检索结果-南通市图书馆

Transarterial chemoembolization combined with radiofrequency ablation in the treatment of large hepatocellular carcinoma with stage C

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第33期10卷 12156-12163页

作者： sha-sha sun Wen-Dong Li Jing-Long Chen Department of Oncology Capital Medical University Affiliated Beijing Ditan HospitalBeijing 100015China

BACKGROUND The combination therapy of transarterial chemoembolization and radiofrequency ablation(TACE-RFA)shows promising efficacy in large hepatocellular carcinoma(HCC).Data on the clinical efficacy and safety of TACE-RFA for large HCC with barcelona clinic liver cancer(BCLC)stage C are lacking in *** To determine the safety and efficacy of TACE-RFA for large,advanced *** Patients of HCC with BCLC stage C who were treated with TACE-RFA or TACE alone at our institute from August 2008 to January 2017 were retrospectively *** complications were *** associations between overall survival(OS)and treatment method were *** Data were collected from 102 HCC *** them,64 underwent TACERFA and 38 underwent *** combination of TACE and RFA was *** complications were *** median OS in the TACE-RFA group was significantly longer than that in the TACE group(8.0 mo vs 4.0 mo,P=0.000).The 6-,12-and 24-mo survival rates of the combination group were 68.8%,34.4%,and 10.9%,respectively,while those of the TACE group were 36.8%,7.9%,and 0%(P<0.05).CONCLUSION TACE-RFA has an advantage over TACE alone in improving OS in large HCC patients with BCLC stage C.

关键词： Large advanced hepatocellular carcinoma Transarterial chemoembolization Radiofrequency ablation Overall survival Combination therapy

Lenvatinib combined with sintilimab plus transarterial chemoembolization as first-line treatment for advanced hepatocellular carcinoma

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第2期12卷 285-292页

作者： sha-sha sun Xiao-Di Guo Wen-Dong Li Jing-Long Chen Department of Oncology Capital Medical University Affiliated Beijing Ditan HospitalBeijing 100015China

BACKGROUND Recently,combination therapy has shown a better trend towards improved tumour response and survival outcomes than monotherapy in patients with hepatocellular carcinoma(HCC).However,research on triple therapy[lenvatinib+sintilimab+transarterial chemoembolization(TACE)]as a first-line treatment for advanced HCC is *** To evaluate the safety and efficacy of triple therapy as a first-line treatment for advanced *** HCC patients with Barcelona Clinic Liver Cancer stage C treated with triple therapy were *** patients were treated with lenvatinib every day and sintilimab once every 3 ***,TACE was performed every 4-6 wk if *** primary outcome of the study was overall survival(OS).The secondary outcomes were the objective response rate(ORR),disease control rate(DCR),and incidence of adverse *** Forty HCC patients who underwent triple therapy were retrospectively analysed from January 2019 to January *** a median follow-up of 8.5 months,the 3-,6-,and 12-mo OS rates were 100%,88.5%,and 22.5%,*** ORR and DCR were 45%and 90%,*** median progressive free survival and median OS were not *** complications were observed in 76%of the patients(grade 3,15%;grade 4,2.5%).CONCLUSION Combination therapy comprising lenvatinib,sintilimab and TACE achieved promising outcomes in advanced HCC patients and had manageable effects.

关键词： Lenvatinib Sintilimab Advanced hepatocellular carcinoma Combination therapy Tumor response

Aminopeptidase Play a Critical Role in the Accumulation of Free Amino Acids in Abalone(Haliotis discus hannai)During Cold Storage

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Ocean University of China 2023年第4期22卷 1049-1058页

作者： REN Qiuying WANG Yujia sun sha ZHANG Lingjing sun Lechang WENG Ling LIU Guangming CAO Minjie College of Marine Food and Biological Engineering Jimei UniversityXiamen 361021China Collaborative Innovation Center for Marine Food Deep Processing Dalian Polytechnic University Dalian 116034China

Abalones reveal unique taste after processing,mainly because of their abundant free amino acids(FAAs)and *** are nutrition components that can contribute to the unique ***,which factor(s)is responsible for the accumulation of FAAs still need further *** analyze the production of FAAs,we studied the variation of FAAs during 7 days of storage at 4℃.The content of taste-active amino acids,including Asp,Glu,Ser,and Gly increased by 1.7-fold,2.0-fold,3.0-fold,and 8.4-fold,*** relative activity of cathepsin L and aminopeptidase(AP)increased significantly during the cold storage *** identify AP in abalone and its function in mediating the production of FAAs,an aminopeptidase with wide substrate specificity was then extracted and purified from abalone muscle to *** AP with a molecular mass of 100 kDa exhibited its maximum activity at 30℃,pH 7.5,and was further confirmed by *** specifically inhibited the activity of AP,and metalloproteinase inhibitors EDTA,EGTA and 1,10-phenanthroline also suppressed its activity to different *** on its highest activity to substrate Leu-MCA and its peptide sequences,the purified enzyme was identified as leucine aminopeptidase(LAP).Our present study indicated the essential role of AP for FAAs accumulation during cold storage of abalone.

关键词： abalone aminopeptidase purification characterization taste endogenous protease texture

Toxicity of perfluorononanoic acid and perfluorooctane sulfonate to Daphnia magna

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Water Science and Engineering 2015年第1期8卷 40-48页

作者： Guang-hua Lu Jian-chao Liu Li-sha sun Lu-jin Yuan Key Laboratory of Integrated Regulation and Resources Development of shallow Lakes of Ministry of Education College of Environment Hohai University

In order to study toxicological effects of perfluorononanoic acid （PFNA）, perfluorooctane sulfonate （PFOS）, and their mixtures （PFNA/ PFOS） on Daphnia magna （D. magna）, a suite of comprehensive toxicity tests were conducted, including a 48-h acute toxicity test, a 21-day chronic test, a feeding experiment, and a biomarker assay. D. magna were exposed to aqueous solutions of PFNA and PFOS （alone and in combination） at concentrations ranging from 0.008 to 5 mg/L. The survival, growth, and reproduction of D. magna were monitored over a 21- day life cycle. The biomarkers, including acetylcholinesterase （ACHE）, superoxide dismutase （SOD）, and catalase （CAT） activities, were determined after seven days of exposure. PFOS was more toxic than PFNA based on the results of the acute toxicity test. Perfluorinated compounds （PFCs） inhibited both growth and reproduction of D. magna during the testing period. The ingestion rates and the biomarkers, including ACHE, SOD, and CAT activities, were significantly inhibited by PFCs in most cases. Moreover, the combined effects related to the growth and reproduction showed the antagonistic effects of PFCs.

关键词： Toxicity effect Perfluorononanoic acid Perfluorooctane sulfonate Daphnia magna Reproduction Ingestion rate Biomarker

Identification of endoplasmic reticulumshaping proteins in Plasmodium parasites

在线全文

学校读者我要写书评

暂无评论

Protein & Cell 2016年第8期7卷 615-620页

作者： sun, sha Lv, Li Yao, Zhi Bhanot, Purnima Hu, Junjie Wang, Qian Nankai Univ Coll Life Sci Dept Genet & Cell Biol Tianjin 300071 Peoples R China Tianjin Key Lab Prot Sci Tianjin 300071 Peoples R China Tianjin Med Univ Sch Basic Med Sci Dept Immunol Tianjin 300070 Peoples R China Tianjin Key Lab Cellular & Mol Immunol Tianjin 300070 Peoples R China Rutgers State Univ Rutgers New Jersey Med Sch Dept Microbiol & Mol Genet Newark NJ 07103 USA Chinese Acad Sci Inst Biophys Natl Lab Biomacromol Beijing 100101 Peoples R China

Dear Editor, In eukaryotic cells, the endoplasmic reticulum （ER） is a continuous membrane system involved in many cdtical cellular processes, including protein synthesis, lipid synthesis, and calcium storage. Morpho...

关键词：

Upper bound seismic rotational stability analysis of gravity retaining walls considering embedment depth

在线全文

学校读者我要写书评

暂无评论

Journal of Central South University 2015年第10期22卷 4083-4089页

作者：刘杰黄达杨超孙莎 School of Civil Engineering Chongqing University School of Civil Engineering Hebei University of Engineering Key Laboratory of New Technology for Construction of Cities in Mountain Area of Ministry of Education College of Aerospacing Engineering Chongqing University

Stability analysis of gravity retaining wall was currently based on the assumption that the wall had no embedment depth. The effect of earth berm was usually neglected. The present work highlighted the importance of embedment depth when assessing the seismic stability of gravity retaining walls with the pattern of pure rotation. In the framework of upper bound theorem of limit analysis, pseudo-static method was applied into two groups of parallel rigid soil slices methods in order to account for the effect of embedment depth on evaluating the critical acceleration of wall-soil system. The present analytical solution is identical to the results obtained from using limit equilibrium method, and the two methods are based on different theory backgrounds. Parameter analysis indicates that the critical acceleration increases slowly when the ratio of the embedment depth to the total height of the wall is from 0 to 0.15 and increases drastically when the ratio exceeds 0.15.

关键词： gravity retaining wall embedment depth seismic rotational stability upper bound analysis parallel rigid soil slices

Human atlastin GTPases mediate differentiated fusion of endoplasmic reticulum membranes

在线全文

学校读者我要写书评

暂无评论

Protein & Cell 2015年第4期6卷 307-311页

作者： Xiaoyu Hu (1) Fuyun Wu (1) sha sun (1) Wenying Yu (1) Junjie Hu (1) (2) 1.Tianjin Key Laboratory of Protein Sciences Department of Genetics and Cell Biology College of Life Sciences Nankai University Tianjin 300071 China 2.National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China

Dear Editor,In eukaryotic cells, the endoplasmic reticulum （ER） is a continuous membrane system with interconnected tubules and sheets. The formation of a typical network requires constant fusion between ER membranes.

关键词：

Dislocation Model and Morphology Simulation of bcc<->fcc Martensitic Transformation

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2000年第4期16卷 370-374页

作者： Xiumu ZHANG, Bin LI, Xianwei sha, Zongqi sun and Rong LI (Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110015, China) Institute of Metal Research Chinese Academy of Sciences Shenyang 110015 China

By using molecular dynamics computer simulation at atomic level, the effects of single dislocation and dipole dislocations on nucleation and growth of martensitic transformation have been studied. It was found that only the location of tension or compression stress fields of the dislocations are favorable for martensite nucleation in NiAl alloy and the dislocations can move to accommodate partly the transformation strain during the nucleation and growth of martensite. Combined with the molecular dynamics simulation, a two dimensional simulation for martensite morphology based on a dislocation model has been performed. Many factors related to martensitic transformation were considered, such as supercooling, interface energy, shear strain, normal strain and hydrostatic pressure. Different morphologies of martensites, similar to lath, lenticular, thin plate, couple-plate and lenticular couple-plate martensites observed in Fe-C and Fe-Ni-C alloys, were obtained.

关键词： fcc Martensitic Transformation Dislocation Model and Morphology Simulation of bcc Simulation

Angle Control Strategy for DNA Nanostructures with Large Molecular Weight

在线全文

学校读者我要写书评

暂无评论

Angle Control Strategy for DNA Nanostructures with Large Mol...