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Open Journal of Soil Science 2015年第9期5卷 193-198页

作者： shahin sultana Md. Abul Kashem Abul K. M. M. Mollah Asian University for Women Chittagong Bangladesh Department of Soil Science Chittagong University Chittagong Bangladesh

A pot experiment was conducted to investigate the comparative effect of cow manure vermicompost and NPK fertilizers on the growth and flower production of Zinnia (Zinnia elegans). An air dried sandy loam soil was mixed with four rates of NPK fertilizer equivalent to 0 (control), 0.5 dose (N-P-K = 69-16-35 kg·haǃ), 1 dose (recommended) (N-P-K = 137-32-70 kg·haǃ), 2 doses (N-P-K = 274-64-140 kg·haǃ) and 4 doses (N-P-K = 548-128-280 kg·haǃ) and three rates of vermicompost equivalent to 5%, 10%, 20% by oven dry weight. Two plants were grown in each pot. After blooming of flowers, the plants were harvested at 50 days of growth and leaves and stems were separated. The growth parameters (shoot height, root length, leaf number, total number of flower, flower diameter, fresh and dry weight of flower) of Zinnia plant increased by the application of vermicompost and the effect of NPK fertilizer was not found effective. The growth performance was similar between 10% and 20% and hence 10% vermicompost should be taken into consideration when ornamental plants are grown in potting media.

关键词： Organic Fertilizer Soil Rates of Fertilizer Flower

DFT-Based Chemical Reactivity Descriptors, Pharmacokinetics and Molecular Docking Studies of Thymidine Derivatives

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Computational Chemistry 2023年第4期11卷 81-103页

作者： Mohammad Ahad Hossain shahin sultana Mohammad Mazherul Islam Sonia Akhter Faria Nur Fatima Majabin Kantom Islam Kazi Jawad Hossain Yasuhiro Ozeki Sarkar M. A. Kawsar Laboratory of Carbohydrate and Nucleoside Chemistry (LCNC) Department of Chemistry Faculty of Science University of Chittagong Bangladesh Graduate School of NanoBio Sciences Yokohama City University Yokohama Japan

Thymidine-containing derivatives are considered to be among the most significant derivatives in medicinal chemistry. In this study, we employed a combined computational approach involving density-functional theory (DFT) calculations, molecular docking simulations, and absorption, distribution, metabolism, excretion, and toxicity (ADMET) property predictions. Prediction of activity spectra for substances (PASS) revealed promising antiviral, antimicrobial and anti-carcinogenic activities of these thymidine derivatives. Using Gaussian 09, we optimized the molecular structures of the thymidine derivatives to obtain their stable conformations and calculate their electronic properties. Subsequently, molecular docking simulations were performed to explore the binding interactions between the thymidine derivatives and the active site of the Candida albicans (PDB: 1IYL and 2Y7L) proteins. The docking results were evaluated based on docking scores, hydrogen bonding, and hydrophobic interactions and revealed favorable binding interactions between the thymidine derivatives and the proteins, suggesting their potential as antifungal agents. The thermodynamic properties, including binding free energy, enthalpy, and entropy changes were determined to assess the stability and strength of the ligands-protein complexes. The calculated pharmacokinetic parameters, such as ADMET properties, provided insights into the drug-likeness and potential bioavailability of the thymidine derivatives. These results offer a foundation for further experimental investigations and the design of novel antifungal agents targeting Candida albicans infections.

关键词： Thymidine DFT Molecular Docking Pharmacokinetics Candida albicans

Comparative studies of elemental composition in leaves and flowers of Catharanthus roseus growing in Bangladesh

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Asian Pacific Journal of Tropical Biomedicine 2016年第1期6卷 50-54页

作者： shahin Aziz Koushik Saha Nasim sultana Husna Parvin Nur Md.Aminul Ahsan Shamim Ahmed Md.Kamal Hossain Chemical Research Division BCSIR Department of Chemistry Jahangirnagar University Bangladesh Council of Scientific and Industrial Research (BCSIR) Laboratories

Objective:To investigate the elemental composition of the leaves and flowers of Catharanthus roseus(***) due to the plant's wide application in the indigenous medicinal system and its chemical constituents' ***:The atomic absorption spectrophotometer was used for quantitative analysis of various ***:Total 13 important elements were analyzed in leaves and flowers of *** indicated the presence of Na,K,Ca,Mg,Cr,Fe,Zn,Al,Cu,Ni,Pb,Cd and Mn in both leaves and *** most important finding of the work was that,leaves of *** showed high concentration of all elements except K and Zn while flowers of *** showed higher concentration of K and ***:The elemental composition in both leaves and flowers of *** were found to be ***,different parts of this medicinal plant are enriched in some micro and macro nutrients like Fe,Ca,Na,K,Zn,which are very important for biological metabolic system as well as human health.

关键词： Bangladesh Catharanthus roseus Indigenous medicinal systems Atomic absorption spectrophotometer Elemental composition

Assessment of Microbial, Physicochemical Quality and Antibiotic Sensitivity Pattern of Bacteria of Drinking Water at Santosh, Tangail, Bangladesh

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Advances in Microbiology 2019年第12期9卷 1023-1038页

作者： Tamalika Saha Arifa sultana Md. Younus Mia Sourav Sarker shahin Mahmud

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癌症的异质性表征与深度表型

中华医学图书情报杂志 2019年第10期28卷 1-6页

作者： shahin Alam Adiba sultana 王姣何雪飞沈百荣苏州大学系统生物学研究中心四川大学华西医院系统遗传研究院

随着老龄化时代的到来,癌症发病率不断增高,癌症的防治和慢病管理已成为推动社会经济发展的关键因素。生物医学和信息技术的迅猛发展以及主动健康、精准医学和大数据范式的兴起等,为癌症的防治带来新的机遇。从信息学角度探讨了癌症异... 详细信息

随着老龄化时代的到来,癌症发病率不断增高,癌症的防治和慢病管理已成为推动社会经济发展的关键因素。生物医学和信息技术的迅猛发展以及主动健康、精准医学和大数据范式的兴起等,为癌症的防治带来新的机遇。从信息学角度探讨了癌症异质性的形成与表征,癌症深度表型挖掘,癌症治疗的组合用药算法,癌症的预防与慢病管理的信息模型、系统与平台等方面的最新研究方向,并对癌症医学信息学领域面临的挑战与机会进行了分析和展望。

关键词：癌症演化与异质性深度表型挖掘协同药物组合算法与模型

Bacteriological Analysis and Public Health Impact of Broiler Meat: A Study on Nalitabari Paurosova, Sherpur, Bangladesh

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Advances in Microbiology 2019年第7期9卷 581-601页

作者： Md. Omar Faruque shahin Mahmud Md. Abul Munayem Razia sultana Md. Tarek Molla Md. Firoz Ali Muhammad Wasim Sourav Sarker Fatematuz Zuhura Evamoni Department of Biotechnology and Genetic Engineering Mawlana Bhashani Science and Technology University Santosh Tangail Bangladesh Department of Biotechnology and Genetic Engineering Noakhali Science and Technology University Sonapur Noakhali Bangladesh

Broiler meat is one of the most important protein sources for Bangladeshi people. Food-borne diseases associated with the consumption of poultry meat and its processed products are of public health concern worldwide. An investigation was conducted to assess the bacteriological quality of poultry meat from some poultry farms and its health impact on consumer of Nalitabari paurosova, Sherpur district, Bangladesh. Total 15 samples were randomly selected and collected from different poultry farms on the basis of farms level and size. Bacteriological quality of the samples was assessed by following the standard microbiological methods. The health impact was evaluated with the help of semi-structured based questionnaire of 400 peoples. The average value of TVC and TCC were found as 4.3 × 106 CFU/g and 3.6 × 104 CFU/g respectively. In this study, the prevalence of fecal coliform was recorded as 33% and the presence of E. coli in 53% samples. The mean value of Salmonella spp. of meat samples was 4.6 × 103 CFU/g. No Shigella spp., Vibrio spp. and fungal species were detected in any sample. Some selected isolates were tested for their sensitivity against some commercially available common antibiotics used in Bangladesh. E. coli was 80% resistance to Ampicillin and 90% sensitive to Ciprofloxacin whereas Salmonella spp. showed 100% resistance to Ampicillin and 80% sensitivity to Ciprofloxacin. The antibacterial activity of renowned medicinal plant Azadirachta indica was also evaluated against some multidrug resistance bacteria. The inhibitory zone of both 30% methanolic and ethanolic extracts of Azadirachta indica was 12 mm and 12.3 mm, where 40% methanolic and ethanolic extracts were 14 mm and 16.3 mm against E. coli. The 40% ethanolic extract showed the better activity between them. The plant extract has no activity against Salmonella spp.. Awareness and health impact of broiler meat was determined among the people of different sectors on the basis of educational qualificatio

关键词： Broiler Meat Total Viable Count (TVC) Total Coliform Count (TCC) Antibiotic Azadirachta indica Public Health Nalitabari

Quality Assessment of Surface and Drinking Water of Nakla Paurosova, Sherpur, Bangladesh

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Advances in Microbiology 2019年第8期9卷 703-727页

作者： Sourav Sarker shahin Mahmud Razia sultana Ritu Biswas Partha Protim Sarkar Md. Abul Munayem Nur-E-Alam Md. Rayhan Ali Muhammad Wasim Md. Firoz Ali Md. Omar Faruque Fatematuz Zuhura Evamoni Department of Biotechnology and Genetic Engineering Mawlana Bhashani Science and Technology University Tangail Bangladesh Department of Biotechnology and Genetic Engineering Noakhali Science and Technology University Noakhali Bangladesh Department of Biotechnology and Genetic Engineering Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalganj Bangladesh Department of Biotechnology Bangladesh Agricultural University Mymensingh Bangladesh

Water is one of the most vital elements of ecosystem and human being, but unfortunately nowadays, the pollution of surface and drinking water is an alarming problem. The present work deals with the assessment of physicochemical and bacteriological profile of several pond, jar and tube-well water samples to ensure its suitability for using and drinking. Total 30 samples were randomly selected and collected from Nakla Paurosova of Sherpur district by following the standard procedure. Bacteriological analysis was carried out by following the standard bacteriological methods. Most of the surface water sampling points were polluted by dumping of waste, cattle wash and were not suitable for drinking or other domestic purposes. Among three heavy metals, only Iron was detected in six tube-well water samples, one was also positive to arsenic, rest of the water bodies were negative to all of these metals. In case of most of the water bodies, different physicochemical properties were below standard limit. In pond water, the Total Viable Count (TVC) ranged from 2.7 × 107 cfu/100ml to 4.4 × 1015 cfu/100ml and Total Coliform Count (TCC) were 3.4 × 105 cfu/100ml to 4.8 × 1013 cfu/100ml, where the mean concentration of Heterotrophic Plate Count (HPC) was 2.4 × 105 cfu/100ml and 1.8 × 105 cfu/100ml in jar and tube-well water respectively. On the other hand, the Total Coliform Count of supply water was 33 cfu/100ml and tube-well water was 14 cfu/100ml. Fecal coliform was detected in all of the pond water samples, four jar and three tube-well water too. E. coli was present in all pond water samples, and also detected in 80% supply and 50% tube-well water also. Shigella spp. was found in two pond water and in one supply water, where tube-well water was free from it. Salmonella spp. was also detected in 30% of pond and 20% of supply water, whereas absent in tube-well water. 50% of pond, 40% of supply and 30% of tube-well water were contaminated with Vibrio spp. The total counts of these

关键词： Physiochemical Parameters Bacterial Load Antibiogram Public Health Nakla Paurosova