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Proteomic analysis of blood level of proteins before and after operation in patients with esophageal squamous cell carcinoma at high-incidence area in Henan Province

引用

World Journal of Gastroenterology 2004年第22期10卷 3365-3368页

作者： Ji-YeAn Zong-MinFan Ze-HaoZhuang Yan-RuQin shah-shahgao Ji-LinLi Li-DongWang LaboratoryforCancerResearchandtheThirdTeachingHospital CollegeofMedicineZhengzhouUniversityZhengzhou450052HenanProvinceChina LaboratoryforCancerResearch CollegeofMedicineZhengzhouUniversityZhengzhou450052HenanProvinceChina DepartmentofPathology YaocunEsophagealCancerHospitalLinzhou456592HenanProvinceChina

AIM: To characterize the protein files in blood from same patients with esophageal squamous cell carcinoma (ESCC) before and after operation at Me high-incidence area for ESCC in Henan Province, China. METHODS: Two-dimensional electrophoresis, silver staining and ImageMaster 2-DE analysis software were applied to the determination of protein files in the blood obtained from normal controls and ESCC patients before and after operation. RESULTS: A total of 655, 662 and 677 protein spots were identified, respectively, from the normal controls and ESCC patients before and after operation. No significant difference in the number of protein spots was observed between Me normal group and ESCC patients. A total of seven protein spots were identified wi~ a dramatic difference among the samples before and after operation. Six protein spots were up-regulated and one protein spot was down-regulated in the group after operation compared with those in normal and before operation. Three protein spots were further characterized by matrix-assisted laser desorption/ionization time of flying mass spectrometry (MALDI-TOF-MS). The proteins from these three spots were identified as serum amyloid A (SAA), amyloid related serum protein and haptoglobin. CONCLUSION: Serum amyloid A, amyloid related serum protein and haptoglobin may be related with ESCC and/or surgery. The significance of ~ese proteins needs to be further characterized. The present study provides informative data for Me establishment of serum protein profiles related with ESCC.

关键词：蛋白分解 ESCC 血液水平诊断方法食道鳞状细胞癌肿瘤高入射范围免疫血清

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