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An integrated approach for GLOF hazard,vulnerability and risk assessment in the Karakoram Mountain Range of northern Pakistan

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Journal of Mountain Science 2025年第1期22卷 142-155页

作者： Sajid ULLAH Muhammad SHAFIQUE Ghazanfar Ali KHATTAK Attaullah shah Yaseen ULLAH National Centre of Excellence in Geology University of PeshawarPeshawar 25000Pakistan GIS and Space Application in Geosciences National Centre of GIS and Space Applications(NCGSA)Islamabad 44000Pakistan Karakoram International University Gilgit 15100Pakistan

Climate change and rising temperatures are accelerating the rate of deglaciation in the Hindu Kush Karakoram Himalaya(HKH)ranges,leading to the formation of new glacial lakes and the expansion of existing *** lakes are often vulnerable to failure,posing a significant threat to downstream communities and ***,a comprehensive assessment of Glacier-Lake Outburst Flood(GLOF)hazards and risk assessment is crucial to evaluate flood runout characteristics and identify settlements and infrastructure that are exposed and vulnerable to floods,aiding in the development and implementation of risk reduction *** study aims to simulate a GLOF event induced by the Shisper glacier lake in northern Pakistan,using the HEC-RAS,and to assess its impact on settlements,infrastructure,and agricultural *** the hydrometeorological analysis of the GLOF event,topographic data from unmanned aerial vehicles(UAVs),stream profiles,discharge data,Manning's roughness coefficient(n),and land use/land cover(LULC)were analyzed using HEC-RAS and geographic information system(GIS).During the GLOF event on May 7,2022,a maximum water depth of 6.3 m and a maximum velocity of 9.5 m/s were *** on the runout characteristics of this event,vulnerability and risk assessments have been *** physical,social,and environmental vulnerabilities of the at-risk elements were evaluated using the analytical hierarchy process(AHP)and integrated with the hazard data to develop a risk *** study identified the areas,infrastructure and settlements susceptible to GLOF hazard to support the development and implementation of targeted and evidence-based mitigation and adaptation strategies.

关键词： GLOF Hazard assessment Glacial lake HEC-RAS Vulnerability and risk Shisper glacier

Restless head syndrome:A retrospective study

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World Journal of Methodology 2025年第1期15卷 51-59页

作者： Sanjay Prakash Varoon Vadodaria Niraj Chawda Chetsi S shah Anurag Prakash Department of Neurology Smt.B.K.Shah Medical Institute and Research CentreSumandeep VidyapeethVadodara 391760GujarātIndia Department of Medicine Smt.B.K.Shah Medical Institute and Research CentreSumandeep VidyapeethVadodara 391760GujarātIndia Department of Medicine Parul Institute of Medical Sciences and Research CentreParul University WaghodiaVadodara 391760India

BACKGROUND Restless legs syndrome(RLS)is characterized by an urge to move with an unpleasant sensation in the lower *** typically affects the ***,it can also affect several other body regions,such as the arms,abdomen,face,neck,head,and genital *** are only a few reports of the RLS variant affecting the *** To assess the epidemiological,clinical,and other aspects of the RLS variant affecting the *** We conducted a retrospective study of 17 adult patients(>18 years)who met the RLS criteria and simultaneously experienced RLS-like symptoms in the *** The median age at which symptoms appeared was 41.6 *** and females were equally affected(1.1:1).All 17 patients had uncomfortable sensations in the lower *** or disturbed sleep was the most common comorbidity(n=16,88.2%).However,headache was the most common presenting or primary symptom(n=10,70.5%).Dizziness or an abnormal sensation in the head was the second most common presenting symptom(5 patients,29.4%).Other presenting features were leg pain,backache,and generalized body *** patients responded favorably to dopaminergic *** If RLS-related unpleasant sensations and pain are felt in the head,they may be misinterpreted as headache,dizziness,or psychosomatic *** and headaches in a subset of patients may be two phenotypic manifestations of the same disorder.

关键词： Restless legs syndrome Restless head syndrome Dopamine Headache Migraine Tension-type headache

Macular microvascular and structural changes on optical coherence tomography angiography in atypical optic neuritis

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World Journal of Methodology 2025年第1期15卷 88-94页

作者： Chinmay Mahatme Madhurima Kaushik Veerappan Rathinasabapathy Saravanan Karthik Kumar Virna M shah Department of General Ophthalmology Aravind Eye HospitalCoimbatore 641014Tamil NāduIndia Department of Neuro-ophthalmology Aravind Eye HospitalCoimbatore 641014Tamil NāduIndia Department of Vitreoretina Aravind Eye HospitalCoimbatore 641014Tamil NāduIndia

BACKGROUND Atypical optic neuritis,consisting of neuromyelitis optica spectrum disorders(NMOSD)or myelin oligodendrocyte glycoprotein antibody disease(MOGAD),has a very similar presentation but different prognostic implications and longterm management *** and metabolic factors are being thought to play a role in such autoimmune neuro-inflammatory disorders,apart from the obvious immune mediated *** the advent of optical coherence tomography angiography(OCTA),it is easy to pick up on these subclinical macular microvascular and structural *** To study the macular microvascular and structural changes on OCTA in atypical optic *** This observational cross-sectional study involved 8 NMOSD and 17 MOGAD patients,diagnosed serologically,as well as 10 healthy *** vascular density(MVD)and ganglion cell+inner plexiform layer thickness(GCIPL)were studied using *** There was a significant reduction in MVD in NMOSD and MOGAD affected as well as unaffected eyes when compared with healthy *** and MOGAD affected eyes had significant GCIPL thinning compared with healthy *** unaffected eyes did not show significant GCIPL thinning compared to healthy controls in contrast to MOGAD unaffected *** comparing NMOSD with MOGAD,there was no significant difference in terms of MVD or GCIPL in the affected or unaffected *** Although significant microvascular and structural changes are present on OCTA between atypical optic neuritis and normal patients,they could not help in differentiating between NMOSD and MOGAD cases.

关键词： Optical coherence tomography angiography Atypical optic neuritis Macular microvascular changes Neuromyelitis optica spectrum disorders Myelin oligodendrocyte glycoprotein antibody disorder

Epidemiology of liver diseases:global disease burden and forecasted research trends

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Science China(Life Sciences) 2025年第2期68卷 541-557页

作者： Jia Xiao Fei Wang Yuan Yuan Jinhang Gao Lu Xiao Chao Yan Feifei Guo Jiajun Zhong Zhaodi Che Wei Li Tian Lan Frank Tacke Vijay H.shah Cui Li Hua Wang Erdan Dong Department of Gastroenterology Qingdao Central HospitalUniversity of Health and Rehabilitation SciencesQingdao 266071China Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment Zhuhai Hospital Affiliated with Jinan UniversityZhuhai 510630China Division of Gastroenterology Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen 518107China School of Biological Sciences Jinan UniversityGuangzhou 519070China Aier Institute of Ophthalmology Central South UniversityChangsha 410015China Lab of Gastroenterology and Hepatology West China HospitalSichuan UniversityChengdu 610041China Clinical Medicine Research Institute and Department of Metabolic and Bariatric Surgery the First Affiliated Hospital of Jinan UniversityGuangzhou 510630China Faculty of Pharmaceutical Sciences Toho UniversityChiba Tokyo 143-8540Japan Department of Hepatology and Gastroenterology Charité-Universitätsmedizin BerlinCampus Virchow-Klinikum and Campus CharitéMitteBerlin 13353Germany Division of Gastroenterology and Hepatology Mayo ClinicRochester MN 55905USA Department of Health Sciences National Natural Science Foundation of ChinaBeijing 100085China Department of Oncology The First Affiliated HospitalInstitute for Liver Diseases of Anhui Medical UniversityHefei 230032China Inflammation and Immune Mediated Diseases Laboratory of Anhui Province Anhui Medical UniversityHefei 230032China Research Center forCardiopulmonary Rehabilitation Universityof Health and Rehabilitation Sciences Qingdao Hospital(Qingdao Municipal Hospital)Schoolof Health andLifeSciencesUniversityof Health and Rehabilitation SciencesQingdao 266071China Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalState Key Laboratory of Vascular Homeostasis and RemodelingPeking UniversityBeijing 100191China

We assessed the global incidence,mortality,and disability-adjusted life years(DALYs)associated with various liver diseases,including alcohol-related liver disease(ALD),hepatitis B/C virus infections(HBV or HCV),liver cancer,metabolic dysfunction-associated steatotic liver disease(MASLD),and other chronic liver diseases,from the 2019 Global Burden of Disease ***,we analyzed the global trends in hepatology research and drug *** 2000 to 2019,prevalence rates increased for ALD,MASLD and other liver diseases,while they decreased for HBV,HCV,and liver *** with a high socio-demographic index(SDI)exhibited the lowest mortality rates and *** burden of liver diseases varied due to factors like sex and *** nine representative countries,MASLD,along with hepatobiliary cancer,showed highest increase in funding in hepatology ***,the major research categories in hepatology papers from 2000 to 2019 were cancer,pathobiology,and *** United States(U.S.)was at the forefront of hepatology research,with China gradually increasing its influence over *** worldwide are increasingly focusing on studying the communication between the liver and other organs,while underestimating the research on ***,HCV,and MASLD were the primary diseases targeted for therapeutic development in clinical ***,the proportion of new drugs approved for the treatment of liver diseases was relatively low among all newly approved drugs in the U.S.,China,Japan,and the European ***,there were no approved drug for the treatment of ALD in the world.

关键词： liver disease disease burden GBD estimate research trend drug development

Rosa moschata ameliorates haloperidol-induced Parkinson's disease via reduction of neurodegeneration and oxidative stress

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Asian Pacific Journal of Tropical Biomedicine 2025年第1期15卷 24-33,I0013-I0015页

作者： Badriyah S.Alotaibi Uzma Saleem Maryam Farrukh Zunera Chaudhary Nabia Anwar Ifat Alsharif Abdullah R.Alanzi Tasahil S.Albishi Fatima A.Jaber Wedad Saeed Al-Qahtani Muhammad Ajmal shah Department of Pharmaceutical Sciences College of PharmacyPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Punjab University College of Pharmacy University of the PunjabLahore-54000Pakistan Department of Pharmacology Faculty of Pharmaceutical SciencesGovt.College UniversityFaisalabad-38000Pakistan Department of Biology Jamoum University CollegeUmm Al-Qura University-21955 MakkahSaudi Arabia Department of Pharmacognosy College of PharmacyKing Saud UniversityRiyadh-11451Saudi Arabia Department of Biology College of SciencesUmm Al-Qura UniversityMakkahSaudi Arabia Department of Biological Sciences College of ScienceUniversity of JeddahJeddah 21589Saudi Arabia Department of Forensic Sciences College of Criminal JusticeNaif Arab University for Security SciencesP.O.Box 6830Riyadh 11452Saudi Arabia Department of Pharmacy Hazara UniversityMansehra-21300Pakistan

Objective:To investigate the effect of Rosa moschata(***)extract on haloperidol-induced Parkinson’s disease(PD)in ***:Haloperidol(1 mg/kg)was given to rats intraperitoneally for 3 weeks for induction of *** extract(150,300 and 600 mg/kg)was administered orally for 21 *** neuroprotective role of *** leaf extract in PD was explored by performing neurobehavioral tests and RT-PCR analysis and measuring neurotransmitters and oxidative stress ***:An improvement in motor functions and muscle strength was observed in PD rats treated with *** *** levels of dopamine,serotonin,noradrenaline,superoxide dismutase,catalase,glutathione,and superoxide dismutase were significantly increased(P<0.001),whereas acetylcholinesterase and malondialdehyde levels were markedly decreased by treatment with *** extract(P<0.001).The extract also markedly downregulated the mRNA expressions of IL-1β,α-synuclein,IL-1α,and TNF-αin brain ***,histopathological analysis indicated that neurofibrillary tangles and plaques were noticeably decreased in a dose-dependent manner in PD rats treated with *** ***:*** extract alleviates haloperidol-induced PD in rats by reducing oxidative stress and *** may be used for management and treatment of *** additional studies are required to confirm its efficacy and molecular mechanisms.

关键词： Parkinson’s disease Rosa moschata Neurotransmitter,α-Synuclein Haloperidol Neurodegeneration

Alternative Strategy for Development of Dielectric Calcium Copper Titanate‑Based Electrolytes for Low‑Temperature Solid Oxide Fuel Cells

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Nano-Micro Letters 2025年第1期17卷 310-332页

作者： Sajid Rauf Muhammad Bilal Hanif Zuhra Tayyab Matej Veis MAKYousaf shah Naveed Mushtaq Dmitry Medvedev Yibin Tian Chen Xia Martin Motola Bin Zhu College of Mechatronics and Control Engineering Shenzhen UniversityShenzhen 518060People’s Republic of China Department of Inorganic Chemistry Faculty of Natural SciencesComenius University BratislavaIlkovicova684215 BratislavaSlovakia Energy Storage Joint Research Center School of Energy and EnvironmentSoutheast UniversityNanjing 210096People’s Republic of China Hydrogen Energy Laboratory Ural Federal University620002 EkaterinburgRussia Laboratory of Electrochemical Devices Based on Solid Oxide Proton Electrolytes Institute of High Temperature Electrochemistry620066 EkaterinburgRussia School of Microelectronics Hubei UniversityWuhan 430062People’s Republic of China

The development of low-temperature solid oxide fuel cells(LT-SOFCs)is of significant importance for realizing the widespread application of *** has stimulated a substantial materials research effort in developing high oxide-ion conductivity in the electrolyte layer of *** this context,for the first time,a dielectric material,CaCu_(3)Ti_(4)O_(12)(CCTO)is designed for LT-SOFCs electrolyte application in this *** individual CCTO and its heterostructure materials with a p-type Ni_(0.8)Co_(0.15)Al_(0.05)LiO_(2−δ)(NCAL)semiconductor are evaluated as alternative electrolytes in LT-SOFC at 450–550℃.The single cell with the individual CCTO electrolyte exhibits a power output of approximately 263 mW cm^(-2) and an open-circuit voltage(OCV)of 0.95 V at 550℃,while the cell with the CCTO–NCAL heterostructure electrolyte capably delivers an improved power output of approximately 605 mW cm^(-2) along with a higher OCV over 1.0 V,which indicates the introduction of high hole-conducting NCAL into the CCTO could enhance the cell performance rather than inducing any potential short-circuiting *** is found that these promising outcomes are due to the interplay of the dielectric material,its structure,and overall properties that led to improve electrochemical mechanism in CCTO–***,density functional theory calculations provide the detailed information about the electronic and structural properties of the CCTO and NCAL and their heterostructure CCTO–*** study thus provides a new approach for developing new advanced electrolytes for LT-SOFCs.

关键词： LT-SOFCs Dielectric CaCu_(3)Ti_(4)O_(12) Semiconductor Ni_(0.8)Co_(0.15)Al_(0.05)LiO_(2−δ) Ionic conductivity Heterostructure electrolyte

Immunohistochemical expression of matrix metalloproteinase-9 and 13 in oral squamous cell carcinoma and their role in predicting lymph node metastasis

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World Journal of Methodology 2025年第2期15卷 108-116页

作者： Bhari Sharanesha Manjunatha Keshav T Handge Vandana Sandeep shah Yasser Eid Al-Thobaiti Deepak Gowda Sadashivappa Pateel Department of Basic Oral Medicine and Allied Dental Sciences Taif UniversityAt`Taif 26571MakkahSaudi Arabia Department of Oral and Maxillofacial Pathology Dr.Vasantrao Pawar Medical CollegeHospital and Research CentreNashik 423101MaharashtraIndia Department of Oral Pathology and Microbiology KM Shah Dental College and HospitalSumandeep VidyapeethVadodara 391760GujaratIndia Department of Oral and Maxillofacial Surgery and Diagnostic Sciences Faculty of DentistryTaif UniversityAl-Haweiah 26571 MakkahSaudi Arabia Department of Oral Pathology and Microbiology Faculty of DentistryMAHSA UniversitySelangor 42610Malaysia

BACKGROUND One of the main characteristics of oral squamous cell carcinoma(OSCC)is that it metastasizes to cervical lymph nodes frequently with a high degree of local invasiveness.A primary feature of malignant tumors is their penetration of neighboring tissues,such as lymphatic and blood arteries,due to the tumor cells'capacity to break down the extracellular matrix(ECM).Matrix metalloproteinases(MMPs)constitute a family of proteolytic enzymes that facilitate tissue remodeling and the degradation of the ***-9 and MMP-13 belong to the group of extracellular matrix degrading enzymes and their expression has been studied in OSCC because of their specific ***-13,a collagenase family member,is thought to play an essential role in the MMP activation cascade by breaking down the fibrillar collagens,whereas MMP-9 is thought to accelerate the growth of *** MMP-13 expression has been associated with tumor behavior and patient prognosis in a number of malignant *** To assess the immunohistochemical expression of MMP-9 and MMP-13 in *** A total of 40 cases with histologically confirmed OSCC by incisional biopsy were included in this cross-sectional retrospective *** protocols for both MMP-9 and MMP-13 immunohistochemical staining were performed according to the manufacturer’s recommendations along with the normal gingival epithelium as a positive *** the observations were recorded and Pearson’sχ²test with Fisher exact test was used for statistical *** Our study showed no significant correlation between MMP-9 and MMP-13 staining intensity and tumor *** majority of the patients were in advanced TNM stages(III and IV),and showed intense expression of MMP-9 and *** The present study suggests that both MMP-9 and MMP-13 play an important and independent role in OSCC progression and *** expression of MMP-9 and MMP-13,irrespective of histological grade of OSCC,correlates well with T

关键词： Matrix metalloproteinases Oral squamous cell carcinoma Tumor staging Immunohistochemistry Invasion Lymph node metastasis TNM stage

Pan-genome analyses add ~1000 genes to the“complete”genome assemblyof chicken

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Journal of Genetics and Genomics 2025年第1期52卷 116-119页

作者： Jilong Ren Wenyan Kou Yuan Xu Meixuan Lu Mian Gong Xinmiao Zhang Zhenyu Liu Hengkuan Li Qimeng Yang Ali Mujtaba shah Feng Zhu Zhuocheng Naiyi Xu Yu Jiang Fei Wang Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYanglingShaanxi 712100China Hou Frontiers Science Center for Molecular Design Breeding(MOE)&College of Animal Science and Technology China Agricultural UniversityBeijing 100193China College of Animal Science and Technology Southwest UniversityChongqing 400715China Chongqing Key Laboratory of Herbivore Science Chongqing 400715China Key Laboratory of Livestock Biology Northwest A&F UniversityYanglingShaanxi 712100China

Chicken(Gallus gallus)is a vital living organism and plays a crucial role in food *** and accurate chicken genomes are critical for insights into chicken breeding,avian evolution,and comparative genomics(Bravo et al.,2021).Pan-genomes possess more power to capture complete gene sets,thus presenting more comprehensive genomic information within species.

关键词： breeding comprehensive chicken

Comparative assessment of mechanical and chemical fluid diversion techniques during hydraulic fracturing in horizontal wells

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Petroleum Science 2023年第6期20卷 3582-3597页

作者： Maunish S.shah Subhash N.shah Drilling Cementingand Stimulation Research CenterDepartment of Petroleum EngineeringSchool of Energy TechnologyPandit Deendayal Energy UniversityRaisanGandhinagarGujaratIndia Mewbourne School of Petroleum and Geological Engineering The University of OklahomaNormanOKUSA

The application of fluid diversion during hydraulic fracturing is an evolving technology and has become popular amongst E&P operators over the past few *** primary objective of the fluid diversion is to improve hydraulic fracturing treatment by increasing stimulated reservoir volume and improving hydrocarbon *** is possible by achieving any of the following objectives:creating uniform distribution of treatment slurry within the target zone;treating unstimulated and under-stimulated zones;or by increasing fracture density by creating a complex fracture *** fluid diversion application is also helpful in decreasing the number of stages(by increasing stage length)for multi-stage plug-n-perf(PnP)fracturing *** is also applied to prevent fracture-driven interactions between adjacent wells,which is currently a major issue,especially in *** addition,for successful refracturing treatment,the diverter application is essential for isolating the existing fractures and redirecting the treatment slurry to the desired unstimulated *** diversion methods can be broadly categorized into the mechanical and chemical *** established mechanical diversion techniques are frac plugs,expandable casing patches,expandable liners,swellable packers,straddle packer assembly,sand plugs,frac sleeves,perforation ball sealers,and limited entry *** different chemical diversion techniques are particulates,fibers,gels,surfactants,perforation pods,and composite *** paper describes the current status of established mechanical and chemical diverter technologies and examines their comparative advantages and *** techniques are suitable for diverter application,but the technique is selected based on the desired objective and conditions of the wellbore and *** general guidelines for selecting diversion techniques and operational considerations are also provided in the *** diagnosis of diversion treatme

关键词： Fluid diversion Diverter Diverting agents Multi-stage fracturing Hydraulic fracturing Horizontal well