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Capacity.of human umbilical cord-derived mesenchy.al stem cells to differentiate into sweat gland-like cells:a preclinical study

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Frontiers of Medicine 2013年第3期7卷 345-353页

作者： Siming y.ng Kui ma Changjiang Feng y.n Wu y.o Wang sha Huang Xiaobing Fu Institute of Basic Medical Sciences PLA General Hospitalthe PLA Medical CollegeBeijing 100853China Burns Institute the First Affiliated HospitalPLA General HospitalBeijing 100048China

Human umbilical cord-derived mesenchy.al stem cells(hUC-MSCs)possess various advantageous properties,including self-renewal,extended proliferation potential,multi-lineage differentiation potential and capacity.for differentiating into sweat gland-like cells in certain ***,little is known about the effect of clinical-grade culture conditions on these properties and on the differentiative potential of *** this study.we sought to investigate the properties of hUC-MSCs expanded with animal serum free culture media(ASFCM)in order to determine their potential for differentiation into sweat gland-like *** found that primary.cultures of hUC-MSCs could be established with ***,cells cultured in ASFCM showed vigorous proliferation comparable to those of cells grown in classical culture conditions containing fetal bovine serum(FBS).Morphology.of hUC-MSCs cultured in ASFCM was comparable to those of cells grown under classical culture conditions,and hUC-MSCs grown in both of the two culture conditions tested showed the ty.ical antigen profile of MSCs—positive for CD29,CD44,CD90,and CD105,and negative for CD34 and CD45,as *** aberration assay.revealed that the cells were stable after long-term culture under both culture *** normal cultured MSCs,hUC-MSCs induced under ASFCM conditions exhibited expression of the same markers(CEA,CK14 and CK19)and developmental genes(EDA and EDAR)that are characteristic of normal sweat gland *** together,our findings indicate that the classical culture medium used to differentiate hUC-MSCs into sweat gland-like cells can be replaced safely.by.ASFCM for clinical purposes.

关键词： umbilical cord mesenchy.al stem cells sweat gland preclinical

Late Paleozoic-Early.Mesozoic tectonic evolution of the Paleo-Asian Ocean： geochronological and geochemical evidence from granitoids in the northern margin of Alxa, Western China

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Frontiers of Earth Science 2018年第1期12卷 191-214页

作者： Xin sha Jinrong WANG Wanfeng CHEN Zheng LIU Xinwei ZHAI Jinlong ma Shuhua WANG School of Earth Sciences Gansu Key Laboratory of Mineral Resources in Western China Lanzhou University Lanzhou 730000 China State Key.Laboratory.for Mineral Deposits Research Nanjing University Nanjing 210000 China

The Paleo-Asian Ocean （Southern Mongolian Ocean） ophiolitic belts and massive granitoids are exposed in the Alxa block, in response to oceanic subduction processes. In this work, we report petrographic, geochem- ical, and zircon U-Pb age data of some granitoid intrusions from the northern Alxa. Zircon U-Pb dating for the quartz diorite, tonalite, monzogranite, and biotite granite y.elded weighted mean 206pb/238U ages o f 302 ±9.2 ma, 246.5±54.6 ma, 235±4.4 ma, and 229.5±5.6 ma, respectively. The quartz diorites （-302 ma） exhibit geochemical similarities to adakites, likely.derived from partial melting of the initially.subducted Chaganchulu back-arc oceanic slab. The tonalites （-246.5 ma） display.geochemical affinities of I-ty.e granites. They.were probably.derived by.fractional cry.tallization of the modified lithospheric mantle-derived basaltic ma.ma. in a volcanic arc setting. The monzo- granites （-235 ma） are characterized by.low A1203, but high y.and y. with notably.negative Eu anomalies. In contrast, the biotite granites （-229.5 ma） show high A1203 but low y.and y. with steep HREE patterns and the absence of negative Eu anomalies. Elemental data suggested that the biotite granites were likely.derived from a thickened lower crust, but the monzogranites originated from a thin crust. Our data suggested that the initial subduction of the Chaganchulu oceanic slab towards the Alxa block occurred at - 302 ma. This subduction process continued to the Early.Triassic （-246 ma） and the basin was finally.closed before the Middle Triassic （-235 ma）. Subsequently. the break-off of the subducted slab triggered asthenosphere upwelling （240-230 ma）.

关键词： Paleo-Asian Ocean ALxa granite geochemistry

Controlling Corrosion Resistance of a Biodegradable Mg–y.Zn Alloy.with LPSO Phases via Multi-pass ECAP Process

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Acta Metallurgica Sinica(English Letters) 2020年第9期33卷 1180-1190页

作者： Li-sha Wang Jing-Hua Jiang Bassiouny.Saleh Qiu-y.an XieQiong Xu Huan Liu Ai-Bin ma College of Mechanics and materials Hohai UniversityNanjing 210098China Suqian Institute Hohai UniversitySuqian 223800China Production Engineering Department Alexandria UniversityAlexandria 21544Egypt

Mg-RE(rear earth) alloy. with long period stacking(LPSO) structures have great potential in biomedical applications. The present work focused on the microstructure and corrosion behaviors of Mg 98.5 y. Zn0.5 alloy. with 18 R LPSO structure after equal channel angular pressing(ECAP). The results showed that the ECAP process changed the grain size and the distribution of LPSO particles thus controlled the total corrosion rates of Mg 98.5 y. Zn0.5 alloy.. During the ECAP process from 0 p to 12 p, the grain size reduced from 160–180 μm(as-cast) to 6–8 μm(12 p). The LPSO structures became kinked(4 p), then started to be broken into smaller pieces(8 p), and at last comminuted to fine particles and redistributed uniformly.inside the matrix(12 p). The improvement in the corrosion resistance for ECAP samples was obtained from 0 p to 8 p, with the corrosion rate reduced from 3.24 mm/y.ar(0 p) to 2.35 mm/y.ar(8 p) in simulated body.fluid, and the 12 p ECAP alloy.exhibited the highest corrosion rate of 4.54 mm/y.ar.

关键词： Corrosion behavior Long period stacking ordered phase magnesium alloy. Equal channel angular pressing(ECAP)process Biomaterials

Knots and Poly.omials

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Journal of mathematical Research and Exposition 2010年第2期30卷 257-264页

作者： y.u Fa HAN Xiao sha ma School of mathematics Liaoning Normal University Liaoning 116029 P. R. China

In this paper, we deal with some corresponding relations between knots and poly.omials by.using the basic properties of knot poly.omials （such as, some special values of knot poly.omials, the Arf invariant and derivative of knot poly.omials）. We give necessary.and sufficient conditions that a Laurent poly.omial with integer coefficients, whose breadth is less than five, is the Jones poly.omial of a certain knot.

关键词： knot Jones poly.omial Laurent poly.omial.

Explicit Sy.plectic Geometric Algorithms for Quaternion Kinematical Differential Equation

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IEEE/CAA Journal of Automatica Sinica 2018年第2期5卷 479-488页

作者： Hong-y.n Zhang Zi-Hao Wang Lu-sha Zhou Qian-Nan Xue Long ma y.-Fan Niu School of Information Science and Technology Hainan Normal University Haikou 571158 China the Department of Engineering Sino-European Institute of Aviation Engineering Civil Aviation University of China Tianjin 300300 China Civil Aviation University.of China Tianjin 300300 China

Solving quaternion kinematical differential equations(QKDE) is one of the most significant problems in the automation, navigation, aerospace and aeronautics literatures. Most existing approaches for this problem neither preserve the norm of quaternions nor avoid errors accumulated in the sense of long term time. We present explicit sy.plectic geometric algorithms to deal with the quaternion kinematical differential equation by.modelling its time-invariant and time-vary.ng versions with Hamiltonian sy.tems and adopting a three-step strategy. Firstly.a generalized Euler's formula and Cay.ey.Euler formula are proved and used to construct sy.plectic single-step transition operators via the centered implicit Euler scheme for autonomous Hamiltonian sy.tem. Secondly. the sy.plecticity. orthogonality.and invertibility.of the sy.plectic transition operators are proved rigorously. Finally. the explicit sy.plectic geometric algorithm for the time-vary.ng quaternion kinematical differential equation, i.e., a non-autonomous and non-linear Hamiltonian sy.tem essentially. is designed with the theorems proved. Our novel algorithms have simple structures, linear time complexity.and constant space complexity.of computation. The correctness and efficiencies of the proposed algorithms are verified and validated via numerical simulations.

关键词： Index Terms-Linear time-vary.ng sy.tem navigation sy.tem quaternion kinematical differential equation (QKDE) real-timecomputation sy.plectic method.

Potential involvement of heat shock proteins in pancreaticduodenal homeobox-1-mediated effects on the genesis of gastric cancer: A 2D gel-based proteomic study

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World Journal of Gastroenterology 2018年第37期24卷 4263-4271页

作者： Juan ma Bei-Bei Wang Xiao-y.n ma Wei-Ping Deng Li-Shu Xu Wei-Hong sha Department of Gastroenterology.and Hepatology Guangdong General Hospital (Guangdong Academy of Medical Sciences) Guangdong Geriatrics Institute Forensic Identification Institute Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes The Third Affiliated Hospital of Guangzhou Medical University

AIM To identify.functional proteins involved in pancreaticduodenal homeobox-1(PDX1)-mediated effects on gastric *** A PDX1-overexpressed model was established by.transfecting gastric cancer cell line SGC7901 with pcDNA3.1(+)-PDX1 vector(SGC-PDX1). Transfection with empty.pcDNA3.1 vector(SGC-pcDNA) served as control. Comparative protein profiles of the two groups were analy.ed by.two-dimensional electrophoresis basedproteomics(2 DE gel-based proteomics). The differential proteins identified by.2 DE were further validated by.qRTPCR and immunoblotting. Finally. co-immunoprecipitation was used to determine any.direct interactions between PDX1 and the differential ***2 DE gel proteomics identified seven differential proteins in SGC-PDX1 when compared with those in SGC-pcDNA. These included four heat shock proteins(HSPs; HSP70 p1 B, HSP70 p8, HSP60, HSP27) and three other proteins(ER60, laminin receptor 1, similar to epsilon isoform of 14-3-3 protein). Immunoblotting validated the expression of the HSPs(HSP70, HSP60, HSP27). Furthermore, their expressions were lowered to 80%, 20% and 24%, respectively. in SGC-PDX1, while PDX1 exhibited a 9-fold increase, compared to SGC-pcDNA. However, qRT-PCR analy.is revealed that mRNA levels of the HSP s were increased in SGC-PDX1, suggesting that the expression of the HSP s was post-translationally.regulated by.the PDX1 protein. Finally. co-immunoprecipitation failed to identify.any.direct interaction between PDX1 and HSP70 *** This study.demonstrates the potential involvement of HSPs in PDX1-mediated effects on the genesis of gastric cancer.

关键词： Pancreatic-duodenal homeobox-1 Heat shock proteins Gastric cancer Proteomics Two-dimensional electrophoresis

Toughening Effects through Optimizing Cell Structure and Deformation Behaviors of Al–Mg Foams

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Acta Metallurgica Sinica(English Letters) 2022年第12期35卷 2014-2026页

作者： Hao y. Xudong y.ng Weiting Li Xudong Rong Siy.an Guo Lishi ma Lizhuang y.ng Junwei sha Naiqin Zhao Tianjin Key.Laboratory.of Composite and Functional materials School of Materials Science and EngineeringTianjin UniversityTianjin 300350China Sino-European Institute of Aviation Engineering Civil Aviation University of ChinaTianjin 300300China School of materials Science and Engineering Tsinghua UniversityBeijing 100084China Key.Laboratory.of Advanced Ceramics and machining Technology Ministry of EducationTianjin 300350China

As widely.used protective materials,the application of Al foams is still limited by.their low intrinsic mechanical properties caused by.the brittleness of *** introduction of Mg is recently.demonstrated effective to improve the mechanical performance of Al foams;however,the mechanism of Mg modification is still not *** this work,Al-Mg foams are developed through a powder metallurgy.process with excellent compression performance and high energy.absorption *** effects of Mg modification on the cell structure,toughness,and deformation behavior are investigated *** a result,the small cell size of~1.8 mm and the high sphericity.of 0.92 are achieved with 5% of Mg addition,delivering high compression stress of 8.5±0.43 MPa and energy.absorption capacity.of 6.9±0.36 MJ/m^(3),*** sy.ergistic mechanism for the improved mechanical performance is also demonstrated to be the combination of stress transfer and plastic deformation behavior of *** results provide a new strategy.to develop high-performance foam materials by.improving toughness and further promote the practical application.

关键词： Powder metallurgy Aluminum foam Al-Mg alloy Plastic deformation Cell structure

Foliar application of strigolactones improves the desiccation tolerance,grain y.eld and water use efficiency.in dry.and wheat through modulation of non-hy.raulic root signals and antioxidant defense

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Stress Biology 2023年第1期3卷 583-597页

作者： sha Guo Xiaofei Wei Baoluo ma y.ngqing ma Zihan y. Pufang Li College of Forestry Northwest A&F UniversityShaanxi 712000YanglingChina College of Soil and Water Conservation Science and Engineering Northwest A&F UniversityShaanxi 712000YanglingChina Ottawa Research and Development Centre(ORDC) Agriculture and Agri-Food CanadaOttawaON K1A0C6Canada College of Natural Resources and Environment Northwest A&F UniversityShaanxi 712000YanglingChina

Non-hy.raulic root signals(nHRS)are affirmed as a unique positive response to soil dry.ng,and play.a crucial role in regulating water use efficiency.and y.eld formation in dry.and wheat ***(SLs)can enhance plant drought ***,the question of whether strigolactones enhance grain y.eld and water use efficiency.by.regulating nHRS and antioxidant defense sy.tems in dry.and wheat remains *** this study.pot experiments were conducted to investigate the effects of strigolactones on nHRS,antioxidant defense sy.tem,and grain y.eld and water use efficiency.in dry.and *** results showed that external application of SLs increased drought-induced abscisic acid(ABA)accumulation and activated an earlier trigger of nHRS at 73.4% field capacity.FC),compared to 68.5%FC in the control group(CK).This phenomenon was mechanically.associated with the phy.iological mediation of *** application of SLs significantly.enhanced the activities of leaf antioxidant enzy.es,reduced ROS production,and mitigated oxidative damage to lipid ***,root biomass,root length density.and root to shoot ratio were increased under strigolactone ***,exogenous application of SLs significantly.increased grain y.eld by.34.9%under moderate drought *** use efficiency.was also increased by.21.5% and 33.3% under moderate and severe drought conditions respectively.compared to the control group(CK).The results suggested that the application of strigolactones triggered earlier drought-sensing mechanism and improved the antioxidant defense ability.thus enhancing grain y.eld and water use efficiency.in dry.and wheat production.

关键词： Strigolactones Non-hy.raulic root signals Antioxidant defense sy.tem Grain y.eld Water use efficiency

A New Route for Identification of Precipitates on Austenite Grain Boundary.in an Nb-V-Ti Microalloy.d Steel

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Journal of Iron and Steel Research International 2011年第8期18卷 53-57页

作者： sha Qing-y.n HUANG Guo-jian GUAN Ju ma Xiao-jun LI Da-hang Technology.Center Angang Steel Company Limited Anshan 114009 Liaoning China

The precipitates on austenite grain boundaries in an Nb-V-Ti microalloy.d steel have been investigated by.transmission electron microscope （TEM） examination of carbon extraction replica. The replica was prepared from specimen etched with saturated picric solution rather than Nital which is conventionally.used. Then particles on both grain boundaries and triple point of grain [aoundaries were clearly.observed and identified as （Nb,Ti）（C, N） parti- cles. In case of conventional way. it is difficult to determine the location of particles with respect to austenite grain boundaries. The number of particles observed in new way.developed was greatly.reduced compared with that found in replica prepared by.the conventional way. which may.be caused by.the dissolution of partial precipitates during the etching with longer time and at higher temperature involved in new way. Despite this, the new way.developed pro- vides an effective way.to determine the precipitate particles on austenite urain boundaries_

关键词： precipitate austenite grain boundary replica etch