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Efficacy and safety of Amla(Phyllanthus emblica L.) in non-erosive reflux disease:a double-blind,randomized,placebo-controlled clinical trial

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Journal of Integrative Medicine 2018年第2期16卷 126-131页

作者： shahnaz karkon varnosfaderani Fataneh Hashem-Dabaghian Gholamreza Amin Mahbubeh Bozorgi Ghazaleh Heydarirad Esmaeil Nazem Mohsen Nasiri Toosi Seyed Hamdollah Mosavat Department of Traditional Medicine School of Traditional MedicineTehran University of Medical Sciences Research Institute for Islamic and Complementary Medicine Iran University of Medical Sciences Department of Traditional Pharmacy Faculty of Traditional MedicineTehran University of Medical Sciences Department of Traditional Medicine School of Traditional MedicineShahid Beheshti University of Medical Sciences Department of Gastroenterology Imam Khomeini Hospital Tehran University of Medical Sciences Research Centre for Traditional Medicine and History of Medicine Shiraz University of Medical Sciences

Background： Gastroesophageal reflux disease （GERD） is one of the most common gastrointestinal com- plaints. GERD, caused by the reflux of stomach contents into the esophagus, leads to troublesome symptoms such as heartburn and regurgitation. It is classified into two types： erosive esophagitis, characterized by visible esophageal mucosa erosion in endoscopy, and non-erosive reflux disease （NERD）. GERD is a chronic and recurrent disease that impairs the quality of life and imposes socioeco- nomic and therapeutic burdens to both patients and society. Objective： Due to the failure of the conventional treatments for GERD and to the traditional use of Amla （Phyllanthus emblica L.）, in addition to beneficial effects shown in recent studies, we evaluated the safety and efficacy of Amla tablet for improvement of symptoms of patients with NERD. Design, setting, participants and interventions： We designed a double-arm, randomized, double-blind, placebo-controlled clinical trial. Sixty-eight patients who had classic symptoms of GERD （heartburn, regurgitation and epigastralgia） for at least three months before the start of the trial were randomized in two parallel groups. Patients in the Amla group received two 500 mg Amla tablets twice a day, after meals, for 4 weeks. In the control group, patients received placebo tablets similar to the Amla prescription. Main outcome measures： The patients were visited at baseline, and at the end of the 2nd and 4th weeks of intervention; their symptoms were measured on a frequency and severity scale for the symptoms of NERD, according to the quality of life in reflux-associated disease questionnaire. Results： Frequencies of heartburn and regurgitation in both groups of the study were significantly reduced after intervention （P 〈 0.001）. Repeated measures logistic regression analysis showed that, in the Amla group, there was a more significant reduction in regurgitation frequency, heartburn frequency, regurgita- tion severity and heartburn se

关键词： Gastroesophageal reflux Non-erosive reflux disease Amla Phyllanthus emblica Phytotherapy Randomized clinical trials

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Distribution changes of woody plants in Western Iran as monitored by remote sensing and geographical information system:a case study of Zagros forest

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Journal of Forestry Research 2017年第1期28卷 145-153页

作者： Mansour karkon varnosfaderani Rasoul Kharazmi Aliakbar Nazari Samani Mohammad Reza Rahdari Seid Hamid Matinkhah Nasrollah Aslinezhad State University of Land Use Planning MoscowRussianFederation St.Petersburg State University PetersburgRussianFederation Faculty of Natural Resource University of TehranKarajIran Isfahan University of Technology IsfahanIran Faculty of Water and Soil Zabol UniversityZabolIran

The status of woody plants in dry-land systems is a fundamental determinant of key ecosystem processes. Monitoring of this status plays an important role in understanding the dynamics of woody plants in arid and semi-arid ecosystems. The present study determined the dynamism of the Zagros forests in Iran using Remote Sensing and Geographic Information System techniques and statistical science. The results show that the density of trees varied from 10 to 53 % according to the physio- graphic and climatic conditions of semi-arid regions. The best and lowest correlation between vegetation indices and forest density were obtained for the global environmental monitoring index （GEMI; R2 = 0.94） and soil adjust vegetation index （R2 = 0.81）, respectively. GEMI is used to monitor land use changes over a 10-year period. Results show that 2720 ha2 of forest have been destroyed by human interference and tillage on steep slopes during this period which also resulted in the loss of the fertile soil layer. GEMI determined the areas with a biomass of trees and could normally separate border regions with low bio- mass density of trees from regions without canopy cover. The results revealed that assessment of forest and vegetation cover in arid and semi-arid arduous forest regions using satellite digital numbers and ordinary sampling is subject to uncertainty. A stratified grouping procedure should be established to increase the accuracy of assessment.

关键词： Monitoring Woody plants Vegetation index RS GIS Zagros forest Iran

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