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Adherence to Advisory Committee on Immunization Practices in diabetes mellitus patients in Saudi Arabia:A multicenter retrospective study

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World Journal of Diabetes 2024年第3期15卷 440-454页

作者： Saleh Fahad Alqifari Aya K Esmail Dalal M Alarifi Ghalya Y Alsuliman Maram M Alhati May R Mutlaq Mohammed Aldhaeefi shaden a alshuaibi Palanisamy Amirthalingam Abrar Abdallah Afaf S Wasel Heba R Hamad Shoroq Alamin Tasneem H Atia Tariq Alqahtani Department of Pharmacy Practice University of TabukTabuk 71491Saudi Arabia Department of Clinical Sciences Sulaiman Alrajhi UniversityQassim 52726Saudi Arabia Department of Family Medicine International Medical CenterJeddah 23214Saudi Arabia Clinical and Administrative Pharmacy Sciences College of PharmacyHoward UniversityWashingtonDC 20059United States Department of Pharmacology King Saud Bin Abdulaziz University for Health SciencesKing Abdullah International Medical Research CenterRiyadh 11481Saudi Arabia

BACKGROUND Patients with diabetes mellitus(DM)are predisposed to an increased risk of infection signifying the importance of vaccination to protect against its potentially severe *** Centers for Disease Control and Prevention/Advisory Committee on Immunization Practices(CDC/ACIP)issued immunization recommendations to protect this patient *** To assess the adherence of patients with DM to the CDC/ACIP immunization recommendations in Saudi Arabia and to identify the factors associated with the vaccine adherence *** An observational retrospective study conducted in 2023 was used to collect data on the vaccination records from 13 diabetes care centers in Saudi Arabia with 1000 eligible patients in phase I with data collected through chart review and 709 patients in phase II through online *** Among participants,10.01%(n=71)had never received any vaccine,while 85.89%(n=609)received at least one dose of the coronavirus disease 2019(COVID-19)vaccine,and 34.83%(n=247)had received the annual influenza *** 2.96%(n=21),2.11%(n=15),and 1.12%(n=8)received herpes zoster,tetanus,diphtheria,and pertussis(Tdap),and human papillomavirus(HPV)vaccines,*** patients with DM in Saudi Arabia,the rate of vaccination for annual influenza and COVID-19 vaccines was higher compared to other vaccinations such as herpes zoster,Tdap,pneumococcal,and *** such as vaccine recommendations provided by family physicians or specialists,site of care,income level,DM-related hospitalization history,residency site,hemoglobin A1c(HbA1c)level,and health sector type can significantly influence the vaccination rate in patients with *** non-vaccinated patients with DM,the most reported barriers were lack of knowledge and fear of side *** signifies the need for large-scale research in this area to identify additional factors that might facilitate adherence to CDC/ACIP vaccine recommendations in patients with *** In S

关键词： Diabetes mellitus Vaccine recommendation COVID-19 vaccine Influenza vaccine Pneumococcal vaccine Immunization Retrospective study

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Impact of rotavirus vaccine implementation on Israeli children:a comparison between pre-and post-vaccination era

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World Journal of Pediatrics 2022年第6期18卷 417-425页

作者： Hussein Zaitoon shaden Hanna Ellen Bamberger Department of Pediatrics Bnai Zion Medical CenterThe Ruth and Bruce Rappaport Faculty of MedicineTechnion-Israel Institute of Technology47 Golomb St.31048HaifaIsrael The Ruth and Bruce Rappaport Faculty of Medicine Technion-Israel Institute of TechnologyHaifaIsrael

Background Worldwide rotavirus vaccination has resulted in a substantial decrease in rotavirus-induced severe gastroenteritis and related hospitalizations among ***,the characterization of patients warranting hospitalization needs to be further *** purpose of the study is to compare the clinical and laboratory features of children hospitalized with acute rotavirus infection before and after the introduction of routine *** This is a retrospective observational *** were pediatric patients who presented to the Bnai Zion Medical Center pediatric emergency department and were diagnosed with rotavirus acute gastroenteritis between 2017 and *** During the pre-vaccination period(2007–2009),114 infants and young children(median age:14 months,range:1–72 months;59 male,55 female)were hospitalized for rotavirus-induced acute gastroenteritis with a rate of 11.71 positive rotavirus tests per 1000 emergency room *** the post-vaccination period(2012–2019),168 infants and young children(median age:17 months,range:0–84 months;90 male,78 female)were hospitalized with a rate of 4.18 positive rotavirus tests per 1000 emergency room *** were no statistical differences between the two groups in gender,breast-feeding rates and sibling(s).The proportion of cases with moderate-to-severe dehydration was higher in the post-vaccination children than in the pre-vaccination *** Rates of rotavirus-attributed acute gastroenteritis hospitalizations declined from the pre-to the post-vaccination *** rates of dehydration were found in the post-vaccination *** surveillance is warranted to better understand the implications of the vaccine.

关键词： Acute gastroenteritis Booster dose Hospitalization Rotavirus Vaccination

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Twitter Arabic Sentiment Analysis to Detect Depression Using Machine Learning

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Computers, Materials & Continua 2022年第5期71卷 3463-3477页

作者： Dhiaa A.Musleh Taef A.Alkhales Reem A.Almakki Shahad E.Alnajim shaden K.Almarshad Rana S.Alhasaniah Sumayh S.Aljameel Abdullah A.Almuqhim Department of Computer Science College of Computer Science and Information TechnologyImam Abdulrahman Bin Faisal UniversityP.O.Box 1982Dammam31441Saudi Arabia

Depression has been a major global concern for a long time,with the disease affecting aspects of many people’s daily lives,such as their moods,eating habits,and social *** Arabic culture,there is a lack of awareness regarding the importance of facing and curing mental health ***,people all over the world,including Arab citizens,tend to express their feelings openly on social media,especially Twitter,as it is a platform designed to enable the expression of emotions through short texts,pictures,or *** are inclined to treat their Twitter accounts as diaries because the platform affords them *** published studies have detected the occurrence of depression among Twitter users on the basis of data on tweets posted in English,but research on Arabic tweets is *** aim of the present work was to develop a model for analyzing Arabic users’tweets and detecting depression among Arabic Twitter *** expand the diversity of user tweets,by adding a new label(“neutral”)so the dataset include three classes(“depressed”,“non-depressed”,“neutral”).The model was created using machine learning classifiers and natural language processing techniques,such as Support Vector Machine(SVM),Random Forest(RF),Logistic Regression(LR),K-nearest Neighbors(KNN),AdaBoost,and Naïve Bayes(NB).The results showed that the RF classifier outperformed the others,registering an accuracy of 82.39%.

关键词： Depression sentiment analysis twitter supervised learning machine learning

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Diabetes mellitus is not associated with worse short term outcome in patients older than 65 years old post-liver transplantation

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World Journal of Hepatology 2023年第2期15卷 274-281页

作者： Saad Alghamdi shaden Alamro Dhari Alobaid Elwy Soliman Ali Albenmousa Khalid Ibrahim Bzeizi Saleh Alabbad Saleh A Alqahtani Dieter Broering Waleed Al-Hamoudi Liver and Small Bowel Health Centre Department KFSHRCRiyadh 11211Saudi Arabia Department of Medicine KFSHRCRiyadh 11211Saudi Arabia Department of Internal Medicine Minia UniversityMinya 61519Egypt Division of Gastroenterology and Hepatology Johns Hopkins UniversityBaltimoreMD 21287United States Liver Disease Research Center Department of MedicineCollege of MedicineKing Saud UniversityRiyadh 11451Saudi Arabia

BACKGROUND Non-alcoholic fatty liver disease is a global health care challenge and a leading indication of liver transplantation(LT).Hence,more patients with diabetes mellitus(DM)are undergoing LT,especially,above the age of *** To evaluate the impact of DM on short-term outcomes post-LT in patients over the age of *** We collected data of patients who underwent LT from January 2001 until December 2019 using our electronic medical *** assessed the impact of DM on short-term outcomes,one-year,post-LT based on the following variables:Survival at one year;acute cellular rejection(ACR)rates;intensive care unit(ICU)and hospital length of stay;and *** Total of 148 patients who are 65 year or older underwent LT during the study *** mean age is 68.5±3.3 years and 67.6%were *** median Model for End-stage Liver Disease score at time of transplantation was 22(6-39),39%of patients had hepatocellular carcinoma and 77.7%underwent living donor *** one-year survival was similar between DM patients and others,91%.ACR occurred in 13.5%of patients(P=0.902).The median ICU stay is 4.5-day P=*** rates of ICU and 90-d readmission were similar(P=0.821)and(P=0.194),*** The short-term outcome of elderly diabetic patients undergoing LT is similar to *** presence of DM in elderly LT candidates should not discourage physicians from transplant consideration in this cohort of patients.

关键词： Acute cellular rejection Diabetes mellitus Elderly Graft survival Liver transplantation

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Effect of Using Mouthwash Solution on Commensal Flora of the Oral Cavity among Female Students in Qassim University

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Journal of Biosciences and Medicines 2020年第3期8卷 135-142页

作者： shaden Mohammed Alhathloul Amal Hussain Mohammed Ali Department of Medical Laboratories College of Applied Medical Sciences Qassim University Qassim Kingdom of Saudi Arabia

Oral health is the pathway to one’s general health and wellness. Mouthwash is a product used as an adjunct to oral hygiene practices as an antiseptic and antiplaque and antimicrobial agent. The awareness of using mouthwash solution is so limited worldwide. And maybe there’s effect of mouthwash on commensal flora. The aim of this study is to measure the effect of using Mouthwash solution on commensal flora of the oral cavity. In this study, we determined three groups, the first group is considered as a basic group where Female students are not using any mouthwash, the second group used mouthwash twice daily for two weeks, group number three used mouthwash twice weekly. We take cytological sample scraping from oral cavity. All the cytological sections of all groups stained with Papanicolaou stain and examined the slides under the microscope. The study came out with the following results: The basic group that did not use any mouthwash remained unchanged, while the second group, who used mouthwash twice daily, showed a clear epithelial tissue for any bacteria and a clear background. Group number three, who used mouthwash twice a week, showed countable bacteria in epithelial tissue with a clear background. Finally, the study concluded: Cosmetic mouthwash solution has a bad effect on commensal flora if you over used it and leads to killing all your normal flora in oral cavity as much as therapeutic mouthwash will do.

关键词： Mouthwash Commensal Oral Flora Papanicolaou Stain Awareness Effect

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Privacy Preserving Risk Mitigation Approach for Healthcare Domain

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E-Health Telecommunication Systems and Networks 2018年第1期7卷 1-42页

作者： shaden S. Al Aqeeli Mznah A. Al-Rodhaan Yuan Tian Abdullah M. Al-Dhelaan Department of Computer Science College of Computer and Information Sciences King Saud University Riyadh Saudi Arabia

In the healthcare domain, protecting the electronic health record (EHR) is crucial for preserving the privacy of the patient. To help protect the sensitive data, access control mechanisms can be utilized to restrict access to only legitimate users. However, an issue arises when the authorized users abuse their access privileges and violate privacy preferences of the patients. While traditional access control schemes fall short of defending against the misbehavior of authorized users, risk-aware access control models can provide adaptable access to the system resources based on assessing the risk of an access request. When an access request is deemed risky, but within acceptable thresholds, risk mitigation strategies can be exploited to minimize the risk calculated. This paper proposes a risk-aware, privacy-preserving risk mitigation approach that can be utilized in the healthcare domain. The risk mitigation approach controls the patient’s medical data that can be exposed to healthcare professionals, according to their trust level as well as the risk incurred of such data exposure, by developing a novel Risk Measure formula. The developed Risk Measure is proven to manage the risk effectively. Furthermore, Risk Mitigation Data Disclosure algorithms, RIMIDI0 and RIMIDI1, which utilize the developed risk measures, are proposed. Experimental results show the feasibility and effectiveness of the proposed method in preserving the privacy preferences of the patient. Since the proposed approach exposes the patient’s data that are relevant to the undergoing medical procedure while preserving the privacy preferences, positive outcomes can be realized, which will ultimately bring forth quality healthcare services.

关键词： Access Control Healthcare HIPAA Risk-Aware Risk Mitigation

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Influence OF anticancer drugs on DNA methylation in liver of female mice

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American Journal of Molecular Biology 2011年第2期1卷 62-69页

作者： shaden Muawia Hanafy Tarek Abd El-Raouf Salem Amal Ahmed Abd El-Aziz Bahgat Abd El-ghafar EL-Fiky Mahmoud Abd El-Azeim Shokair 不详

Epigenetic changes such as DNA methylation regulate gene expression in normal development. Methotrexate and Adriamycine are antineoplastic drugs that target DNA and enzymes acting on DNA. We aimed to evaluate their cytotoxic effect on cell lines and on female mice to investigate the in vivo influence of both drugs on the DNA methylation and subsequently the protein expression. The total level of DNA methylation showed a significant reduction from 62.2% to 36.7%, 36.6% as compared to control group, when using different doses of MTX and ADR. Hepatic protein pattern revealed five bands with low MW (16 - 6.1 KDa) in acute and LD50 doses. In conclusion DNA methylation is influenced by anticancer drugs in a dose - dependent manner. Some specific protein fragments may be considered as a potential markers associated with high dose of anticancer drugs.

关键词： Epigenetic DNA Methylation Methotrexate (MTX) and Adriamycine (ADR).

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Influence of anticancer drugs on DNA methylation in liver of female mice

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American Journal of Molecular Biology（美国分子生物学期刊） 2011年第2期

作者： shaden Muawia Hanafy Tarek Abd El-Raouf Salem Amal Ahmed Abd El-Aziz Bahgat Abd El-Ghafar El Fiky Mahmoud Abd El-Azeim Shokair Molecular Biology Department Genetic Engineering and Biotechnology Institute Minufia University Shibin El Kom Egypt Animal Biotechnology Department Genetic Engineering and Biotechnology Institute Minufia University Shibin El Kom Egypt.

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