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HNS-Ⅳ基PBX的冲击起爆点火增长模型参数

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含能材料 2025年第1期33卷 65-72页

作者：赵雅琦杨沙曹威郭伟宋清官段英良黄兵韩勇中国工程物理研究院化工材料研究所四川绵阳621999 中国工程物理研究院安全弹药研究中心四川绵阳621999

为了获得HNS-Ⅳ(Ⅳ型六硝基茋)基高聚物粘结炸药的冲击起爆点火增长模型参数,采用炸药平面波加载冲击波的方法,冲击波经隔板衰减后作用到被测炸药上,使用光学多普勒测速技术获得被测炸药与LiF窗口的界面粒子速度曲线。一发试验的隔板上... 详细信息

为了获得HNS-Ⅳ(Ⅳ型六硝基茋)基高聚物粘结炸药的冲击起爆点火增长模型参数,采用炸药平面波加载冲击波的方法,冲击波经隔板衰减后作用到被测炸药上,使用光学多普勒测速技术获得被测炸药与LiF窗口的界面粒子速度曲线。一发试验的隔板上可同时放置多发不同厚度药片,通过调整隔板厚度改变输入压力,可以获得界面粒子速度的增长过程。同时,基于反向撞击法获得了被测炸药的未反应冲击绝热线,基于直径10 mm圆筒试验获得了圆筒膨胀速度时间曲线,采用遗传算法拟合试验结果分别获得了未反应炸药和爆轰产物JWL状态方程参数。最后,采用点火增长模型对不同厚度炸药与LiF窗口的界面粒子速度曲线进行了拟合。结果表明,未反应炸药和爆轰产物状态方程参数曲线拟合相关性较高,获得的点火增长模型参数很好地模拟了冲击起爆试验结果,可以满足起爆传爆序列设计需要。

关键词：高聚物粘结炸药(PBX) 冲击起爆点火增长 HNS-Ⅳ 状态方程

Microstructural evolution and mechanical properties of 55NiCrMoV7 hot-work die steel during quenching and tempering treatments

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Advances in Manufacturing 2021年第4期9卷 520-537页

作者： Xing-Sheng Yu Chuan Wu Ru-Xing Shi ya-sha Yuan Luoyang CITIC HIC Casting&Forging Co. LtdLuoyang 471039HenanPeople’s Republic of China National-Local Joint Engineering Laboratory of Intelligent Manufacturing Oriented Automobile Die&Mould Tianjin University of Technology and EducationTianjin 300222People’s Republic of China CITIC Heavy Industries Co. LtdLuoyang 471039HenanPeople’s Republic of China

55NiCrMoV7 hot-work die steel is mainly used to manufacture heavy forgings in the fields of aerospace and *** study aims to clarify the effects of heat treatment on the microstructural evolution and mechanical properties of the steel,in order to find out an optimal heat treatment scheme to obtain an excellent balance of strength,ductility and *** steel was quenched at temperature from 790℃ to 910℃ followed by tempering treatments of 100–650℃ for 5 *** mechanical property tests were carried out by tensile,impact toughness and *** microscope(OM),scanning electron microscope(SEM)and transmission electron microscope(TEM)were used to observe the austenite grains,lath martensite,carbides and fracture *** results show that the quenching temperature mainly influences the austenite grain size and the volume fraction of undissolved carbides(UCs),while the tempering temperature mainly influences the size and morphology of the martensite with a body centered cubic(BCC)and the carbides with a face centered cubic(FCC).The mechanical properties of the steel,including yield and tensile strength,ductility,impact toughness and hardness,get an excellent balance at a quenching range of 850–870*** the tempering temperature increases,the yield and tensile strength and hardness decrease,while the ductility and impact toughness *** variation trends can be further verified by fracture SEM observation and *** with a macro-micro coupled finite element(MMFE)modeling technique,the cooling rate,microstructural evolution and yield strength of the steel were predicted and compared with the tested data.

关键词： Hot-work die steel Microstructural evolution Mechanical properties Heat treatment Macro-micro coupled modeling and simulation

电针“丰隆”“足三里”对非酒精性脂肪肝大鼠SIRT1/FOXO1信号通路的影响

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针刺研究 2025年第2期50卷 150-158页

作者：胡馨月罗亚祖芳张华雨甄文桧肖莎莎吴杰饶佳佳杨孝芳张宁贵州中医药大学针灸推拿学院贵州中医药大学第一附属医院

目的：观察电针对非酒精性脂肪肝（NAFLD）大鼠的肝功能、血脂代谢、肝脏病理形态及沉默信息调节因子1(SIRT1)/叉头框蛋白（O1FOXO1）信号通路分子表达的影响，探讨电针治疗NAFLD的潜在机制。方法：将13只SD大鼠作为空白组；43只SD大鼠... 详细信息

目的：观察电针对非酒精性脂肪肝（NAFLD）大鼠的肝功能、血脂代谢、肝脏病理形态及沉默信息调节因子1(SIRT1)/叉头框蛋白（O1FOXO1）信号通路分子表达的影响，探讨电针治疗NAFLD的潜在机制。方法：将13只SD大鼠作为空白组；43只SD大鼠以高脂饲料喂养12周建立NAFLD模型，造模成功后随机分为模型组、电针组、电针+抑制剂组及激动剂组，每组10只。空白组和模型组仅抓取固定；激动剂组腹腔注射SIRT1激动剂白藜芦醇（200 mg/kg）；电针组于“丰隆”和“足三里”进行电针治疗，每次30 min；电针+抑制剂组腹腔注射SIRT1抑制剂EX527(5 mg/kg)，其余治疗同电针组；以上治疗均每周3次，持续4周。干预结束后，比色法检测大鼠血清高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、总胆固醇（TC）、甘油三酯（TG）含量及谷丙转氨酶（ALT）和谷草转氨酶（AST）活性；苏木精-伊红（HE）和油红O染色观察肝脏病理形态学变化；采用Western blot和实时荧光定量PCR法分别检测大鼠肝组织中SIRT1、FOXO1、ATP结合盒转运体A1(ABCA1)的蛋白与mRNA表达，以及乙酰化（AC）-FOXO1的蛋白表达。结果：与空白组比较，模型组大鼠血清HDL-C含量降低（P<0.05）,LDL-C、TC、TG含量及ALT、AST活性升高（P<0.01,P<0.05）,HE和油红O染色显示肝细胞排列紊乱、脂肪空泡化明显，肝脏SIRT1、FOXO1、ABCA1的蛋白和mRNA表达水平降低（P<0.05,P<0.01）,AC-FOXO1蛋白表达水平升高（P<0.05）。与模型组比较，电针组和激动剂组血清HDL-C含量升高（P<0.05）,LDL-C、TC、TG含量及ALT、AST活性降低（P<0.01,P<0.05）,HE和油红O染色结果显示肝组织形态改善，脂肪变性减轻，肝脏SIRT1、FOXO1、ABCA1的蛋白和mRNA表达水平升高（P<0.05,P<0.01）,AC-FOXO1蛋白表达水平降低（P<0.05）。与电针组比较，电针+抑制剂组血清HDL-C含量降低（P<0.05）,LDL-C、TC、TG含量及ALT、AST活性升高（P<0.01,P<0.05）,HE和油红O染色显示脂肪空泡较多，脂滴沉积明显，肝脏SIRT1、FOXO1、ABCA1蛋白和mRNA表达水平降低（P<0.05,P<0.01）,AC-FOXO1蛋白表达水平升高（P<0.05）。结论：电针可能通过激活SIRT1/FOXO1信号通路促进胆固醇流出减轻NAFLD大鼠的肝脏损伤。

关键词：非酒精性脂肪肝电针沉默信息调节因子1 叉头框蛋白O1

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CUSTOMS REGULATIONS OF THEPEOPLE'S REPUBLIC OF CHINA CONCERNING THE CONTROL OVER DECLARANTS

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大经贸 1997年第5期 87-89页

作者： yang ya sha

Chapter Ⅰ General Provisions Article 1 This set of regulations has been formulated in accordancewith the Customs Laws of the People’s Republic of China andOther Related laws and regulations for the purpose of strengthening the control over declarants, preserving the order of customs clearanceand standardizing the customs clearance. Article 2 the term "declarants" as used in these Regulations refers tosuch personnel who have obtained the qualifications of a declarant andregistered with the customs according to the procedures as provided inthese Regulations, and shall declare at the customs import and exportgoods. Article 3 The customs of the People’s Republic of China shall be thecompetent institution responsible for the qualification examinations, registration of declarants and supervision and control over the performanceof declarants. Article 4 Delarants shall abide by the relevant national laws rulesand regulations as well as the relevant customs regulations, declare

关键词：入门

Anterior segment OCT application in quantifying posterior capsule opacification severity with varied intraocular lens designs

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International Journal of Ophthalmology(English edition) 2021年第9期14卷 1384-1391页

作者： sha-sha Yu Cheng-Zhe Lu ya-Wen Guo Yun Zhao Xiao-Yong Yuan Tianjin Eye Hospital Tianjin Key Lab of Ophthalmology and Visual ScienceTianjin Eye InstituteClinical College of OphthalmologyTianjin Medical UniversityNankai University Eye HospitalTianjin 300020China

AIM:To evaluate the application of anterior segmentoptical coherence tomography(AS-OCT)in posterior capsule opacification(PCO)severity assessment and analyse the relationship between PCO severity and intraocular lens(IOL)***:PCO patients were prospectively ***-sectional images of the anterior segment at horizontal and vertical meridians were acquired with *** area of the IOL-PC(posterior capsular)space and PCO severity(area,thickness,and density at 3 mm and 5 mm IOL optic regions)were *** relationship between PCO severity and visual acuity,comparisons of PCO severity and IOL-PC space using varied IOL designs were ***:One hundred PCO eyes were ***-PC space,PCO thickness and area were positively correlated with axial *** addition,PCO area and thickness were positively correlated with visual acuity when it was≤0.52 log *** cut-off level of visual acuity should be 0.52 log *** varied IOL designs,3-piece C haptic IOL showed a smaller PCO area and thickness than the 1-piece 3 haptic IOL and 1-piece 4 haptic *** area and thickness values for an IOL with a diameter≤11.0 mm was greater than for an IOL with a diameter of 12.5 mm,and the differences were statistically *** area and thickness increased when IOL haptic angulation increased(from 0 to 12 degrees).CONCLUSION:In PCO eyes,cut-off level of visual acuity is 0.52 log *** more severe PCO,visual acuity maybenot enough to describe the visual function *** severity and IOL-PC space are significantly correlated with axial length and IOL design and material.

关键词： posterior capsule opacification anterior segment-optical coherence tomography IOL-posterior capsule space IOL-posterior capsule distance severity

Reaction mechanism of lanthanum nitrate-doped Mo–La material during solid–liquid spray doping processing

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Rare Metals 2015年第11期34卷 814-817页

作者： Peng-Fa Feng Qin-Li yang Xiao-Ming Dang sha Xi ya-Qi Wang Jinduicheng Molybdenum Co. Ltd

At three critical temperatures which were obtained by thermo-gravimetry-differential thermal analysis–differential scanning calorimetry（TG/DTG/DSC）curves of lanthanum nitrate crystal, the air thermal decomposition experiments and solid–liquid spray doping simulation procedures of lanthanum nitrate crystal were carried out, and their products were analyzed by X-ray diffraction（XRD）. Meanwhile, the spray doping processing of Mo O2–50 wt% La（NO3）3composite powder was undergone with lanthanum nitrate solution as the dopant,and doped Mo O2powder was analyzed by XRD. The results demonstrate that during the traditional solid–liquid spray doping processing, lanthanum nitrate, in the form of either crystal or aqueous solution, would be converted into La（NO3）3á4H2O by the dehydration reaction, rather than be decomposed to La2O3and NO or NO2. Therefore, it is inferred that the oxynitride gas produced from the process is attributed to the decomposition of residual HNO3in lanthanum nitrate crystal. The source of HNO3is supported by the chemical composition of lanthanum nitrate crystal.

关键词： Solid–liquid spray doping processing Mo O2 Lanthan

VOC emission caps constrained by air quality targets based on response surface model:A case study in the Pearl River Delta Region,China

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Journal of Environmental Sciences 2023年第1期123卷 430-445页

作者： ya’nan Hu Bowen Shi Xin Yuan Chuanzeng Zheng Qing’e sha Yufan Yu Zhijiong Huang Junyu Zheng Institute for Environmental and Climate Research Jinan UniversityGuangzhou 511436China Guangdong Polytechnic of Environmental Protection Engineering Guangzhou 528216China

Because of the recent growth in ground-level ozone and increased emission of volatile organic compounds(VOCs),VOC emission control has become a major concern in *** response,emission caps to control VOC have been stipulated in recent policies,but few of them were constrained by the co-control target of PM_(2.5)and ozone,and discussed the factor that influence the emission cap ***,we proposed a framework for quantification of VOC emission caps constrained by targets for PM_(2.5)and ozone via a new response surface modeling(RSM)technique,achieving 50%computational cost savings of the *** the Pearl River Delta(PRD)region,the VOC emission caps constrained by air quality targets varied greatly with the NOxemission reduction *** control measures in the surrounding areas of the PRD region were not considered,there could be two feasible strategies for VOC emission caps to meet air quality targets(160μg/m^(3)for the maximum 8-hr-average 90th-percentile(MDA8-90%)ozone and 25μg/m^(3)for the annual average of PM_(2.5)):a moderate VOC emission cap with60%NOxemission *** the ozone concentration target were reduced to 155μg/m^(3),deep NOxemission reductions is the only feasible ozone control measure in *** of seasonal VOC emission caps based on the Monte Carlo simulation could allow us to gain higher ozone benefits or greater VOC emission *** VOC emissions were further reduced in autumn,MDA8-90%ozone could be lowered by 0.3-1.5μg/m^(3),equaling the ozone benefits of 10%VOC emission reduction *** method for VOC emission cap quantification and optimization proposed in this study could provide scientific guidance for coordinated control of regional PM_(2.5)and O_(3)pollution in China.

关键词： Volatile organic compounds Emission caps Air quality targets Response surface model Monte Carlo(MC)simulations

Cold plasma promotes Sertoli cell proliferation via AMPK–mTOR signaling pathway

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Journal of Integrative Agriculture 2022年第9期21卷 2700-2719页

作者： ZHANG Jiao-jiao LI ya-qi SHI Mei WANG Yu-sha TANG yao WANG Xian-zhong Chongqing Key Laboratory of Forage and Herbivore College of Veterinary MedicineSouthwest UniversityChongqing 400715P.R.China

This study investigated cold plasmas for multiple biological applications. Our previous work has found dielectric barrier discharge plasma improves chicken sperm quality. The number of Sertoli cells(SCs) decides spermatogenesis. However, whether cold plasma can regulate SC proliferation remains unclear. This study explored the effects of cold plasma on immature chicken SC proliferation and the regulation mechanism. Results showed that cold plasma exposure at 2.4 W for 30 s twice with an interval of 6 h produced(P<0.05) the maximum SC viability, cell growth, and cell cycle progression. SC proliferation-promoting effect of cold plasma treatment was regulated by increasing(P<0.05) the adenosine triphosphate production and the respiratory enzyme activity in the mitochondria. This process was potentially mediated by the adenosine monophosphate-activated protein kinase(AMPK)–mammalian target of rapamycin(m TOR) signaling pathway, which was regulated by the micro RNA(mi RNA) targeting regulation directly and by the intracellular reactive oxygen species homeostasis indirectly. The cold plasma treatment increased(P<0.01) the mi R-7450-5 p expression and led to a decreased(P<0.01) AMPKα1 level. On the other hand, mi R-100-5 p expression was reduced(P<0.05) and led to an increased(P<0.05) m TOR level in SCs. A single-stranded synthetic mi R-7450-5 p antagomir and a double-stranded synthetic mi R-100-5 p agomir reduced(P<0.05) the SC proliferation. However, this could be ameliorated(P<0.05) by the cold plasma treatment. Our findings suggest that appropriate cold plasma treatment provides a safe strategy to improve SC proliferation, which is beneficial to elevating male chicken reproductive capacity.

关键词： cold plasma Sertoli cell proliferation AMPK mTOR miRNAs

A two-year(2020–2021)observation of marine phycotoxins in phytoplankton in typical mariculture areas of East China Sea

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Journal of Oceanology and Limnology 2022年第6期40卷 2256-2266页

作者： Xiaoqing TIAN Chengqi FAN Yunyu TANG Haiyan ZHANG Wei KANG sha CHEN Chongbin LI ya’nan LU Key Laboratory of East China Sea&Oceanic Fishery Resources Exploitation and Utilization Ministry of Agriculture and Rural AffairsEast China Sea Fisheries Research InstituteChinese Academy of Fishery SciencesShanghai 200090China shanghai Ocean University Shanghai 201306China

To learn the marine phycotoxins(MPTs)contamination status in mariculture areas in the East China Sea(ECS),from May 2020 to October 2021,80 net-concentrated phytoplankton samples were collected from 12 stations in three typical areas with high incidence of red tides,namely,Gouqi Island,Sandu’ao-Lianjiang,and Zhangzhou-Dongshan Island in ECS,and MPTs of the samples were *** types of toxins were detected in 24 samples from 9 *** marine toxins(LMTs)were more common and diverse in these *** 2(PTX2)was the main lipophilic marine toxin(LMT)in the concentrated phytoplankton samples and the occurrence showed seasonal differences from north to *** to the potential risks of pectenotoxin(PTXs)to seafood safety,it is suggested to execute regular monitoring on PTXs in ECS and a mandatory standard should be formulated based on the comprehensive analysis of in-situ monitoring and lab ***,contamination risks of cyclic imine toxins in the north and domoic acid(DA)in the south of ECS should also be paid with attention *** 2 paralytic shellfish toxins(PSTs),N-sulfocarbamoyl toxin C2(C2),and decarbamoyl gonyatoxin 3(dcGTX3),were found from spring samples in the north of *** the biggest mussel culture county of China,Gouqi Island showed higher toxin diversity and the toxin detection rate was higher than the other two *** Gouqi Island area,PSTs were a serious potential threat in spring,and LMTs instead of PSTs became the main risk in summer-autumn *** ensure the safety of seafood and marine environmental health,it is recommended to conduct long-term targeted tracking and monitoring of MPTs in this and similar mariculture areas.

关键词： marine phycotoxins(MPTs) pectenotoxin 2(PTX2) mariculture areas East China Sea seafood safety