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Additively manufactured metallic biomaterials

Bioactive Materials 2022年第9期7卷 214-249页

作者： Elham Davoodi Hossein Montazerian Anooshe Sadat Mirhakimi Masoud Zhianmanesh Osezua Ibhadode shahriar imani shahabad Reza Esmaeilizadeh Einollah Sarikhani Sahar Toorandaz Shima ASarabi Rohollah Nasiri Yangzhi Zhu Javad Kadkhodapour Bingbing Li Ali Khademhosseini Ehsan Toyserkan Multi-Scale Additive Manufacturing(MSAM)Laboratory Mechanical and Mechatronics Engineering DepartmentUniversity of WaterlooWaterlooOntario N2L 3G1Canada Department of Bioengineering University of CaliforniaLos AngelesCalifornia 90095United States California NanoSystems Institute(CNSI) University of CaliforniaLos AngelesCalifornia 90095United States Terasaki Institute for Biomedical Innovation Los AngelesCalifornia 90024United States Department of Mechanical Engineering Isfahan University of TechnologyIsfahanIsfahan 84156-83111Iran School of Biomedical Engineering University of SydneySydneyNew South Wales 2006Australia Department of Nanoengineering Jacobs School of EngineeringUniversity of CaliforniaSan DiegoCalifornia 92093United States Mechanical and Aerospace Engineering Department University of CaliforniaLos AngelesCalifornia 90095United States Department of Mechanical Engineering Shahid Rajaee Teacher Training UniversityTehranTehran 16785-163Iran Institute for Materials Testing Materials Science and Strength of MaterialsUniversity of StuttgartStuttgart 70569Germany Department of Manufacturing Systems Engineering and Management California State UniversityNorthridgeCalifornia 91330United States

Metal additive manufacturing(AM)has led to an evolution in the design and fabrication of hard tissue substitutes,enabling personalized implants to address each patient’s specific *** addition,internal pore architectures integrated within additively manufactured scaffolds,have provided an opportunity to further develop and engineer functional implants for better tissue integration,and long-term *** this review,the latest advances in different aspects of the design and manufacturing of additively manufactured metallic biomaterials are *** introducing metal AM processes,biocompatible metals adapted for integration with AM machines are ***,we elaborate on the tools and approaches undertaken for the design of porous scaffold with engineered internal architecture including,topology optimization techniques,as well as unit cell patterns based on lattice networks,and triply periodic minimal ***,the new possibilities brought by the functionally gradient porous structures to meet the conflicting scaffold design requirements are thoroughly ***,the design constraints and physical characteristics of the additively manufactured constructs are reviewed in terms of input parameters such as design features and AM processing *** assess the proposed applications of additively manufactured implants for regeneration of different tissue types and the efforts made towards their clinical ***,we conclude the review with the emerging directions and perspectives for further development of AM in the medical industry.

关键词： Additive manufacturing Metal implant Porous scaffold Tissue engineering Biomaterials

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Optimization and comparison of two different 3D culture methods to prepare cell aggregates as a bioink for organ printing

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BIOCELL 2012年第1期36卷 37-45页

作者： RANA imani shahriar HOJJATI EMAMI HOSSEIN FAKHRZADEH NAFISEH BAHEIRAEI ALI M SHARIFI Department of Biomedical Engineering Amirkabir University of TechnologyTehranIran Endocrinology and Metabolism Research Institute Tehran University of Medical SciencesTehranIran Razi Institute for Drug research Department of PharmacologySchool of MedicineTehran University of Medical SciencesTehranIran Department of Tissue Engineering and Cell therapy School of advanced sciences in MedicineTehran University of Medical Sciences.TehranIran

The ultimate goal of tissue engineering is to design and fabricate functional human tissues that are similar to natural cells and are capable of *** of cell aggregates is one of the important steps in 3D tissue engineering technology,particularly in organ *** simple methods,hanging drop(HD)and conical tube(CT)were utilized to prepare cell *** size and viability of the aggregates obtained at different initial cell densities and pre-culture duration were *** proliferative ability of the cell aggregates and their ability to spread in culture plates were also *** both methods,the optimum average size of the aggregates was less than 500μ*** aggregates were smaller than HD aggregates.5,000 cells per drop HD aggregates showed a marked ability to attach and spread on the culture *** proliferative ability reduced when the initial cell density was *** these methods,we found that the HD method having better size controlling ability as well as enhanced ability to maintain higher rates of viability,spreading,and *** conclusion,smaller HD aggregates might be a suitable choice as building blocks for making bioink particles in bioprinting technique.

关键词： tissue engineering hanging drop conical tube bioprinting

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