检索结果-南通市图书馆

含糖饮料消费和抑郁风险:前瞻性队列研究的Meta分析

在线全文

学校读者我要写书评

暂无评论

营养学报 2024年第2期46卷 183-191页

作者：谢亦莎环冬香马婕妤栾文雪尚思源李新莉苏州大学苏州医学院公共卫生学院营养与食品卫生学系苏州215123

目的已发表的研究对含糖饮料(SSBs)消费与抑郁风险增加之间的关系得出了不一致的结论,为此,本Meta分析拟进一步评估SSBs摄入与抑郁风险之间的关系。方法检索PubMed、Web of Science、Embase、Cochrane、中国期刊全文数据库(CNKI)、万方... 详细信息

目的已发表的研究对含糖饮料(SSBs)消费与抑郁风险增加之间的关系得出了不一致的结论,为此,本Meta分析拟进一步评估SSBs摄入与抑郁风险之间的关系。方法检索PubMed、Web of Science、Embase、Cochrane、中国期刊全文数据库(CNKI)、万方数据库,搜集有关SSBs消费与抑郁风险的前瞻性队列研究,检索时间为建库至2023年3月1日。采用DerSimonian-Laird法进行异质性检验。采用随机效应模型进行效应量的合并,并通过亚组分析和敏感性分析寻找异质性的来源。通过漏斗图和Egger检验是否存在发表偏倚,并采用剪补法(Duval and Tweedie nonparametric trimandfillmethod)探究发表偏倚对结论的影响。结果本Meta分析纳入了7项队列研究,共294910名参与者。Meta分析结果显示,与SSBs摄入量最低组相比,摄入量最高组发生抑郁的综合风险为1.28(95%CI:1.08-1.51)。亚组分析结果显示,SSBs消费与抑郁风险的关联存在性别、年龄、地区和随访时间的差异。敏感性分析显示,本次所纳入的研究对SSBs摄入与抑郁风险的合并效应均没有过度影响。结论过量摄入SSBs有增加抑郁风险的可能,但仍需进一步证实。

关键词：含糖饮料抑郁风险前瞻性队列研究 Meta分析

Mechanical and Microstructural Characteristics of Superplastic Al-4. 42Mg Aluminum Alloy

在线全文

学校读者我要写书评

暂无评论

Journal of Harbin Institute of Technology(New Series) 2013年第5期20卷 96-100页

作者： sha-sha Zhao Rehan Qayyume Hao-Yan Diao Chao-Li ma Xiao-Wei Wu Yong Wang Key Laboratory of Aerospace Advanced materials and Performance Ministry of EducationSchool of Materials Science and EngineeringBeihang University Beijing Research Institute of Mechenical & Electrical Technology

Abstract： The superplastic response of commercial 5083 alloy （Al-4. 42Mg） under uniaxial tension at strain rates ranging from 5 × 10-5 to 10-2s -1 in the temperature interval 400 -550℃ was systematically studied in this paper. The tension test was conducted on samples of rolling direction. The maximum elongation-to-failure of 486% was found at 500 % and strain rate of 10-4s-1. To identify the main characteristics of superplastic deformation and to determine the mechanism of superplastic deformation of the alloy, the microstructure and fracture of the alloy were analyzed as a function of strain, strain rate and temperature using optical microscopy （OM） and scanning electron microscopy （SEM）, the apparent strain rate sensitivity exponent ma and the apparent activation energy Qa were also studied. Based on the fracture analysis and the calculated data of m and Qa, it is suggested that the dominant deformation mechanism in the present alloy is grain boundary sliding （GBS） during the best deformation condition.

关键词： 5083 alloy superplastieity cavity fracture microstructure

Lithiophilic seeds and rigid arrays synergistic induced dendrite-free and stable Li anode towards long-life lithium-oxygen batteries

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2022年第10期31卷 268-276,I0006页

作者： Yue Li Haichang Zhang Rui Zhang Junwei sha Liying ma Dongdong Zhao Chunsheng Shi Naiqin Zhao School of materials Science and Engineering and Tianjin Key Laboratory of Composite and Functional materials Tianjin UniversityTianjin 300350China Key Laboratory of Advanced Ceramics and machining Technology of Ministry of Education Tianjin 300072China Collaborative Innovation Center of Chemical Science and Engineering Tianjin 300072China China Science and Technology on Power Sources Laboratory Tianjin Institute of Power SourcesTianjin 300384China

High energy density lithium-oxygen battery(LOB) is currently regraded as a promising candidate for next-generation power ***,the dendrite and instability issues of Li metal anode lead to its poor cyclic stability and low energy *** this work,lithiophilic Al_(2) O_(3) seeds induced rigid carbon nanotube arrays(CNTA)/three-dimensional graphene(3 DG) is developed as a host material for Li anode,namely Al_(2) O_(3)-CNTA/3 *** is demonstrated that the lithiophilic feature of Al_(2) O_(3) seeds and the enhanced rigidity of arrays can synergistically induce the uniform Li flux,inhibit the collapse of arrays,and stabilize electrolyte/electrode *** a result,the Al_(2) O_(3)-CNTA/3 DG-Li anode delivers a high Coulombic efficiency above 97% after 140 cycles(8 mah cm^(-2) at 4 ma cm^(-2)).With this anode and the breathable CNTA/3 DG cathode,the full LOB exhibits a significantly increased life-span up to 160 cycles(500 mah g^(-1) at 100 ma g^(-1)),which is almost 3 times longer than that with pure Li foil as the *** work demonstrates a new approach to highly reversibly long-cycling performance of LOBs towards practical application.

关键词： Caron nanotube array Al_(2)O_(3) Li-O_(2)battery Li metal Anode

Kinetics and Thermodynamics of Adsorption of VB12 onto Mesoporous Carbon Coated with PMma

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2010年第3期26卷 431-435页

作者： GUO Zhuo ZHANG Wei-wei DING Xiang-ping LI Sha.ma.Lei School of materials Science and Engineering Shenyang Institute of Chemical Technology Shenyang 110142 P R. China State Key Laboratory of lnorgnic Synthesis and Preparative Chemistry Jilin University Changchun 130012 P. R. China

Ordered mesoporous carbons CMK-3, CMK-I coated with poly（methyl methacrylate）（PMma）（CMK-3- PMma and CMK-1-PMma） and pristine mesoporous carbons CMK-3, CMK-1 were employed to adsorb vitamin B12（VB12） from water solution. Adsorption isotherm and kinetics of adsorption were investigated via batch experiments. It was found that the adsorption capacity of VB 12 at 30, 40 and 50 ℃ can reach 688.2, 572.4 and 428.7 mg/g, respectively. The adsorption isotherm can be described by Langmuir model. The pseudo first- and second-order kinetic models were employed to fit the dynamic adsorption. It was found that the dynamic adsorption follows the pseudo second-order model. The thermodynamic equilibrium coefficients obtained at different temperatures were used to evaluate the thermodynamic constants △G^0, △H^0 and △S^0. The negative value of Gibbs free energy, △G^0 indicates that the adsorption occurred via a spontaneous process. The increase in the value of-△G^0 with increasing temperature indicates that higher temperatures were favourable to the sorption process. The enthalpy values of △H^0〉40 kJ/mol（66.36 kJ/mol and 56.43 kJ/mol） for CMK-3-PMma and CMK-1-PMma confirm that chemisorption were involved in the adsorption process. This is consistent with the IR spectra and is another evidence for the formation of hydrogen bond between PMma in the pore of CMK-3 and VB 12.

关键词： Mesoporous carbon VB12 adsorption Equilibrium Kinetics Thermodynamics

在线全文

学校读者我要写书评

暂无评论

基于扩张卷积融合时序特征异常行为检测

计算机与现代化 2024年第2期 75-80,120页

作者：马彩莎焦立男柳有权李欣长安大学信息工程学院陕西西安710018

本文提出一个基于扩张卷积的多尺度融合行人原型和时空特征的深度自编码器网络。为了更好地利用视频中行人的时序特征,在编码器和解码器的潜在空间处添加一个双分支结构,分别是预测时空特征的递归神经网络分支和保存行人正常模式的记忆... 详细信息

本文提出一个基于扩张卷积的多尺度融合行人原型和时空特征的深度自编码器网络。为了更好地利用视频中行人的时序特征,在编码器和解码器的潜在空间处添加一个双分支结构,分别是预测时空特征的递归神经网络分支和保存行人正常模式的记忆存储模块。为了增强行人特征提取,忽略背景信息影响,增加模型的泛化能力,在编码器中加入改进的空洞空间金字塔池化(Atrous Spatial Pyramid Pooling,ASPP)模块,并在卷积块中使用混合扩张卷积(Hybrid Di-lated Convolution,HDC)原则,解决行人大小变化的问题,同时在解码器中引入多级残差信道注意力机制,获取更多的上下文信息。模型在数据集USCD Ped2,CUHK Avenue的曲线下面积(Area Under the Curve,AUC)分别达到了0.982,0.928。

关键词：混合扩张卷积残差注意力异常行为检测深度自编码器

PET示踪剂在阿尔茨海默病早期诊断中的研究进展

在线全文

学校读者我要写书评

暂无评论

河北科技大学学报 2024年第2期45卷 181-188页

作者：刘文清刘明松杨莎马文杰朱华结徐志栋河北科技大学化学与制药工程学院河北石家庄050018 河北省药用分子重点实验室河北石家庄050018

阿尔茨海默病(Alzheimer′s disease,AD)是一种发病机理极其复杂的神经退行性疾病,以认知功能障碍和记忆丧失为特征,涉及多种生理、病理过程。早期诊断是AD预防和治疗的关键。正电子发射断层成像(PET)技术能够在分子层面准确检测神经元... 详细信息

阿尔茨海默病(Alzheimer′s disease,AD)是一种发病机理极其复杂的神经退行性疾病,以认知功能障碍和记忆丧失为特征,涉及多种生理、病理过程。早期诊断是AD预防和治疗的关键。正电子发射断层成像(PET)技术能够在分子层面准确检测神经元与脑组织中细微的生理变化,为AD早期诊断提供依据。从生物标志物的分类入手,介绍了脑中蛋白变性与神经元损伤的相关靶点,根据亲和力、半衰期、结合区域、药代动力学、分析方法以及结果相关性等几个重要参数,综述了各类PET示踪剂的研究现状,指出目前PET示踪剂开发面临的问题,认为未来研究应从以下几个方面展开:神经炎症相关PET示踪剂的开发;已有示踪剂的进一步评估和优化;示踪剂结果分析方法的规范化和标准化。

关键词：医学影像学正电子发射断层成像技术 PET示踪剂阿尔茨海默病临床诊断

HPLC法同时测定香砂和胃丸中6种成分的含量

在线全文

学校读者我要写书评

暂无评论

山西医科大学学报 2024年第4期55卷 509-514页

作者：马莎崔庆德王黛莹吕晋李桂香曲靖医学高等专科学校药学院药物制剂教研室曲靖655000 曲靖市食品药品检验检测中心化学室曲靖市妇幼保健院药学部曲靖医学高等专科学校药学院药物分析教研室

目的建立高效液相色谱法同时测定香砂和胃丸中芸香柚皮苷、柚皮苷、橙皮苷、新橙皮苷、和厚朴酚以及厚朴酚的含量。方法HPLC法色谱柱采用依利特SinoChrom ODS-BP C 18柱(250 mm×4.6 mm,5μm);以0.2%磷酸水溶液(A)-乙腈(B)为流动相,梯... 详细信息

目的建立高效液相色谱法同时测定香砂和胃丸中芸香柚皮苷、柚皮苷、橙皮苷、新橙皮苷、和厚朴酚以及厚朴酚的含量。方法HPLC法色谱柱采用依利特SinoChrom ODS-BP C 18柱(250 mm×4.6 mm,5μm);以0.2%磷酸水溶液(A)-乙腈(B)为流动相,梯度洗脱;流速1.0 mL/min;检测波长230 nm;进样量10μL;柱温30℃。结果芸香柚皮苷、柚皮苷、橙皮苷、新橙皮苷、和厚朴酚、厚朴酚分别在3.274~32.740μg/mL(r=0.9998)、6.882~68.820μg/mL(r=0.9999)、20.966~209.660μg/mL(r=0.9999)、5.754~57.540μg/mL(r=0.9999)、1.980~19.800μg/mL(r=0.9999)、2.274~22.740μg/mL(r=0.9999)范围内线性关系良好;平均加样回收率分别为101.00%(RSD=0.71%)、101.92%(RSD=0.60%)、102.37%(RSD=0.58%)、98.05%(RSD=0.43%)、100.98%(RSD=0.81%)、100.64%(RSD=0.83%)。结论建立的HPLC法灵敏度高、操作简便、专属性好,可为香砂和胃丸的质量控制提供依据。

关键词：香砂和胃丸高效液相色谱法芸香柚皮苷柚皮苷橙皮苷新橙皮苷和厚朴酚厚朴酚

Metabolic alteration of neuroactive steroids and protective effect of progesterone in Alzheimer's disease-like rats

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2013年第30期8卷 2800-2810页

作者： sha Liu Honghai Wu Gai Xue Xin ma Jie Wu Yabin Qin Yanning Hou Hebei Medical University Department of Pha.ma.y Bethune International Peace Hospital of Chinese PLA

A correlation between metabolic alterations of neuroactive steroids and Alzheimer’s disease remains unknown. In the present study, amyloid beta （Aβ） 25-35 （Aβ25-35） injected into the bilateral campus CA1 region significantly reduced learning and memory. At the biochemical level, hippocampal levels of pregnenolone were significantly reduced with Aβ25-35 treatment. Furthermore, progesterone was considerably decreased in the prefrontal cortex and hippocampus, and 17β-estradiol was signifi-cantly elevated. To our knowledge, this is the first report showing that Aβ25-35, a.ma.n etiological factor of Alzheimer’s disease, can alter the level and metabolism of neuroactive steroids in the prefrontal cortex and hippocampus, which are brain regions significantly involved in learning and memory. Aβ25-35 exposure also increased the expression of infla.ma.ory mediators, tumor necrosis factor-αand interleukin-1β. However, subcutaneous injection of progesterone reversed the upregulation of tumor necrosis factor-αand interleukin-1βin a dose-dependent manner. Concomitant with improved cognitive abilities, progesterone blocked Aβ-mediated infla.ma.ion and increased the survival rate of hippocampal pyramidal cells. We thus hypothesize that Aβ-mediated cognitive deficits may occur via changes in neuroactive steroids. Moreover, our findings provide a possible therapeutic strategy for Alzheimer’s disease via neuroactive steroids, particularly progesterone.

关键词： neural regeneration neurodegenerative disease neuroactive steroids Alzheimer's disease pro-gesterone amyloid beta cognition neuroprotection neuroregeneration

Capacity of human umbilical cord-derived mesenchymal stem cells to differentiate into sweat gland-like cells:a preclinical study

在线全文

学校读者我要写书评

暂无评论

Frontiers of Medicine 2013年第3期7卷 345-353页

作者： Siming Yang Kui ma Changjiang Feng Yan Wu Yao Wang sha Huang Xiaobing Fu Institute of Basic Medical Sciences PLA General Hospitalthe PLA Medical CollegeBeijing 100853China Burns Institute the First Affiliated HospitalPLA General HospitalBeijing 100048China

Human umbilical cord-derived mesenchymal stem cells(hUC-MSCs)possess various advantageous properties,including self-renewal,extended proliferation potential,multi-lineage differentiation potential and capacity for differentiating into sweat gland-like cells in certain ***,little is known about the effect of clinical-grade culture conditions on these properties and on the differentiative potential of *** this study,we sought to investigate the properties of hUC-MSCs expanded with animal serum free culture media(ASFCM)in order to determine their potential for differentiation into sweat gland-like *** found that primary cultures of hUC-MSCs could be established with ***,cells cultured in ASFCM showed vigorous proliferation comparable to those of cells grown in classical culture conditions containing fetal bovine serum(FBS).Morphology of hUC-MSCs cultured in ASFCM was comparable to those of cells grown under classical culture conditions,and hUC-MSCs grown in both of the two culture conditions tested showed the typical antigen profile of MSCs—positive for CD29,CD44,CD90,and CD105,and negative for CD34 and CD45,as *** aberration assay revealed that the cells were stable after long-term culture under both culture *** normal cultured MSCs,hUC-MSCs induced under ASFCM conditions exhibited expression of the same markers(CEA,CK14 and CK19)and developmental genes(EDA and EDAR)that are characteristic of normal sweat gland *** together,our findings indicate that the classical culture medium used to differentiate hUC-MSCs into sweat gland-like cells can be replaced safely by ASFCM for clinical purposes.

关键词： umbilical cord mesenchymal stem cells sweat gland preclinical