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Determinants of Occipital Involvement in Males and Females with Pattern Hair Loss: A Retrospective Study

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Journal of Cosmetics, Dermatological Sciences and Applications 2024年第2期14卷 128-140页

作者： shadi Zari Department of Dermatology College of Medicine University of Jeddah Jeddah Saudi Arabia

Background: Pattern hair loss (PHL) is the most common form of hair loss affecting both men and women. The occipital region, located at the back of the scalp, has been considered resistant to hair loss in PHL. It is often used as a donor site for hair transplantation procedures. However, evidence suggests that the occipital region may also be affected by PHL, although to a lesser extent compared to the frontal and vertex regions. Objective: To assess the levels and determinants of occipital involvement in PHL, focusing on gender and disease severity. Such data would enhance the comprehensive understanding of PHL progression and inform development of improved treatment strategies. Methods: This retrospective study involved 1993 adults (1000 males, 993 females) following for PHL at a specialized hair clinic in Jeddah, Saudi Arabia. Any patient who had hair transplantation in the past and any male who had balding areas (Hamilton-Norwood scales 4 to 7) at the initial consultation was excluded. The primary outcome was occipital involvement, defined as >10% thin hairs in the trichometry assessments of the occipital region. Additional data included patients age, treatment status, disease severity, and other trichometry parameters. Results: The prevalence of occipital involvement was found to be 23.8% overall, significantly more frequent in females (35.6%) than males with early PHL (Hamilton-Norwood scales 2 and 3) (12.1%) (p Conclusion: This study underscored the relevance of gender and disease severity in occipital involvement in PHL. Females had significantly higher rates of occipital involvement, suggesting that gender differences are critical in understanding PHL progression. Future research should aim to validate these findings, with an aim to refine therapeutic and surgical approaches to improve patient outcomes.

关键词： Pattern Hair Loss Occipital Involvement Gender Trichometry Donor Zone

Clinical approach to diarrheal disorders in allogeneic hematopoietic stem cell transplant recipients

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World Journal of Hematology 2016年第1期5卷 23-30页

作者： shadi hamdeh Abd Almonem M Abdelrahman Osama Elsallabi Ranjan Pathak Smith Giri Kailash Mosalpuria Vijaya Raj Bhatt Department of Internal Medicine Creighton University School of Medicine Department of Medicine Reading Health System Reading Department of Medicine University of Tennessee Health Science Center Department of Internal Medicine Division of Hematology-Oncology University of Nebraska Medical Center

Diarrhea is a common complication of allogeneic hematopoietic stem cell transplant(HSCT), with an average incidence of approximately 40%-50%. A wide variety of etiologies can contribute to diarrhea in HSCT patients, including medication-induced mucosal inflammation, infections, graft-vs-host disease and cord colitis syndrome in umbilical cord blood transplant. Clinical manifestations can vary from isolated diarrheal episodes, to other organ involvement including pneumonia or myocarditis, and rarely multiorgan failure. The approach for diagnosis of diarrheal disorders in HSCT patients depends on the most likely cause. Given the risk of life-threatening conditions, the development of clinically significant diarrhea requires prompt evaluation, supportive care and specific therapy, as indicated. Serious metabolic and nutritional disturbances can happen in HSCT patients, and may even lead to mortality. In this review, we aim to provide a practical approach to diagnosis and management of diarrhea in the post-transplant period.

关键词： Diarrhea Medication-induced diarrhea Allogeneic hematopoietic stem cell transplant Enteric infection Graft-vs-host disease

Mapping the global research landscape on nonalcoholic fatty liver disease and insulin resistance:A visualization and bibliometric study

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World Journal of Hepatology 2024年第6期16卷 951-965页

作者： Sa'ed H Zyoud Omar E Hegazi Samer O Alalalmeh Muna Shakhshir Faris Abushamma shadi Khilfeh Samah W Al-Jabi Department of Clinical and Community Pharmacy College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Clinical Research Center An-Najah National University HospitalNablus 44839Palestine College of Pharmacy and Health Sciences Ajman UniversityAjman 346United Arab Emirates Department of Nutrition An-Najah National University HospitalNablus 44839Palestine Department of Medicine College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Department of Urology An-Najah National University HospitalNablus 44839Palestine Department of Gastroenterology Hepatology and EndoscopyAn-Najah National University HospitalNablus 44839Palestine

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is a liver condition that is prevalent worldwide and associated with significant health risks and economic *** it has been linked to insulin resistance(IR),this study aimed to perform a bibliometric analysis and visually represent the scientific literature on IR and *** To map the research landscape to underscore critical areas of focus,influential studies,and future directions of NAFLD and *** This study conducted a bibliometric analysis of the literature on IR and NAFLD indexed in the SciVerse Scopus database from 1999 to *** search strategy used terms from the literature and medical subject headings,focusing on terms related to IR and *** software was used to visualize research trends,collaborations,and key thematic *** analysis examined publication type,annual research output,contributing countries and institutions,funding agencies,journal impact factors,citation patterns,and highly cited *** This analysis identified 23124 documents on NAFLD,revealing a significant increase in the number of publications between 1999 and *** search retrieved 715 papers on IR and NAFLD,including 573(80.14%)articles and 88(12.31%)*** most productive countries were China(n=134;18.74%),the United States(n=122;17.06%),Italy(n=97;13.57%),and Japan(n=41;5.73%).The leading institutions included the Universitàdegli Studi di Torino,Italy(n=29;4.06%),and the Consiglio Nazionale delle Ricerche,Italy(n=19;2.66%).The top funding agencies were the National Institute of Diabetes and Digestive and Kidney Diseases in the United States(n=48;6.71%),and the National Natural Science Foundation of China(n=37;5.17%).The most active journals in this field were Hepatology(27 publications),the Journal of Hepatology(17 publications),and the Journal of Clinical Endocrinology and Metabolism(13 publications).The main research hotspots were“therapeutic approaches for IR and NAFLD”and“inflamma

关键词： Nonalcoholic fatty liver disease Insulin resistance Bibliometric Visualization

Cardioprotective mechanism of Qixuan Yijianing(芪玄抑甲宁) formula in Graves′ disease mice using miRNA sequencing approach

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Journal of Traditional Chinese Medicine 2024年

作者： GAO Changjiu DING Song shadi A.D.Mohammed LU Fang LIU Changfeng TENG Zhan XU Peng LIU Shumin School of Pharmacy， Mudanjiang Medical University Graduate School， Heilongjiang University of Chinese Medicine School of Pharmacy， Lebanese International University Institute of Traditional Chinese Medicine， Heilongjiang University of Chinese Medicine

OBJECTIVE: To investigate the mechanism of Qixuan Yijianing (芪玄抑甲宁，QYN) in minimizing cardiac injury in Graves′ disease (GD) mice using microRNA (miRNA) sequencing analysis. METHODS: Female BALB/c mice were randomly divided into the modeling and control groups (CG). The modeling group was established with Ad-TSHR289. Following 10 weeks of successful modeling， the mice were randomly assigned to four groups: model (MG)， methimazole (MMI)， QYN low-dose (LD)， and high-dose (HD). After four weeks of treatment， the heart rate， heart volume， and heart index were measured， and the levels of aspartate aminotransferase (AST)， lactate dehydrogenase (LDH)， α-hydroxybutyrate dehydrogenase (α-HBD)， creatine kinase (CK)， and creatine kinase MB isoenzyme (CK-MB) in the serum were detected using a biochemical analyzer. Hematoxylin-eosin and Masson staining were used to determine histological changes in cardiac tissue. The heart tissues in the CG， MG， and HD groups were selected， and miRNA sequencing was used to identify differentially expressed miRNAs. A bioinformatics database was used to predict the target genes of differential miRNAs， and Gene Ontology (GO)， and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were conducted on the predicted target ***: As compared to the CG group， the MG group's heart rate， heart volume， heart index， AST， CK， CK-MB， LDH， α-HBD， myocardial fiber thickness， and collagen fiber significantly increased， all P < 0.01， while following QYN， these indicators improved in the HD group， all P < 0.01 or P < 0.05. Compared to the CG group， the MG group identified 151 differentially expressed miRNAs， with 42 miRNAs downregulated and 109 miRNAs upregulated; compared to the MG group， the HD group identified 70 differentially expressed miRNAs， 40 were downregulated， and 30 were upregulated. The GO functions of differential miRNA target genes are mostly enriched in cardiac development regulation， cardiac contraction control， heart rate

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An End-to-End Authentication Scheme for Healthcare IoT Systems Using WMSN

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Computers, Materials & Continua 2021年第7期68卷 607-642页

作者： shadi Nashwan Department of Computer Science College of Computer and Information SciencesJouf UniversitySakaka42421Saudi Arabia

The healthcare internet of things(IoT)system has dramatically reshaped this important industry *** system employs the latest technology of IoT and wireless medical sensor networks to support the reliable connection of patients and healthcare *** goal is the remote monitoring of a patient’s physiological data by ***,this system can reduce the number and expenses of healthcare centers,make up for the shortage of healthcare centers in remote areas,enable consultation with expert physicians around the world,and increase the health awareness of *** major challenges that affect the rapid deployment and widespread acceptance of such a system are the weaknesses in the authentication process,which should maintain the privacy of patients,and the integrity of remote medical *** research results indicate the need of a flexible authentication *** study proposes a scheme with enhanced security for healthcare IoT systems,called an end-to-end authentication scheme for healthcare IoT systems,that is,an *** proposed scheme supports security services such as a strong and flexible authentication process,simultaneous anonymity of the patient and physician,and perfect forward secrecy services.A security analysis based on formal and informal methods demonstrates that the proposed scheme can resist numerous security-related attacks.A comparison with related authentication schemes shows that the proposed scheme is efficient in terms of communication,computation,and storage,and therefore cannot only offer attractive security services but can reasonably be applied to healthcare IoT systems.

关键词： Healthcare IoT systems wireless medical sensor networks mutual authentication service anonymity service perfect forward secrecy service COVID-19

Analysis of the Desynchronization Attack Impact on the E2EA Scheme

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Computer Systems Science & Engineering 2022年第5期41卷 625-644页

作者： shadi Nashwan Computer Science Department College of Computer and Information SciencesJouf UniversitySakaka42421Saudi Arabia

The healthcare IoT system is considered to be a significant and modern medical *** is broad consensus that these systems will play a vital role in the achievement of economic growth in numerous growth *** the major challenges preventing the fast and widespread adoption of such systems is the failure to maintain the data privacy of patients and the integrity of remote clinical ***,the author proposed an end-to-end authentication scheme for healthcare IoT systems(E2EA),to provide a mutual authentication with a high data rate between the communication nodes of the healthcare IoT *** the E2EA authentication scheme supports numerous attractive security services to resist various types of attack,there is an ambiguous view of the impact of the desynchronization attack on the E2EA authentication *** general,the performance of the authentication scheme is considered a critical issue when evaluating the applicability of such schemes,along with the security services that can be ***,this paper discusses how the E2EA authentication scheme can resist the desynchronization attack through all possible attack ***,the effect of the desynchronization attack on the E2EA scheme performance is analyzed in terms of its computation and communication costs,based on a comparison with the recently related authentication schemes that can prevent such ***,this research paper finds that the E2EA authentication scheme can not only prevent the desynchronization attack,but also offers a low cost in terms of computations and communications,and can maintain consistency and synchronization between the communication nodes of the healthcare IoT systems during the next authentication sessions.

关键词： Desynchronization attack healthcare IoT systems E2EA scheme mutual authentication anonymity perfect forward secrecy

Effects of CuO Nanoparticles on Microstructure,Physical,Mechanical and Thermal Properties of Self-Compacting Cementitious Composites

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Journal of Materials Science & Technology 2011年第1期27卷 81-92页

作者： Ali Nazari shadi Riahi Department of Technical and Engineering Sciences Islamic Azad University(Saveh Branch)

In the present study,split tensile strength of self-compacting concrete with different amount of CuO nanoparticles has been *** nanoparticles with the average particle size of 15 nm were added partially to self compacting concrete and split tensile strength of the specimens has been *** results indicate that CuO nanoparticles are able to improve the split tensile strength of self compacting concrete and recover the negative effects of polycarboxylate superplasticizer on split tensile *** nanoparticle as a partial replacement of cement up to 4 wt% could accelerate C-S-H gel formation as a result of increased crystalline Ca（OH）2 amount at the early ages of *** increase of the CuO nanoparticles more than 4 wt% causes the decrease of the split tensile strength because of unsuitable dispersion of nanoparticles in the concrete *** peak appearance in conduction calorimetry tests,more weight loss in thermogravimetric analysis and more rapid appearance of related peaks to hydrated products in X-ray diffraction（XRD） results all also indicate that CuO nanoparticles up to4 wt% could improve the mechanical and physical properties of the ***,CuO nanoparticles could improve the pore structure of concrete and shift the distributed pores to harmless and few-harm pores.

关键词： Self-compacting concrete(SCC) CuO nanoparticles Split tensile strength Thermogravimetric analysis(TGA) X-ray diffraction(XRD) Pore structure

Computer-aided Prediction of the ZrO_2 Nanoparticles' Effects on Tensile Strength and Percentage of Water Absorption of Concrete Specimens

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Journal of Materials Science & Technology 2012年第1期28卷 83-96页

作者： Ali Nazari shadi Riahi Department of Materials Science and Engineering Saveh BranchIslamic Azad University

In the present paper, two models based on artificial neural networks and genetic programming for predicting split tensile strength and percentage of water absorption of concretes containing ZrO2 nanoparticles have been developed at different ages of curing. For building these models, training and testing using experimental results for 144 specimens produced with 16 different mixture proportions were conducted. The data used in the multilayer feed forward neural networks models and input variables of genetic programming models were arranged in a format of eight input parameters that cover the cement content, nanoparticle content, aggregate type, water content, the amount of superplasticizer, the type of curing medium, age of curing and number of testing try. According to these input parameters, in the neural networks and genetic programming models, the split tensile strength and percentage of water absorption values of concretes containing ZrO2 nanoparticles were predicted. The training and testing results in the neural network and genetic programming models have shown that two models have strong potential for predicting the split tensile strength and percentage of water absorption values of concretes containing ZrO2 nanoparticles. It has been found that neural network （NN） and gene expression programming （GEP） models will be valid within the ranges of variables. In neural networks model, as the training and testing ended when minimum error norm of network gained, the best results were obtained and in genetic programming model, when 4 genes were selected to construct the model, the best results were acquired. Although neural network have predicted better results, genetic programming is able to predict reasonable values with a simpler method rather than neural network.

关键词： Concrete Curing medium Zr02 nanoparticles Artificial neural network Geneticprogramming Split tensile strength Percentage of water absorption

Secure and Anonymous Three-Factor Authentication Scheme for Remote Healthcare Systems

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Computer Systems Science & Engineering 2022年第8期42卷 703-725页

作者： Munayfah Alanazi shadi Nashwan Department of Computer Science College of Computer and Information SciencesJouf UniversitySakaka42421Saudi Arabia

Wireless medical sensor networks(WMSNs)play a significant role in increasing the availability of remote healthcare *** vital and physiological data of the patient can be collected using the WMSN via sensor nodes that are placed on his/her body and then transmitted remotely to a healthcare professional for proper *** protection of the patient’s privacy and their data from unauthorized access is a major concern in such ***,an authentication scheme with a high level of security is one of the most effective mechanisms by which to address these security *** authentication schemes for remote patient monitoring have been proposed ***,the majority of these schemes are extremely vulnerable to attacks and are unsuitable for practical *** paper proposes a secure three-factor authentication scheme for a patient-monitoring healthcare system that operates remotely using a *** proposed authentication scheme is formally verified using the Burrows,Abadi and Needham’s(BAN)logic model and an automatic cryptographic protocol verifier(ProVerif)*** show that our authentication scheme can prevent relevant types of security breaches in a practical context according to the discussed possible attack *** of the security and performance are carried out with recently proposed authentication *** results of the analysis show that the proposed authentication scheme is secure and practical for use,with reasonable storage space,computation,and communication efficiency.

关键词： Mutual authentication biometric feature perfect forward secrecy user anonymity proVerif tool BAN logic model