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Effects of leaf removal and cluster thinning on berry quality of Vitis vinifera cultivars in the region of Weibei Dryland in China

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Journal of Integrative Agriculture 2018年第7期17卷 1620-1630页

作者： SONG Chang-zheng WANG Chao XIE sha ZHANG Zhen-wen College of Enology Northwest A&F UniversityYangling 712100P.R.China shaanxi Engineering Research Center for Viti-Viniculture Yangling 712100P.R.China

Leaf removal and cluster thinning were carried out prior to veraison to evaluate the effects on berry quality of two Vitis vinifera cultivars（Cabernet Sauvignon and Ugni Blanc） in the Weibei Dryland of China in 2013 and 2014, and comprehensive analysis of the chemical and volatile composition in berries was performed. The results showed that content of reducing sugar in both varieties was not affected while total acid was generally decreased by leaf removal and cluster thinning. The pH of berry juice was correspondingly higher in most treatment groups. Meanwhile, promoting effects on accumulation of total phenols, tannin in both varieties and total anthocyanins in Cabernet Sauvignon were found. As for monomeric anthocyanins, percentage of malvidin and its derivatives was decreased by leaf removal and cluster thinning. Besides, cinnamylated anthocyanins decreased with the intensity of cluster thinning. The accumulation of non-anthocyanin phenolics was similarly affected in the two varieties. Notably, cluster thinning was more effective on enhancing the phenolics content than leaf removal. The combination of middle level of leaf removal and cluster thinning was the most favor to the accumulation of phenolic acids. Furthermore, cluster thinning could also significantly enhance the synthesis of flavanols and stilbenes. Lastly, content and variety of aroma compounds in both grape varieties were also significantly affected by the treatments. The results provided a theoretical basis for a combination of leaf removal and cluster thinning to improve quality of grapes and wines.

关键词： leaf removal cluster thinning wine grape quality comprehensive analysis

Lenvatinib combined with sintilimab plus transarterial chemoembolization as first-line treatment for advanced hepatocellular carcinoma

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World Journal of Clinical Cases 2024年第2期12卷 285-292页

作者： sha-sha Sun Xiao-Di Guo wen-Dong Li Jing-Long Chen Department of Oncology Capital Medical University Affiliated Beijing Ditan HospitalBeijing 100015China

BACKGROUND Recently,combination therapy has shown a better trend towards improved tumour response and survival outcomes than monotherapy in patients with hepatocellular carcinoma(HCC).However,research on triple therapy[lenvatinib+sintilimab+transarterial chemoembolization(TACE)]as a first-line treatment for advanced HCC is *** To evaluate the safety and efficacy of triple therapy as a first-line treatment for advanced *** HCC patients with Barcelona Clinic Liver Cancer stage C treated with triple therapy were *** patients were treated with lenvatinib every day and sintilimab once every 3 ***,TACE was performed every 4-6 wk if *** primary outcome of the study was overall survival(OS).The secondary outcomes were the objective response rate(ORR),disease control rate(DCR),and incidence of adverse *** Forty HCC patients who underwent triple therapy were retrospectively analysed from January 2019 to January *** a median follow-up of 8.5 months,the 3-,6-,and 12-mo OS rates were 100%,88.5%,and 22.5%,*** ORR and DCR were 45%and 90%,*** median progressive free survival and median OS were not *** complications were observed in 76%of the patients(grade 3,15%;grade 4,2.5%).CONCLUSION Combination therapy comprising lenvatinib,sintilimab and TACE achieved promising outcomes in advanced HCC patients and had manageable effects.

关键词： Lenvatinib Sintilimab Advanced hepatocellular carcinoma Combination therapy Tumor response

Rational distribution of Ru nanodots on 2D Ti_(3−x)C_(2)T_(y)/g-C_(3)N_(4)heterostructures for boosted photocatalytic H_(2)evolution

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Nano Research 2023年第5期16卷 6652-6660页

作者： wen-Jing Yi Xin Du Meng Zhang sha-sha Yi Rui-Hao Xia Chuan-Qi Li Yan Liu Zhong-Yi Liu wen-Lei Zhang Xin-Zheng Yue College of Chemistry Zhengzhou UniversityZhengzhou 450001China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China

Incorporating metal nanodots(NDs)into heterostructures for high charge separation and transfer capacities is one of the most effective strategies for improving their photocatalytic ***,controlling the space distribution of metal NDs for optimizing charge transport pathways remains a significant challenge,particularly in two-dimensional(2D)face-to-face ***,we develop a simple targeted self-reduction strategy for selectively loading Ru NDs onto the Ti_(3−x)C_(2)T_(y)(TC)surface of 2D TC/g-C_(3)N_(4)(CN)heterojunction based on the reductive Ti vacancy defects creatively increased during the preparation of TC/CN by reducing ***,the optimized Ru/TC/CN photocatalyst exhibits an outstanding H_(2)evolution rate of 3.21 mmol·g^(−1)·h^(−1)and a high apparent quantum efficiency of 30.9%at 380 nm,which is contributed by the unidirectional transfer of the photogenerated electrons from CN to Ru active sites(CN→TC→Ru)and the suppressed backflow of electrons from Ru sites to CN,as revealed by comprehensive characterizations and density functional theory(DFT)*** work provides a novel strategy for synthesizing the highly efficient photocatalysts with a controllable charge transfer paths,which will boost the development of photocatalysis.

关键词： Ru/Ti_(3−x)C_(2)T_(y)/g-C_(3)N_(4) targeted self-reduction strategy selective growth unidirectional electron migration photocatalytic H_(2)evolution

Theoretical and experimental study on high-entropy flotation of micro-fine cassiterite

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International Journal of Mining Science and Technology 2025年第1期35卷 19-39页

作者： Shuming wen Yongchao Miao Yanyu Tang Zhengyong Song Qicheng Feng State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization Faculty of Land Resource EngineeringKunming University of Science and TechnologyKunming 650093China

Tin is a critical metal for various industries,making its recovery from low-grade cassiterite ores *** study aimed to optimize the flotation recovery of cassiterite using multi-component collector *** collectors were initially selected through micro-flotation tests,leading to the identification of optimal proportions for a four-component collector system(sha-OHA-SPA-DBIA in a 4:3:2:1 ratio).Molecular dynamics simulations and surface tension tests were used to investigate the micellar behavior of these collectors in aqueous *** adsorption characteristics were quantified using microcalorimetry,enabling the determination of collection entropy and changes in Gibbs free *** four-component collector system showed the highest entropy change and the most favorable Gibbs free energy,leading to a cassiterite recovery of above 90%at a concentration of 8.0×10^(5)mol/*** analytical techniques were employed to systematically characterize the adsorption *** findings revealed a positive correlation between the adsorption products formed by the multicomponent collectors on the cassiterite surface and the entropy ***-scale testing of the high-entropy collector system produced a tin concentrate with an Sn grade of 6.17%and an Sn recovery of 82.43%,demonstrating its substantial potential for practical applications in cassiterite flotation.

关键词： High-entropy Flotation Cassiterite Adsorption Molecular dynamics QCM-D

L-type Calcium Channels are Involved in Iron-induced Neurotoxicity in Primary Cultured Ventral Mesencephalon Neurons of Rats

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Neuroscience Bulletin 2020年第2期36卷 165-173页

作者： Yu-Yu Xu wen-Ping Wan sha Zhao Ze-Gang Ma Department of Physiology School of Basic MedicineQingdao UniversityQingdao 266071China Institute of Brain Science and Disorders Qingdao UniversityQingdao 266071China

In the present study,we investigated the mechanisms underlying the mediation of iron transport by Ltype Ca^2+ channels(LTCCs)in primary cultured ventral mesencephalon(VM)neurons from *** found that cotreatment with 100 lmol/L FeSO4 and MPP^+(1-methyl-4-phenylpyridinium)significantly increased the production of intracellular reactive oxygen species,decreased the mitochondrial transmembrane potential and increased the caspase-3 activation compared to MPP^+ treatment ***-treatment with 500 lmol/L CaCl2 further aggravated the FeSO4-induced neurotoxicity in MPP^+-treated VM ***-treatment with 10 lmol/L isradipine,an LTCC blocker,alleviated the neurotoxicity induced by co-application of FeSO4 and FeSO4/*** studies indicated that MPP^+treatment accelerated the iron influx into VM *** addition,FeSO4 treatment significantly increased the intracellular Ca^2+ *** effects were blocked by *** results suggest that elevated extracellular Ca^2+ aggravates ironinduced *** mediate iron transport in dopaminergic neurons and this,in turn,results in elevated intracellular Ca^2+ and further aggravates iron-induced neurotoxicity.

关键词： L-type Ca^2+channels Iron overload Parkinson’s disease Isradipine Dopamine neuron

ANALYTICAL STUDY ON FLOW PROCESS OF FLOATING-OIL RECOVERY DEVICE FROM OIL-CONTAMINATED SEAWATER BY MHD METHOD

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Journal of Hydrodynamics 2007年第2期19卷 195-200页

作者： ZHANG Guo-yan PENG Yan ZHAO Ling-zhi LI Ran sha Ci-wen Institute of Electrical Engineering Chinese Academy of Sciences Beijing 100080 China

A new method of recovering maritime oil-spill based on electromagnetic force, the so-called MHD oil-spill recovery method was proposed in the IEECAS. The operating process of MHD channel was described in this article. Numerical study was carried out using a two-dimensional water-air two-phase model and the VOF method. The agreement between the numerical and the experimental results was reached.

关键词： numerical simulation water-air two phaseflow VOF method MHD

Distinguishable multi-substance detection based on three-channel NIR fluorescent probe in physiology and pathology of living cells and zebrafish

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Chinese Chemical Letters 2021年第12期32卷 3870-3875页

作者： sha Li Fangjun Huo Yongkang Yue Kaiqing Ma Ying wen Caixia Yin Institute of Molecular Science Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of EducationShanxi UniversityTaiyuan 030006China Research Institute of Applied Chemistry Shanxi UniversityTaiyuan 030006China

Mitochondria is the main organelle for the production of reactive sulfur species(RSS), such as homocysteine(Hcy), cysteine(Cys), glutathione(GSH) and sulfur dioxide(SO_(2)). These compounds participate in a large number of physiological processes and play an extremely important role in maintaining the balance of life systems. Abnormal concentration and metabolism are closely related to many diseases. Due to their similarities in chemical properties, it is challenging to develop a single fluorescent probe to distinguish them simultaneously. Here, we synthesized the probe PI-CO–NBD with three fluorophores, NBD-Cl and benzopyranate as the reaction sites of GSH/Cys/Hcy and SO_(2), respectively. Three biothiols all could cleavage ether bond to release benzopyrylium and coumarin moiety, which emitted red and blue fluorescence,but Cys/Hcy also could do intramolecular rearrangement after nucleophilic substitution, resulting in yellow fluorescence. Thus the probe can distinguish Cys/Hcy and GSH. Subsequently, only SO_(2)could quench red fluorescence by adding C=C of benzopyrylium. The probe also could localize well in mitochondria by oxonium ion for all kinds of cells. The probe not only could detect above sulfur-containing active substances of intracellular and extracellular but also monitor the level of them under oxidative stress and apoptosis process in living cells and zebrafish.

关键词： Mitochondrial-targeted Discrimination detection Distinguishable Multi-substance Three channels

Optimized postconditioning algorithm protects liver graft after liver transplantation in rats

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Hepatobiliary & Pancreatic Diseases International 2018年第1期17卷 32-38页

作者： Jian-Hui Li Jun-Jun Jia wen Shen sha-sha Chen Li Jiang Hai-Yang Xie Lin Zhou Shu-Sen Zheng Division of Hepatobiliary and Pancreatic Surgery Department of Surgery First Affiliated Hospital Zhejiang Univeristy School of Medicine Hangzhou 310003 China NHFPC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003 China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Hangzhou China Zhejiang Chinese Medical University Hangzhou 310053 China Department of Anesthesia First Affiliated Hospital Zhejiang Univeristy School of Medicine Hangzhou 310003 China

Background: Ischemia reperfusion injury(IRI) causes postoperative complications and influences the outcome of the patients undergoing liver surgery and transplantation. Postconditioning(Post C) is a known manual conditioning to decrease the hepatic IRI. Here we aimed to optimize the applicable Post C protocols and investigate the potential protective ***: Thirty Sprague–Dawley rats were randomly divided into 3 groups: the sham group(n = 5),standard orthotopic liver transplantation group(OLT, n = 5), Post C group(OLT followed by clamping and re-opening the portal vein for different time intervals, n = 20). Post C group was then subdivided into 4 groups according to the different time intervals:(10 s × 3, 10 s × 6, 30 s × 3, 60 s × 3, n = 5 in each subgroup). Liver function, histopathology, malondialdehyde(MDA), myeloperoxidase(MPO), expressions of p-Akt and endoplasmic reticulum stress(ERS) related genes were ***: Compared to the OLT group, the grafts subjected to Post C algorithm(without significant prolonging the total ischemic time) especially with short stimulus and more cycles(10 s × 6) showed significant alleviation of morphological damage and graft function. Besides, the production of reactive oxidative agents(MDA) and neutrophil infiltration(MPO) were significantly depressed by Post C algorithm. Most of ERS related genes were down-regulated by Post C(10 s × 6), especially ATF4, Casp12, hspa4, ATF6 and ELF2, while p-Akt was ***: Post C algorithm, especially 10 s × 6 algorithm, showed to be effective against rat liver graft IRI. These protective effects may be associated with its antioxidant, inhibition of ERS and activation of p-Akt expression of reperfusion injury salvage kinase pathway.

关键词： Liver transplantation Ischemia reperfusion injury Postconditioning

Re-recognition of the Effects of Phosphorus and Boron on the γ’’ and γ’ Phases in IN718 Alloy

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Acta Metallurgica Sinica(English Letters) 2019年第3期32卷 372-380页

作者： An-wen Zhang Yang Li sha Zhang Fang Liu Wei-Hong Zhang Lian-Xu Yu wen-Ru Sun Institute of Metal Research Chinese Academy of Sciences College of Material Science and Engineering University of Science and Technology of China

The effects of P and B on the matrix strength and precipitations of γ’ and γ’’ phases in the grain interior were re-recognized in this study. The combination addition of P and B markedly accelerated the precipitations of γ’ and γ’’ phases and strengthened the matrix of IN718 alloy when air-cooled from high temperature, while made no difference when waterquenched from high temperature. The effect of single addition of P on the precipitations of γ’’ and γ’ phases was the same with that of the combination addition of P and B, while the single addition of B had no effect on the precipitations of the two phases. Therefore, it was P rather than B which accelerated the precipitations of γ’ and γ’’ phases. P could take part in the precipitations of γ’ and γ’’ phases, which was revealed by electrochemical extraction and quantitative analysis of chemical composition. It also revealed that P atoms were dissolved in the c matrix to a relatively high degree at the temperature that γ’ and γ’’ phases began to precipitate, and consequently the precipitations of γ’ and γ’’ phases were accelerated. The first-principle calculation indicated that P decreased the formation enthalpies of γ’ and γ’’ phases when it occupied the Ni lattice sites in the two phases, which explained the effect of P on the γ’ and γ’’ phases.

关键词： IN718 superalloy Phosphorus and boron γ’’ and γ’phases Hardness