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Rice science 2024年第1期31卷 1-5,I0001-I0008页

作者： sha Gan SHEN Xin WU Zini XU Xiaocan XU Xin TAN Yanping LIU Xinqiong TANG Xianyin WANG Chuntai QIN Yonghua Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area College of Life SciencesSouth Central Minzu UniversityWuhan 430074China Huazhong Agricultural University Wuhan 430070China

A rice cyclase gene,OsCYL4b,identified as an alternative splice variant of the cyclase gene OsCYL4a,is involved in the regulation of drought stress and oxidative *** with OsCYL4a,OsCYL4b lacks the second exon,which is located in the conserved motif 3,and may be a functionally important *** results suggested that OsCYL4b was responsive to multiple abiotic stresses,and was localized to both the cytoplasm and plasma *** overexpression of OsCYL4b resulted in significantly enhanced drought and osmotic stress tolerance,reduced water loss,and increased abscisic acid(ABA)content compared with the wild type(WT).

关键词： drought Oxygen stress

Biomimetic Integrated Nanozyme for Flare and Recurrence of Gouty Arthritis

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Asian Journal of Pharmaceutical Sciences 2024年第3期19卷 131-145页

作者： Rui Wang Tongyao Liu Xinhong Li Enhao Lu Yiting Chen Kuankuan Luo Tao Wang Xueli Huang Zhiwen Zhang Shilin Du Xianyi sha Key Laboratory of Smart Drug Delivery(Ministry of Education) Institutes of Integrative MedicineDepartment of PharmaceuticsSchool of PharmacyFudan UniversityShanghai 201203China Department of Emergency Medicine Shanghai Geriatric Medical CenterShanghai 201104China Department of Emergency Medicine Zhongshan HospitalFudan UniversityShanghai 200032China

Flare and multiple recurrences pose significant challenges in gouty *** treatments provide temporary relief from inflammation but fail to promptly alleviate patient pain or effectively prevent subsequent *** should also be noted that both anti-inflammation and metabolism of uric acid are necessary for gouty arthritis,calling for therapeutic systems to achieve these two goals *** this study,we propose a biomimetic integrated nanozyme,HMPB-Pt@MM,comprising platinum nanozyme and hollow Prussian *** demonstrates anti-inflammatory properties by eliminating reactive oxygen species and reducing infiltration of inflammatory ***,it rapidly targets inflamed ankles through the camouflage of macrophage ***,HMPB-Pt@MM exhibits urate oxidase-like capabilities,continuously metabolizing locally elevated uric acid concentrations,ultimately inhibiting multiple recurrences of gouty *** summary,HMPB-Pt@MM integrates ROS clearance with uric acid metabolism,offering a promising platform for the treatment of gouty arthritis.

关键词： Gouty arthritis Inflammation Nanozyme Platinum Prussian blue

Gut microbiota dysbiosis contributes toα-synuclein-related pathology associated with C/EBPβ/AEP signaling activation in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2024年第9期19卷 2081-2088页

作者： Xiaoli Fang sha Liu Bilal Muhammad Mingxuan Zheng Xing Ge Yan Xu Shu Kan Yang Zhang Yinghua Yu Kuiyang Zheng Deqin Geng Chun-Feng Liu Department of Neurology and Clinical Research Center of Neurological Disease The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Jiangsu Key Laboratory of Immunity and Metabolism Department of Pathogen Biology and ImmunologyXuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Neurology Xuzhou Central HospitalXuzhouJiangsu ProvinceChina Jiangsu Key Laboratory of Neuropsychiatric Disease and Institute of Neuroscience Soochow UniversitySuzhouJiangsu ProvinceChina

Parkinson’s disease is a neurodegenerative disease characterized by motor and gastrointestinal *** dysfunction can precede the onset of motor symptoms by several *** microbiota dysbiosis is involved in the pathogenesis of Parkinson’s disease,whether it plays a causal role in motor dysfunction,and the mechanism underlying this potential effect,remain ***/enhancer binding proteinβ/asparagine endopeptidase(C/EBPβ/AEP)signaling,activated by bacterial endotoxin,can promoteα-synuclein transcription,thereby contributing to Parkinson’s disease *** this study,we aimed to investigate the role of the gut microbiota in C/EBPβ/AEP signaling,α-synuclein-related pathology,and motor symptoms using a rotenone-induced mouse model of Parkinson’s disease combined with antibiotic-induced microbiome depletion and fecal microbiota *** found that rotenone administration resulted in gut microbiota dysbiosis and perturbation of the intestinal barrier,as well as activation of the C/EBP/AEP pathway,α-synuclein aggregation,and tyrosine hydroxylase-positive neuron loss in the substantia nigra in mice with motor ***,treatment with rotenone did not have any of these adverse effects in mice whose gut microbiota was depleted by pretreatment with ***,we found that transplanting gut microbiota derived from mice treated with rotenone induced motor deficits,intestinal inflammation,and *** of fecal microbiota from healthy control mice alleviated rotenone-induced motor deficits,intestinal inflammation,endotoxemia,and intestinal barrier *** results highlight the vital role that gut microbiota dysbiosis plays in inducing motor deficits,C/EBPβ/AEP signaling activation,andα-synuclein-related pathology in a rotenone-induced mouse model of Parkinson’s ***,our findings suggest that supplementing with healthy microbiota may be a safe and effective treatment that c

关键词： C/EBP/AEP signaling pathway endotoxemia fecal microbiota transplantation intestinal barrier intestinal inflammation microbiota-gut-brain axis Parkinson’s disease

Effect of percutaneous electrical stimulation at the Baliao point on preventing postpartum urinary retention after labor analgesia

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World Journal of Clinical Cases 2024年第16期12卷 2758-2764页

作者： Xiao-Qing Wang Li-sha Guan Department of Obstetrics and Gynecology Suzhou Ninth Affiliated Hospital of Suzhou UniversitySuzhou 215200Jiangsu ProvinceChina

BACKGROUND Anesthetic drugs used in labor analgesia also paralyze the bladder muscle by blocking the sacral plexus,thereby affecting maternal postpartum spontaneous urination and increasing the risk of postpartum urinary retention(PUR).AIM To analyze the effect of percutaneous electrical stimulation at the Baliao point combined with biofeedback therapy for PUR *** We selected 182 pregnant women who received labor analgesia in obstetrics between June 2022 and December *** were divided into the combined therapy group(transcutaneous electrical stimulation of the Baliao point combined with biofeedback therapy)and the control group(biofeedback therapy alone).The first spontaneous urination time,first postpartum urine volume,bladder residual urine volume,postpartum hemorrhage volume,pre-urination waiting time,PUR incidence,adverse reactions,and the intervention’s clinical efficacy were compared between the two *** The first spontaneous urination time after delivery was more delayed(2.92±1.04 h vs 3.61±1.13 h,P0.001),with fewer initial postpartum urine(163.54±24.67 mL vs 143.72±23.95 mL,P0.001),more residual bladder urine(54.81±10.78 mL vs 65.25±13.52 mL,P0.001),more postpartum bleeding(323.15±46.95 mL vs 348.12±45.03 mL,P=0.001),and longer waiting time for urination(0.94±0.31 min vs 1.29±0.42 min,P0.001),in the control group than in the combined therapy *** control group also had higher PUR incidence(4.65%vs 15.85%,P=0.016).Both groups had no adverse reactions,but the clinical total efficacy rate of the intervention was significantly higher in the combined therapy group than in the control group(95.35%vs 84.15%,P=0.016).CONCLUSION Percutaneous electrical stimulation of the Baliao point combined with biofeedback can significantly promote postpartum micturition of parturients with labor analgesia,thereby effectively preventing PUR occurrence.

关键词： Transcutaneous electrical stimulation Baliao acupoint Biofeedback Pain relief during childbirth Postpartum uroschesis

Comprehensive reutilization of herbal waste:Coproduction of magnolol,honokiol,and β-amyrin from Magnolia officinalis residue

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Green Energy & Environment 2024年第2期9卷 403-412页

作者： Lukun Xiao Anyi Zhao Jie Qiu An Liu sha Chen Jinzhu Jiang Jun Zhang Cong Guo Jipeng Di Jintang Cheng Chang Chen Kangxin Hou Aiping Zhang Yan Liu Caixia Wang Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing100700China School of Pharmacy Shanxi Medical UniversityTaiyuan030001China

Herbal extraction residues(HERs)cause serious environmental pollution and resource *** this study,a novel green route was designed for the comprehensive reutilization of all components in HERs,taking Magnolia officinalis residues(MOR)as an *** reluctant structure of MOR was first destroyed by alkali pretreatment to release the functional ingredients(magnolol and honokiol)originally remaining in MOR and to make MOR more accessible for hydrolysis.A metal–organic frame material MIL-101(Cr)with a maximum absorption capacity of 255.64 mg g^(-1)was synthesized to absorb the released honokiol and magnolol from the pretreated MOR solutions,and 40 g L^(-1)reducing sugars were obtained with 81.8%enzymatic hydrolysis rate at 10%MOR solid ***,382 mg L-1β-amyrin was produced from MOR hydrolysates by an engineered yeast *** total,1 kg honokiol,8 kg magnolol,and 7.64 kg β-amyrin could produce from 1 ton MOR by this cleaner process with a total economic output of 170,700 RMB.

关键词： Magnolia officinalis residues(MOR) Comprehensive utilization Metal-organic frame material Biosynthesis

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旅游疗愈理论:构成系统与作用机制

旅游学刊 2024年第3期39卷 35-47页

作者：杨振之沙莎四川大学旅游学院四川成都610065 成都中医药大学养生康复学院四川成都611137

文章基于多学科交叉研究,提出了旅游疗愈理论,构建了由“天”“地”“人”三大系统及其构成要素,以及“天人地交互效应”作用机制组成的旅游疗愈理论模型,阐述了各构成要素之间的内在生成机制,以及对人体健康提升的作用路径,为进一步了... 详细信息

文章基于多学科交叉研究,提出了旅游疗愈理论,构建了由“天”“地”“人”三大系统及其构成要素,以及“天人地交互效应”作用机制组成的旅游疗愈理论模型,阐述了各构成要素之间的内在生成机制,以及对人体健康提升的作用路径,为进一步了解“天”“地”与“人”的健康互动关系提供了理论支撑。受旅游疗愈主体“人”的健康需求驱动,会产生此类“应时而宜”的康复性旅游流动,让人“远离”惯常环境中的“烦”与“身心不适”,置身于“迷人”的环境中,会产生更多的非定向注意力和健康效益,进而提升生命质量,实现健康的体魄在诗与远方遨游。该研究进一步发掘了旅游的社会价值和社会贡献,使更多符合游客健康需求的产品供给、资源利用、空间开发成为可能,从而促进旅游学与生命科学的跨学科理论实践。

关键词：旅游疗愈构成系统作用机制康复性旅游流动

流动作为方法:数字游民在中国乡村——以光山数字游民基地为例

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新闻界 2024年第4期 28-35,47页

作者：沙垚中国社会科学院大学新闻传播学院北京100021 中国社会科学院新闻与传播研究所北京100021

近年来,数字游民的概念和模式在乡村振兴领域颇受欢迎,但舶来的数字游民本质上是一个互联网产品,乡村在其框架中更多是作为文化和生态的空间消费场景而出现的,青年与乡村很难有深刻的互动。但是,在该概念旅行的过程中,一些数字游民基地... 详细信息

近年来,数字游民的概念和模式在乡村振兴领域颇受欢迎,但舶来的数字游民本质上是一个互联网产品,乡村在其框架中更多是作为文化和生态的空间消费场景而出现的,青年与乡村很难有深刻的互动。但是,在该概念旅行的过程中,一些数字游民基地也开始了本土化的调试。通过对这些新实践的田野观察,研究发现:中国乡村的数字游民基地建设,不再将互联网逻辑作为主导性逻辑,而是以县域高质量发展中的问题为导向,结合乡村振兴战略,致力于解决青年入乡的最后一公里问题,在创造青年和乡村见面机会的同时,探索性地发展出兼具城乡要素的融合式的生产生活新方式,以青年流动为方法,破解城乡之间资源要素双向流动的难题。聚焦流动,也是在理论层面重返传播。

关键词：数字游民流动乡村振兴城乡融合

微塑料和菲对土壤化学性质、酶活性及微生物群落的影响

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环境科学 2024年第1期45卷 496-507页

作者：刘沙沙秦建桥吴贤格肇庆学院环境与化学工程学院广东省环境健康与资源利用重点实验室肇庆526061

微塑料和多环芳烃(PAHs)因在土壤环境中广泛存在及其潜在生态风险而受到越来越多的关注.然而,关于微塑料-PAHs复合污染对土壤生态系统的影响鲜有报道.选用聚乙烯(PE)/聚丙烯(PP)和菲(PHE)作为微塑料和PAHs的代表,进行为期300d的微宇宙... 详细信息

微塑料和多环芳烃(PAHs)因在土壤环境中广泛存在及其潜在生态风险而受到越来越多的关注.然而,关于微塑料-PAHs复合污染对土壤生态系统的影响鲜有报道.选用聚乙烯(PE)/聚丙烯(PP)和菲(PHE)作为微塑料和PAHs的代表,进行为期300d的微宇宙培养实验,利用土壤农业化学分析方法和16S扩增子测序技术研究PE/PP和PHE的单一和复合污染对土壤化学特性、酶活性和微生物群落(数量、结构、功能)的影响,分析PE/PP和PHE存在下土壤性质、酶活性和菌群的互作关系.结果表明,PE/PP和PHE的单一和复合污染对土壤pH值、有效磷(AP)和微生物(细菌、放线菌、霉菌)数量没有产生明显影响,但显著提高了荧光素二乙酸酯酶(FDAse)活性;PE、PP、PHE-PE和PHE-PP的添加显著增加了土壤有机质(SOM)含量和脲酶活性,PHE、PHEPE和PHE-PP显著增强了脱氢酶和磷酸酶活性及速效氮(AN)含量;PHE的添加对微生物群落影响不大,PE、PP、PHE-PE和PHE-PP对群落产生了一定的影响.PE/PP和PHE能够促进微生物产生能量、生长和繁殖,加快污染物的代谢/降解和细胞膜转运等功能.PE/PP和PHE引起的AN和SOM变化是影响土壤酶活性的关键因子,AN、AP和pH的改变是微生物数量增加的主要原因;微生物群落结构的改变与土壤化学性质、酶活性具有一定的相关性,其中SOM对菌群的影响达到了显著水平,土壤中不同碳源(PE/PP和PHE)的存在及菌与菌之间的互作关系也会影响微生物群落的组成.综上,PE/PP和PHE通过改变土壤化学性质、酶活性和微生物群落及其互作过程来促进菌群适应污染物胁迫.

关键词：微塑料菲(PHE) 土壤性质酶活性微生物群落

PAN-TB治疗策略的实施对结核病防控的意义及挑战

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中国防痨杂志 2024年第10期46卷 1188-1192页

作者：沙巍同济大学附属上海市肺科医院结核病临床研究中心上海200433

全球耐药结核病的防控仍面临巨大挑战,PAN-TB方案是适用于所有结核病的一线方案,即确诊活动性结核病后即启动该方案,而不需要获得患者的耐药情况。推行PAN-TB方案的目的是旨在尽快启动有效治疗,降低传播,并可以大幅度减轻结核病规划管... 详细信息

全球耐药结核病的防控仍面临巨大挑战,PAN-TB方案是适用于所有结核病的一线方案,即确诊活动性结核病后即启动该方案,而不需要获得患者的耐药情况。推行PAN-TB方案的目的是旨在尽快启动有效治疗,降低传播,并可以大幅度减轻结核病规划管理的复杂性。它不仅是临床治疗方法,更是公共卫生手段。本文就PAN-TB策略的定义、方案的要求、全球的研究进展,以及对于结核病防控的意义和目前面临的挑战进行阐述,以期为中国结核病的防控提供新的思路。

关键词：结核抗结核药治疗应用方案评价

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自然的几何化:切萨尔皮诺的植物分类思想

科学技术哲学研究 2024年第2期41卷 93-100页

作者：杨莎西北大学科学史高等研究院西安710127

意大利植物学家切萨尔皮诺通常被认为是近现代植物分类学的奠基者,是植物分类学史上“第一个真正的体系构建者”。他在构建体系时将亚里士多德先验原则与他观察、解剖植物的实际经验相结合,采用逻辑划分法,以结实部分的形态为主要分类... 详细信息

意大利植物学家切萨尔皮诺通常被认为是近现代植物分类学的奠基者,是植物分类学史上“第一个真正的体系构建者”。他在构建体系时将亚里士多德先验原则与他观察、解剖植物的实际经验相结合,采用逻辑划分法,以结实部分的形态为主要分类依据。由于采用了划分法,其体系常被后来学者诟病“不自然”,但事实上切萨尔皮诺也清楚这一点,只是当时所知植物数量有限,他没有太多选择。切萨尔皮诺对植物分类学更重要的贡献在于将分类依据限于植物的几何形态方面,排除了颜色、生境、用途等属性,这点与当时学者对“形式”概念的发展密切相关。依据形态分类并用数学语言来描述形态,这意味着欧洲16—17世纪对生物体的研究同样受到了数学化、几何化潮流的影响。

关键词：切萨尔皮诺植物分类学史自然的几何化形式本质