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Enhanced axonal regeneration and functional recovery of the injured sciatic nerve in a rat model by lithium-loaded electrospun nanofibrous scaffolds

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BIO-DESIGN AND MANUFACTURING 2024年第5期7卷 701-720页

作者： Dolatyar, Banafsheh Zeynali, Bahman shabani, iman Tafreshi, Azita Parvaneh Karimi-Soflou, Reza Univ Tehran Coll Sci Sch Biol Dev Biol Lab Tehran *** Iran Natl Inst Genet Engn & Biotechnol Fac Med Biotechnol Dept Mol Med Tehran *** Iran Amirkabir Univ Technol Tehran Polytech Dept Biomed Engn Tehran *** Iran

Increasing evidence indicates that engineered nerve grafts have great potential for the regeneration of peripheral nerve injuries (PNIs). While most studies have focused only on the topographical features of the grafts, we have considered both the biophysical and biochemical manipulations in our applied nanoscaffold. To achieve this, we fabricated an electrospun nanofibrous scaffold (ENS) containing polylactide nanofibers loaded with lithium (Li) ions, a Wnt/beta-catenin signaling activator. In addition, we seeded human adipose-derived mesenchymal stem cells (hADMSCs) onto this engineered scaffold to examine if their differentiation toward Schwann-like cells was induced. We further examined the efficacy of the scaffolds for nerve regeneration in vivo via grafting in a PNI rat model. Our results showed that Li-loaded ENSs gradually released Li within 11 d, at concentrations ranging from 0.02 to (3.64 +/- 0.10) mmol/L, and upregulated the expression of Wnt/beta-catenin target genes (cyclinD1 and c-Myc) as well as those of Schwann cell markers (growth-associated protein 43 (GAP43), S100 calcium binding protein B (S100B), glial fibrillary acidic protein (GFAP), and SRY-box transcription factor 10 (SOX10)) in differentiated hADMSCs. In the PNI rat model, implantation of Li-loaded ENSs with/without cells improved behavioral features such as sensory and motor functions as well as the electrophysiological characteristics of the injured nerve. This improved function was further validated by histological analysis of sciatic nerves grafted with Li-loaded ENSs, which showed no fibrous connective tissue but enhanced organized myelinated axons. The potential of Li-loaded ENSs in promoting Schwann cell differentiation of hADMSCs and axonal regeneration of injured sciatic nerves suggests their potential for application in peripheral nerve tissue engineering. (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(si

关键词： Stem cell Schwann cell differentiation Electrospun nanofibrous scaffold Lithium ion Nerve regeneration CATENIN SIGNALING PATHWAY WNT/BETA-CATENIN STEM-CELLS POLYAMIDE FILMS DIFFERENTIATION REMYELINATION DEGENERATION INHIBITION EXPRESSION CHLORIDE

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Enhanced axonal regeneration and functional recovery of the injured sciatic nerve in a rat model by lithium-loaded electrospun nanofibrous scaffolds

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Bio-Design and Manufacturing 2024年第05期 701-720页

作者： Banafsheh Dolatyar Bahman Zeynali iman shabani Azita Parvaneh Tafreshi Reza Karimi-Soflou Developmental Biology Laboratory School of BiologyCollege of Science University of Tehran Department of Biomedical Engineering Amirkabir University of Technology (Tehran Polytechnic) Department of Molecular Medicine Faculty of Medical Biotechnology National Institute of Genetic Engineering and Biotechnology

Increasing evidence indicates that engineered nerve grafts have great potential for the regeneration of peripheral nerve injuries(PNIs). While most studies have focused only on the topographical features of the grafts, we have considered both the biophysical and biochemical manipulations in our applied nanoscaffold. To achieve this, we fabricated an electrospun nanofibrous scaffold(ENS) containing polylactide nanofibers loaded with lithium(Li) ions, a Wnt/β-catenin signaling activator. In addition, we seeded human adipose-derived mesenchymal stem cells(h ADMSCs) onto this engineered scaffold to examine if their differentiation toward Schwann-like cells was induced. We further examined the efficacy of the scaffolds for nerve regeneration in vivo via grafting in a PNI rat model. Our results showed that Li-loaded ENSs gradually released Li within11 d, at concentrations ranging from 0.02 to(3.64 ± 0.10) mmol/L, and upregulated the expression of Wnt/β-catenin target genes(cyclin D1 and c-Myc) as well as those of Schwann cell markers(growth-associated protein 43(GAP43), S100 calcium binding protein B(S100B), glial fibrillary acidic protein(GFAP), and SRY-box transcription factor 10(SOX10)) in differentiated h ADMSCs. In the PNI rat model, implantation of Li-loaded ENSs with/without cells improved behavioral features such as sensory and motor functions as well as the electrophysiological characteristics of the injured nerve. This improved function was further validated by histological analysis of sciatic nerves grafted with Li-loaded ENSs, which showed no fibrous connective tissue but enhanced organized myelinated axons. The potential of Li-loaded ENSs in promoting Schwann cell differentiation of h ADMSCs and axonal regeneration of injured sciatic nerves suggests their potential for application in peripheral nerve tissue engineering.

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Improvement of Surface Mechanical and Tribological Characteristics of L-PBF Processed Commercially Pure Titanium through Ultrasonic Impact Treatment

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Acta Metallurgica Sinica(English Letters) 2024年第6期37卷 1034-1046页

作者： iman Ansarian Reza Taghiabadi Saeid Amini Mohammad Hossein Mosallanejad Luca Iuliano Abdollah Saboori Department of Materials Science and Metallurgy Imam Khomeini International University(IKIU)QazvinIran Department of Mechanical Engineering University of KashanKashanIran Integrated Additive Manufacturing Center Department of Management and Production EngineeringPolitecnico di TorinoCorso Duca Degli Abruzzi 2410129TurinItaly

Multi-pass ultrasonic impact treatment(UIT)was applied to modify the microstructure and improve the mechanical and tribological characteristics at the near-surface region of commercially pure Ti(CP-Ti)specimens produced by the laser powder bed fusion(L-PBF)*** considerably refined the L-PBF process-related acicular martensites(α′-M)and produced a well-homogenized and dense surface microstructure,where the porosity content of 1-,3-,and 5-pass UITed samples was reduced by 43,60,and 67%,*** UITed samples showed an enhancement in their near-surface mechanical properties up to a depth of about 300μ*** nanoindentation results for the 3-pass UITed sample revealed an increase of about 53,45,and 220%in its nanohardness,H/E_(r),and H_(3)/E_(r)^(2)indices,*** stylus profilometry results showed that performing the UIT removed the L-PBF-related features/defects and offered a smooth *** roughness average(R_(a))and the skewness(R_(sk))of the 3-pass UITed sample were found to be lower than those of the L-PBFed sample by 95 and 223%,*** the UIT also enhanced the material ratio,where the maximum load-bearing capacity(~100%)in as-L-PBFed(as-built)and 3-pass UITed samples was obtained at 60-and 10-µm depths,*** tribological investigations showed that applying the UIT resulted in a significant reduction of wear rate and average coefficient of friction(COF)of *** instance,under the normal pressures of 0.05 and 0.2 MPa,the wear rate and COF of the 3-pass UITed sample were lower than those of the L-PBFed sample by 65 and 58%,and 20 and 17%,respectively.

关键词： Laser powder bed fusion Ultrasonic impact treatment Commercially pure Ti(CP-Ti) Surface mechanical properties Tribological properties

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Efficacy of tadalafil on improvement of men with erectile dysfunction caused by COVID-19:A randomized placebo-controlled trial

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Asian Journal of Urology 2024年第1期11卷 128-133页

作者： iman Shamohammadi Seyedmohammad Kazemeyni Mohammadali Sadighi Tara Hasanzadeh Alireza Dizavi Department of Urology Nemazee HospitalShiraz University of Medical ScienceShirazIran Department of Urology Shariati HospitalTehran University of Medical ScienceTehranIran

Objective: According to the high prevalence of COVID-19 and the subsequent risk of men's sexual health, we decided to investigate the efficacy of tadalafil on improvement of men with erectile dysfunction caused by ***: In this study, 70 outpatients who were recovered from COVID-19 without acute respiratory distress syndrome with negative polymerase chain reaction test and a complaint of erectile dysfunction were divided into two groups: 35 patients who received tadalafil 5 mg daily and 35 who received placebo. For each patient, basic assessment of sexual function was performed using the 5-item version of the International Index of Erectile Function (IIEF-5) questionnaire. Then, treatment was started from 2 months after complete recovery of COVID-19 with negative polymerase chain reaction test for 3 months. At the end of the treatments, the patients were re-evaluated for sexual function using the complete version of IIEF questionnaire. Finally, the results before and after treatment in the intervention group were compared with those of the control ***: Treatment with both tadalafil and placebo improved the patients' sexual function criteria compared to the baseline. However, this improvement was significantly higher in the intervention group with tadalafil than the control group with placebo (p<0.05).Conclusion: Daily administration of tadalafil 5 mg seems to be effective and safe for improvement of erectile dysfunction caused by COVID-19.

关键词： Tadalafil Erectile dysfunction COVID-19 Sexual function

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Leveraging Nanotechnology for Addressing COVID-19: Revealing Antiviral Approaches and Hurdles

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World Journal of Nano Science and Engineering 2024年第1期14卷 1-14页

作者： Mehrnaz Mostafavi Mahtab shabani Department of Physics Faculty of Allied Medicine Shahid Beheshti University of Medical Sciences Tehran Iran Department of Internal Medicine Loghman Hakim Hospital Shahid Beheshti University of Medical Sciences Tehran Iran

The emergence of COVID-19 has caused extensive harm and is recognized as a significant threat to human life worldwide. Currently, the application of nanomedicine techniques in pre-clinical studies related to various infections, such as respiratory viruses, herpes viruses, human papillomavirus, and HIV, has demonstrated success. Nanoparticles, due to their specific attributes, have garnered considerable attention in combating COVID-19. Strategies employing nanomaterials for COVID-19 prevention encompass the development of rapid, precise diagnostic tools, the creation of effective disinfectants, the delivery of mRNA vaccines to the biological system, and the administration of antiretroviral medications within the body. This article focuses on recent research regarding the effectiveness of nano platforms as antiviral measures against coronaviruses. It delves into the molecular characteristics of coronaviruses and the affected target systems, highlighting challenges and limitations in combating SARS-CoV-2. Additionally, it explores potential nanotechnology-based treatments to confront current and future variants of coronaviruses associated with COVID-19 infections.

关键词： COVID-19 Coronavirus Nanomaterials Nano-Based Vaccine SARS-CoV-2

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Exactly Solvable Two-Parameter Models of Relativistic δ′s -Sphere Interactions in Quantum Mechanics

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Journal of Applied Mathematics and Physics 2024年第4期12卷 1263-1285页

作者： Jules Manirambona Juma shabani Alfred Vyabandi Doctoral School University of Burundi Bujumbura Burundi Faculty of Sciences Doctoral School University of Burundi Bujumbura Burundi Institute of Applied Pedagogy University of Burundi Bujumbura Burundi

We make a systematic study of two-parameter models of δ ′ s -sphere interaction and δ ′ s -sphere plus a Coulomb interaction. Where δ ′ s interaction denotes the δ ′ -sphere interaction of the second kind. We provide the mathematical definitions of Hamiltonians and obtain new results for both models, in particular the resolvents equations, spectral properties and some scattering quantities.

关键词： Boundary Conditions Problem -Sphere Interactions Self-Adjoint Operator Resolvent Equation Spectral Properties Scattering Theory

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Modelling Foot and Mouth Disease in the Context of Active Immigrants

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Journal of Applied Mathematics and Physics 2024年第1期12卷 147-167页

作者： Issa shabani Mfinanga Nyimvua Shaban Theresia Marijani Department of Mathematics University of Dar es Salaam Dar es Salaam Tanzania Department of Mathematics and Statistics Sokoine University of Agriculture Morogoro Tanzania

This study employs mathematical modeling to analyze the impact of active immigrants on Foot and Mouth Disease (FMD) transmission dynamics. We calculate the reproduction number (R0) using the next-generation matrix approach. Applying the Routh-Hurwitz Criterion, we establish that the Disease-Free Equilibrium (DFE) point achieves local asymptotic stability when R0 α1 and α2) are closely associated with reduced susceptibility in animal populations, underscoring the link between immigrants and susceptibility. Furthermore, our findings emphasize the interplay of disease introduction with population response and adaptation, particularly involving incoming infectious immigrants. Swift interventions are vital due to the limited potential for disease establishment and rapid susceptibility decline. This study offers crucial insights into the complexities of FMD transmission with active immigrants, informing effective disease management strategies.

关键词： Next-Generation Matrix Approach Routh-Hurwitz Quadratic Lyapunov Function Active Immigrants Reproduction Number Analysis

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Automated Extraction and Analysis of CBC Test from Scanned Images

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Journal of Software Engineering and Applications 2024年第2期17卷 129-141页

作者： iman S. Alansari Computer Science Department College of Computer Science and Engineering Taibah University Madinah Saudi Arabia

Health care is an important part of human life and is a right for everyone. One of the most basic human rights is to receive health care whenever they need it. However, this is simply not an option for everyone due to the social conditions in which some communities live and not everyone has access to it. This paper aims to serve as a reference point and guide for users who are interested in monitoring their health, particularly their blood analysis to be aware of their health condition in an easy way. This study introduces an algorithmic approach for extracting and analyzing Complete Blood Count (CBC) parameters from scanned images. The algorithm employs Optical Character Recognition (OCR) technology to process images containing tabular data, specifically targeting CBC parameter tables. Upon image processing, the algorithm extracts data and identifies CBC parameters and their corresponding values. It evaluates the status (High, Low, or Normal) of each parameter and subsequently presents evaluations, and any potential diagnoses. The primary objective is to automate the extraction and evaluation of CBC parameters, aiding healthcare professionals in swiftly assessing blood analysis results. The algorithmic framework aims to streamline the interpretation of CBC tests, potentially improving efficiency and accuracy in clinical diagnostics.

关键词： Image Processing Optical Character Recognition Tesseract OCR Health Care Application

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CuO–TiO_(2) based self-powered broad band photodetector

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Nano Materials Science 2024年第3期6卷 345-354页

作者： Chiranjib Ghosh Arka Dey iman Biswas Rajeev Kumar Gupta Vikram Singh Yadav Ashish Yadav Neha Yadav Hongyu Zheng Mohamed Henini Aniruddha Mondal Department of Physics National Institute of Technology DurgapurWest BengalIndia Department of Physics University of Petroleum&Energy Studies DehradunUttarakhandIndia Babasaheb Bhimrao Ambedkar University Lucknow226031India Center for Advanced Laser Manufacturing(CALM) Shandong University of TechnologyZibo255000PR China School of Physics and Astronomy University of NottinghamNottinghamNG72RDUnited Kingdom

An efficient room-temperature self-powered,broadband(300 nm–1100 nm)photodetector based on a CuO–TiO_(2)/TiO_(2)/p-Si(100)heterostructure is *** CuO–TiO_(2)nanocomposites were grown in a two-zone horizontal tube furnace on a 40 nm TiO_(2)thin film deposited on a p-type Si(100)*** CuO–TiO_(2)/TiO_(2)/p-Si(100)devices exhibited excellent rectification characteristics under dark and individual photoillumination *** devices showed remarkable photo-response under broadband(300–1100 nm)light illumination at zero bias voltage,indicating the achievement of highly sensitive self-powered photodetectors at visible and near-infrared light *** maximum response of the devices is observed at 300 nm for an illumination power of 10 *** response and recovery times were calculated as 86 ms and 78 ms,***,under a small bias,the devices showed a prompt binary response by altering the current from positive to negative under illumination *** main reason behind this binary response is the low turn-on voltage and photovoltaic characteristics of the *** illumination conditions,the generation of photocurrent is due to the separation of photogenerated electron-hole pairs within the built-in electric field at the CuO–TiO_(2)/TiO_(2)*** characteristics make the CuO–TiO_(2)/TiO_(2)broadband photodetectors suitable for applications that require high response speeds and self-sufficient functionality.

关键词： Self-powered CuO–TiO_(2) nanocomposite Broadband photodetector Two-zone horizontal tube furnace Responsivity

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Adult neurogenesis:a real hope or a delusion?

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Neural Regeneration Research 2024年第1期19卷 6-15页

作者： Ghulam Hussain Rabia Akram Haseeb Anwar Faiqa Sajid Tehreem iman Hyung Soo Han Chand Raza Jose-Luis Gonzalez De Aguilar Neurochemicalbiology and Genetics Laboratory(NGL) Department of PhysiologyFaculty of Life SciencesGovernment College UniversityFaisalabadPunjabPakistan Department of Physiology School of MedicineClinical Omics InstituteKyungpook National UniversityDaeguKorea Department of Zoology Faculty of Chemistry and Life SciencesGovernment College UniversityLahorePakistan INSERM U1118Mécanismes Centraux et Péripheriques de la NeurodégénérescenceStrasbourgFranceUniversitéde StrasbourgStrasbourgFrance

Adult neurogenesis,the process of creating new neurons,involves the coordinated division,migration,and differentiation of neural stem *** process is restricted to neurogenic niches located in two distinct areas of the brain:the subgranular zone of the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricle,where new neurons are generated and then migrate to the olfactory *** has been thought to occur only during the embryonic and early postnatal stages and to decline with age due to a continuous depletion of neural stem ***,recent years have seen tremendous progress in our understanding of adult brain neurogenesis,bridging the knowledge gap between embryonic and adult ***,we discuss the current status of adult brain neurogenesis in light of what we know about neural stem *** this notion,we talk about the importance of intra cellular signaling molecules in mobilizing endogenous neural stem cell prolife *** on the current understanding,we can declare that these molecules play a role in targeting neurogenesis in the mature ***,to achieve this goal,we need to avoid the undesired proliferation of neural stem cells by controlling the necessary checkpoints,which can lead to tumorigenesis and prove to be a curse instead of a blessing or hope.

关键词： adult neurogenesis aging brain-derived neurotrophic factor dentate gyrus hippocampus neural stem cells neurotrophic factors Notch oxidative stress stem cells subgranular zone

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