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Prospects of Using Platelets as Peripheral Marker to Study the Role of GABA in Autism

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World Journal of Neuroscience 2014年第5期4卷 437-442页

作者： Saima Khan Kaneez Fatima-Shad Hashmet parveen Ghouse Department of Biomedical Sciences PAP RSB Institute of Health Sciences University Brunei Darussalam Brunei Darussalam School of Medical and Molecular Biosciences Faculty of Science University of Technology Sydney Australia

Literature indicated that platelets could be used as a model for neuronal receptors such as γ-amino butyric acid (GABA) and serotonin. Research work exhibited the presence of low levels of GABA and high levels of serotonin concentration in the platelets of autistic children as compare to their healthy counter parts. There are also other evidences pointing out to the significant role of GABA in autism such as association of g-band frequency with the cortical concentration of GABA and gabapentin (GABA analogue) specifically inhibits the cytosolic branched chain amino transferase (BCATc);an enzyme responsible to modulate glutamate availability for the synthesis of GABA.

关键词： Autism GABA Serotonin Platelets Neurotransmitters

Ovarian Vein Thrombosis, Critical Diagnosis at Al-Hasahisa Obstetrics & Gynecology Teaching Hospital in Geziera State, Sudan

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Open Journal of Obstetrics and Gynecology 2023年第6期13卷 1020-1024页

作者： Mohamed ElAmin M. A. Elkhazein Atif B. E. Fazari Mohamed Bakry Habeeb parveen B. Mohammed Elrasheed H. A. Mohammed Al-Hasahisa Obstetrics & Gynecology Teaching Hospital Rufaa Sudan Faculty of Medicine Albutana University Rufaa Sudan Latifa Hospital DHA Dubai UAE Faculty of Medicine University of Medical Sciences & Technology Khartoum Sudan

Ovarian vein thrombosis (OVT) is a rare thrombotic condition commonly attributed to the puerperium. The complications of OVT can be significant, and diagnosis relies on a high clinical index of suspicion. It can occur with lower quadrant pain that may mimic a surgical abdomen, especially in the setting of recent pregnancy, abdominal surgery, inflammatory disease, or malignancy. Diagnosis can be made with confidence using ultrasound, computed tomography, or magnetic resonance imaging. Management of OVT is particularly important in postpartum patients, with anticoagulation therapy being the treatment of choice.

关键词： Ovarian Vein Thrombosis Puerperium Pregnancy

Qualitative and Quantitative Estimation of Hydroquinone in Skin Whitening Cosmetics

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Journal of Cosmetics, Dermatological Sciences and Applications 2012年第3期2卷 224-228页

作者： Saima Siddique Zahida parveen Zeeshan Ali Muhammad Zaheer PCSIR Labs Complex Lahore Pakistan

Hydroquinone has been used for decades as a skin lightening agent. Its use in cosmetics has been banned as a result of skin problems including contact dermatitis and ochronosis. A total of 22 samples of different skin whitening cosmetics were collected from local market. They were analyzed by using thin layer chromatography and HPLC for qualitative and quantitative determination of their hydroquinone contents. The hydroquinone was extracted from samples by using 96% ethanol and was subjected to TLC analysis. Eleven out of 22 samples were found to contain hydroquinone. The HPLC analysis showed the concentration of hydroquinone ranged from 0.002% to 0.092% in the cosmetic samples.

关键词： Hydroquinone HPLC Whitening Cosmetics Thin Layer Chromatography

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百蕊草中黄酮类化合物研究

中药材 2009年第4期32卷 518-520页

作者：刘洋 Zahida parveen 邓玉林张经华戴荣继北京市理化分析测试中心北京100089 北京理工大学生命科学与技术学院北京100081

目的:研究百蕊草抗炎有效部位中的黄酮类化合物。方法:采用多种层析分离方法进行分离纯化,通过HPLC-DAD对黄酮类化合物进行快速定性,并结合1H-NMR1、3C-NMR和ESI-MS等技术确定了化合物的结构。结果:分离并鉴定了5个黄酮类化合物分别为... 详细信息

目的:研究百蕊草抗炎有效部位中的黄酮类化合物。方法:采用多种层析分离方法进行分离纯化,通过HPLC-DAD对黄酮类化合物进行快速定性,并结合1H-NMR1、3C-NMR和ESI-MS等技术确定了化合物的结构。结果:分离并鉴定了5个黄酮类化合物分别为紫云英苷(Ⅰ)、芸香苷(Ⅱ)、木樨草素7-O-葡萄糖苷(Ⅲ)、5-甲基山奈酚(Ⅳ)、芹菜素-5-O-葡萄糖-鼠李糖苷(Ⅴ)。结论:其中化合物Ⅳ和Ⅴ为首次从该植物中分离得到。

关键词：百蕊草黄酮有效部位

Acetylcholinesterase and Cytotoxic Activity of Chemical Constituents of Clutia lanceolata Leaves and its Molecular Docking Study

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Natural Products and Bioprospecting 2016年第6期6卷 267-278页

作者： Mehtab parveen Faheem Ahmad Ali Mohammed Malla Shaista Azaz Mahboob Alam Omer A.Basudan Manuela Ramos Silva Pedro S.Pereira Silva Department of Chemistry Aligarh Muslim UniversityAligarh 202002India Division of Bioscience Dongguk UniversityGyeongju 780-714Republic of Korea Pharmacognosy College of PharmacyKing Saud UniversityRiyadh 4451Saudi Arabia CFisUC Department of PhysicsUniversity of Coimbra3004-516 CoimbraPortugal

Phytochemical investigations of the ethanolic extract of leaves of Clutia lanceolata(Family:Euphorbiaceae)resulted in the isolation of four compounds viz.3,4-dihydroxy-2-methylbenzoic acid(1),2,20-dihydroxy-1,10-binaphthyl(2),1,3,8-trihydroxy-6-methylanthracene-9,10-dione(3)and 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one(4).Although all the isolated compounds were known but this was the first report from this plant *** structures were established on the basis of chemical and physical evidences *** analysis,FT-IR,1 H-NMR,13CNMR and mass spectral *** of compound 2 and 4 was further authenticated by single-crystal X-ray analysis and density functional theory *** isolated compounds(1–4)were screened for AChE enzyme inhibition assay in which compound 3 and 4 were found to be more potent AChE *** docking study of potent AChE inhibitor was performed to find the probable binding mode of the compounds into the active site of ***,the isolated compounds were also screened for in vivo cytotoxicity by brine shrimp lethality assay.

关键词： Clutia lanceolata X-ray crystallography AChE Molecular docking Cytotoxicity

Fractionation of Organic Carbon and Stock Measurement in the Sundarbans Mangrove Soils of Bangladesh

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American Journal of Climate Change 2021年第4期10卷 561-580页

作者： Sayada Momotaz Akther Md Mahfuz Islam Md Faruque Hossain Zakia parveen Department of Soil Water and Environment University of Dhaka Dhaka Bangladesh Department of Crop and Soil Sciences North Carolina State University Raleigh NC 27695 USA OSCM FBA American International University-Bangladesh Kuril Dhaka Bangladesh

Mangrove soils are well known for their high capacity of storing organic carbon (SOC) in various pools;however, a relatively small change in SOC pools could cause significant impacts on greenhouse gas concentrations. Thus, for an in-depth understanding of SOC distribution and stock to predict the role of Sundarbans mangrove in mitigating global warming and greenhouse effects, different extraction methods were employed to fractionate the SOC of Sundarbans soils into cold-water (CWSC) and hot-water (HWSC) soluble, moderately labile (MLF), microbial biomass carbon (MBC), and resistant fractions (RF) using a newly developed modified-method. A significant variation in total SOC (p −2 in 1 m soil profile and has an average of 31.80 kg·C·m−2. The substratum soils had more carbon than the upper layers in the Sundarbans wetland due to burial and preservation of carbon by frequent tidal inundation. A higher SOC stock in

关键词： Carbon Sequestration Carbon Sink Carbon Source Soil Organic Carbon Stock Sundarbans Mangrove Forest

Characterization of hepatic progenitors from human fetal liver using CD34 as a hepatic progenitor marker

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World Journal of Gastroenterology 2007年第16期13卷 2319-2323页

作者： parveen Nyamath Ayesha Alvi Aejaz Habeeb Sanjeev Khosla Aleem A Khan CM Habibullah Center for Liver Research and Diagnostics Deccan College of Medical Sciences and Allied Hospitals Kanchanbagh Hyderabad-58 Andhra Pradesh India Centre for DNA Fingerprinting and Diagnostics Nacharam Hyderabad 500072 India

AIM: To enrich putative hepatic progenitors from the developing human fetal liver using CD34 as a marker. METHODS: Aborted fetuses of 13-20 wk were used for the isolation of liver cells. The cells were labeled with anti CD34; a marker used for isolating progenitor population and the cells were sorted using magnetic cell sorting. The positive fractions of cells were assessed for specific hepatic markers. Further, these cells were cultured in vitro for long term investigation. RESULTS: Flow cytometric and immunocytochemical analysis for alphafetoprotein (AFP) showed that the majority of the enriched CD34 positive cells were positive for AFP. Furthermore, these enriched cells proliferated in the long term and maintained hepatic characteristics in in vitro culture. CONCLUSION: The study shows that aborted human fetal liver is a potential source for isolation of hepatic progenitors for clinical applications. The study also demonstrates that CD34 can be a good marker for the enrichment of progenitor populations.

关键词：肝脏祖细胞胎儿肝脏 CD34 标记免疫组化特性

Adverse Drug Reactions in Patients on Second Line Anti-Tubercular Drugs for Drug Resistant Tuberculosis in Rural Tertiary Care Hospital in North India

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Journal of Tuberculosis Research 2018年第3期6卷 207-214页

作者： Anita Kumari parveen Kumar Sharma Dinesh Kansal Rekha Bansal Rajan Negi Department of Pharmacology Dr. YSP Government Medical College Nahan (HP) India Department of Pharmacology SLBS Government Medical College Mandi at Nerchowk (HP) India Department of Pharmacology Dr. RP Government Medical College Kangra at Tanda (HP) India Department of Pulmonary Medicine Dr. RP Government Medical College Kangra at Tanda (HP) India

Introduction: The adverse drug events (ADEs) to second-line anti-TB drugs are one of the major reasons for the patients default on treatment. A general awareness of various adverse drug events (ADE) and their management is essential for the effective management of tuberculosis. Identification of adverse drug reaction profile of patients can be useful for the early detection, management and prevention of adverse drug events. Material and methods: It was a prospective observational study conducted after approved Institutional Ethics Committee. A total of 104 drug resistant tuberculosis patients registered from 1st November 2012 to 31st October 2013 started with second line anti-tubercular drugs under PMDT-RNCP after taking written informed consent. Adverse drug reaction during treatment recorded and assessed by Hart wig and WHO scale. Results: 87% patients experienced adverse drug reactions. Total 346 ADR were reported. Most common were gastritis (65%) and arthralgia (60.6%), others were nausea (35.6%), vomiting (32.7%), hyperuricemia (30.8%), giddiness (27%), anorexia (17.3), generalized weakness (15.4), insomnia (10.6%), psychosis (8.6%), hearing impairment (6.7%), hypersensitivity reaction (5.8%), peripheral neuropathy (4.8%), visual disturbance (3.8%), nephrotoxicity (2.9%), forgetfulness (2.9%), gynaecomastia (1.9%), hypothyroidism (1%), seizure (1%), and thrombocytopenia (1%). Conclusion: Majority of patients experienced wide range adverse drug reactions. Most of patients faced the problem within 2 - 3 months of initiation of treatment and managed by symptomatic. Early identification, prompt management and standardized reporting adverse drug reactions at all the level of healthcare are needed.

关键词： Drug Resistant Tuberculosis ADR: Second line Anti-Tubercular Drugs

Vulnerability of Sunflower Germination and Metal Translocation under Heavy Metals Contamination

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American Journal of Plant Sciences 2019年第5期10卷 738-751页

作者： Rumana Sadiq Nazimah Maqbool Bader-Un-Nisa &ensp Kauser parveen Mumtaz Hussain Faculty of Science and Technology Government College Women University Faisalabad Pakistan Department of Botany University of Sargodha Lyallpur Campus Faisalabad Pakistan Department of Botany University of Agriculture Faisalabad Pakistan

The germination and metal translocation ability of two sunflower seedlings were compared to identify the cultivar differences towards metal contamination at juvenile stage. The heavy metal treatments include: 0, 50, 100, 150 and 200 mM Ni, Cd and Pb applied in sand filled pots to Hysun-33 and FH-533 sunflower. The highest germination percentage (79%) and vigor index were recorded for Hysun-33 with no heavy metal treatment. Pb and Cd treatments reduced the growth attributes of 20 days old seedlings of both the cultivars. The Ni translocation effectively enhanced the shoot and root biomass of Hysun-33. The high concentration of 150 and 200 mM Cd and Pb drastically reduced Mn and K contents, vigor, length and biomass of two sunflower cultivars. Among three of the heavy metals, Cd was found more toxic than Pb and Ni. Roots of 20 days old seedlings of Hysun-33 were able to hold more Cd metal and stop its translocation to epigenous parts. Although 150 and 200 mM Ni effects the germination and vigor of sunflower cultivars more than 50 and 100 mM Ni, it is found less toxic in comparison to Cd and Pb. The Cd accumulation in roots suggests that it is physiologically most active sink for Cd metal while epigenous parts of sunflower cultivars are sink for Pb and Ni metal as shoot of sunflower cultivars accumulates high contents of Pb and Ni.

关键词： Translocation Germination Heavy Metals Contamination Sunflower