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Berberine Inhibits Ferroptosis and Stabilizes Atherosclerotic Plaque through NRF2/SLC7A11/GPX4 Pathway

Chinese Journal of Integrative Medicine 2024年第10期30卷 906-916页

作者： WANG Ting-ting YU Li-li ZHENG Jun-meng HAN Xin-yi JIN Bo-yuan HUA Cheng-jun CHEN Yu-shan shaNG sha-sha LIANG Ya-zhou WANG Jian-ru Heart Center the First Affiliated Hospital of Henan University of Chinese Medicine

Objective: To investigate potential mechanisms of anti-atherosclerosis by berberine（BBR） using ApoE-/-mice. Methods: Eight 8-week-old C57BL/6J mice were used as a blank control group（normal）, and 56 8-week-old AopE-/-mice were fed a high-fat diet for 12 weeks, according to a completely random method, and were divided into the model group, BBR low-dose group（50 mg/kg, BBRL）, BBR medium-dose group（100 mg/kg, BBRM）, BBR high-dose group（150 mg/kg, BBRH）, BBR+nuclear factor erythroid 2-related factor 2（NRF2） inhibitor group（100 mg/kg BBR+30 mg/kg ML385, BBRM+ML385）, NRF2 inhibitor group（30 mg/kg, ML385）, and positive control group（2.5 mg/kg, atorvastatin）, 8 in each group. After 4 weeks of intragastric administration, samples were collected and serum, aorta, heart and liver tissues were isolated. Biochemical kits were used to detect serum lipid content and the expression levels of malondialdehyde（MDA） and superoxide dismutase（SOD） in all experimental groups. The pathological changes of atherosclerosis（AS） were observed by aorta gross Oil Red O, aortic sinus hematoxylin-eosin（HE） and Masson staining. Liver lipopathy was observed in mice by HE staining. The morphology of mitochondria in aorta cells was observed under transmission electron microscope. Flow cytometry was used to detect reactive oxygen species（ROS） expression in aorta of mice in each group. The content of ferrous ion Fe2+in serum of mice was detected by biochemical kit. The mRNA and protein relative expression levels of NRF2, glutathione peroxidase 4（GPX4） and recombinant solute carrier family 7 member 11（SLC7A11） were detected by quantitative real time polymerase chain reaction（RT-q PCR） and Western blot, respectively. Results: BBRM and BBRH groups delayed the progression of AS and reduced the plaque area（P<0.01）. The characteristic morphological changes of ferroptosis were rarely observed in BBR-treated AS mice, and the content of Fe2+in BBR group was significantly lower than that in the model group（P<0.01）

关键词： ApoE−/− NRF2/SLC7A11/GPX4 pathway atherosclerosis berberine ferroptosis oxidative stress

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Gastrointestinal problems in a valproic acid-induced rat model of autism: From maternal intestinal health to offspring intestinal function

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World Journal of Psychiatry 2024年第7期14卷 1095-1105页

作者： sha Li Nan Zhang Wang Li Han-Lai Zhang Xiao-Xi Wang Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijing 100000China Institute of Basic Theory for Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100000China

BACKGROUND Autism spectrum disorder(ASD)is a developmental disorder characterized by social deficits and repetitive ***(GI)problems,such as constipation,diarrhea,and inflammatory bowel disease,commonly occur in patients with ***,GI problems of ASD patients were attributed to intestinal inflammation and vertical mother-to-infant microbiome *** To explore whether GI problems in ASD are related to maternal intestinal inflam-mation and gut microbiota *** An ASD rat model was developed using valproic acid(VPA).Enzyme-linked immunosorbent assay and fecal 16S rRNA sequencing were used to test GI *** VPA exposure during pregnancy led to pathological maternal intestinal changes,resulting in alterations in maternal gut ***,the levels of inflammatory factors also ***,prenatal exposure to VPA resulted in impaired duodenal motility in the offspring as well as increased levels of infla-mmatory *** GI problems in ASD may be associated with maternal intestinal inflammation and microbiota *** research is required to find more evidence on the etiology and treatment of GI problems in ASD.

关键词： Autism spectrum disorder Gastrointestinal problems Gut microbiota Intestinal inflammation Intestinal motility

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Carbene-catalyzed enantioselective seleno-Michael addition as access to antimicrobial active Se-containing heterocycles

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Science China Chemistry 2024年第7期67卷 2199-2205页

作者： Hongyan Long sha Zhao Chunyan Jian Xiuli Wu Fengfei Lu Minghong Liao Fengrui Che Xingxing Wu Yonggui Robin Chi State Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityGuiyang 550025China School of Chemistry Chemical Engineeringand BiotechnologyNanyang Technological UniversitySingapore 637371Singapore

Organoseleniums exhibit a diverse set of biological activities that are pivotal for drug discovery and are widely explored in synthetic chemistry and material *** many transformations have been developed for non-enantioselective C–Se bond formations,the catalyst-controlled stereoselective preparation of chiral organoseleniums continues to be of considerable *** particular,there are limited studies on the enantioselective seleno-Michael addition reactions to access chiral selenium functional ***,we disclose a carbene-catalyzed highly enantioselective nucleophilic C–Se bond construction through formal[3+3]annulations between selenocarboxamides and bromoenals,affording seleno-thiazinone products with good yields and excellent *** choice of a weak inorganic base was pivotal to suppressing the unproductive racemization and decomposition of the selenium ***,the catalytically generated chiral selenium-containing heterocyclic products feature remarkable antimicrobial activities that could serve as promising lead scaffolds for further agrochemical development.

关键词： seleno-Michael addition organocatalysis N-heterocyclic carbene seleno-heterocycles antimicrobial activity

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High-entropy catalysts for electrochemical water-electrolysis of hydrogen evolution and oxygen evolution reactions

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Frontiers in Energy 2024年第3期18卷 265-290页

作者： Simiao sha Riyue GE Ying LI Julie M.CAIRNEY Rongkun ZHENG Sean LI Bin LIU Jiujun ZHANG Wenxian LI School of Materials Science and Engineering Shanghai UniversityShanghai 200444China School of Chemical and Environmental Engineering Anhui Polytechnic UniversityWuhu 241000China Australian Centre for Microscopy and Microanalysis School of AerospaceMechanical and Mechatronic EngineeringThe University of SydneySydney NSW 2006Australia School of Physics The University of SydneySydney NSW 2006Australia School of Materials Science and Engineering UNSW Materials&Manufacturing Futures InstituteUniversity of New South WalesSydney NSW 2052Australia College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108China

High entropy materials (HEMs) have developed rapidly in the field of electrocatalytic water-electrolysis for oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) due to their unique properties. In particular, HEM catalysts are composed of many elements. Therefore, they have rich active sites and enhanced entropy stability relative to single atoms. In this paper, the preparation strategies and applications of HEM catalysts in electrochemical water-electrolysis are reviewed to explore the stabilization of HEMs and their catalytic mechanisms as well as their application in support green hydrogen production. First, the concept and four characteristics of HEMs are introduced based on entropy and composition. Then, synthetic strategies of HEM catalysts are systematically reviewed in terms of the categories of bottom-up and top-down. The application of HEMs as catalysts for electrochemical water-electrolysis in recent years is emphatically discussed, and the mechanisms of improving the performance of electrocatalysis is expounded by combining theoretical calculation technology and ex-situ/in situ characterization experiments. Finally, the application prospect of HEMs is proposed to conquer the challenges in HEM catalyst fabrications and applications.

关键词： high-entropy electrocatalysis synthetic methods water-electrolysis hydrogen and oxygen evolutions

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Self-powered stimuli responsive material for dual stimulation of heat and guest molecules

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Chinese Chemical Letters 2024年第2期35卷 590-593页

作者： Jintao Men Ke Xu Taiting sha Lei He Yan Xu Jie Mu Tijian Yin Qiong Ye Jiangsu Key Laboratory for Science and Applications of Molecular Ferroelectrics and School of Chemistry and Chemical Engineering Southeast UniversityNanjing 211189China

Stimuli-responsive smart materials exhibit reverse chemical/physical changes in response to external stimuli and research on stimuli-responsive smart materials with self-powered properties is still uncultivated ***,we report perovskite crystalline self-powered multiple stimuli-responsive materials triggered by chemical and thermal stimuli.[HMEP]PbI_(3)·(H_(2)O)(1;HMEP is a hydroxytris(1-methylethyl)phosphorus cation)crystallizes in a chiral space group P 21 at 293 K and has the piezoelectric reaction(d_(33)=10 pC/N and output voltage=1 V)of self-powered modes,this value is larger than the value of 3 pC/N for the classical piezoelectric material *** materials can generate energy due to mechanical deformation,and using thermal heating to lose water,[HMEP]PbI_(3)(2)can be obtained.2 crystallizes in the non-centrosymmetric space group,undergoes two reversible phase transitions at 243/255 K and 315/348 K,and shows second harmonic generation ***,2 can return to the hydrated form 1 after absorbing *** work will lay the foundation for self-powered stimuli-responsive compounds and contribute to the construction of novel organic-inorganic hybrid materials with second harmonic generation switching.

关键词： Self-powered Dual stimulation reactive Phase transition SHG switch Organic-inorganic hybrid perovskite

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Spin-orbit torque effect in silicon-based sputtered Mn_(3)Sn film

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Chinese Physics B 2024年第10期33卷 394-399页

作者： sha Lu Dequan Meng Adnan Khan Ziao Wang Shiwei Chen Shiheng Liang School of Physics Hubei UniversityWuhan 430062China Key Laboratory for Intelligent Sensing System and Security of Ministry of Education Wuhan 430062China

Noncollinear antiferromagnet Mn_(3)Sn has shown remarkable efficiency in charge-spin conversion,a novel magnetic spin Hall effect,and a stable topological antiferromagnetic state,which has resulted in great interest from researchers in the field of spin-orbit *** research has primarily focused on the spin-orbit torque effect of epitaxially grown noncollinear antiferromagnet Mn_(3)Sn ***,this method is not suitable for large-scale industrial *** this study,amorphous Mn_(3)Sn films and Mn_(3)Sn/Py heterostructures were prepared using magnetron sputtering on silicon *** spin-torque ferromagnetic resonance measurement demonstrated that only the conventional spin-orbit torque effect generated by in-plane polarized spin currents existed in the Mn_(3)Sn/Py heterostructure,with a spin-orbit torque efficiency of ***,we prepared the perpendicular magnetized Mn_(3)Sn/CoTb heterostructure based on amorphous Mn_(3)Sn film,where the spin-orbit torque driven perpendicular magnetization switching was achieved with a lower critical switching current density(3.9×10^(7)A/cm^(2))compared to Ta/CoTb *** research reveals the spin-orbit torque effect of amorphous Mn_(3)Sn films and establishes a foundation for further advancement in the practical application of Mn_(3)Sn materials in spintronic devices.

关键词： spintronics noncollinear antiferromagnetism spin-orbit torque

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Improved simulation of winter wheat yield in North China Plain by using PRYM-Wheat integrated dry matter distribution coefficient

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Journal of Integrative Agriculture 2024年第4期23卷 1381-1392页

作者： Xuan Li shaowen Wang Yifan Chen Danwen Zhang shanshan Yang Jingwen Wang Jiahua Zhang Yun Bai sha Zhang Research Center for Remote Sensing and Digital Earth College of Computer Science and TechnologyQingdao UniversityQingdao266071China Center for Geospatial Information Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China School of Geographical Sciences Hebei Normal UniversityShijiazhuang 050024China

The accurate simulation of regional-scale winter wheat yield is important for national food security and the balance of grain supply and demand in ***,most remote sensing process models use the“biomass×harvest index(HI)”method to simulate regional-scale winter wheat ***,spatiotemporal differences in HI contribute to inaccuracies in yield simulation at the regional ***-series dry matter partition coefficients(Fr)can dynamically reflect the dry matter partition of winter *** this study,Fr equations were fitted for each organ of winter wheat using site-scale *** equations were then coupled into a process-based and remote sensingdriven crop yield model for wheat(PRYM-Wheat)to improve the regional simulation of winter wheat yield over the North China Plain(NCP).The improved PRYM-Wheat model integrated with the fitted Fr equations(PRYM-Wheat-Fr)was validated using data obtained from provincial yearbooks.A 3-year(2000-2002)averaged validation showed that PRYM-Wheat-Fr had a higher coefficient of determination(R^(2)=0.55)and lower root mean square error(RMSE=0.94 t ha^(-1))than PRYM-Wheat with a stable HI(abbreviated as PRYM-Wheat-HI),which had R^(2) and RMSE values of 0.30 and 1.62 t ha^(-1),*** PRYM-Wheat-Fr model also performed better than PRYM-Wheat-HI for simulating yield in verification years(2013-2015).In conclusion,the PRYM-Wheat-Fr model exhibited a better accuracy than the original PRYM-Wheat model,making it a useful tool for the simulation of regional winter wheat yield.

关键词： dry matter partition remote sensing model winter wheat yield North China Plain

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A local rainfall-triggered giant landslide occurred in a region along a high-speed railway on the Qinghai‒Tibetan Plateau

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Journal of Mountain Science 2024年第9期21卷 2939-2955页

作者： LI Qingpeng LIU Wenhui HE Renjie YING Chunye LIU Hairui DOU Zengning LIU Yabing YANG sha SONG Xianteng School of Geological Engineering Qinghai UniversityXining 810016China Key Lab of Cenozoic Resource and Environment in North Margin of the Tibetan Plateau Qinghai UniversityXining 810016China College of Eco-Environmental Engineering Qinghai UniversityXining 810016China Qinghai Transportation Planning and Design Institute Co Ltd Xining 810000China Xining Center for Integrated Natural Resources Survey China Geological SurveyXining 810000QinghaiChina

An increasing number of geological hazards along high-speed railways on the Qinghai‒Tibetan Plateau have occurred and have resulted in a profound influence on old infrastructure,which has attracted increasing *** landslide event that occurred on September 15,2022,in Jiujiawan village,Xining city,Qinghai Province,is a typical *** on field investigations and remote sensing interpretations,a comprehensive analysis was conducted on the ***,the potential secondary failure of the current Jiujiawan landslide was assessed using Fast Lagrangian Analysis of Continua in Three Dimensions(FLAC3D).Based on the application of the small baseline subset-interferometric synthetic aperture radar(SBAS-InSAR)technique to SAR images from February 24,2017 to September 14,2022,a significant westward horizontal deformation was found to have been formed prior to the occurrence of the *** maximum annual average deformation rate in the line of sight(LOS)direction reached-45 mm/yr,with a maximum cumulative deformation of-178 *** value was consistent with the continual increase in annual precipitation(2.51 mm/yr)prior to the occurrence of the *** accumulated precipitation before the landslide was 279.8 mm,accounting for 54.2%of the total annual precipitation,with a particularly notable surge in monthly precipitation observed during August(250.3 mm).Additionally,the occurrence of a seismic event with a magnitude of Ms 6.9 in Menyuan County,80 km away from Xining,could be a potential triggering factor to the landslide,as evidenced by an abrupt subsidence alteration observed prior to and following the *** maximum subsidence in the line of sight(LOS)direction exceeded 11 mm,exhibiting a highly consistent spatial distribution with the occurrence range of *** results suggest that the Jiujiawan landslide was likely induced by earthquake events in the early stage and heavy rainfall in the later *** FLAC3D numerical

关键词： Landslide Development characteristic Driver Mudstone Xining Basin

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Deep electrical structures of Qinzhou-Fangcheng Junction Zone in Guangxi and seismogenic environment of the 1936 Lingshan M6^(3/4)earthquake

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Science China Earth Sciences 2024年第2期67卷 584-603页

作者： Bin ZHOU Chunheng YAN Yan ZHAN Xiangyu SUN sha LI Xiang WEN Yajun MO Yongdong YUAN Yuan YUAN Meili HUANG Earthquake Agency of Guangxi Zhuang Autonomous Region Nanning530022China State Key Laboratory of Earthquake Dynamics Institute of GeologyChina Earthquake AdministrationBeijing100029China Guangxi Geophysical Survey Institute Liuzhou545005China

The tectonic position of the southwest section of the Qinzhou Bay-Hangzhou Bay Tectonic Junction Zone(QHTJZ)can be determined by examining the Qinzhou-Fangcheng Junction Zone(QFJZ)in *** zone is significant because it was the location of the largest earthquake ever recorded in the inland region of South China,specifically the 1936 Lingshan M6^(3/4)earthquake in ***,this region serves as an optimal location for researching the origins of intraplate earthquakes in South *** study presents a display of a broadband magnetotelluric(MT)prospecting profile that traverses the Guangxi QFJZ and the Lingshan earthquake zone,extending from the northwest(NW)to the southeast(SE).A resistivity structure model was generated using three-dimensional(3D)inversion technology along the *** main faults in QFJZ were analyzed in terms of their deep extension forms and tectonic *** analysis was performed by integrating the results obtained from geology,gravity,wave velocity ratio,Global Position System(GPS),and geothermal *** results showed that(1)the Dongzhong-Xiaodong fault(DXf),the eastern Fangcheng-Lingshan fault(FLf2),and the eastern Hepu-Beiliu fault(HBf2)were all trans-crustal deep faults,and crust-mantle ductile shear zones developed in the deep *** electrical boundary zones,DXf and HBf2,were *** inclined towards the northwest,while HBf2 inclined towards the *** FangchengLingshan fault(FLf)exhibits a tectonic style resembling a“flower”shape in the upper *** the deeper section,it is characterized by an electrical boundary zone that gradually slopes towards the southeast direction.(2)The Hunan-Guangxi Passive Continental Margin(HGPCM)on the NW side of DXf had a stratified resistivity structure and relatively stable Bouguer gravity anomalies,which conformed to the quasi-craton tectonic attribute of the local failure at the southeastern margin of the Yangtze Block(YB).The southeastern side of this bloc

关键词： South China Block Qinzhou-Fangcheng Junction Zone Magnetotelluric 1936 Lingshan M6^(3/4)earthquake Deep seismogenic environment

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Effect of different drying methods on the amino acids,α-dicarbonyls and volatile compounds of rape bee pollen

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Food Science and Human Wellness 2024年第1期13卷 517-527页

作者： Yanxiang Bi Jiabao Ni Xiaofeng Xue Zidan Zhou Wenli Tian Valérie Orsat sha Yan Wenjun Peng Xiaoming Fang State Key Laboratory of Resource Insects Institute of Apicultural ResearchChinese Academy of Agricultural SciencesBeijing 100093China College of Engineering China Agricultural UniversityBeijing 100083China Bioresource Engineering Dept. McGill UniversitySte-Anne-de-Bellevue QC H9X 3V9Canada

The significant demand for high quality food has motivated us to adopt appropriate processing methods to improve the food nutritional quality and *** this study,the effects of five drying methods,namely,pulsed vacuum drying(PVD),freeze drying(FD),infrared drying(IRD),hot-air drying(HAD)and sun drying(SD)on free amino acids(FAAs),α-dicarbonyl compounds(α-DCs)and volatile compounds(VOCs)in rape bee pollen(RBP)were *** results showed that FD significantly released the essential amino acids(EAAs)compared with fresh samples while SD caused the highest *** was the dominantα-DCs in RBP and the highest loss was observed after *** were the dominant volatiles of RBP and SD samples contained more new volatile substances(especially aldehydes)than the other four drying ***,FD and PVD would be potential methods to effectively reduce the quality deterioration of RBP in the drying process.

关键词： Drying Bee pollen Free amino acids α-Dicarbonyl compounds Volatile compounds

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