability ***,ROS formation,induction of apoptosis,and autophagic vacuoles were significantly increased in HepG2 cells without marked changes in mitochondrial membrane potential and mitochondrial ***,syringic acid+Cu(Ⅱ)reduced the plating efficiency and surviving fraction ***:The combination of syringic acid with Cu(Ⅱ)was toxic to cancer cells and showed pro-oxidant *** addition,this combination induced autophagy in cancer cells with less cytotoxic effects on normal cells,which is a potential candidate for the development of novel therapeutics towards cancer.

关键词： Syringic acid Copper Iron Cancer cell Pro-oxidant Autophagy

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