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Identification of Inference Genes in Breast Cancer Network

Journal of Biosciences and Medicines 2017年第9期5卷 29-42页

作者： Keilash Chirom shahnawaz ali Md. Zubbair Malik Romana Ishrat R. K. Brojen Singh School of Computational & Integrative Sciences Jawaharlal Nehru University New Delhi India Centre for Interdisciplinary Research in Basic Sciences Jamia Millia Islamia New Delhi India

Complex breast cancer network constructed from experimentally verified seventy genes, by coordinating standard seven human protein and genome databases, follows hierarchical scale free features. Centrality based method of identification of inferred genes is implemented to this network and has predicted forty nine breast cancer genes, and nineteen non-breast cancer genes. As predicting good candidate genes before experimental analysis will save time and effort both. Fourteen genes out of nineteen are found to involve in various types of cancer and diseases, and five genes are engaged in non-cancer diseases. Some of the inferred genes need proper experimental investigation to understand fundamental roles of these genes in regulating breast cancer network.

关键词： Breast Cancer Network Theory Inference Genes Topological Propreties Centrality

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Input-parallel output-parallel configuration of boost half bridge DC-DC converter with control strategy

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Journal of Beijing Institute of Technology 2014年第1期23卷 47-52页

作者： SOOMRO Amir Mahmood KHAHRO shahnawaz Farhan KHASKHELI Murad ali 廖晓钟 FARHAN Manzoor School of Automation Beijing Institute of Technology Mehran University of Engineering and Technology Institute of Physics University of Sindh

The concept of connecting two boost half bridge DC-DC converter modules in input-paral- lel output-parallel configuration is presented. The input-parallel-output-parallel （IPOP） converter consists of multiple boost half bridge （BHB） DC-DC converter modules which are connected in par- allel at the input and output side. This kind of converter is an attractive solution for high power ap- plications. The correlation between input current sharing （ICS） and output current sharing （OCS） of the IPOP converter basic modules is described. Two loop control strategies, consisting of input cur- rent loop and output voltage loop, have been developed to achieve equal ICS and OCS in this present work. The control strategy for the IPOP configuration of boost haft bridge DC-DC converter has been verified for different load conditions （half load and full load）, The IPOP system proposed here is comprising of two modules but it can be extended to three or more. The performance of the pro- posed system along with the control strategy is verified by simulation in MATLAB using Simpower tool. Finally the satisfactory simulation results are obtained.

关键词： boost half bridge ( BHB ) input current sharing ( ICS ) input-parallel output-parallel(IPOP) output current sharing (OCS)

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Detection of Babesia bovis in blood samples and its effect on the hematological and serum biochemical profile in large ruminants from Southern Punjab

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Asian Pacific Journal of Tropical Biomedicine 2012年第2期2卷 104-108页

作者： Samreen Zulfiqar Sadia shahnawaz Muhammad ali Arif Mahmood Bhutta Shahid Iqbal Sikandar Hayat Shazia Qadir Muhammad Latif Nazia Kiran ali Saeed Muhammad ali Furhan Iqbal Institute of Pure and Applied Biology.Zoology Division Bahauddin Zakariya University Faculty of Veterinary Sciences Bahauddin Zakariya University Institute of Biotechnology Bahauddin Zakariya University

Objective:To determine the presence of Babesia bovis(***) in large ruminants in southern Punjab and its effect on hematological and serum biochemical profile of host ***:Blood samples were collected from 144 large ruminants,including 105 cattle and 39 buffaloes,from six districts in southern Punjab including Multan,Layyah,Muzaffar Garh,Bhakar,Bahawalnagar and *** on the characteristics of animals and herds were collected through *** blood(hemoglobin,glucose) and serum(ALT,AST,LDH,cholesterol)parameters of calves and cattle were measured and compared between parasite positive and negative samples to demonstrate the effect of *** on the blood and serological profile of infected ***:27 out of 144 *** 5 out of 6 sampling districts,produced the541-bp fragment specific for *** of animals(P=0.02).presence of ticks on animals(P=0.04)and presence of ticks on dogs associated with herds(P=0.5) were among the major risk factors involved in the spread of bovine babesiosis in the study *** concentrations were the only serum biochemical values that significantly varied between parasite positive and negative ***:This study has reported for the first time the presence of *** in large ruminant and the results can lead to the prevention of babesiosis in the region to increase the livestock output.

关键词： Babesia bovis PCR amplification Cattle Hematology Serum biochemistry Ruminant Babesiosis Serological profile Cattle

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高效液相色谱-紫外检测法同时测定药物制剂及人体血清中的奥美沙坦酯和厄贝沙坦及氢氯噻嗪(英文)

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色谱 2008年第5期26卷 544-549页

作者： SULTANA Najma ARAYNE M Saeed ali S Shahid SAJID shahnawaz Department of Pharmaceutical Chemistry Research Institute of Pharmaceutical SciencesFaculty of PharmacyUniversity of Karachi Department of Chemistry Faculty of ScienceUniversity of Karachi

A simple,selective,sensitive,precise,simultaneous high performance liquid chromatographic analysis of serum samples and commercial tablet formulation containing hydrochlorothiazide,olmesartan medoxomil and irbesartan are *** chromatographic separation was achieved using a μ-Bondapak,C18 column(15 cm×4.6 mm,5 μm),and a mobile phase consisting of acetonitrile-0.2% acetic acid aqueous solution(50∶50,v/v)at a flow rate of 1.0 mL/*** ultraviolet detector was set at a wavelength of 260 ***,olmesartan medoxomil,and irbesartan were eluted at 1.2,3.8,and 4.4 min,*** extraneous materials were found to *** method uses protein precipitation with acetonitrile for the preparation of serum *** linear ranges for hydrochlorothiazide,olmesartan medoxomil,and irbesartan were 6.25-18.75,20-60,and 75-225 ng/mL,*** recoveries of hydrochlorothiazide,olmesartan medoxomil,and irbesartan in spiked samples were all greater than 98%,and their relative standard deviations were less than 2.0%.The limits of detection were 1,2,and 2 ng/mL for hydrochlorothiazide,olmesartan medoxomil,and irbesartan,respectively,and the limits of quantification were 3 ng/mL,which allow their determination at the expected serum concentration levels.

关键词：二氢氯噻色谱血清药物化学分析分析方法

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Etiology of Upper GI Bleeding on Endoscopy

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Neuroscience & Medicine 2018年第1期9卷 16-21页

作者： Junaid Khan Muhammad ali Hareem Bakhsh Sobhi Sheikh Moazzam Waheed Ifrah shahnawaz Muhammad Abdullah Sardar Muhammad Omer Naseem Omer Kamal Farah Bashir Muhammad Nadeem University College of Medicine University of Lahore Lahore Pakistan King Edward Medical University Lahore Pakistan Liaquat University of Medical and Health Sciences Jamshoro Pakistan University at Buffalo Buffalo NY USA

Background: Several circumstances and conditions lead to UGIB. The commonest among them peptic ulcer to an approximation of 50% in cases. The second major cause may be esoghageal varices and third is mallory-weis tears. There are also other causes, which may include erosins, tumors and other malformations like arteriovenous. Methods: This was an observational retrospective study of all patients referred to endoscopy. The study exclusion criteria include all patients who had repeat endoscopies within one month of the previous endoscopy whereas all the patients with UGIB were included in this study. Results: We retrieved data of total 150 patients who had experienced upper gastrointestinal endoscopy during the selected time period covered in the study, March 2015 to February 2016. The mean age of the patients was 43.3 ± 13.80. 80 (53.3%) of the patients were male and 70 (46.7%) were females. Exploring more into UGIB causes the majority of patients were with esophageal varices 68 (45.3%) with male to female share was 2:1. The second most cause was esophagitis (n = 22, (14.67%)), the distribution of the cause was similar in male to female. Conclusion: We may conclude from our findings that the most common cause of UGIB is esophageal varices in our population.

关键词： Upper Gastrointestinal Endoscopy Esophageal Varices Upper Gastrointestinal Bleeding Peptic Ulcer

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