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Mechanical behavior of sliding zone soil under compression considering periodic saturation-drying: example from a giant reservoir landslide

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Journal of Earth Science 2024年

作者： sha Lu Huiming Tang Liangqing Wang Xuexue Su Bing Lü Badong National Observation and Research Station of Geohazards， China University of Geosciences Faculty of Engineering， China University of Geosciences Wuhan， China

The reservoir landslide undergoes periodic saturation-drying cycles affected by reservoir fluctuation in hydropower project area， leading to the irreversible impact on the landslide materials. Sliding zone is the shearing part in formation of landslide and controls the further development of landslide. The mechanical behavior of sliding zone soil under compression is a crucial factor in the stability analysis in landslide. In this paper， the sliding zone soil from a giant landslide in the biggest hydropower project area， Three Gorges area， is taken as the research case. The particle-size distribution of the sliding zone soil from this landslide is studied and fractal dimension is adopted as representation. Periodic saturation-drying is introduced as the affecting factor on sliding zone soil properties. The triaxial compression test is conducted to reveal the mechanical behavior of the soil， including stress-strain behavior， elastic modulus， failure stress and strength parameters. These behavior of sliding zone soils with different fractal dimensions are studied under the effects of periodic saturation-drying cycles. The normalized stress-strain curves are displayed for further calculation. The data considering saturation-drying cycles are obtained and compared with the experimental results.

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A Physical Security Technology Based upon Doubly Multiple Parameters Weighted Fractional Fourier Transform

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China Communications 2024年第10期 200-209页

作者： Li Yong Sun Teng sha Xuejun Song Zhiqun Wang Bin Science and Technology on Communication Networks Laboratory The 54th Research Institute of China Electronics Technology Group Corporation harbin Institute of Technology

Enhancing the security of the wireless communication is necessary to guarantee the reliable of the data transmission, due to the broadcast nature of wireless channels. In this paper, we provide a novel technology referred to as doubly multiple parameters weighted fractional Fourier transform(DMWFRFT), which can strengthen the physical layer security of wireless communication. This paper introduces the concept of DM-WFRFT based on multiple parameters WFRFT(MP-WFRFT), and then presents its four properties. Based on these properties, the parameters decryption probability is analyzed in terms of the number of parameters. The number of parameters for DM-WFRFT is more than that of the MP-WFRFT,which indicates that the proposed scheme can further strengthen the the physical layer security. Lastly, some numerical simulations are carried out to illustrate that the efficiency of proposed DM-WFRFT is related to preventing eavesdropping, and the effect of parameters variety on the system performance is associated with the bit error ratio(BER).

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Sandwich structures with tapered tubes as core:A quasi-static investigation

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Defence Technology（防务技术） 2024年第3期33卷 447-462页

作者： Xinmei Xiang Dehua shao Xin Zhang Umer sharif Ngoc San ha Li Xiang Jing Zhang Jiang Yi School of Civil Engineering Guangzhou UniversityGuangzhouChina Department of Mechanics and Aerospace Engineering Southern University of Science and TechnologyShenzhenGuangdongChina School of Engineering Centre for Innovative Structures and MaterialsRMIT UniversityMelbourneAustralia China Southern Airlines Co. LtdShenzhen BranchShenzhen518000China

In this article,the experimental and finite element analysis is utilized to investigate the quasi-static compression features of sandwich constructions built with tapered tubes.3D printing technology was utilized to create the hollow centers of the tapering tubes,with and without *** results demonstrate that the energy absorption(EA)and specific energy absorption(SEA)of the single corrugated tapered tube sandwich are 51.6% and 19.8% higher,respectively,than those of the conical tube ***,the results demonstrate that energy absorbers can benefit from corrugation in order to increase their ***,the tapered corrugated tubes'resistance to oblique impacts was *** to a straight tube,the tapered tube is more resistant to oblique loads and has a lower initial peak crushing force(PCF),according to numerical *** conducting a parametric study,it was discovered that the energy absorption performance of the sandwich construction is significantly affected by the amplitude,number of corrugations,and wall *** and SEA of DTS with corrugation number of 8 increased by 17.4%and 29.6%,respectively,while PCF decreased by 9.2% compared to DTS with corrugation number of 10.

关键词： Sandwich structure Corrugated tube Tapered tube Quasi-static Energy absorption

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Development and validation of an immunogenic cell death-related prognostic model, and landscape of the tumor immune microenvironment in glioblastoma

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Genes & Diseases 2024年第3期11卷 72-74页

作者： sha Yang Mei Deng Yunbiao Xiong Bing Xiong Junwu Fu Jia Wang Jiqin Zhang Guoqiang han Jian Liu Ying Tan Guizhou University Medical College GuiyangGuizhou 550025China Department of Neurosurgery Guizhou Provincial People's HospitalGuiyangGuizhou 550002China Department of Anesthesiology Guizhou Provincial People's HospitalGuiyangGuizhou 550002China Department of Neurosurgery Chongqing Emergency Medical CenterChongqing400000China

The important role of immunogenic cell death(ICD)in many tumors is increasingly being ***,its mechanisms and potential as a biomarker and therapeutic target in glioblastoma(GBM)have not been well *** obtained GBM samples from the Cancer Genome Atlas(TCGA)and Gene Expression Omnibus(GEO)databases,as well as the immunotherapy cohort from the IMvigor210 *** used unsupervised clustering to obtain two ICDrelated clusters,corresponding to the ICD-low and ICD-high subtypes respectively,and the tumor immune microenvironment and prognosis of the two subtypes were significantly different.

关键词： immune Cancer prognosis

A potential threat from biodegradable microplastics: mechanism of cadmium adsorption and desorption in the simulated gastrointestinal environment

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Frontiers of Environmental Science & Engineering 2024年第2期18卷 63-75页

作者： Timing Jiang Xiang Wu Shushan Yuan Changfei Lai Shijie Bian Wenbo Yu sha Liang Jingping Hu Liang Huang Huabo Duan Yafei Shi Jiakuan Yang School of Environmental Science&Engineering Huazhong University of Science and TechnologyWuhan 430074China School of Resources and Environmental Science Hubei UniversityWuhan 430062China Hubei Provincial Engineering Laboratory for Solid Waste Treatment Disposal and Recycling Wuhan 430074China School of Civil Engineering Architecture and EnvironmentHubei University of TechnologyWuhan 430068China State Key Laboratory of Coal Combustion Huazhong University of Science and TechnologyWuhan 430074China

It has been demonstrated that microplastics (MPs) can accumulate heavy metals from the environment and transfer them into organisms via the food chain. However, adsorption and desorption capacities for biodegradable MPs relative to those for conventional MPs remain poorly understood. In this study, cadmium (Cd(II)) adsorption and desorption characteristics of polylactic acid (PLA), a typical biodegradable MP, were investigated. Two conventional MPs, i.e., polypropylene (PP) and polyamide (PA) were used for comparison. The maximum Cd(II) adsorption capacities of the MPs studied in the adsorption experiments decreased in the order PA (0.96 ± 0.07 mg/g) > PLA (0.64 ± 0.04 mg/g) > PP (0.22 ± 0.03 mg/g). The Pseudo-second-order kinetic model and Freundlich isothermal model described the Cd(II) adsorption behaviors of PLA MPs well. X-ray photoelectron spectroscopy and two-dimensional Fourier transform infrared correlation spectroscopy analysis indicated that oxygen functional groups were the major and preferential binding sites of PLA MPs, which contributed to their high Cd(II) adsorption capacities. Simulated gastric and intestinal fluids both significantly enhanced the desorption capacities of the examined MPs. Notably, degradation of the PLA MPs during in vitro human digestion made the Cd(II) on the PLA MPs more bioaccessible (19% in the gastric phase and 62% in the intestinal phase) than Cd(II) on the PP and PA MPs. These results indicate the remarkable capacities of biodegradable MPs to accumulate Cd(II) and transfer it to the digestive system and show that biodegradable MPs might pose more severe threats to human health than conventional nonbiodegradable MPs.

关键词： Biodegradable microplastics Cadmium Adsorption and desorption Gastrointestinal environment Two-dimensional correlation spectroscopy Bioaccessibility

Acoustofluidic separation of prolate and spherical micro-objects

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Microsystems & Nanoengineering 2024年第1期10卷 217-230页

作者： Muhammad Soban Khan Mushtaq Ali Song ha Lee Keun Young Jang Seong Jae Lee Jinsoo Park Department of Mechanical Engineering Chonnam National University77 Yongbong-roBuk-guGwangju 61186Republic of Korea Department of Polymer Engineering The University of Suwon17 Wauan-gilBongdam-eupHwaseongGyeonggi 18323Republic of Korea

Most microfluidic separation techniques rely largely on object size as a separation *** ability to separate micro-objects based on their shape is crucial in various biomedical and chemical ***,we develop an ondemand,label-free acoustofluidic method to separate prolate ellipsoids from spherical microparticles based on traveling surface acoustic wave-induced acoustic radiation force and *** freely rotating non-spherical microobjects were aligned under the progressive acoustic field by the counterrotating radiation torque,and the major axis of the prolate ellipsoids was parallel to the progressive wave *** specific alignment of the ellipsoidal particles resulted in a reduction in the cross-sectional area perpendicular to the wave *** a consequence,the acoustic backscattering decreased,resulting in a decreased magnitude of the radiation *** the variation in radiation force,which depended on the micro-object morphology enabled the acoustofluidic shape-based *** conducted numerical simulations for the wave scattering of spherical and prolate objects to elucidate the working mechanism underlying the proposed method.A series of experiments with polystyrene microspheres,prolate ellipsoids,and peanut-shaped microparticles were performed for *** quantitative analysis of the separation efficiency,we confirmed the high purity and high recovery rate of the proposed acoustofluidic shapebased separation of *** a bioparticle,we utilize Thalassiosira eccentrica to perform shape-based separation,as the species has a variety of potential applications in drug delivery,biosensing,nanofabrication,bioencapsulation and immunoisolation.

关键词： separation spherical rotating

Fibroblast growth factor 21 inhibits ferroptosis following spinal cord injury by regulating heme oxygenase-1

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Neural Regeneration Research 2024年第7期19卷 1568-1574页

作者： Qi Gu Weiping sha Qun Huang Jin Wang Yi Zhu Tianli Xu Zhenhua Xu Qiancheng Zhu Jianfei Ge Shoujin Tian Xiaolong Lin Department of Orthopaedic Surgery Zhangjiagang Hospital Affiliated to Soochow UniversitySuzhouJiangsu ProvinceChina Orthopedics Laboratory The First People’s Hospital of Zhangjiagang CitySuzhouJiangsu ProvinceChina Department of Anesthesiology Zhangjiagang Hospital Affiliated to Soochow UniversitySuzhouJiangsu ProvinceChina

Interfering with the ferroptosis pathway is a new strategy for the treatment of spinal cord *** growth factor 21 can inhibit ferro ptosis and promote neurofunctional recovery,while heme oxygenase-1 is a regulator of iron and reactive oxygen species *** relationship between heme oxygenase-1and ferroptosis remains controve *** this study,we used a spinal co rd injury rat model to show that the levels of fibroblast growth factor 21 in spinal co rd tissue decreased after spinal cord *** addition,there was a significant aggravation of ferroptosis and a rapid increase in heme oxygenase-1 expression after spinal cord *** r,heme oxygenase-1 aggravated fe rroptosis after spinal cord injury,while fibroblast growth factor 21 inhibited fe rroptosis by downregulating heme ***,the activation of fibroblast growth factor 21 may provide a potential treatment for spinal co rd *** findings could provide a new potential mechanistic explanation for fibroblast growth factor 21 in the treatment of spinal cord injury.

关键词： ferroptosis fibroblast growth factor 21 functional recovery heme oxygenase-1 lipid peroxidation neuron reactive oxygen species spinal cord injury

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Curcumin inhibits colorectal cancer development by blocking the YAP/TAZ signaling axis

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BIOCELL 2024年第3期48卷 443-451页

作者： FEI sha DAIshaN XIN JUN XU ZHIWEI ZHENG WENXIN LIN XIAORUI CAI FEI LIN MINGhaO ZHENG JIAOLING CHEN Department of Pharmacy Affiliated Cancer Hospital of Shantou University School of MedicineShantouChina Department of Pharmacy Shantou University Mental Health CenterShantouChina Static Distribution Center Affiliated Cancer Hospital of Shantou University School of MedicineShantouChina

Background:Curcumin is a plant polyphenol with antitumor properties and inhibits the development of colorectal cancer(CRC).However,as the molecular mechanism associated is still unclear,our study aimed to explore the underlying molecular mechanisms by which curcumin inhibits ***:HT29 and SW480 cells were treated with curcumin or/and Doxycycline(DOX),and cell viability,colony forming ability,migration and invasion were conﬁrmed by cell counting kit-8(CCK-8),colony forming,Transwell *** Yes-associated protein 1(YAP)and PDZ-binding motif(TAZ)signaling-related genes or proteins were analyzed using reverse transcription quantitative real-time PCR(RT-qPCR),western blot,and immunoﬂuorescence *** nude mice xenograft tumor model was constructed,YAP and Ki67 expressions were tested by immunohistochemistry(IHC)***:In our study,we proved that curcumin signiﬁcantly inhibited the CRC cell viability,cell migration,and cell invasion *** addition,curcumin inhibited YAP and Transcriptional coactivator with TAZ or the YAP/TAZ signaling axis in CRC ***,in the nude mice model,curcumin treatment signiﬁcantly decreased the size and weight of xenotransplant ***:Therefore,curcumin signiﬁcantly inhibited CRC development and invasion by regulating the YAP/TAZ signaling axis.

关键词： Curcumin Colorectal cancer YAP/TAZ signaling axis

NIR-triggered on-site NO/ROS/RNS nanoreactor:Cascade-amplified photodynamic/photothermal therapy with local and systemic immune responses activation

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Opto-Electronic Advances 2024年第6期7卷 58-73页

作者： Ziqing Xu Yakun Kang Jie Zhang Jiajia Tang hanyao Sun Yang Li Doudou He Xuan sha Yuxia Tang Ziyi Fu Feiyun Wu Shouju Wang Laboratory of Molecular Imaging Department of RadiologyThe First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Breast Surgery The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Women&Children Research Center The First Affiliated HospitalNanjing Medical UniversityNanjing 210029China

Photothermal and photodynamic therapies(PTT/PDT)hold promise for localized tumor treatment,yet their full potential is hampered by limitations such as the hypoxic tumor microenvironment and inadequate systemic immune *** these challenges,we present a novel near-infrared(NIR)-triggered RNS nanoreactor(PBNO-Ce6)to amplify the photodynamic and photothermal therapy efficacy against triple-negative breast cancer(TNBC).The designed PBNOCe6 combines sodium nitroprusside-doped Prussian Blue nanoparticles with Chlorin e6 to enable on-site RNS production through NIR-induced concurrent NO release and ROS *** not only enhances tumor cell eradication but also potentiates local and systemic antitumor immune responses,protecting mice from tumor *** in vivo evaluations revealed that treatment with PBNO-Ce6 leads to a remarkable 2.7-fold increase in cytotoxic T lymphocytes and a 62%decrease in regulatory T cells in comparison to the control PB-Ce6(Prussian Blue nanoparticles loaded with Chlorin e6),marking a substantial improvement over traditional PTT/*** such,the PBNO-Ce6 nanoreactor represents a transformative approach for improving outcomes in TNBC and potentially other malignancies affected by similar barriers.

关键词： photothermal therapy photodynamic therapy nitric oxide reactive nitrogen species triple-negative breast cancer immune response nanoreactor

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