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Resolvin D1 Induces mTOR-independent and ATG5-dependent Autophagy in BV-2 Microglial Cells

Current Medical Science 2023年第6期43卷 1096-1106页

作者： shang-wen PAN Li-sha HU Han WANG Rui-ting LI Ya-jun HE You shaNG Zhong-liang DAI Li-xin CHEN Wei XIONG Department of Critical Care Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Anesthesiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Anesthesiology Qingdao Women and Children’s HospitalQingdao UniversityQingdao266034China Department of Anesthesiology The Second Clinical Medical College(Shenzhen People’s Hospital)Jinan UniversityShenzhen518020China Department of Pharmacology Medical CollegeJinan UniversityGuangzhou510632China Integrated Chinese and Western Medicine Postdoctoral Research Station Jinan UniversityGuangzhou510632China

Objective The activation state of microglia is known to occupy a central position in the pathophysiological process of cerebral *** is a catabolic process responsible for maintaining cellular *** recent years,autophagy has been demonstrated to play an important role in *** D1(RvD1)is a promising therapeutic mediator that has been shown to exert substantial anti-inflammatory and proresolving ***,whether RvD1-mediated resolution of inflammation in microglia is related to autophagy regulation needs further *** present study aimed to explore the effect of RvD1 on microglial autophagy and its corresponding *** Mouse microglial cells(BV-2)were cultured,treated with RvD1,and examined by Western blotting,confocal immunofluorescence microscopy,transmission electron microscopy,and flow *** RvD1 promoted autophagy in both BV-2 cells and mouse primary microglia by favoring the maturation of autophagosomes and their fusion with ***,RvD1 had no significant effect on the activation of mammalian target of rapamycin(mTOR)***,RvD1-induced mTOR-independent autophagy was confirmed by observing reduced cytoplasmic calcium levels and suppressed calcium/calmodulin-dependent protein kinase II(CaMK II)***,by downregulating ATG5,the increased phagocytic activity induced by RvD1 was demonstrated to be tightly controlled by ATG5-dependent *** The present work identified a previously unreported mechanism responsible for the role of RvD1 in microglial autophagy,highlighting its therapeutic potential against neuroinflammation.

关键词： resolvin D1 microglia mTOR-independent autophagy ATG5-dependent autophagy phagocytosis

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Coupling Frequency Band of the In-Phase Locked Gain Waveguide Array Lasers

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Chinese Physics Letters 2011年第4期28卷 115-117页

作者： sha Peng-Fei XIN Jian-Guo FANG Li-Ping LIU Zheng-Fan ZHOU Ying YU Song-Lin wen Jian-Guo School of Optoelectronics Beijing Institute of TechnologyBeijing 100081 North China Research Institute of Electro-optics(NCRIEO) Beijing 100015

A coupling frequency band of an in-phase locked sliced gain waveguide array laser is experimentally *** experimental data show that for an in-phase locked single peak intensity distribution output without side lobes of the sliced gain waveguide array laser,there exists a coupling frequency band and the coupling frequency band increases as the transmissivity of the laser output coupler decreases.

关键词： waveguide laser Waveguide

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Alternative splicing in breast cancer

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Journal of Bio-X Research 2023年第4期6卷 133-137页

作者： Xin wen Ze Yan Li sha College of Basic Medical Sciences Dalian Medical UniversityDalian 116044China

Alternative splicing allows a gene to produce multiple proteins and is the main source of human proteome *** regulation of alternative splicing produces proteins with different structures and can lead to altered protein function,inactivation,or deleterious variants,which can have severe effects on normal cellular function,leading to many diseases,including *** splicing abnormalities are often found in diseases,so alternative splicing is highly correlated with diseases and *** to relevant statistics,breast cancer is an important factor that threatens women’s lives and health.A common sign of tumors in humans is abnormal alternative *** increasing amount of evidence shows that abnormal alternative splicing plays an important role in the occurrence and development of breast *** the same time,in the related treatment of breast cancer,alternative splicing can lead to the failure of existing treatment methods and induce drug ***,targeted therapy is still the key strategy for breast cancer *** this review,we discuss the five classifications of alternative splicing and aberrant alternative splicing in breast *** role of alternative splicing in the drug resistance of breast cancer is also *** has shown that aberrant alternative splicing can lead to drug resistance to current *** splicing factors are involved in many aspects of cancer,splicing factors may provide a new strategy for cancer treatment and a powerful tool for progress in the fight against breast *** oligonucleotides form a double-stranded structure by complementary pairing with mRNA,which prevents the binding of mRNA and ribosomes,thus inhibiting protein ***,after finding effective targets,antisense oligonucleotides can be applied in gene therapy,drug research and development,biological research,and other fields to improve therapeutic effects.

关键词： aberrant regulation alternative splicing breast cancer drug resistance splicing factors

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van der Waals Interactions in Bimolecular Reactions

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Chinese Journal of Chemical Physics 2019年第2期32卷 157-166,I0002页

作者： Jian-wei Cao Feng-yi Li wen-sha Xia wen-sheng Bian Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China

The van der Waals (vdW) interaction is very important in fields of physics, biology and chemistry, and its role in reaction dynamics is an issue of great interest. In this review, we focus on the recent progresses in the theoretical and experimental studies on the vdW interaction in bimolecular reactions. In particular, we review those studies that have advanced our understanding of how the vdW interaction can strongly influence the dynamics in both direct activated and complex-forming reactions, and further extend the discussion to the polyatomic reactions involving more atoms and those occurring at cold and ultracold temperatures. We indicate that an accurate description of the delicate vdW structure and long-range potential remains a challenge nowadays in either ab initio calculations or the fitting of the potential energy surfaces. We also present an explanation on the concept of vdW saddle proposed by us recently which may have general importance.

关键词： van der Waals interaction Complex-forming reactions Reaction mechanisms Ultracold chemical reactions Ab initio potential energy surfaces

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Qiming granule in treating type 2 diabetic kidney disease patients:study protocol for a randomized controlled trial

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Traditional Medicine Research 2021年第1期6卷 7-15页

作者： Jian Huo Jun-Guo Duan Xue-Jing Lu Fu-wen Zhang wen-Yuan Jian Jia-Qing Sui Jia-Ling Ai Li-sha Liu College of Ophthalmology Chengdu University of Traditional Chinese MedicineChengdu 610075China Chengdu Women’s and Children’s Central Hospital School of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 611731China Ineye Hospital Chengdu 610084China

Background:Diabetic kidney disease(DKD)is a chronic renal microvascular complication associated with abnormal glucose *** to traditional Chinese medicine(TCM)theory,Qi and Yin deficiency with blood stasis(the name of TCM symptoms,its main clinical features are fatigue,dry mouth,red or pale tongue,weak pulse,etc.)is the primary TCM syndrome of DKD,and Qiming granule(QMG)is suitable for the treatment of Qi and Yin deficiency with blood stasis *** view of this,we designed a randomized controlled trial to assess whether QMG is efficacious and safe in treating DKD ***:This protocol is for a randomized,double-blind,placebo-controlled,parallel group,six-centre clinical trial.A total of 180 participants will be randomized into the QMG group or placebo group,with a 1:1 *** study will last for 50 weeks,including a 2-week run-in period,24 weeks of intervention,and 24 weeks of *** experimental intervention will be QMG,and the control intervention will be a *** primary outcome will be the 24h urinary albumin excretion ratio and the change in the albumin-to-creatinine *** secondary outcome will be evaluation of renal function,fundus changes,management of blood lipids,TCM symptom improvement and safety *** events will be recorded during the ***:This study is a randomized controlled trial to test the effectiveness and safety of QMG for DKD *** findings of this study will help to provide evidence-based recommendations in treating DKD *** registration:Chinese Clinical Trial Registry,*** 23 December 2012.

关键词： Diabetic kidney disease Qiming granule Traditional Chinese medicine Randomized controlled trial

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A rapid and convenient experimental method of absolutely calibrating transmission of x-ray flat-response filter

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Chinese Physics B 2018年第10期27卷 271-275页

作者： Jian Yu Li-Fei Hou Jing Wang wen-Hai Zhang Ming Chen Bao-Chong Zhou sha-Li Xiao Shen-Ye Liu Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China Research Center of Laser Fusion China Academy of Engineering PhysicsR O.Box 919-986Mianyang 621900China College of Optoelectronic Engineering Chongqing UniversityChongqing 400044China

We develop a rapid and convenient experimental method of absolutely calibrating the transmission of an x-ray flatresponse filter. The calibration experiment is performed on a small laser-target facility, and a set of high resolution holographic flat-field grating spectrometers is used as a discrimination system of the laser-produced x-ray source. Given that the holographic flat-field grating has a relatively large width, the grating is divided into two regions for use in that direction,where one region has the filter added and the other region does not. The filter transmission is determined by dividing the x-ray signal counts detected when the filter is in the line of sight by those detected when the filter is out of the line of *** find that the calibration results of this experiment agree with the calibration results using a synchrotron radiation source,as well as simulation results. Our method is not only highly reliable but also rapid and convenient.

关键词： flat-response filter absolute transmission flat-field grating spectrometer x-ray CCD camera

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Manganese salts function as potent adjuvants

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Cellular & Molecular Immunology 2021年第5期18卷 1222-1234页

作者： Rui Zhang Chenguang Wang Yukun Guan Xiaoming Wei Mengyin sha Mengran Yi Miao Jing Mengze Lv wen Guo Jing Xu Yi Wan Xin-Ming Jia Zhengfan Jiang Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education School of Life SciencesPeking UniversityBeijingChina Peking-Tsinghua Center for Life Sciences Peking UniversityBeijingChina Clinical Medicine Scientific and Technical Innovation Center Shanghai Tenth People’s HospitalTongji University School of MedicineShanghaiChina CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology of ChinaBeijingChina Laboratory for Earth Surface Processes College of Urban and Environmental SciencesPeking UniversityBeijingChina

Aluminum-containing adjuvants have been used for nearly 100 years to enhance immune responses in billions of doses of *** date,only a few adjuvants have been approved for use in humans,among which aluminum-containing adjuvants are the only ones widely ***,the medical need for potent and safe adjuvants is currently continuously increasing,especially those triggering cellular immune responses for cytotoxic T lymphocyte activation,which are urgently needed for the development of efficient virus and cancer *** is an essential micronutrient required for diverse biological activities,but its functions in immunity remain *** previously reported that Mn^(2+) is important in the host defense against cytosolic dsDNA by facilitating cGAS-STING activation and that Mn^(2+)alone directly activates cGAS independent of dsDNA,leading to an unconventional catalytic synthesis of 2′3′-***,we found that Mn^(2+) strongly promoted immune responses by facilitating antigen uptake,presentation,and germinal center formation via both cGAS-STING and NLRP3 ***,a colloidal manganese salt(Mn jelly,MnJ)was formulated to act not only as an immune potentiator but also as a delivery system to stimulate humoral and cellular immune responses,inducing antibody production and CD4^(+)/CD8^(+)T-cell proliferation and activation by either intramuscular or intranasal *** administered intranasally,MnJ also worked as a mucosal adjuvant,inducing high levels of secretory *** showed good adjuvant effects for all tested antigens,including T cell-dependent and T cell-independent antigens,such as bacterial capsular polysaccharides,thus indicating that it is a promising adjuvant candidate.

关键词： Manganese(Mn^(2+)) adjuvant cGAS-STING NLRP3 antigen presentation

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无线协作网络的物理层网络编码研究进展

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数据采集与处理 2016年第3期31卷 415-428,623页

作者：陈文韦莎上海交通大学电子信息与电气工程学院上海200240

随着网络编码技术的发展和对干扰无线信道的研究,提出了无线多源信息的物理层网络编码,它能够有效融合干扰并提高无线网络的频谱效率。本文从物理层网络编码的研究背景和研究进展介绍了无线协作网络的物理层网络编码。本文从几种中继技... 详细信息

随着网络编码技术的发展和对干扰无线信道的研究,提出了无线多源信息的物理层网络编码,它能够有效融合干扰并提高无线网络的频谱效率。本文从物理层网络编码的研究背景和研究进展介绍了无线协作网络的物理层网络编码。本文从几种中继技术入手,针对多源中继系统,介绍了典型模拟网络编码和数字网络编码的特征和性能,同时也给出了作者的部分工作。本文对中继通信和无线网络编码的研究有一定参考价值。

关键词：中继通信网络编码物理层网络编码模拟网络编码数字网络编码

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Advances in the management of arteriosclerosis of the lower extremity:Integrating Western and Chinese medicine approaches

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World Journal of Clinical Cases 2024年第36期12卷 6871-6876页

作者： sha Cheng Jia-Xin Xu wen-Jie Long Department of Cardiovascular The Affiliated Traditional Chinese Medicine HospitalGuangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina Department of Geriatrics The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina

This editorial provides a commentary on the recent *** paper reviews current literature and explores innovative treatment strategies for lower extremity arteriosclerosis obliterans(LEASO)through an integrative *** highlights the effectiveness of combination therapies that merge traditional Chinese medicine(TCM)with Western medical practices,suggesting that such integrative methods may improve patient compliance and outcomes through personalized *** paper stresses the importance of rigorous clinical trials to evaluate the efficacy and safety of TCM interventions within LEASO treatment protocols,advocating for evidence-based validation of these combined *** recommendations emphasize accurate diagnosis,appropriate pharmacological in-terventions,the use of advanced surgical and endovascular techniques,and the inclusion of TCM to address underlying ***,continuous monitoring,patient education,and lifestyle modifications are essential to slow disease progression and achieve optimal patient *** paper concludes by calling for further research to develop standardized treatment protocols that effectively integrate both Western and Chinese medical approaches in managing LEASO.

关键词： Lower extremity arteriosclerosis obliterans Traditional Chinese medicine Integrative healthcare Vascular therapy Combination therapies

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基于K-GMM算法的SAR海冰图像分类

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地理与地理信息科学 2018年第5期34卷 42-48页

作者：任莎莎郎文辉合肥工业大学计算机与信息学院安徽合肥230009

为适应SAR海冰图像的斑点噪声和入射角效应,已有的基于随机场模型的海冰分割算法常引入复杂的语境模型,容易导致过平滑现象,不仅降低了部分图像的分割精度,而且运行效率较低。该文依据海冰业务化分类(分割)的特点,提出了一种基于GMM与K... 详细信息

为适应SAR海冰图像的斑点噪声和入射角效应,已有的基于随机场模型的海冰分割算法常引入复杂的语境模型,容易导致过平滑现象,不仅降低了部分图像的分割精度,而且运行效率较低。该文依据海冰业务化分类(分割)的特点,提出了一种基于GMM与K-均值的改进聚类方法:首先,在K-均值聚类步骤中集成了合并操作,为基于GMM的聚类提供初值,而且大大缩减了GMM聚类步骤的迭代次数,提高了输出结果的稳定性;然后,利用EM方法学习GMM,完成ML分类,将每个像素分配到最终类别中。实验结果表明,在分类精度可比甚至更高的情况下,与其他几种常见算法相比,该方法有效降低了分类算法的计算复杂度,减少了对计算资源的需求,易于移植到小型化、移动化设备上。

关键词： SAR海冰图像非监督分类 K-均值高斯混合模型

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